Cefazedone (BioDeep_00000769836)

   

Chemicals and Drugs


代谢物信息卡片


Cefazedone

化学式: C18H15Cl2N5O5S3 (546.961236)
中文名称: 头孢西酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=C(C(=O)C(=C4)Cl)Cl)SC2)C(=O)O
InChI: InChI=1S/C18H15Cl2N5O5S3/c1-7-22-23-18(33-7)32-6-8-5-31-16-12(15(28)25(16)13(8)17(29)30)21-11(26)4-24-2-9(19)14(27)10(20)3-24/h2-3,12,16H,4-6H2,1H3,(H,21,26)(H,29,30)/t12-,16-/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Cefazedone (Refosporen), a first-generation cephalosporin, is a time-dependent antibiotic with activity against Gram-positive and Gram-negative bacteria[1].

同义名列表

2 个代谢物同义名

Cefazedone; Refosporen



数据库引用编号

8 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dan Wu, Zhen-Yu Qian, Tingting Guo, Wenyan Tang, Yi Xiang, Heng Zheng. Determination of cefazedone in human plasma by high performance liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study on Chinese volunteers. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Oct; 878(28):2911-5. doi: 10.1016/j.jchromb.2010.08.008. [PMID: 20813593]
  • L Adamek, F Mayer, R Wolf, T Raguse. [Use of preventive intra-operative antibiotic administration in appendectomy. A pharmacokinetic study]. Zentralblatt fur Chirurgie. 1991; 116(13):801-8. doi: NULL. [PMID: 1950215]
  • P H Degen, W Dieterle, W Schneider, W Theobald, U Sinterhauf. Pharmacokinetics of diclofenac and five metabolites after single doses in healthy volunteers and after repeated doses in patients. Xenobiotica; the fate of foreign compounds in biological systems. 1988 Dec; 18(12):1449-55. doi: 10.3109/00498258809042267. [PMID: 3245235]
  • G Hitzenberger, I Jaschek. [Pharmacokinetics and tolerance of Cefazedone compared with Cefazoline (author's transl)]. Wiener medizinische Wochenschrift (1946). 1980 Feb; 130(3):135-42. doi: NULL. [PMID: 7368759]
  • D Adam, A G Hofstetter, B Reichart, C Schneider, H Wolff, E Koch. [The diffusion of cefazedone into heart muscle, prostatic and skin tissue and into bile]. Arzneimittel-Forschung. 1979; 29(12):1901-6. doi: NULL. [PMID: 546431]