Ramosetron (BioDeep_00000771298)
代谢物信息卡片
化学式: C17H17N3O (279.1371552)
中文名称: 拉莫司琼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C=C(C2=CC=CC=C21)C(=O)C3CCC4=C(C3)NC=N4
InChI: InChI=1S/C17H17N3O/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14/h2-5,9-11H,6-8H2,1H3,(H,18,19)/t11-/m1/s1
描述信息
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D002491 - Central Nervous System Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:135156
- KEGGdrug: D08466
- PubChem: 108000
- DrugBank: DB09290
- ChEMBL: CHEMBL1643895
- CAS: 132036-88-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Mitsuhiro Goda, Masaya Kanda, Toshihiko Yoshioka, Ami Yoshida, Yoichi Murai, Yoshito Zamami, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Masayuki Chuma, Yuki Izawa-Ishizawa, Keisuke Ishizawa. Effects of 5-HT₃ receptor antagonists on cisplatin-induced kidney injury.
Clinical and translational science.
2021 09; 14(5):1906-1916. doi:
10.1111/cts.13045
. [PMID: 33982438] - Seong Heon Lee, Soo Young Cho, Kyung Yeon Yoo, Seongwook Jeong. Population pharmacokinetics of ramosetron.
Journal of pharmacokinetics and pharmacodynamics.
2016 Feb; 43(1):73-83. doi:
10.1007/s10928-015-9455-8
. [PMID: 26558626] - Shin Fukudo, Motoko Ida, Hiraku Akiho, Yoshihiro Nakashima, Kei Matsueda. Effect of ramosetron on stool consistency in male patients with irritable bowel syndrome with diarrhea.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2014 Jun; 12(6):953-9.e4. doi:
10.1016/j.cgh.2013.11.024
. [PMID: 24315882] - Madhusudan Grover, Michael Camilleri. Ramosetron in irritable bowel syndrome with diarrhea: new hope or the same old story?.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2014 Jun; 12(6):960-2. doi:
10.1016/j.cgh.2013.12.025
. [PMID: 24393804] - Toshiro Niwa, Sachiko Yamamoto, Miho Saito, Naoto Kobayashi, Kaoru Ikeda, Yasuo Noda, Akira Takagi. Effects of serotonin-3 receptor antagonists on cytochrome P450 activities in human liver microsomes.
Biological & pharmaceutical bulletin.
2006 Sep; 29(9):1931-5. doi:
10.1248/bpb.29.1931
. [PMID: 16946512] - R Yahagi, Y Machida, H Onishi. Mucoadhesive suppositories of ramosetron hydrochloride utilizing Carbopol.
International journal of pharmaceutics.
2000 Jan; 193(2):205-12. doi:
10.1016/s0378-5173(99)00338-5
. [PMID: 10606783] - S Matsumoto, Y Kawasaki, M Mikami, M Nakamoto, H Tokuyasu, Y Kometani, H Chikumi, Y Hitsuda, Y Matsumoto, T Sasaki. [Relationship between cancer chemotherapeutic drug-induced delayed emesis and plasma levels of substance P in two patients with small cell lung cancer].
Gan to kagaku ryoho. Cancer & chemotherapy.
1999 Mar; 26(4):535-8. doi:
NULL
. [PMID: 10097753] - H Tabata, T Matsuzawa, T Hanada, A Ishikawa, M Yamada, H Ozaki, N Izumisawa, M H Barker, R A Cox, D P Buist. Acute, subacute and chronic oral toxicity studies of the new serotonin (5-HT)3-receptor antagonist ramosetron in beagle dogs.
Arzneimittel-Forschung.
1995 Jul; 45(7):760-6. doi:
NULL
. [PMID: 8573218] - H Miura, T Takeshige, S Kobayashi, S Higuchi. A simple method for the determination of YM060 in plasma and urine by high performance liquid chromatography.
Biomedical chromatography : BMC.
1994 Mar; 8(2):103-4. doi:
10.1002/bmc.1130080212
. [PMID: 8044021]