pargyline hydrochloride (BioDeep_00000770032)
代谢物信息卡片
pargyline hydrochloride
化学式: C11H14ClN (195.0814714)
中文名称: 盐酸帕吉林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(CC#C)CC1=CC=CC=C1.Cl
InChI: 1H
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianan Guo, Yujia Zhang, Changjun Zhang, Chuansheng Yao, Jingqi Zhang, Xiaoying Jiang, Zhichao Zhong, Jiamin Ge, Tao Zhou, Renren Bai, Yuanyuan Xie. N-Propargylamine-hydroxypyridinone hybrids as multitarget agents for the treatment of Alzheimer's disease.
Bioorganic chemistry.
2021 08; 113(?):105013. doi:
10.1016/j.bioorg.2021.105013. [PMID: 34062405] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Dongyang Ma, Tong Han, Mohammad Karimian, Naser Abbasi, Hori Ghaneialvar, Akram Zangeneh. Immobilized Ag NPs on chitosan-biguanidine coated magnetic nanoparticles for synthesis of propargylamines and treatment of human lung cancer.
International journal of biological macromolecules.
2020 Dec; 165(Pt A):767-775. doi:
10.1016/j.ijbiomac.2020.09.193. [PMID: 32991899] - Prakash Bansode, R Anantacharya, Maruti Dhanavade, Subodh Kamble, Sagar Barale, Kailas Sonawane, Nayak D Satyanarayan, Gajanan Rashinkar. Evaluation of drug candidature: In silico ADMET, binding interactions with CDK7 and normal cell line studies of potentially anti-breast cancer enamidines.
Computational biology and chemistry.
2019 Dec; 83(?):107124. doi:
10.1016/j.compbiolchem.2019.107124. [PMID: 31563021] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Silvio Aprile, Rossana Canavesi, Rosanna Matucci, Cristina Bellucci, Erika Del Grosso, Giorgio Grosa. New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone.
Xenobiotica; the fate of foreign compounds in biological systems.
2018 May; 48(5):478-487. doi:
10.1080/00498254.2017.1342288. [PMID: 28608746] - Yasushi Ishida, Kosuke Ebihara, Masahiro Tabuchi, Sachiko Imamura, Kyoji Sekiguchi, Kazushige Mizoguchi, Yoshio Kase, Go Koganemaru, Hiroshi Abe, Yasushi Ikarashi. Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT.
Biological & pharmaceutical bulletin.
2016; 39(1):104-13. doi:
10.1248/bpb.b15-00691. [PMID: 26725433] - Min Wang, Xiuheng Liu, Jia Guo, Xiaodong Weng, Guanjun Jiang, Zhishun Wang, Li He. Inhibition of LSD1 by Pargyline inhibited process of EMT and delayed progression of prostate cancer in vivo.
Biochemical and biophysical research communications.
2015 Nov; 467(2):310-5. doi:
10.1016/j.bbrc.2015.09.164. [PMID: 26435505] - Beatriz Vega, Holger Wondraczek, Leonore Bretschneider, Tuomas Näreoja, Pedro Fardim, Thomas Heinze. Preparation of reactive fibre interfaces using multifunctional cellulose derivatives.
Carbohydrate polymers.
2015 Nov; 132(?):261-73. doi:
10.1016/j.carbpol.2015.05.048. [PMID: 26256349] - N G R Dayan Elshan, Thanuja Jayasundera, Bobbi L Anglin, Craig S Weber, Ronald M Lynch, Eugene A Mash. Trigonal scaffolds for multivalent targeting of melanocortin receptors.
Organic & biomolecular chemistry.
2015 Feb; 13(6):1778-91. doi:
10.1039/c4ob02094d. [PMID: 25502141] - H M-F Viart, T S Larsen, C Tassone, T L Andresen, M H Clausen. Propargylamine-isothiocyanate reaction: efficient conjugation chemistry in aqueous media.
Chemical communications (Cambridge, England).
2014 Jul; 50(58):7800-2. doi:
10.1039/c4cc00863d. [PMID: 24903342] - Zhongyue Sun, Cuiping Han, Miaomiao Song, Long Wen, Demei Tian, Haibing Li, Lei Jiang. Fabrication of cysteine-responsive biomimetic single nanochannels by a thiol-yne reaction strategy and their application for sensing in urine samples.
Advanced materials (Deerfield Beach, Fla.).
2014 Jan; 26(3):455-60. doi:
10.1002/adma.201303158. [PMID: 24151224] - S Nag, G Kettschau, T Heinrich, A Varrone, L Lehmann, B Gulyas, A Thiele, É Keller, C Halldin. Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.
Bioorganic & medicinal chemistry.
2013 Jan; 21(1):186-95. doi:
10.1016/j.bmc.2012.10.050. [PMID: 23211968] - Hua-jin Zeng, Ran Yang, Cheng Guo, Qing-wen Wang, Ling-bo Qu, Jian-jun Li. Pharmacokinetic study of six flavones in rat plasma and tissues after oral administration of 'JiangYaBiFeng' using SPE-HPLC-DAD.
Journal of pharmaceutical and biomedical analysis.
2011 Dec; 56(4):815-9. doi:
10.1016/j.jpba.2011.07.015. [PMID: 21831556] - Suyan Qiu, Sen Gao, Qida Liu, Zhenyu Lin, Bin Qiu, Guonan Chen. Electrochemical impedance spectroscopy sensor for ascorbic acid based on copper(I) catalyzed click chemistry.
Biosensors & bioelectronics.
2011 Jul; 26(11):4326-30. doi:
10.1016/j.bios.2011.04.029. [PMID: 21596552] - Rana Chaaya, Chiara Alfarano, Céline Guilbeau-Frugier, Christelle Coatrieux, Anne-Sylvie Kesteman, Angelo Parini, Nassim Fares, Michelle Gue, Joost P Schanstra, Jean-Loup Bascands. Pargyline reduces renal damage associated with ischaemia-reperfusion and cyclosporin.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Feb; 26(2):489-98. doi:
10.1093/ndt/gfq445. [PMID: 20667995] - Elodie Trouche, Celine Mias, Marie-Helene Seguelas, Catherine Ordener, Daniel Cussac, Angelo Parini. Characterization of monoamine oxidases in mesenchymal stem cells: role in hydrogen peroxide generation and serotonin-dependent apoptosis.
Stem cells and development.
2010 Oct; 19(10):1571-8. doi:
10.1089/scd.2009.0353. [PMID: 20073575] - Olayinka A Dina, Sachia G Khasar, Nicole Alessandri-Haber, Oliver Bogen, Xiaojie Chen, Paul G Green, David B Reichling, Robert O Messing, Jon D Levine. Neurotoxic catecholamine metabolite in nociceptors contributes to painful peripheral neuropathy.
The European journal of neuroscience.
2008 Sep; 28(6):1180-90. doi:
10.1111/j.1460-9568.2008.06425.x. [PMID: 18783367] - Yana Kleiner, Orit Bar-Am, Tamar Amit, Alexandra Berdichevski, Esti Liani, Gila Maor, Irina Reiter, Moussa B H Youdim, Ofer Binah. TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity.
Journal of cardiovascular pharmacology.
2008 Sep; 52(3):268-77. doi:
10.1097/fjc.0b013e3181862441. [PMID: 18806608] - Fernanda Barbosa Lima, Raphael Escorsim Szawka, Janete Aparecida Anselmo-Franci, Celso Rodrigues Franci. Pargyline effect on luteinizing hormone secretion throughout the rat estrous cycle: correlation with serotonin, catecholamines and nitric oxide in the medial preoptic area.
Brain research.
2007 Apr; 1142(?):37-45. doi:
10.1016/j.brainres.2007.01.045. [PMID: 17303090] - Luis O Ruzo. Physical, chemical and environmental properties of selected chemical alternatives for the pre-plant use of methyl bromide as soil fumigant.
Pest management science.
2006 Feb; 62(2):99-113. doi:
10.1002/ps.1135. [PMID: 16308867] - Orit Bar-Am, Orly Weinreb, Tamar Amit, Moussa B H Youdim. Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2005 Nov; 19(13):1899-901. doi:
10.1096/fj.05-3794fje. [PMID: 16148027] - Virgile Visentin, Sandy Bour, Jérémie Boucher, Danielle Prévot, Philippe Valet, Catherine Ordener, Angelo Parini, Christian Carpéné. Glucose handling in streptozotocin-induced diabetic rats is improved by tyramine but not by the amine oxidase inhibitor semicarbazide.
European journal of pharmacology.
2005 Oct; 522(1-3):139-46. doi:
10.1016/j.ejphar.2005.08.051. [PMID: 16202994] - Orly Weinreb, Tamar Amit, Orit Bar-Am, Orly Chillag-Talmor, Moussa B H Youdim. Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway.
Annals of the New York Academy of Sciences.
2005 Aug; 1053(?):348-55. doi:
10.1196/annals.1344.030. [PMID: 16179541] - Fernando R Ibarra, Inés Armando, Susana Nowicki, Andrea Carranza, Verónica De Luca Sarobe, Elvira E Arrizurieta, Marta Barontini. Dopamine is metabolised by different enzymes along the rat nephron.
Pflugers Archiv : European journal of physiology.
2005 Jun; 450(3):185-91. doi:
10.1007/s00424-005-1386-6. [PMID: 15864503] - Kimberly M O'Connell, David B Langley, Eric M Shepard, Anthony P Duff, Heung-Bae Jeon, Gang Sun, Hans C Freeman, J Mitchell Guss, Lawrence M Sayre, David M Dooley. Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation.
Biochemistry.
2004 Aug; 43(34):10965-78. doi:
10.1021/bi0492004. [PMID: 15323556] - Chunhua Qiao, Heung-Bae Jeon, Lawrence M Sayre. Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif.
Journal of the American Chemical Society.
2004 Jun; 126(25):8038-45. doi:
10.1021/ja049568o. [PMID: 15212554] - Hijiri Watanabe, Yasuko Muramatsu, Rumiko Kurosaki, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai, Tsutomu Araki. Protective effects of neuronal nitric oxide synthase inhibitor in mouse brain against MPTP neurotoxicity: an immunohistological study.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2004 Mar; 14(2):93-104. doi:
10.1016/s0924-977x(03)00065-8. [PMID: 15013024] - Heung-Bae Jeon, Lawrence M Sayre. Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase.
Biochemical and biophysical research communications.
2003 May; 304(4):788-94. doi:
10.1016/s0006-291x(03)00681-8. [PMID: 12727226] - P Berger-Twelbeck, P Hofmeister, S Emmling, A Dorn. Ovicide-induced serosa degeneration and its impact on embryonic development in Manduca sexta (Insecta: Lepidoptera).
Tissue & cell.
2003 Apr; 35(2):101-12. doi:
10.1016/s0040-8166(03)00009-0. [PMID: 12747932] - Michael Neal, Joanna Cunningham, Isobel Lever, Sophie Pezet, Marzia Malcangio. Mechanism by which brain-derived neurotrophic factor increases dopamine release from the rabbit retina.
Investigative ophthalmology & visual science.
2003 Feb; 44(2):791-8. doi:
10.1167/iovs.02-0557. [PMID: 12556415] - Oxana R Kunduzova, Pascale Bianchi, Nathalie Pizzinat, Ghislaine Escourrou, Marie-Helene Seguelas, Angelo Parini, Claudie Cambon. Regulation of JNK/ERK activation, cell apoptosis, and tissue regeneration by monoamine oxidases after renal ischemia-reperfusion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2002 Jul; 16(9):1129-31. doi:
10.1096/fj.01-1008fje. [PMID: 12039844] - Stéphanie Barc, Guylène Page, Laurence Barrier, François Huguet, Bernard Fauconneau. Progressive alteration of neuronal dopamine transporter activity in a rat injured by an intranigral injection of MPP+.
Brain research.
2002 Jun; 941(1-2):72-81. doi:
10.1016/s0006-8993(02)02567-2. [PMID: 12031549] - W G Tatton, R M E Chalmers-Redman, W J H Ju, M Mammen, G W Carlile, A W Pong, N A Tatton. Propargylamines induce antiapoptotic new protein synthesis in serum- and nerve growth factor (NGF)-withdrawn, NGF-differentiated PC-12 cells.
The Journal of pharmacology and experimental therapeutics.
2002 May; 301(2):753-64. doi:
10.1124/jpet.301.2.753. [PMID: 11961082] - Kenichi Kitani, Chiyoko Minami, Takako Yamamoto, Setsuko Kanai, Gwen O Ivy, Maria-Cristina Carrillo. Pharmacological interventions in aging and age-associated disorders: potentials of propargylamines for human use.
Annals of the New York Academy of Sciences.
2002 Apr; 959(?):295-307. doi:
10.1111/j.1749-6632.2002.tb02101.x. [PMID: 11976204] - H K Wayment, J O Schenk, B A Sorg. Characterization of extracellular dopamine clearance in the medial prefrontal cortex: role of monoamine uptake and monoamine oxidase inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2001 Jan; 21(1):35-44. doi:
. [PMID: 11150317] - T Kawano, R Pinontoan, N Uozumi, Y Morimitsu, C Miyake, K Asada, S Muto. Phenylethylamine-induced generation of reactive oxygen species and ascorbate free radicals in tobacco suspension culture: mechanism for oxidative burst mediating Ca2+ influx.
Plant & cell physiology.
2000 Nov; 41(11):1259-66. doi:
10.1093/pcp/pcd053. [PMID: 11092911] - M Benoit-Marand, M Jaber, F Gonon. Release and elimination of dopamine in vivo in mice lacking the dopamine transporter: functional consequences.
The European journal of neuroscience.
2000 Aug; 12(8):2985-92. doi:
10.1046/j.1460-9568.2000.00155.x. [PMID: 10971639] - N Pizzinat, J P Girolami, A Parini, C Pecher, C Ordener. Serotonin metabolism in rat mesangial cells: involvement of a serotonin transporter and monoamine oxidase A.
Kidney international.
1999 Oct; 56(4):1391-9. doi:
10.1046/j.1523-1755.1999.00673.x. [PMID: 10504491] - D L Murphy, F Karoum, D Pickar, R M Cohen, S Lipper, A M Mellow, P N Tariot, T Sunderland. Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline).
Journal of neural transmission. Supplementum.
1998; 52(?):39-48. doi:
10.1007/978-3-7091-6499-0_5. [PMID: 9564606] - R Pino, G A Lyles. [Effect of activity of semicarbazide-sensitive aminooxidases and cellular glutathione on the cytotoxic effect of allylamine, acrolein, and formaldehyde in human cultured endothelial cells].
Voprosy meditsinskoi khimii.
1997 Nov; 43(6):537-47. doi:
. [PMID: 9503571] - Y Okuma, K Yokotani, Y Murakami, Y Osumi. Brain histamine mediates the bombesin-induced central activation of sympatho-adrenomedullary outflow.
Life sciences.
1997; 61(26):2521-8. doi:
10.1016/s0024-3205(97)01006-0. [PMID: 9416774] - G A Korte-Bouws, S M Korte, E R De Kloet, B Bohus. Blockade of corticosterone synthesis reduces serotonin turnover in the dorsal hippocampus of the rat as measured by microdialysis.
Journal of neuroendocrinology.
1996 Nov; 8(11):877-81. doi:
10.1046/j.1365-2826.1996.05389.x. [PMID: 8933365] - T Obata, Y Yamanaka. Monoamine oxidase released into plasma treated with the hepatotoxin allyl formate.
Research communications in molecular pathology and pharmacology.
1996 Jun; 92(3):365-8. doi:
. [PMID: 8827833] - C L Martel, J B Mackic, J D Adams, J G McComb, M H Weiss, B V Zlokovic. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine.
Pharmaceutical research.
1996 Feb; 13(2):290-5. doi:
10.1023/a:1016007601794. [PMID: 8932451] - C Pons, P M Dansette, J Gregeois, J C Homberg, E E Billett, D Mansuy. Human anti-mitochondria autoantibodies appearing in iproniazid-induced immunoallergic hepatitis recognize human liver monoamine oxidase B.
Biochemical and biophysical research communications.
1996 Jan; 218(1):118-24. doi:
10.1006/bbrc.1996.0021. [PMID: 8573115] - R A Brown, A O Savage. Effects of acute acetaldehyde, chronic ethanol, and pargyline treatment on agonist responses of the rat aorta.
Toxicology and applied pharmacology.
1996 Jan; 136(1):170-8. doi:
10.1006/taap.1996.0021. [PMID: 8560471] - B Friedgen, R Wölfel, K H Graefe. The contribution by monoamine oxidase and catechol-O-methyltransferase to the total-body and pulmonary plasma clearance of catecholamines.
Naunyn-Schmiedeberg's archives of pharmacology.
1996 Jan; 353(2):193-9. doi:
10.1007/bf00168757. [PMID: 8717160] - Z He, D V Nadkarni, L M Sayre, F T Greenaway. Mechanism-based inactivation of porcine kidney diamine oxidase by 1,4-diamino-2-butene.
Biochimica et biophysica acta.
1995 Nov; 1253(1):117-27. doi:
10.1016/0167-4838(95)00158-q. [PMID: 7492592] - S Ravanel, M Droux, R Douce. Methionine biosynthesis in higher plants. I. Purification and characterization of cystathionine gamma-synthase from spinach chloroplasts.
Archives of biochemistry and biophysics.
1995 Jan; 316(1):572-84. doi:
10.1006/abbi.1995.1077. [PMID: 7840669] - Y Machida, J Zhang, K Hashimoto, H Wakiguchi, T Kurashige, N Masuoka, T Ubuka, H Kodama. Identification of perhydro-1,4-thiazepine-3,5-dicarboxylic acid, cystathionine mono-oxo acids, cystathionine ketimines, cystathionine sulfoxide and N-acetylcystathionine sulfoxide in the urine sample of D,L-propargylglycine treated rats.
Physiological chemistry and physics and medical NMR.
1995; 27(3):203-16. doi:
NULL. [PMID: 8868580] - B Senthilkumaran, K P Joy. A turnover study of hypothalamic monoamine oxidase (MAO) and effects of MAO inhibition on gonadotropin secretion in the female catfish, Heteropneustes fossilis.
General and comparative endocrinology.
1995 Jan; 97(1):1-12. doi:
10.1006/gcen.1995.1001. [PMID: 7713373] - M Pestana, P Soares-da-Silva. Effect of type A and B monoamine oxidase selective inhibition by Ro 41-1049 and Ro 19-6327 on dopamine outflow in rat kidney slices.
British journal of pharmacology.
1994 Dec; 113(4):1269-74. doi:
10.1111/j.1476-5381.1994.tb17135.x. [PMID: 7889283] - Y Ogasawara, S Isoda, S Tanabe. Tissue and subcellular distribution of bound and acid-labile sulfur, and the enzymic capacity for sulfide production in the rat.
Biological & pharmaceutical bulletin.
1994 Dec; 17(12):1535-42. doi:
10.1248/bpb.17.1535. [PMID: 7735193] - J Zhang, Y Machida, K Sugahara, H Kodama. Determination of D,L-propargylglycine and N-acetylpropargylglycine in urine and several tissues of D,L-propargylglycine-treated rats using liquid chromatography-mass spectrometry.
Journal of chromatography. B, Biomedical applications.
1994 Oct; 660(2):375-9. doi:
10.1016/0378-4347(94)00296-7. [PMID: 7866528] - W G Tatton, W Y Ju, D P Holland, C Tai, M Kwan. (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis.
Journal of neurochemistry.
1994 Oct; 63(4):1572-5. doi:
10.1046/j.1471-4159.1994.63041572.x. [PMID: 7931312] - A Oohara, H Yoshimatsu, M Kurokawa, R Oishi, K Saeki, T Sakata. Neuronal glucoprivation enhances hypothalamic histamine turnover in rats.
Journal of neurochemistry.
1994 Aug; 63(2):677-82. doi:
10.1046/j.1471-4159.1994.63020677.x. [PMID: 8035192] - H Rommelspacher, T May, B Salewski. Harman (1-methyl-beta-carboline) is a natural inhibitor of monoamine oxidase type A in rats.
European journal of pharmacology.
1994 Jan; 252(1):51-9. doi:
10.1016/0014-2999(94)90574-6. [PMID: 8149995] - C Ríos, S Bravo-Velazquez, M Altagracia, J Kravzov. Enhancement of striatal lipid peroxidation induced by 1-methyl-4-phenylpyridinium in mouse brain is blocked by MAO-B inhibitors.
Proceedings of the Western Pharmacology Society.
1994; 37(?):159-60. doi:
". [PMID: 7984654] - H Ishii, D B Stanimirovic, C J Chang, B B Mrsulja, M Spatz. Dopamine metabolism and free-radical related mitochondrial injury during transient brain ischemia in gerbils.
Neurochemical research.
1993 Nov; 18(11):1193-201. doi:
10.1007/bf00978373. [PMID: 8255372] - B Boudíková-Girard, M C Scott, R Weinshilboum. Histamine N-methyltransferase: inhibition by monoamine oxidase inhibitors.
Agents and actions.
1993 Sep; 40(1-2):1-10. doi:
10.1007/bf01976745. [PMID: 8147263] - G Huether, B Poeggeler, L Adler, E Rüther. Effects of indirectly acting 5-HT receptor agonists on circulating melatonin levels in rats.
European journal of pharmacology.
1993 Jul; 238(2-3):249-54. doi:
10.1016/0014-2999(93)90854-b. [PMID: 8405095] - T D Buckman, M S Sutphin, B Mitrovic. Oxidative stress in a clonal cell line of neuronal origin: effects of antioxidant enzyme modulation.
Journal of neurochemistry.
1993 Jun; 60(6):2046-58. doi:
10.1111/j.1471-4159.1993.tb03489.x. [PMID: 8492117] - M Satoh, D M Kloth, S A Kadhim, J L Chin, A Naganuma, N Imura, M G Cherian. Modulation of both cisplatin nephrotoxicity and drug resistance in murine bladder tumor by controlling metallothionein synthesis.
Cancer research.
1993 Apr; 53(8):1829-32. doi:
NULL. [PMID: 8467502] - M Lai, H Griffiths, H Pall, A Williams, J Lunec. An investigation into the role of reactive oxygen species in the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity using neuronal cell lines.
Biochemical pharmacology.
1993 Feb; 45(4):927-33. doi:
10.1016/0006-2952(93)90178-y. [PMID: 8452568] - E P Gomez-Sanchez, C E Gomez-Sanchez. The effect of gonadectomy and aromatase inhibition on the excretion of 19-nordeoxycorticosterone in rats.
The Journal of steroid biochemistry and molecular biology.
1991 Aug; 39(2):185-8. doi:
10.1016/0960-0760(91)90061-9. [PMID: 1888677] - N A Alexiuk, J Vriend. Effects of daily afternoon melatonin administration on monoamine accumulation in median eminence and striatum of ovariectomized hamsters receiving pargyline.
Neuroendocrinology.
1991 Jul; 54(1):55-61. doi:
. [PMID: 1922678] - E Spinedi, R C Gaillard. Stimulation of the hypothalamo-pituitary-adrenocortical axis by the central serotonergic pathway: involvement of endogenous corticotropin-releasing hormone but not vasopressin.
Journal of endocrinological investigation.
1991 Jul; 14(7):551-7. doi:
10.1007/bf03346866. [PMID: 1658112] - M C Anderson, P C Waldmeier, K F Tipton. The inhibition of monoamine oxidase by brofaromine.
Biochemical pharmacology.
1991 Jun; 41(12):1871-7. doi:
10.1016/0006-2952(91)90126-p. [PMID: 2039542] - G T Griffing, J C Melby, M Holbrook, O N Johnston. Antihypertensive effects of an aromatase inhibitor in inbred salt-sensitive rats.
Hypertension (Dallas, Tex. : 1979).
1991 Jun; 17(6 Pt 1):771-5. doi:
10.1161/01.hyp.17.6.771. [PMID: 2045138] - E S Cho, J Hovanec-Brown, R J Tomanek, L D Stegink. Propargylglycine infusion effects on tissue glutathione levels, plasma amino acid concentrations and tissue morphology in parenterally-fed growing rats.
The Journal of nutrition.
1991 Jun; 121(6):785-94. doi:
10.1093/jn/121.6.785. [PMID: 2033464] - M H Fernandes, M Pestana, P Soares-da-Silva. Deamination of newly-formed dopamine in rat renal tissues.
British journal of pharmacology.
1991 Mar; 102(3):778-82. doi:
10.1111/j.1476-5381.1991.tb12250.x. [PMID: 1364853] - L Raimondi, R Pirisino, G Ignesti, S Capecchi, G Banchelli, F Buffoni. Semicarbazide-sensitive amine oxidase activity (SSAO) of rat epididymal white adipose tissue.
Biochemical pharmacology.
1991 Feb; 41(3):467-70. doi:
10.1016/0006-2952(91)90549-k. [PMID: 1899791] - E Schömig, J Babin-Ebell, M Gliese, H Russ. Extraneuronal inactivation of noradrenaline in tissue culture.
Journal of neural transmission. Supplementum.
1991; 34(?):43-9. doi:
10.1007/978-3-7091-9175-0_6. [PMID: 1817163] - K Koike, A Miyake, T Aono, T Sakumoto, M Ohmichi, M Yamaguchi, O Tanizawa. Effect of prolactin on the secretion of hypothalamic GnRH and pituitary gonadotropins.
Hormone research.
1991; 35 Suppl 1(?):5-12. doi:
10.1159/000181921. [PMID: 1752606] - T Zaccheo, D Giudici, G Ornati, A Panzeri, E di Salle. Comparison of the effects of the irreversible aromatase inhibitor exemestane with atamestane and MDL 18962 in rats with DMBA-induced mammary tumours.
European journal of cancer (Oxford, England : 1990).
1991; 27(9):1145-50. doi:
10.1016/0277-5379(91)90313-3. [PMID: 1835626] - A Kawaji, T Sone, R Natsuki, M Isobe, E Takabatake, Y Yamaura. In vitro toxicity test of poisonous mushroom extracts with isolated rat hepatocytes.
The Journal of toxicological sciences.
1990 Aug; 15(3):145-56. doi:
10.2131/jts.15.145. [PMID: 2243367] - M H Stipanuk, J De la Rosa, L L Hirschberger. Catabolism of cyst(e)ine by rat renal cortical tubules.
The Journal of nutrition.
1990 May; 120(5):450-8. doi:
10.1093/jn/120.5.450. [PMID: 2111378] - N Mizobuchi, T Ageta, H Kodama. Determination of N-monoacetylcystathionine in biological samples using isotachophoresis.
Journal of chromatography.
1990 Apr; 526(2):550-5. doi:
10.1016/s0378-4347(00)82539-6. [PMID: 2361995] - J de Ceaurriz, M Ban. Role of gamma-glutamyltranspeptidase and beta-lyase in the nephrotoxicity of hexachloro-1,3-butadiene and methyl mercury in mice.
Toxicology letters.
1990 Feb; 50(2-3):249-56. doi:
10.1016/0378-4274(90)90017-g. [PMID: 1689880] - M Strolin Benedetti, G Cocchiara, M Colombo, P Dostert. Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide?.
Journal of neural transmission. Supplementum.
1990; 32(?):351-6. doi:
10.1007/978-3-7091-9113-2_48. [PMID: 2128509] - S Awata, K Nakayama, I Suzuki, H Kodama. Effect of cysteine on the inactivation of cystathionine gamma-lyase by D,L-propargylglycine.
Acta medica Okayama.
1989 Dec; 43(6):329-35. doi:
10.18926/amo/30862. [PMID: 2624140] - M Garbarg, H Pollard, M D Trung Tuong, J C Schwartz, C Gros. Sensitive radioimmunoassays for histamine and tele-methylhistamine in the brain.
Journal of neurochemistry.
1989 Dec; 53(6):1724-30. doi:
10.1111/j.1471-4159.1989.tb09237.x. [PMID: 2809587] - Y Kitamura, Y Kamisaki, T Itoh. Hepatoprotective effects of cystathionine against acetaminophen-induced necrosis.
The Journal of pharmacology and experimental therapeutics.
1989 Aug; 250(2):667-71. doi:
. [PMID: 2760849] - M B Youdim, D K Banerjee, K Kelner, L Offutt, H B Pollard. Steroid regulation of monoamine oxidase activity in the adrenal medulla.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
1989 Apr; 3(6):1753-9. doi:
10.1096/fasebj.3.6.2495232. [PMID: 2495232] - A M O'Carroll, M C Anderson, I Tobbia, J P Phillips, K F Tipton. Determination of the absolute concentrations of monoamine oxidase A and B in human tissues.
Biochemical pharmacology.
1989 Mar; 38(6):901-5. doi:
10.1016/0006-2952(89)90278-5. [PMID: 2495009] - G A Lyles, S A McDougall. The enhanced daily excretion of urinary methylamine in rats treated with semicarbazide or hydralazine may be related to the inhibition of semicarbazide-sensitive amine oxidase activities.
The Journal of pharmacy and pharmacology.
1989 Feb; 41(2):97-100. doi:
10.1111/j.2042-7158.1989.tb06401.x. [PMID: 2568436] - S M Evans, K J Collard. The mechanism by which monoamine oxidase inhibitors give rise to a non-calcium-dependent component in the depolarization-induced release of 5-HT from rat brain synaptosomes.
British journal of pharmacology.
1988 Nov; 95(3):950-6. doi:
10.1111/j.1476-5381.1988.tb11725.x. [PMID: 3264736] - M E Brandt, D Puett, D F Covey, S J Zimniski. Characterization of pregnant mare's serum gonadotropin-stimulated rat ovarian aromatase and its inhibition by 10-propargylestr-4-ene-3,17-dione.
Journal of steroid biochemistry.
1988 Sep; 31(3):317-24. doi:
10.1016/0022-4731(88)90356-1. [PMID: 3419162] - K Ramos, S L Grossman, L R Cox. Allylamine-induced vascular toxicity in vitro: prevention by semicarbazide-sensitive amine oxidase inhibitors.
Toxicology and applied pharmacology.
1988 Aug; 95(1):61-71. doi:
10.1016/s0041-008x(88)80008-5. [PMID: 2842890] - M E Brewster, K S Estes, R Perchalski, N Bodor. A dihydropyridine conjugate which generates high and sustained levels of the corresponding pyridinium salt in the brain does not exhibit neurotoxicity in cynomolgus monkeys.
Neuroscience letters.
1988 May; 87(3):277-82. doi:
10.1016/0304-3940(88)90461-2. [PMID: 3380349] - C Longcope, A Femino, J O Johnston. Inhibition of peripheral aromatization in baboons by an enzyme-activated aromatase inhibitor (MDL 18,962).
Endocrinology.
1988 May; 122(5):2007-11. doi:
10.1210/endo-122-5-2007. [PMID: 3359974] - G E Kass, J M Wright, P Nicotera, S Orrenius. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: role of intracellular calcium.
Archives of biochemistry and biophysics.
1988 Feb; 260(2):789-97. doi:
10.1016/0003-9861(88)90509-7. [PMID: 2963592] - P R Bieck, K H Antonin, R Balon, G Oxenkrug. Effect of brofaromine and pargyline on human plasma melatonin concentrations.
Progress in neuro-psychopharmacology & biological psychiatry.
1988; 12(1):93-101. doi:
10.1016/0278-5846(88)90064-4. [PMID: 3363166] - J C Melby, M Holbrook, G T Griffing, J O Johnston. Antihypertensive effects of an aromatase inhibitor in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979).
1987 Nov; 10(5):484-7. doi:
10.1161/01.hyp.10.5.484. [PMID: 3666863] - C Longcope. Peripheral aromatization: studies on controlling factors.
Steroids.
1987 Jul; 50(1-3):253-67. doi:
10.1016/0039-128x(83)90076-4. [PMID: 2847371] - S Harvey, T R Hall. Somatostatin immunoneutralization overcomes the inhibitory effects of quipazine and pargyline on growth hormone secretion in domestic fowl.
Experientia.
1987 Jun; 43(6):602-4. doi:
10.1007/bf02126345. [PMID: 2885213] - J N Johannessen, J M Savitt, C J Markey, J P Bacon, A Weisz, D S Hanselman, S P Markey. The development of amine substituted analogues of MPTP as unique tools for the study of MPTP toxicity and Parkinson's disease.
Life sciences.
1987 Feb; 40(8):697-704. doi:
10.1016/0024-3205(87)90296-7. [PMID: 2433563] - F Karoum. N-propargylbenzylamine, a major metabolite of pargyline, is a potent inhibitor of monoamine oxidase type B in rats in vivo: a comparison with deprenyl.
British journal of pharmacology.
1987 Feb; 90(2):335-45. doi:
10.1111/j.1476-5381.1987.tb08963.x. [PMID: 3103805]