Talaporfin (BioDeep_00000771850)
代谢物信息卡片
Talaporfin
化学式: C38H41N5O9 (711.2904136000001)
中文名称: 他拉泊芬
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=C(C2=CC3=C(C(=C(N3)C=C4C(C(C(=N4)C(=C5C(=C(C(=N5)C=C1N2)C)C(=O)O)CC(=O)NC(CC(=O)O)C(=O)O)CCC(=O)O)C)C)C=C)C
InChI: InChI=1S/C38H41N5O9/c1-7-20-16(3)24-12-26-18(5)22(9-10-32(45)46)35(42-26)23(11-31(44)41-30(37(49)50)15-33(47)48)36-34(38(51)52)19(6)27(43-36)14-29-21(8-2)17(4)25(40-29)13-28(20)39-24/h7,12-14,18,22,30,39-40H,1,8-11,15H2,2-6H3,(H,41,44)(H,45,46)(H,47,48)(H,49,50)(H,51,52)/t18-,22-,30-/m0/s1
描述信息
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
D000970 - Antineoplastic Agents
C1420 - Photosensitizing Agent
D003879 - Dermatologic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:135875
- PubChem: 5486799
- DrugBank: DB11812
- ChEMBL: CHEMBL2111186
- CAS: 110230-98-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xing-Jie Zhang, Ming-Hui Liu, Yu-Sha Luo, Gui-Yan Han, Zhi-Qiang Ma, Fei Huang, Yuan Wang, Zhen-Yuan Miao, Wan-Nian Zhang, Chun-Quan Sheng, Jian-Zhong Yao. Novel dual-mode antitumor chlorin-based derivatives as potent photosensitizers and histone deacetylase inhibitors for photodynamic therapy and chemotherapy.
European journal of medicinal chemistry.
2021 May; 217(?):113363. doi:
10.1016/j.ejmech.2021.113363. [PMID: 33744687] - Takahiro Nishimura, Keisuke Hara, Norihiro Honda, Shigetoshi Okazaki, Hisanao Hazama, Kunio Awazu. Determination and analysis of singlet oxygen quantum yields of talaporfin sodium, protoporphyrin IX, and lipidated protoporphyrin IX using near-infrared luminescence spectroscopy.
Lasers in medical science.
2020 Aug; 35(6):1289-1297. doi:
10.1007/s10103-019-02907-0. [PMID: 31853809] - Toshiki Fuse, Tatsuaki Tagami, Masafumi Tane, Tetsuya Ozeki. Effective light-triggered contents release from helper lipid-incorporated liposomes co-encapsulating gemcitabine and a water-soluble photosensitizer.
International journal of pharmaceutics.
2018 Apr; 540(1-2):50-56. doi:
10.1016/j.ijpharm.2018.01.040. [PMID: 29410222] - Emiyu Ogawa, Tsunenori Arai. Development of a practical animal model of photodynamic therapy using a high concentration of extracellular talaporfin sodium in interstitial fluid: influence of albumin animal species on myocardial cell photocytotoxicity in vitro.
Lasers in medical science.
2017 Dec; 32(9):2105-2109. doi:
10.1007/s10103-017-2324-5. [PMID: 28980086] - Emiyu Ogawa, Hiromi Takenoya, Tsunenori Arai. Temperature Influence on Myocardial Cell Cytotoxicity of the Extracellular Photosensitization Reaction with Talaporfin Sodium and Serum Proteins at 17°-37°C.
Photomedicine and laser surgery.
2017 Oct; 35(10):555-559. doi:
10.1089/pho.2015.4052. [PMID: 28613976] - Risa Hamada, Emiyu Ogawa, Tsunenori Arai. Phototoxicity of Vascular Endothelial Cells Caused by Contact with Talaporfin Sodium for 15-120 Min: In Vitro and In Vivo Studies.
Photomedicine and laser surgery.
2017 Jun; 35(6):305-310. doi:
10.1089/pho.2016.4164. [PMID: 28437192] - Mariko Kurotsu, Masahiro Yajima, Mei Takahashi, Emiyu Ogawa, Tsunenori Arai. Evaluation of human and bovine serum albumin on oxidation characteristics by a photosensitization reaction under complete binding of talaporfin sodium.
Photodiagnosis and photodynamic therapy.
2015 Sep; 12(3):408-13. doi:
10.1016/j.pdpdt.2015.05.008. [PMID: 26072295] - E Ogawa, H Takenoya, A Ito, T Arai. Talaporfin sodium binding and photocytotoxicity of photosensitization reaction on myocardial cell under various albumin concentrations and temperature.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference.
2015 Aug; 2015(?):1295-8. doi:
10.1109/embc.2015.7318605. [PMID: 26736505] - M Takahashi, T Arai. Fluorescence sensing system by Soret-band LED light excitation for estimating relative talaporfin sodium concentration in skin.
Photodiagnosis and photodynamic therapy.
2014 Dec; 11(4):586-94. doi:
10.1016/j.pdpdt.2014.09.001. [PMID: 25220883] - David Kessel, Michael Price, Joseph Caruso, John Reiners. Effects of photodynamic therapy on the endocytic pathway.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2011 Apr; 10(4):491-8. doi:
10.1039/c0pp00276c. [PMID: 21125114] - Elizabeth Bromley, Brittany Briggs, Llew Keltner, Sy-Shi Wang. Characterization of cutaneous photosensitivity in healthy volunteers receiving talaporfin sodium.
Photodermatology, photoimmunology & photomedicine.
2011 Apr; 27(2):85-9. doi:
10.1111/j.1600-0781.2011.00573.x. [PMID: 21392111] - Andrew L Chan, Maya Juarez, Roblee Allen, William Volz, Timothy Albertson. Pharmacokinetics and clinical effects of mono-L-aspartyl chlorin e6 (NPe6) photodynamic therapy in adult patients with primary or secondary cancer of the skin and mucosal surfaces.
Photodermatology, photoimmunology & photomedicine.
2005 Apr; 21(2):72-8. doi:
10.1111/j.1600-0781.2005.00138.x. [PMID: 15752124] - Shigeru Tsukagoshi. [Development of a novel photosensitizer, talaporfin sodium, for the photodynamic therapy (PDT)].
Gan to kagaku ryoho. Cancer & chemotherapy.
2004 Jun; 31(6):979-85. doi:
". [PMID: 15222124] - Dariusz Biały, Arkadiusz Derkacz, Magdalena Wawrzyńska, Artur Bednarkiewicz, Piotr Ziółkowski, Halina Nowosad, Wiesław Strek. In vitro photodynamic diagnosis of atherosclerotic wall changes with the use of mono-l-aspartyl chlorin e6. A preliminary report.
Kardiologia polska.
2003 Oct; 59(10):293-301. doi:
". [PMID: 14618213] - K Saito, N Mikuniya, K Aizawa. Effects of photodynamic therapy using mono-L-aspartyl chlorin e6 on vessels and its contribution to the antitumor effect.
Japanese journal of cancer research : Gann.
2000 May; 91(5):560-5. doi:
10.1111/j.1349-7006.2000.tb00981.x. [PMID: 10835502] - I Sheyhedin, K Aizawa, M Araake, H Kumasaka, T Okunaka, H Kato. The effects of serum on cellular uptake and phototoxicity of mono-L-aspartyl chlorin e6 (NPe6) in vitro.
Photochemistry and photobiology.
1998 Jul; 68(1):110-4. doi:
10.1111/j.1751-1097.1998.tb03260.x. [PMID: 9679456] - D Kessel. Pharmacokinetics of N-aspartyl chlorin e6 in cancer patients.
Journal of photochemistry and photobiology. B, Biology.
1997 May; 39(1):81-3. doi:
10.1016/s1011-1344(96)00009-7. [PMID: 9210325] - K Aizawa, Y Kuroiwa, T Tsuchida, I Xiahedin, H Shibuya, K Saito. [Dynamics of photosensitizer in the cell].
Gan to kagaku ryoho. Cancer & chemotherapy.
1996 Jan; 23(1):22-6. doi:
NULL. [PMID: 8546464] - D Kessel. Interactions between N-aspartyl chlorin e6, detergent micelles and plasma lipoproteins.
Photochemistry and photobiology.
1995 Jun; 61(6):646-9. doi:
10.1111/j.1751-1097.1995.tb09882.x. [PMID: 7568411] - J D Spikes, J C Bommer. Photosensitizing properties of mono-L-aspartyl chlorin e6 (NPe6): a candidate sensitizer for the photodynamic therapy of tumors.
Journal of photochemistry and photobiology. B, Biology.
1993 Feb; 17(2):135-43. doi:
10.1016/1011-1344(93)80006-u. [PMID: 8459317] - D Kessel, K L Whitcomb, V Schulz. Lipoprotein-mediated distribution of N-aspartyl chlorin-E6 in the mouse.
Photochemistry and photobiology.
1992 Jul; 56(1):51-6. doi:
10.1111/j.1751-1097.1992.tb09601.x. [PMID: 1508982] - A Ferrario, D Kessel, C J Gomer. Metabolic properties and photosensitizing responsiveness of mono-L-aspartyl chlorin e6 in a mouse tumor model.
Cancer research.
1992 May; 52(10):2890-3. doi:
NULL. [PMID: 1581904] - C J Gomer, A Ferrario. Tissue distribution and photosensitizing properties of mono-L-aspartyl chlorin e6 in a mouse tumor model.
Cancer research.
1990 Jul; 50(13):3985-90. doi:
NULL. [PMID: 2354446] - D Kessel. Determinants of photosensitization by mono-L-aspartyl chlorin e6.
Photochemistry and photobiology.
1989 Apr; 49(4):447-52. doi:
10.1111/j.1751-1097.1989.tb09193.x. [PMID: 2727084]