AeroBid (BioDeep_00000771570)
代谢物信息卡片
FLUNISOLIDE
化学式: C48H64F2O13 (886.4314757999999)
中文名称: 氟尼缩松
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)F)C.CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)F)C.O
InChI: /m00./s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents
D000893 - Anti-Inflammatory Agents
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ahmad Kantar, Salman Mroueh, Alessandro Fiocchi. A reappraisal of the clinical efficacy of nebulized flunisolide in pediatric asthma: the Italian experience.
Allergy and asthma proceedings.
2007 Nov; 28(6):671-87. doi:
10.2500/aap.2007.28.2979. [PMID: 17883883] - Carol R Reinero, Lisa Brownlee, Kendra C Decile, Bernard Seguin, Roy D Berghaus, Richard W Nelson, Laurel J Gershwin. Inhaled flunisolide suppresses the hypothalamic-pituitary-adrenocortical axis, but has minimal systemic immune effects in healthy cats.
Journal of veterinary internal medicine.
2006 Jan; 20(1):57-64. doi:
10.1892/0891-6640(2006)20[57:ifstha]2.0.co;2. [PMID: 16496924] - Carol R Reinero, Kendra C Decile, Jenni R Byerly, Roy D Berghaus, William E Walby, Londa J Berghaus, Dallas M Hyde, Edward S Schelegle, Laurel J Gershwin. Effects of drug treatment on inflammation and hyperreactivity of airways and on immune variables in cats with experimentally induced asthma.
American journal of veterinary research.
2005 Jul; 66(7):1121-7. doi:
10.2460/ajvr.2005.66.1121. [PMID: 16111148] - Arno Nolting, Wattanaporn Abramowitz. Multiple-dose proportionality study of flunisolide hydrofluoroalkane.
Allergy and asthma proceedings.
2002 Sep; 23(5):311-8. doi:
NULL. [PMID: 12476540] - Richard J Martin, Stanley J Szefler, Vernon M Chinchilli, Monica Kraft, Myrna Dolovich, Homer A Boushey, Reuben M Cherniack, Timothy J Craig, Jeffrey M Drazen, Joanne K Fagan, John V Fahy, James E Fish, Jean G Ford, Elliott Israel, Susan J Kunselman, Stephen C Lazarus, Robert F Lemanske, Stephen P Peters, Christine A Sorkness. Systemic effect comparisons of six inhaled corticosteroid preparations.
American journal of respiratory and critical care medicine.
2002 May; 165(10):1377-83. doi:
10.1164/rccm.2105013. [PMID: 12016099] - Harold S Nelson, Wes Stricker, Thomas B Casale, Hershel Raff, Jon A Fourré, David C Aron, Kenneth B Newman. A comparison of methods for assessing hypothalamic-pituitary-adrenal (HPA) axis activity in asthma patients treated with inhaled corticosteroids.
Journal of clinical pharmacology.
2002 Mar; 42(3):319-26. doi:
10.1177/00912700222011355. [PMID: 11865969] - Arno Nolting, Suryanarayana Sista, Wattanaporn Abramowitz. Single-dose study to compare the pharmacokinetics of HFA flunisolide and CFC flunisolide.
Journal of pharmaceutical sciences.
2002 Feb; 91(2):424-32. doi:
10.1002/jps.10030. [PMID: 11835202] - A Nolting, S Sista, W Abramowitz. Flunisolide HFA vs flunisolide CFC: pharmacokinetic comparison in healthy volunteers.
Biopharmaceutics & drug disposition.
2001 Dec; 22(9):373-82. doi:
10.1002/bdd.274. [PMID: 11870676] - B I Florea, I C van der Sandt, S M Schrier, K Kooiman, K Deryckere, A G de Boer, H E Junginger, G Borchard. Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3).
British journal of pharmacology.
2001 Dec; 134(7):1555-63. doi:
10.1038/sj.bjp.0704390. [PMID: 11724763] - T B Casale, H S Nelson, W E Stricker, H Raff, K B Newman. Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patients.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2001 Nov; 87(5):379-85. doi:
10.1016/s1081-1206(10)62918-3. [PMID: 11730179] - J Richards, P Hirst, G Pitcairn, S Mahashabde, W Abramowitz, A Nolting, S P Newman. Deposition and pharmacokinetics of flunisolide delivered from pressurized inhalers containing non-CFC and CFC propellants.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.
2001; 14(2):197-208. doi:
10.1089/08942680152484126. [PMID: 11681651] - T B Kaye. Effect of an inhaled glucocorticoid, flunisolide, on bone mineral density: a 2-year prospective, controlled trial.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2000 Jul; 6(4):311-7. doi:
10.4158/ep.6.4.311. [PMID: 11242608] - N Esmailpour, P Högger, P Rohdewald. Binding of glucocorticoids to human nasal tissue in vitro.
International archives of allergy and immunology.
2000 Jun; 122(2):151-4. doi:
10.1159/000024371. [PMID: 10878494] - G R Dickens, D P Wermeling, C J Matheny, W John, W Abramowitz, S M Sista, T Foster, S Choudhury. Pharmacokinetics of flunisolide administered via metered dose inhaler with and without a spacer device and following oral administration.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2000 May; 84(5):528-32. doi:
10.1016/s1081-1206(10)62517-3. [PMID: 10831007] - R Brus. Effects of high-dose inhaled corticosteroids on plasma cortisol concentrations in healthy adults.
Archives of internal medicine.
1999 Sep; 159(16):1903-8. doi:
10.1001/archinte.159.16.1903. [PMID: 10493320] - O M Hauache, E C Amarante, J G Vieira, S M Faresin, A L Fernandes, J R Jardim, M Lazaretti-Castro. Evaluation of bone metabolism after the use of an inhaled glucocorticoid (flunisolide) in patients with moderate asthma.
Clinical endocrinology.
1999 Jul; 51(1):35-9. doi:
10.1046/j.1365-2265.1999.00658.x. [PMID: 10468963] - C A Sorkness, C LaForce, W Storms, W R Lincourt, L Edwards, P R Rogenes. Effects of the inhaled corticosteroids fluticasone propionate, triamcinolone acetonide, and flunisolide and oral prednisone on the hypothalamic-pituitary-adrenal axis in adult patients with asthma.
Clinical therapeutics.
1999 Feb; 21(2):353-67. doi:
10.1016/s0149-2918(00)88292-2. [PMID: 10211538] - M Bernareggi, S Radice, G Rossoni, G Oriani, E Chiesara, F Berti. Hyperbaric oxygen increases plasma exudation in rat trachea: involvement of nitric oxide.
British journal of pharmacology.
1999 Feb; 126(3):794-800. doi:
10.1038/sj.bjp.0702354. [PMID: 10188993] - A M Wilson, L C McFarlane, B J Lipworth. Effects of low and high doses of inhaled flunisolide and triamcinolone acetonide on basal and dynamic measures of adrenocortical activity in healthy volunteers.
The Journal of clinical endocrinology and metabolism.
1998 Mar; 83(3):922-5. doi:
10.1210/jcem.83.3.4637. [PMID: 9506749] - H Möllmann, H Derendorf, J Barth, B Meibohm, M Wagner, M Krieg, H Weisser, J Knöller, A Möllmann, G Hochhaus. Pharmacokinetic/pharmacodynamic evaluation of systemic effects of flunisolide after inhalation.
Journal of clinical pharmacology.
1997 Oct; 37(10):893-903. doi:
10.1002/j.1552-4604.1997.tb04263.x. [PMID: 9505980] - S Rauli, M Del Puppo, L De Angelis, M Galli Kienle. [Determination of flunisolide and its principal hydrolytic metabolite in urine and plasma by LC-NICI-MS with a particle beam interface].
Bollettino chimico farmaceutico.
1997 Apr; 136(4):308-15. doi:
NULL. [PMID: 9312218] - R L ZuWallack, J P Rosen, L Cohen, G S Rachelefsky, H Gong, A B Goldsobel, M A Kaliner, M V White, E A Bronsky, P Chervinsky, G Z Lotner, J Corren, S Bodenheimer. The effectiveness of once-daily dosing of inhaled flunisolide in maintaining asthma control.
The Journal of allergy and clinical immunology.
1997 Mar; 99(3):278-85. doi:
10.1016/s0091-6749(97)70043-5. [PMID: 9058681] - L G Sensi, A Seri, A Siracusa, L Pertici, F Marcucci. Allergic rhinitis in children: effects of flunisolide and disodium cromoglycate on nasal eosinophil cationic protein.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1997 Mar; 27(3):270-6. doi:
. [PMID: 9088653] - R H Brus, S Bodenheimer. High-dose inhaled steroids in asthmatic children.
Lancet (London, England).
1996 Sep; 348(9030):820-1; author reply 821. doi:
10.1016/s0140-6736(05)65235-x. [PMID: 8813997] - Z Siergiejko, Z Zietkowski, S Chyrek-Borowska. [Effect of flunisolide on exacerbation of clinical symptoms, spirometric parameters, consumption of B2-adrenergic drugs and levels of cortisol and ECP in serum of patients with bronchial asthma].
Pneumonologia i alergologia polska.
1995; 63 Suppl 2(?):76-82. doi:
. [PMID: 8640152] - R Paganelli, I Quinti, A di Sabatino, G P d'Offizi, E Scala, P Meglio, F Aiuti. Topical flunisolide treatment of perennial rhinitis: clinical and immunological effects.
Allergologia et immunopathologia.
1992 May; 20(3):124-6. doi:
. [PMID: 1414859] - R Paganelli, I Quinti, A di Sabatino, G P d'Offizi, E Scala, P Meglio, F Aiuti. Topical flunisolide treatment of perennial rhinitis: clinical and immunological effects.
Allergologia et immunopathologia.
1991 Sep; 19(5):194-6. doi:
. [PMID: 1811415] - G L Piacentini, L Sette, D G Peroni, C Bonizzato, S Bonetti, A L Boner. Double-blind evaluation of effectiveness and safety of flunisolide aerosol for treatment of bronchial asthma in children.
Allergy.
1990 Nov; 45(8):612-6. doi:
10.1111/j.1398-9995.1990.tb00947.x. [PMID: 2288396] - P C Turkeltaub, P S Norman, J D Johnson, S Crepea. Treatment of seasonal and perennial rhinitis with intranasal flunisolide.
Allergy.
1982 Jul; 37(5):303-11. doi:
10.1111/j.1398-9995.1982.tb01916.x. [PMID: 6812449] - R V Tomlinson, R Runkel, M D Chaplin, L Bowen, J Kanagy, N Chu. In vitro studies on the binding of cloprednol to human plasma proteins.
Journal of steroid biochemistry.
1982 Jan; 16(1):75-80. doi:
10.1016/0022-4731(82)90146-7. [PMID: 7062742] - J H Toogood, B Jennings, S B Crepea, J D Johnson. Efficacy of safety of concurrent use of intranasal flunisolide and oral beclomethasone aerosols in treatment of asthmatics with rhinitis.
Clinical allergy.
1982 Jan; 12(1):95-105. doi:
10.1111/j.1365-2222.1982.tb03131.x. [PMID: 7067071] - S L Rusnak. Concurrent administration of flunisolide nasal solution with beclomethasone dipropionate bronchial aerosol in patients with both rhinitis and asthma.
Annals of allergy.
1981 Nov; 47(5 Pt 1):320-4. doi:
NULL. [PMID: 7032370] - C Nerenberg, S B Matin. Radioimmunoassay of flunisolide in human plasma.
Journal of pharmaceutical sciences.
1981 Aug; 70(8):900-4. doi:
10.1002/jps.2600700817. [PMID: 7310659] - P J Teitelbaum, N I Chu, D Cho, L Tökés, J W Patterson, P J Wagner, M D Chaplin. Mechanism for the oxidative defluorination of flunisolide.
The Journal of pharmacology and experimental therapeutics.
1981 Jul; 218(1):16-22. doi:
. [PMID: 7241375] - D E Clayton, J B Kooistra, M Geller, J Ouellette, M Cohen, C E Reed, W Busse. Short-term efficacy trial and twenty-four-month follow-up of flunisolide nasal spray in the treatment of perennial rhinitis.
The Journal of allergy and clinical immunology.
1981 Jan; 67(1):2-7. doi:
10.1016/0091-6749(81)90037-3. [PMID: 7005293] - S H Leech, B S Rolston, A E Izu. Episodic asthma as a bronchial provocation test.
Annals of allergy.
1980 Nov; 45(5):288-93. doi:
. [PMID: 7001961] - R G Slavin, A E Izu, I L Bernstein, M N Blumenthal, J F Bolin, J J Ouellette, C E Reed, J Oren. Multicenter study of flunisolide aerosol in adult patients with steroid-dependent asthma.
The Journal of allergy and clinical immunology.
1980 Nov; 66(5):379-85. doi:
10.1016/0091-6749(80)90117-7. [PMID: 7440855] - A E Gale, E Solomon, B S Tao. Intranasal topical flunisolide therapy in children with seasonal allergic rhinitis.
Clinical allergy.
1980 Sep; 10(5):527-33. doi:
10.1111/j.1365-2222.1980.tb02133.x. [PMID: 7438413] - G E Pakes, R N Brogden, R D Heel, T M Speight, G S Avery. Flunisolide: a review of its pharmacological properties and therapeutic efficacy in rhinitis.
Drugs.
1980 Jun; 19(6):397-411. doi:
10.2165/00003495-198019060-00001. [PMID: 6771116] - M D Chaplin, W C Cooper, E J Segre, J Oren, R E Jones, C Nerenberg. Correlation of flunisolide plasma levels to eosinopenic response in humans.
The Journal of allergy and clinical immunology.
1980 Jun; 65(6):445-453. doi:
10.1016/0091-6749(80)90238-9. [PMID: 7372965] - M D Chaplin, W Rooks, E W Swenson, W C Cooper, C Nerenberg, N I Chu. Flunisolide metabolism and dynamics of a metabolite.
Clinical pharmacology and therapeutics.
1980 Mar; 27(3):402-13. doi:
10.1038/clpt.1980.54. [PMID: 7357797] - M K McAllen, P R Portillo, E J Parr, A Seaton, C Engler. Intranasal flunisolide, placebo and beclomethasone dipropionate in perennial rhinitis.
British journal of diseases of the chest.
1980 Jan; 74(1):32-6. doi:
10.1016/0007-0971(80)90005-4. [PMID: 6986896] - G Incaudo, M Schatz, F Yamamoto, M Mellon, S Crepea, J D Johnson. Intranasal flunisolide in the treatment of perennial rhinitis: Correlation with immunologic parameters.
The Journal of allergy and clinical immunology.
1980 Jan; 65(1):41-9. doi:
10.1016/0091-6749(80)90175-x. [PMID: 7350203] - R K Sy. Flunisolide intranasal spray in the treatment of perennial rhinitis.
Archives of otolaryngology (Chicago, Ill. : 1960).
1979 Nov; 105(11):649-53. doi:
10.1001/archotol.1979.00790230019004. [PMID: 387010] - L M Jones, S L Spector, G M English, K Taylor-Dawson. Treatment of perennial rhinitis with flunisolide corticosteroid spray.
Annals of allergy.
1979 Mar; 42(3):139-44. doi:
. [PMID: 106747] - N I Chu, B A Amos, L Tökés, M L Maddox, S B Matin, K M Hama, J W Patterson, P J Wagner, J P Bell, M D Chaplin. Disposition of flunisolide in the rat, mouse, dog, rhesus monkey, and cynomolgus monkey.
Drug metabolism and disposition: the biological fate of chemicals.
1979 Mar; 7(2):81-9. doi:
NULL. [PMID: 38078] - D R Webb, M F Mullarkey, M I Freeman. Flunisolide in chronic bronchial asthma.
Annals of allergy.
1979 Feb; 42(2):80-2. doi:
NULL. [PMID: 420422] - J D Horan, J D Johnson. Flunisolide nasal spray in the treatment of perennial rhinitis.
Canadian Medical Association journal.
1978 Aug; 119(4):334-8. doi:
. [PMID: 356948] - J I Schulz, J D Johnson, S O Freedman. Double-blind trial comparing flunisolide and placebo for the treatment of perennial rhinitis.
Clinical allergy.
1978 Jul; 8(4):313-20. doi:
10.1111/j.1365-2222.1978.tb00466.x. [PMID: 361281] - P C Turkeltaub, P S Norman, S Crepea. Treatment of ragweed hay fever with an intranasal spray containing fluinsolide, a new synthetic corticosteroid.
The Journal of allergy and clinical immunology.
1976 Nov; 58(5):597-606. doi:
10.1016/0091-6749(76)90206-2. [PMID: 789436]