Prucalopride Succinate (BioDeep_00000771832)
Antitumor activity
代谢物信息卡片
化学式: C22H32ClN3O7 (485.1928672)
中文名称: 琥珀酸普卡必利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
InChI: 1-2H2,(H,5,6)(H,7,8)
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
D005765 - Gastrointestinal Agents > D054368 - Laxatives
Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3][4].
同义名列表
3 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D10152
- PubChem: 9870009
- ChEMBL: CHEMBL2105748
- CAS: 179474-85-2
- medchemexpress: HY-12694
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Yun Wang, Xinyu Xu, Lin Lin. Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats.
International journal of molecular medicine.
2022 Jul; 50(1):. doi:
10.3892/ijmm.2022.5143. [PMID: 35543167] - Baoyan Liu, Jiani Wu, Shiyan Yan, Kehua Zhou, Liyun He, Jianqiao Fang, Wenbin Fu, Ning Li, Tongsheng Su, Jianhua Sun, Wei Zhang, Zenghui Yue, Hongxing Zhang, Jiping Zhao, Zhongyu Zhou, Hujie Song, Jian Wang, Li'an Liu, Linpeng Wang, Xiaoying Lv, Xiaofang Yang, Yan Liu, Yuanjie Sun, Yang Wang, Zongshi Qin, Jing Zhou, Zhishun Liu. Electroacupuncture vs Prucalopride for Severe Chronic Constipation: A Multicenter, Randomized, Controlled, Noninferiority Trial.
The American journal of gastroenterology.
2021 05; 116(5):1024-1035. doi:
10.14309/ajg.0000000000001050. [PMID: 33273258] - Tao Yang, Kaili Wang, Yibo Cao, Jianxia Wen, Shizhang Wei, Haotian Li, Xiangdong Yang, Tianbao Xiao. Different doses of prucalopride in treating chronic idiopathic constipation: a meta-analysis and Bayesian analysis.
BMJ open.
2021 02; 11(2):e039461. doi:
10.1136/bmjopen-2020-039461. [PMID: 33589446] - Ziye Zhou, Chenxiang Wang, Xuyong Zheng, Xuben Yu, Chao Yu, Dongchuan Zhang, Yan Xia, Huafang Chen, Xiaoxiao Huang, Xiuhua Zhang. Pharmacokinetics, Bioequivalence, and Safety Studies of Prucalopride in Healthy Chinese Subjects.
Clinical pharmacology in drug development.
2020 08; 9(6):671-676. doi:
10.1002/cpdd.754. [PMID: 31797570] - Kelly Conlon, Joris H De Maeyer, Chris Bruce, Jan A J Schuurkes, Lee Christie, James McRedmond, Katayoun Derakhchan, Paul R Wade. Nonclinical Cardiovascular Studies of Prucalopride, a Highly Selective 5-Hydroxytryptamine 4 Receptor Agonist.
The Journal of pharmacology and experimental therapeutics.
2018 02; 364(2):156-169. doi:
10.1124/jpet.117.244079. [PMID: 29180358] - Lihua Zuo, Zhi Sun, Zhenhui Wang, Shuzhang Du, Xiangzhen Kong, Lifeng Li, Jie Yang, Jian Kang, Xiaojian Zhang. Pharmacokinetics and tissue distribution study of prucalopride in rats by ultra high performance liquid chromatography with tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2016 Nov; 131(?):246-255. doi:
10.1016/j.jpba.2016.08.030. [PMID: 27611096] - Zhi Sun, Lihua Zuo, Jian Kang, Lin Zhou, Mengmeng Jia, Zeyun Li, Zhiheng Yang, Xiaojian Zhang, Zhenfeng Zhu. Development and validation of a sensitive UHPLC-MS/MS method for quantitation of prucalopride in rat plasma and its application to pharmacokinetics study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Oct; 1033-1034(?):328-333. doi:
10.1016/j.jchromb.2016.09.006. [PMID: 27614256] - Stephen Flach, Graeme Scarfe, Jeffrey Dragone, Jie Ding, Mark Seymour, Mike Pennick, Todd Pankratz, Steven Troy, Jay Getsy. A Phase I Study to Investigate the Absorption, Pharmacokinetics, and Excretion of [(14)C]Prucalopride After a Single Oral Dose in Healthy Volunteers.
Clinical therapeutics.
2016 Sep; 38(9):2106-15. doi:
10.1016/j.clinthera.2016.08.003. [PMID: 27614912] - J Broad, V W S Kung, G Boundouki, Q Aziz, J H De Maeyer, C H Knowles, G J Sanger. Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility.
British journal of pharmacology.
2013 Nov; 170(6):1253-61. doi:
10.1111/bph.12397. [PMID: 24032987] - Harland S Winter, Carlo Di Lorenzo, Marc A Benninga, Mark A Gilger, Gregory L Kearns, Paul E Hyman, Lieve Vandeplassche, Jannie Ausma, Mieke Hoppenbrouwers. Oral prucalopride in children with functional constipation.
Journal of pediatric gastroenterology and nutrition.
2013 Aug; 57(2):197-203. doi:
10.1097/mpg.0b013e318292f9ea. [PMID: 23535761] - Ramakrishna Nirogi, Vishwottam Kandikere, Gopinadh Bhyrapuneni, Ramanatha Saralaya, Devender Reddy Ajjala, Raghupathi Reddy Aleti, Mohammed Abdul Rasheed. In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145.
The Journal of pharmacy and pharmacology.
2013 May; 65(5):704-12. doi:
10.1111/jphp.12030. [PMID: 23600388] - Vera Van de Velde, Lieve Vandeplassche, Mieke Hoppenbrouwers, Mark Boterman, Jannie Ausma. Effect of prucalopride on the pharmacokinetics of oral contraceptives in healthy women.
Drugs in R&D.
2013 Mar; 13(1):43-51. doi:
10.1007/s40268-013-0008-6. [PMID: 23539257] - Xia Chen, Ji Jiang, Tao Liu, Hongzhong Liu, Wen Zhong, Pei Hu. Pharmacokinetics of single and repeated oral doses prucalopride in healthy Chinese volunteers.
International journal of clinical pharmacology and therapeutics.
2012 Nov; 50(11):797-804. doi:
10.5414/cp201769. [PMID: 22943932] - David E Johnson, Elena Drummond, Sarah Grimwood, Aarti Sawant-Basak, Emily Miller, Elaine Tseng, Laura L McDowell, Michelle A Vanase-Frawley, Katherine E Fisher, David M Rubitski, Kim J Stutzman-Engwall, Robin T Nelson, Weldon E Horner, Roxanne R Gorczyca, Mihaly Hajos, Chester J Siok. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations.
The Journal of pharmacology and experimental therapeutics.
2012 Jun; 341(3):681-91. doi:
10.1124/jpet.112.192351. [PMID: 22408061] - William B Smith, Erik Mannaert, Tom Verhaeghe, René Kerstens, Lieve Vandeplassche, Vera Van de Velde. Effect of renal impairment on the pharmacokinetics of prucalopride: a single- dose open-label Phase I study.
Drug design, development and therapy.
2012; 6(?):407-15. doi:
10.2147/dddt.s36142. [PMID: 23269861] - M Camilleri, G Beyens, R Kerstens, P Robinson, L Vandeplassche. Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2009 Dec; 21(12):1256-e117. doi:
10.1111/j.1365-2982.2009.01398.x. [PMID: 19751247] - Hugh Chapman, Michael Pasternack. The action of the novel gastrointestinal prokinetic prucalopride on the HERG K+ channel and the common T897 polymorph.
European journal of pharmacology.
2007 Jan; 554(2-3):98-105. doi:
10.1016/j.ejphar.2006.10.019. [PMID: 17109852] - A M P De Schryver, G I Andriesse, M Samsom, A J P M Smout, H G Gooszen, L M A Akkermans. The effects of the specific 5HT(4) receptor agonist, prucalopride, on colonic motility in healthy volunteers.
Alimentary pharmacology & therapeutics.
2002 Mar; 16(3):603-12. doi:
10.1046/j.1365-2036.2002.01195.x. [PMID: 11876716]