temocillin (BioDeep_00000770279)
代谢物信息卡片
temocillin
化学式: C16H18N2O7S2 (414.05553979999996)
中文名称: 替莫西林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(N2C(S1)C(C2=O)(NC(=O)C(C3=CSC=C3)C(=O)O)OC)C(=O)O)C
InChI: InChI=1S/C16H18N2O7S2/c1-15(2)9(12(22)23)18-13(24)16(25-3,14(18)27-15)17-10(19)8(11(20)21)7-4-5-26-6-7/h4-6,8-9,14H,1-3H3,(H,17,19)(H,20,21)(H,22,23)/t8?,9-,14+,16-/m0/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:51817
- KEGGdrug: D06064
- PubChem: 171758
- DrugBank: DB12343
- ChEMBL: CHEMBL1276310
- CAS: 66148-78-5
- MetaboLights: MTBLC51817
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- N Layios, C Visée, V Mistretta, R Denooz, N Maes, J Descy, F Frippiat, S Marchand, N Grégoire. Modelled Target Attainment after Temocillin Treatment in Severe Pneumonia: Systemic and Epithelial Lining Fluid Pharmacokinetics of Continuous versus Intermittent Infusions.
Antimicrobial agents and chemotherapy.
2022 03; 66(3):e0205221. doi:
10.1128/aac.02052-21. [PMID: 35099273] - Charlotta Edlund, Anders Ternhag, Gunilla Skoog Ståhlgren, Petra Edquist, Åse Östholm Balkhed, Simon Athlin, Emeli Månsson, Maria Tempé, Jakob Bergström, Christian G Giske, Håkan Hanberger. The clinical and microbiological efficacy of temocillin versus cefotaxime in adults with febrile urinary tract infection, and its effects on the intestinal microbiota: a randomised multicentre clinical trial in Sweden.
The Lancet. Infectious diseases.
2022 03; 22(3):390-400. doi:
10.1016/s1473-3099(21)00407-2. [PMID: 34756180] - Tristan Delory, Simon Gravier, Diane Le Pluart, Géraldine Gaube, Soline Simeon, Benjamin Davido, Emilie Piet, Raphaël Lepeule, Philippe Lesprit, Matthieu Lafaurie. Temocillin versus carbapenems for urinary tract infection due to ESBL-producing Enterobacteriaceae: a multicenter matched case-control study.
International journal of antimicrobial agents.
2021 Jul; 58(1):106361. doi:
10.1016/j.ijantimicag.2021.106361. [PMID: 34000372] - Rachel Chenouard, Rafael Mahieu, David Luque Paz, Estelle Marion, Matthieu Eveillard, Vincent Dubée. Impact of ceftriaxone and temocillin on fecal abundance of extended-spectrum β-lactamase producing Escherichia coli in a mouse model.
PloS one.
2021; 16(3):e0248177. doi:
10.1371/journal.pone.0248177. [PMID: 33690674] - Guillaume Dumangin, Matthieu Brenkman, Elise Pape, Allan Kolodziej, Nicolas Gambier, Isabelle Vrillon, Alexandre Charmillon, Julien Scala-Bertola. Temocillin dosage adjustment in a preterm infant with severe renal disease: a case report.
The Journal of antimicrobial chemotherapy.
2020 12; 75(12):3652-3655. doi:
10.1093/jac/dkaa356. [PMID: 32814946] - Peter Matzneller, Perrin Ngougni Pokem, Arnaud Capron, Edith Lackner, Beatrix Wulkersdorfer, Alina Nussbaumer-Pröll, Zoe Österreicher, Michael Duchek, Sebastien Van de Velde, Pierre E Wallemacq, Johan W Mouton, Françoise Van Bambeke, Markus Zeitlinger. Single-dose pharmacokinetics of temocillin in plasma and soft tissues of healthy volunteers after intravenous and subcutaneous administration: a randomized crossover microdialysis trial.
The Journal of antimicrobial chemotherapy.
2020 09; 75(9):2650-2656. doi:
10.1093/jac/dkaa176. [PMID: 32433753] - Grégoire Petitjean, Fabrice Aman-Pommier, François Coudoré, Najoua El Helali, Alban Le Monnier. A rapid, automatic and accurate assay for quantifying temocillin in human serum and CSF using turbulent flow liquid chromatography coupled to high-resolution mass spectrometry. Clinical application.
Biomedical chromatography : BMC.
2020 Feb; 34(2):e4759. doi:
10.1002/bmc.4759. [PMID: 31758604] - Kévin Alexandre, Anaïs Soares, Françoise Chau, Bruno Fantin, François Caron, Manuel Etienne. Temocillin breakpoints in pyelonephritis: evaluation in a murine model due to ESBL-producing Escherichia coli clinical isolates.
The Journal of antimicrobial chemotherapy.
2019 05; 74(5):1323-1326. doi:
10.1093/jac/dky569. [PMID: 30689887] - Perrin Ngougni Pokem, Arnaud Capron, Pierre Wallemacq, Paul M Tulkens, Françoise Van Bambeke, Pierre-François Laterre. Temocillin plasma and pancreatic tissue concentrations in a critically ill patient with septic shock.
The Journal of antimicrobial chemotherapy.
2019 05; 74(5):1459-1461. doi:
10.1093/jac/dky565. [PMID: 30649374] - Hala Kandil, Rebecca Scott, Suresh Mathavakkhannan, Sebastien Van de Velde, Omar Naji. Appropriate dosing regimen of temocillin in patients with underlying kidney diseases: a retrospective study at a large District Hospital in the UK.
The Journal of antimicrobial chemotherapy.
2019 02; 74(2):530-531. doi:
10.1093/jac/dky449. [PMID: 30403773] - C Duployez, C Loïez, C Cattoen, F Wallet, A Vachée. In vitro activity of temocillin against extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae strains isolated from urinary tract infections in France.
Medecine et maladies infectieuses.
2019 Feb; 49(1):47-53. doi:
10.1016/j.medmal.2018.10.007. [PMID: 30396720] - K Alexandre, M Réveillon-Istin, R Fabre, V Delbos, M Etienne, M Pestel-Caron, S Dahyot, F Caron. Temocillin against Enterobacteriaceae isolates from community-acquired urinary tract infections: low rate of resistance and good accuracy of routine susceptibility testing methods.
The Journal of antimicrobial chemotherapy.
2018 07; 73(7):1848-1853. doi:
10.1093/jac/dky101. [PMID: 29635629] - Ana C Miranda Bastos, Stefaan J Vandecasteele, Anne Spinewine, Paul M Tulkens, Françoise Van Bambeke. Temocillin dosing in haemodialysis patients based on population pharmacokinetics of total and unbound concentrations and Monte Carlo simulations.
The Journal of antimicrobial chemotherapy.
2018 06; 73(6):1630-1638. doi:
10.1093/jac/dky078. [PMID: 29579214] - Margaret Ip, Christopher K Lai, Kitty S C Fung, K-Tak Wong, Chendi Zhu, Sebastien Van de Velde, Dominic N Tsang, Peter Hawkey. Activity of temocillin and 15 other agents, including fosfomycin and colistin, against Enterobacteriaceae in Hong Kong.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2017 Dec; 36(12):2491-2494. doi:
10.1007/s10096-017-3091-8. [PMID: 28840351] - M Vallée, F Bruyère, F Roblot, L Brureau. [Temocillin and urinary tract infections].
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie.
2017 Oct; 27(12):609-617. doi:
10.1016/j.purol.2017.07.242. [PMID: 28869169] - K Alexandre, F Chau, F Guérin, L Massias, A Lefort, V Cattoir, B Fantin. Activity of temocillin in a lethal murine model of infection of intra-abdominal origin due to KPC-producing Escherichia coli.
The Journal of antimicrobial chemotherapy.
2016 07; 71(7):1899-904. doi:
10.1093/jac/dkw066. [PMID: 27029848] - Stefaan J Vandecasteele, Ana C Miranda Bastos, Arnaud Capron, Anne Spinewine, Paul M Tulkens, Françoise Van Bambeke. Thrice-weekly temocillin administered after each dialysis session is appropriate for the treatment of serious Gram-negative infections in haemodialysis patients.
International journal of antimicrobial agents.
2015 Dec; 46(6):660-5. doi:
10.1016/j.ijantimicag.2015.09.005. [PMID: 26603304] - Perrin Ngougni Pokem, Ana C Miranda Bastos, Paul M Tulkens, Pierre Wallemacq, Françoise Van Bambeke, Arnaud Capron. Validation of a HPLC-MS/MS assay for the determination of total and unbound concentration of temocillin in human serum.
Clinical biochemistry.
2015 May; 48(7-8):542-5. doi:
10.1016/j.clinbiochem.2015.02.006. [PMID: 25712752] - Vincent De Coninck, Dirk Michielsen. Emphysematous cystitis presenting as severe confusion and abdominal pain: two case reports.
Journal of medical case reports.
2015 Mar; 9(?):54. doi:
10.1186/s13256-015-0530-y. [PMID: 25889217] - Ana C Miranda Bastos, Stefaan J Vandecasteele, Paul M Tulkens, Anne Spinewine, Françoise Van Bambeke. Development and validation of a high performance liquid chromatography assay for the determination of temocillin in serum of haemodialysis patients.
Journal of pharmaceutical and biomedical analysis.
2014 Mar; 90(?):192-7. doi:
10.1016/j.jpba.2013.12.002. [PMID: 24389461] - Christine Ferreiro, Amy Piepsz, Cécile Nogarède, Marianne Tondeur, Marc Hainaut, Jack Levy. Late renal sequelae in intravenously treated complicated urinary tract infection.
European journal of pediatrics.
2013 Sep; 172(9):1243-8. doi:
10.1007/s00431-013-2024-5. [PMID: 23677250] - Carine Magoué Lonchel, Cécile Meex, Joseph Gangoué-Piéboji, Raphaël Boreux, Marie-Claire Okomo Assoumou, Pierrette Melin, Patrick De Mol. Proportion of extended-spectrum ß-lactamase-producing Enterobacteriaceae in community setting in Ngaoundere, Cameroon.
BMC infectious diseases.
2012 Mar; 12(?):53. doi:
10.1186/1471-2334-12-53. [PMID: 22405322] - Joris F H Duerinckx. Case report: subacute synovitis of the knee after a rose thorn injury: unusual clinical picture.
Clinical orthopaedics and related research.
2008 Dec; 466(12):3138-42. doi:
10.1007/s11999-008-0482-2. [PMID: 18773251] - Magdalena Stoczko, Jean-Marie Frère, Gian Maria Rossolini, Jean-Denis Docquier. Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora.
Antimicrobial agents and chemotherapy.
2008 Jul; 52(7):2473-9. doi:
10.1128/aac.01062-07. [PMID: 18443127] - Raf De Jongh, Ria Hens, Violetta Basma, Johan W Mouton, Paul M Tulkens, Stéphane Carryn. Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection.
The Journal of antimicrobial chemotherapy.
2008 Feb; 61(2):382-8. doi:
10.1093/jac/dkm467. [PMID: 18070831] - D H Staniforth, H Clarke, B E Davies. Temocillin: lymph penetration and protein binding.
International journal of clinical pharmacology, therapy, and toxicology.
1990 Jul; 28(7):286-91. doi:
NULL. [PMID: 2201651] - G Woodnutt, E J Catherall, I Kernutt, L Mizen. Temocillin efficacy in experimental Klebsiella pneumoniae meningitis after infusion into rabbit plasma to simulate antibiotic concentrations in human serum.
Antimicrobial agents and chemotherapy.
1988 Nov; 32(11):1705-9. doi:
10.1128/aac.32.11.1705. [PMID: 3252752] - E W Taylor, G Lindsay. Antibiotic prophylaxis in transurethral resection of the prostate with reference to the influence of preoperative catheterization.
The Journal of hospital infection.
1988 Aug; 12(2):75-83. doi:
10.1016/0195-6701(88)90129-6. [PMID: 2905724] - M Verboven, S Lauwers, H Pintens. Temocillin in the treatment of pyelonephritis in children.
Drugs under experimental and clinical research.
1987; 13(3):171-3. doi:
NULL. [PMID: 3622246] - M J Basker, D J Merrikin, R J Ponsford, B Slocombe, T C Tasker. BRL 20330, an oral prodrug of temocillin: bioavailability studies in man.
The Journal of antimicrobial chemotherapy.
1986 Sep; 18(3):399-405. doi:
10.1093/jac/18.3.399. [PMID: 3095301] - H Goris, F de Boer, D van der Waaij. Oral administration of antibiotics and intestinal flora associated endotoxin in mice.
Scandinavian journal of infectious diseases.
1986; 18(1):55-63. doi:
10.3109/00365548609032307. [PMID: 3008311] - Z Modr, J Morávek, K Dvorácek, T Sechser, I Janků, V Krebs. Pharmacokinetics of temocillin after intravenous and intramuscular administration.
Czechoslovak medicine.
1986; 9(4):181-6. doi:
NULL. [PMID: 3102181] - D van der Waaij. Selective decontamination of the digestive tract with oral aztreonam and temocillin.
Reviews of infectious diseases.
1985 Nov; 7 Suppl 4(?):S628-34. doi:
10.1093/clinids/7.supplement_4.s628. [PMID: 3909318] - B E Davies. Displacement of bilirubin from cord serum by sulphadimethoxine, amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin.
British journal of clinical pharmacology.
1985 Oct; 20(4):345-8. doi:
10.1111/j.1365-2125.1985.tb05075.x. [PMID: 4074603] - M P Hazenberg, A M Pennock-Schröder, J P van de Merwe. Binding to and antibacterial effect of aztreonam, temocillin, gentamicin and tobramycin on human faeces.
The Journal of hygiene.
1985 Oct; 95(2):255-63. doi:
10.1017/s0022172400062689. [PMID: 4067288] - R J Boon, A S Beale. Studies with temocillin in a hamster model of antibiotic-associated colitis.
Antimicrobial agents and chemotherapy.
1985 Jun; 27(6):980-1. doi:
10.1128/aac.27.6.980. [PMID: 3875312] - B Nunn, A Baird, P D Chamberlain. Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers.
Antimicrobial agents and chemotherapy.
1985 May; 27(5):858-62. doi:
10.1128/aac.27.5.858. [PMID: 4015075] - E A Guest, R Horton, G Mellows, B Slocombe, A J Swaisland, T C Tasker. Human pharmacokinetics of temocillin (BRL 17421) side chain epimers.
The Journal of antimicrobial chemotherapy.
1985 Mar; 15(3):327-36. doi:
10.1093/jac/15.3.327. [PMID: 3997707] - D Höffler, P Koeppe. Temocillin pharmacokinetics in normal and impaired renal function.
Drugs.
1985; 29 Suppl 5(?):135-9. doi:
10.2165/00003495-198500295-00028. [PMID: 4029017] - D Overbosch, C van Gulpen, H Mattie. Renal clearance of temocillin in volunteers.
Drugs.
1985; 29 Suppl 5(?):128-34. doi:
10.2165/00003495-198500295-00027. [PMID: 4029016] - E A Guest, R Horton, G Mellows, B Slocombe, A J Swaisland, T C Tasker, A R White. Human pharmacokinetics and antimicrobial activities of the temocillin epimers.
Drugs.
1985; 29 Suppl 5(?):154-61. doi:
10.2165/00003495-198500295-00032. [PMID: 4029021] - B Hampel, M Feike, P Koeppe, H Lode. Pharmacokinetics of temocillin in volunteers.
Drugs.
1985; 29 Suppl 5(?):99-102. doi:
10.2165/00003495-198500295-00020. [PMID: 4029032] - J Boelaert, R Daneels, M Schurgers, G Mellows, A J Swaisland, A M Lambert, H W Van Landuyt. Effect of renal function and dialysis on temocillin pharmacokinetics.
Drugs.
1985; 29 Suppl 5(?):109-13. doi:
10.2165/00003495-198500295-00023. [PMID: 4029012] - F Spelsberg, A Bauernfeind, W Wiest, P Hanser. Biliary concentrations of temocillin.
Drugs.
1985; 29 Suppl 5(?):122-7. doi:
10.2165/00003495-198500295-00026. [PMID: 4029015] - R R Wittke, D Adam, H E Klein. Therapeutic results and tissue concentrations of temocillin in surgical patients.
Drugs.
1985; 29 Suppl 5(?):221-6. doi:
10.2165/00003495-198500295-00049. [PMID: 4029028] - T Bergan, W L Olszewski, A Engeset. Temocillin penetration of peripheral lymph.
Drugs.
1985; 29 Suppl 5(?):114-7. doi:
10.2165/00003495-198500295-00024. [PMID: 4029013] - J G Gould, G Meikle, D L Cooper, R Horton. Temocillin concentrations in human tissues.
Drugs.
1985; 29 Suppl 5(?):167-70. doi:
10.2165/00003495-198500295-00034. [PMID: 3928320] - J S Legge, T M Reid, J B Palmer. Clinical efficacy, tolerance and pharmacokinetics of temocillin in patients with respiratory tract infections.
Drugs.
1985; 29 Suppl 5(?):118-21. doi:
10.2165/00003495-198500295-00025. [PMID: 4029014] - M Uwaydah, S Vartivarian, H Harakeh, A Awdeh, F Najjar. Potential role of temocillin in the treatment of biliary sepsis.
Drugs.
1985; 29 Suppl 5(?):186-90. doi:
10.2165/00003495-198500295-00040. [PMID: 4029024] - D P Maudgal, A Lanzini, T C Northfield, C Bridges, A E Joseph. Quantification of temocillin biliary excretion and gallbladder bile concentration in healthy subjects.
Drugs.
1985; 29 Suppl 5(?):146-50. doi:
10.2165/00003495-198500295-00030. [PMID: 4029019] - H W Mittermayer. Influence of temocillin on human bowel flora.
Drugs.
1985; 29 Suppl 5(?):43-8. doi:
10.2165/00003495-198500295-00010. [PMID: 3849424] - A Cockburn, G Mellows, D Jackson, D J White. Temocillin. Summary of safety studies.
Drugs.
1985; 29 Suppl 5(?):103-5. doi:
10.2165/00003495-198500295-00021. [PMID: 4029010] - W Cowan, A Baird, J D Sleigh, J M Gray, J M Leiper, D H Lawson. Lung tissue penetration of temocillin.
Drugs.
1985; 29 Suppl 5(?):151-3. doi:
10.2165/00003495-198500295-00031. [PMID: 4029020] - H W Asbach, E Becker-Boost, M D Melekos. Clinical evaluation of temocillin in urinary tract infections.
Drugs.
1985; 29 Suppl 5(?):175-7. doi:
10.2165/00003495-198500295-00037. [PMID: 3896736] - G J Poston, A Greengrass, C J Moryson. Biliary concentrations of temocillin.
Drugs.
1985; 29 Suppl 5(?):140-5. doi:
10.2165/00003495-198500295-00029. [PMID: 4029018] - M R Lockley, R M Brown, R Wise. Pharmacokinetics and tissue penetration of temocillin.
Drugs.
1985; 29 Suppl 5(?):106-8. doi:
10.2165/00003495-198500295-00022. [PMID: 4029011] - O Brückner, M Trautmann, K Borner. A study of the penetration of temocillin in the cerebrospinal fluid.
Drugs.
1985; 29 Suppl 5(?):162-6. doi:
10.2165/00003495-198500295-00033. [PMID: 4029022] - R Wise, I A Donovan, J Drumm, A Dyas, C Cross. The intraperitoneal penetration of temocillin.
The Journal of antimicrobial chemotherapy.
1983 Jul; 12(1):93-6. doi:
10.1093/jac/12.1.93. [PMID: 6619048] - T Bergan, A Engeset, W Olszewski. Temocillin in peripheral lymph.
The Journal of antimicrobial chemotherapy.
1983 Jul; 12(1):59-63. doi:
10.1093/jac/12.1.59. [PMID: 6619047] - A Leroy, G Humbert, J P Fillastre, F Borsa, M Godin. Pharmacokinetics of temocillin (BRL 17421) in subjects with normal and impaired renal function.
The Journal of antimicrobial chemotherapy.
1983 Jul; 12(1):47-58. doi:
10.1093/jac/12.1.47. [PMID: 6619046] - N Wright, R Wise, J D Price. Temocillin elimination in patients with varying degrees of renal failure.
The Journal of antimicrobial chemotherapy.
1983 May; 11(5):481-4. doi:
10.1093/jac/11.5.481. [PMID: 6874633] - J Boelaert, R Daneels, M Schurgers, A M Lambert, H W Van Landuyt, G Mellows, J Wolf, A J Swaisland. The pharmacokinetics of temocillin in patients with normal and impaired renal function.
The Journal of antimicrobial chemotherapy.
1983 Apr; 11(4):349-56. doi:
10.1093/jac/11.4.349. [PMID: 6853404] - K Jules, H C Neu. Antibacterial activity and beta-lactamase stability of temocillin.
Antimicrobial agents and chemotherapy.
1982 Sep; 22(3):453-60. doi:
10.1128/aac.22.3.453. [PMID: 6982681] - H Lagast, J Klastersky. Comparative in vitro activities of temocillin and cefazolin against Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy.
1982 Aug; 22(2):330-1. doi:
10.1128/aac.22.2.330. [PMID: 6765417] - D Greenwood, A Cowlishaw, A Eley. In vitro activity of temocillin, a new beta-lactamase-stable penicillin active against enterobacteria.
Antimicrobial agents and chemotherapy.
1982 Aug; 22(2):198-200. doi:
10.1128/aac.22.2.198. [PMID: 6821453] - R Bolivar, S S Weaver, G P Bodey. Comparative in vitro study of temocillin (BRL 17421), a new penicillin.
Antimicrobial agents and chemotherapy.
1982 Apr; 21(4):641-5. doi:
10.1128/aac.21.4.641. [PMID: 6919412] - B Slocombe, M J Basker, P H Bentley, J P Clayton, M Cole, K R Comber, R A Dixon, R A Edmondson, D Jackson, D J Merrikin, R Sutherland. BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans.
Antimicrobial agents and chemotherapy.
1981 Jul; 20(1):38-46. doi:
10.1128/aac.20.1.38. [PMID: 6974539]