Vardenafil HCl Trihydrate (BioDeep_00000770127)
代谢物信息卡片
Vardenafil hydrochloride trihydrate
化学式: C23H39ClN6O7S (578.2289334)
中文名称: 盐酸瓦地那非三水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.O.O.O.Cl
InChI: 1H
描述信息
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058986 - Phosphodiesterase 5 Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
D000089162 - Genitourinary Agents > D064804 - Urological Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rakesh C Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi. Treating diabetes with combination of phosphodiesterase 5 inhibitors and hydroxychloroquine-a possible prevention strategy for COVID-19?.
Molecular and cellular biochemistry.
2023 Mar; 478(3):679-696. doi:
10.1007/s11010-022-04520-2. [PMID: 36036333] - Milos Krivokapic, Israpil Alisultanovich Omarov, Vladimir Zivkovic, Tamara Nikolic Turnic, Vladimir Jakovljevic. Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion.
Medicina (Kaunas, Lithuania).
2023 Feb; 59(3):. doi:
10.3390/medicina59030458. [PMID: 36984459] - Silvia Limoncella, Clara Lazzaretti, Elia Paradiso, Sara D'Alessandro, Federica Barbagallo, Salvatore Pacifico, Remo Guerrini, Simonetta Tagliavini, Tommaso Trenti, Daniele Santi, Manuela Simoni, Marco Sola, Giulia Di Rocco, Livio Casarini. Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line.
Molecular and cellular endocrinology.
2022 02; 542(?):111527. doi:
10.1016/j.mce.2021.111527. [PMID: 34875337] - Heba Samir Elama, Shereen M Shalan, Yasser El-Shabrawy, Manal I Eid, Abdallah M Zeid. Utilization of a micellar matrix for simultaneous spectrofluorimetric estimation of alfuzosin hydrochloride and vardenafil hydrochloride.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Feb; 266(?):120420. doi:
10.1016/j.saa.2021.120420. [PMID: 34619505] - Michael A Eldon, Edwin L Parsley, Mari Maurer, Thomas E Tarara, Jerry Okikawa, Jeffry G Weers. Safety, Tolerability, and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human, Ascending Single- and Multiple-Dose Study in Healthy Subjects.
Journal of aerosol medicine and pulmonary drug delivery.
2021 08; 34(4):251-261. doi:
10.1089/jamp.2020.1651. [PMID: 33325799] - Barbara Dhooghe, Caroline Bouzin, Angélique Mottais, Emmanuel Hermans, Martial Delion, Nadtha Panin, Sabrina Noel, Teresinha Leal. Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells.
Biology open.
2020 08; 9(8):. doi:
10.1242/bio.053116. [PMID: 32747447] - R J Zhang, Y Y He, D Jiang, S F Liu, Y J Zhang, W S Zheng, S Wu, Z C Jing. [Feasibility of the determination of plasma vardenafil level in rat by performance liquid chromatography-tandem mass spectrometry].
Zhonghua xin xue guan bing za zhi.
2020 Jun; 48(6):507-512. doi:
10.3760/cma.j.cn112148-20200307-00170. [PMID: 32842262] - A Zucchi, E Costantini, F I Scroppo, M Silvani, Z Kopa, E Illiano, M G Petrillo, L Cari, G Nocentini. The first-generation phosphodiesterase 5 inhibitors and their pharmacokinetic issue.
Andrology.
2019 11; 7(6):804-817. doi:
10.1111/andr.12683. [PMID: 31350821] - Gül Doğan, Hülya İpek, Yılmaz Baş, Güvenç Doğan, Selçuk Kayır. Experimental study on prophylactic effects of vardenafil in ischemia-reperfusion model with intestinal volvulus injury in rats.
Journal of pediatric surgery.
2019 Oct; 54(10):2172-2177. doi:
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Annales pharmaceutiques francaises.
2019 Jan; 77(1):28-37. doi:
10.1016/j.pharma.2018.08.003. [PMID: 30172351] - Elif Öztürk Er, Belma Özbek, Sezgin Bakırdere. Accurate and sensitive determination of sildenafil, tadalafil, vardenafil, and avanafil in illicit erectile dysfunction medications and human urine by LC with quadrupole-TOF-MS/MS and their behaviors in simulated gastric conditions.
Journal of separation science.
2019 Jan; 42(2):475-483. doi:
10.1002/jssc.201800734. [PMID: 30358113] - Mai Ahmed Tawfik, Mina Ibrahim Tadros, Magdy Ibrahim Mohamed. Lipomers (Lipid-polymer Hybrid Particles) of Vardenafil Hydrochloride: a Promising Dual Platform for Modifying the Drug Release Rate and Enhancing Its Oral Bioavailability.
AAPS PharmSciTech.
2018 Nov; 19(8):3650-3660. doi:
10.1208/s12249-018-1191-0. [PMID: 30291543] - Aaa Salama, R E Mostafa, E A Omara. Effects of phosphodiestrase type 5 inhibitors in epinephrine-induced arrhythmia in rats: Involvement of lactate dehydrogenase and creatine kinase downregulation and adiponectin expression.
Human & experimental toxicology.
2018 Mar; 37(3):256-264. doi:
10.1177/0960327117695638. [PMID: 29233027] - Dina S El-Agamy, Hamdi H Almaramhy, Nishat Ahmed, Bsmah Bojan, Waad D Alrohily, Mohamed A Elkablawy. Anti-Inflammatory Effects of Vardenafil Against Cholestatic Liver Damage in Mice: a Mechanistic Study.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 47(2):523-534. doi:
10.1159/000489986. [PMID: 29794447] - Daniele Santi, Michela Locaso, Antonio R Granata, Tommaso Trenti, Laura Roli, Chiara Pacchioni, Vincenzo Rochira, Cesare Carani, Manuela Simoni. Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus?.
PloS one.
2018; 13(6):e0199299. doi:
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Nitric oxide : biology and chemistry.
2017 Sep; 69(?):28-34. doi:
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Endocrine.
2017 May; 56(2):426-437. doi:
10.1007/s12020-016-1055-x. [PMID: 27515804] - Hamit H Alp, Zübeyir Huyut, Serkan Yildirim, Yıldıray Başbugan, Levent Ediz, Mehmet R Şekeroğlu. The effect of PDE5 inhibitors on bone and oxidative damage in ovariectomy-induced osteoporosis.
Experimental biology and medicine (Maywood, N.J.).
2017 05; 242(10):1051-1061. doi:
10.1177/1535370217703352. [PMID: 28399643] - S Azab, H Aoud, N Nabil. The correlation between high sensitivity C-reactive protein and erectile dysfunction patients with hypertension treated with vardenafil.
International journal of impotence research.
2017 Mar; 29(2):82-85. doi:
10.1038/ijir.2016.51. [PMID: 27904146] - Nishat Ahmed, Nada F Bakhashwain, Alaa F Alsehemi, Dina S El-Agamy. Hepatoprotective role of vardenafil against experimentally induced hepatitis in mice.
Journal of biochemical and molecular toxicology.
2017 Mar; 31(3):. doi:
10.1002/jbt.21867. [PMID: 27762466] - Haider A J Al Lawati, Idris Al Busaidi, Afsal M Kadavilpparampu, FakhrEldin O Suliman. Determination of Common Adulterants in Herbal Medicine and Food Samples using Core-shell Column Coupled to Tandem Mass Spectrometry.
Journal of chromatographic science.
2017 03; 55(3):232-242. doi:
10.1093/chromsci/bmw175. [PMID: 27881492] - O A El-Kawy, J A García-Horsman, R K Tuominen. Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2016 Dec; 118(?):258-265. doi:
10.1016/j.apradiso.2016.09.023. [PMID: 27693738] - Daniele Santi, Antonio R M Granata, Alessandro Guidi, Elisa Pignatti, Tommaso Trenti, Laura Roli, Roberto Bozic, Stefano Zaza, Chiara Pacchioni, Stefania Romano, Jerzy Roch Nofer, Vincenzo Rochira, Cesare Carani, Manuela Simoni. Six months of daily treatment with vardenafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial.
European journal of endocrinology.
2016 Apr; 174(4):513-22. doi:
10.1530/eje-15-1100. [PMID: 26792933] - Mohammed Abu Bakr Abu El-Enin, Mohammed El-Sayed Abd Al-Ghaffar Hammouda, Dina Tawfik El-Sherbiny, Dalia Rashad El-Wasseef, Saadia Mahmoud El-Ashry. Validated spectrofluorimetric method for determination of two phosphodiesterase inhibitors tadalafil and vardenafil in pharmaceutical preparations and spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2016 Feb; 31(1):173-8. doi:
10.1002/bio.2941. [PMID: 26019060] - Dan Henrohn, Anna Sandqvist, Hanna Egeröd, Mikael Hedeland, Lisa Wernroth, Ulf Bondesson, Gerhard Wikström. Changes in plasma levels of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine after a single dose of vardenafil in patients with pulmonary hypertension.
Vascular pharmacology.
2015 Oct; 73(?):71-7. doi:
10.1016/j.vph.2015.04.010. [PMID: 25934511] - Renato Chavasco de Sousa, Antonio Augusto Moreira Neto, Vera Luíza Capelozzi, Alexandre Muxfeldt Ab'Saber, Olavo Ribeiro Rodrigues. Effects of vardenafil on the kidney of Wistar rats submitted to acute ischemia and reperfusion.
Acta cirurgica brasileira.
2015 May; 30(5):339-44. doi:
10.1590/s0102-865020150050000005. [PMID: 26016933] - D Essiz, M Sozmen, M Sudagidan, A K Devrim. Phosphodiesterase type 5 inhibition attenuates cyclosporine A induced nephrotoxicity in mice.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2015 Apr; 90(3):167-78. doi:
10.3109/10520295.2014.976270. [PMID: 25420893] - Usama A Fahmy. Nanoethosomal transdermal delivery of vardenafil for treatment of erectile dysfunction: optimization, characterization, and in vivo evaluation.
Drug design, development and therapy.
2015; 9(?):6129-37. doi:
10.2147/dddt.s94615. [PMID: 26604700] - Dany-Jan Yassin, Yousef El Douaihy, Aksam A Yassin, James Kashanian, Ridwan Shabsigh, Peter G Hammerer. Lower urinary tract symptoms improve with testosterone replacement therapy in men with late-onset hypogonadism: 5-year prospective, observational and longitudinal registry study.
World journal of urology.
2014 Aug; 32(4):1049-54. doi:
10.1007/s00345-013-1187-z. [PMID: 24135918] - Linda Vignozzi, Sandra Filippi, Paolo Comeglio, Ilaria Cellai, Erica Sarchielli, Annamaria Morelli, Giulia Rastrelli, Elena Maneschi, Andrea Galli, Gabriella Barbara Vannelli, Farid Saad, Edoardo Mannucci, Luciano Adorini, Mario Maggi. Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: an experimental study in the rabbit.
Molecular and cellular endocrinology.
2014 Mar; 384(1-2):143-54. doi:
10.1016/j.mce.2014.01.014. [PMID: 24486698] - Abdelkader E Ashour, A F M Motiur Rahman, Mohammed G Kassem. Vardenafil dihydrochloride.
Profiles of drug substances, excipients, and related methodology.
2014; 39(?):515-44. doi:
10.1016/b978-0-12-800173-8.00009-x. [PMID: 24794912] - Dhavalkumar Narendrabhai Patel, Lin Li, Chee-Leong Kee, Xiaowei Ge, Min-Yong Low, Hwee-Ling Koh. Screening of synthetic PDE-5 inhibitors and their analogues as adulterants: analytical techniques and challenges.
Journal of pharmaceutical and biomedical analysis.
2014 Jan; 87(?):176-90. doi:
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The journal of sexual medicine.
2013 Dec; 10(12):3110-20. doi:
10.1111/jsm.12324. [PMID: 24112450] - Fang-Fang Chen, Xiao-Yu Xie, Yan-Ping Shi. Magnetic molecularly imprinted polymer for the selective extraction of sildenafil, vardenafil and their analogs from herbal medicines.
Talanta.
2013 Oct; 115(?):482-9. doi:
10.1016/j.talanta.2013.06.009. [PMID: 24054622] - You-Fei Fan, Rui Zhang, Xin Jiang, Li Wen, Dan-Chen Wu, Dong Liu, Ping Yuan, Yu-Lin Wang, Zhi-Cheng Jing. The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.
Cardiovascular research.
2013 Aug; 99(3):395-403. doi:
10.1093/cvr/cvt109. [PMID: 23650288] - Changqin Xiao, Minqiong Tang, Jian Li, Chen-ru Yin, Guangya Xiang, Li Xu. Determination of sildenafil, vardenafil and aildenafil in human plasma by dispersive liquid-liquid microextraction-back extraction based on ionic liquid and high performance liquid chromatography-ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Jul; 931(?):111-6. doi:
10.1016/j.jchromb.2013.05.013. [PMID: 23774245] - Asghar Ali, Andrew Binder, Asad Mohmand, Helen Stewart, Margaret Pipkin, Lisa Martin, Szabolcs Szentpetery, Gundars Katlaps, Ion S Jovin. The safety of preoperative vardenafil in patients undergoing coronary artery bypass graft surgery.
Journal of cardiovascular pharmacology.
2013 Jul; 62(1):106-9. doi:
10.1097/fjc.0b013e318291be81. [PMID: 23519141] - Iason Kyriazis, George C Kagadis, Panagiotis Kallidonis, Ioannis Georgiopoulos, Antonia Marazioti, Aikaterini Geronasiou, Despοina Liourdi, George Loudos, Vasilios Schinas, Dimitris Apostolopoulos, Helen Papadaki, Christodoulos Flordellis, George C Nikiforidis, Andreas Papapetropoulos, Evangelos Nu Liatsikos. PDE5 inhibition against acute renal ischemia reperfusion injury in rats: does vardenafil offer protection?.
World journal of urology.
2013 Jun; 31(3):597-602. doi:
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Journal of pharmaceutical and biomedical analysis.
2013 Feb; 74(?):83-91. doi:
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European journal of clinical pharmacology.
2013 Feb; 69(2):197-207. doi:
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British journal of clinical pharmacology.
2012 Dec; 74(6):990-8. doi:
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Therapeutic drug monitoring.
2012 Dec; 34(6):729-35. doi:
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Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):529-33. doi:
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Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):40-6. doi:
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International journal of cardiology.
2012 Oct; 160(3):187-91. doi:
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Journal of andrology.
2012 Sep; 33(5):801-4. doi:
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Cancer science.
2012 Aug; 103(8):1531-7. doi:
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The journal of sexual medicine.
2012 Jun; 9(6):1624-33. doi:
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Neurobiology of learning and memory.
2012 May; 97(4):370-9. doi:
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Journal of pharmaceutical and biomedical analysis.
2011 Dec; 56(4):705-12. doi:
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Pharmacogenetics and genomics.
2011 Dec; 21(12):820-8. doi:
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Journal of chromatography. A.
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The journal of sexual medicine.
2011 Apr; 8(4):1061-71. doi:
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Clinical drug investigation.
2011; 31(1):27-41. doi:
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The Kaohsiung journal of medical sciences.
2011 Jan; 27(1):15-9. doi:
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International journal of impotence research.
2011 Jan; 23(1):27-31. doi:
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BJU international.
2010 Oct; 106(8):1181-5. doi:
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Zhonghua nan ke xue = National journal of andrology.
2010 Sep; 16(9):856-9. doi:
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The journal of sexual medicine.
2010 Sep; 7(9):3161-9. doi:
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Biomedical chromatography : BMC.
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