Flurazepam hydrochloride (BioDeep_00000769639)

   


代谢物信息卡片


Flurazepam dihydrochloride

化学式: C21H25Cl3FN3O (459.1047142)
中文名称: 盐酸氟安定
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl
InChI: 2*1H

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

2 个代谢物同义名

Flurazepam dihydrochloride; Flurazepam hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Yu-Dong Jeong, Min Kyung Kim, Sung Ill Suh, Moon Kyo In, Jin Young Kim, Ki-Jung Paeng. Rapid determination of benzodiazepines, zolpidem and their metabolites in urine using direct injection liquid chromatography-tandem mass spectrometry. Forensic science international. 2015 Dec; 257(?):84-92. doi: 10.1016/j.forsciint.2015.07.043. [PMID: 26282513]
  • Jing Zhou, Koji Yamaguchi, Youkichi Ohno. Quantitative analysis of quazepam and its metabolites in human blood, urine, and bile by liquid chromatography-tandem mass spectrometry. Forensic science international. 2014 Aug; 241(?):e5-12. doi: 10.1016/j.forsciint.2014.04.027. [PMID: 24856286]
  • Susanne Vogt, Jürgen Kempf, Jürgen Buttler, Volker Auwärter, Wolfgang Weinmann. Desalkylflurazepam found in patients' samples after high-dose midazolam treatment. Drug testing and analysis. 2013 Sep; 5(9-10):745-7. doi: 10.1002/dta.1484. [PMID: 23713025]
  • Stephanie J Marin, Gwendolyn A McMillin. LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium. Methods in molecular biology (Clifton, N.J.). 2010; 603(?):89-105. doi: 10.1007/978-1-60761-459-3_9. [PMID: 20077062]
  • Sofia A C Lima, Anabela Cordeiro-da-Silva, Baltazar de Castro, Paula Gameiro. Sensitivity of P-glycoprotein tryptophan residues to benzodiazepines and ATP interaction. Biophysical chemistry. 2007 Jan; 125(1):143-50. doi: 10.1016/j.bpc.2006.07.006. [PMID: 16919386]
  • Franz E Dussy, Cornelia Hamberg, Thomas A Briellmann. Quantification of benzodiazepines in whole blood and serum. International journal of legal medicine. 2006 Nov; 120(6):323-30. doi: 10.1007/s00414-005-0042-1. [PMID: 16220317]
  • Simona Martello, Antonio Oliva, Fabio De Giorgio, Marcello Chiarotti. Acute flurazepam intoxication: a case report. The American journal of forensic medicine and pathology. 2006 Mar; 27(1):55-7. doi: 10.1097/01.paf.0000201106.59902.fb. [PMID: 16501350]
  • Victoria F Safiulina, Giorgia Fattorini, Fiorenzo Conti, Enrico Cherubini. GABAergic signaling at mossy fiber synapses in neonatal rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Jan; 26(2):597-608. doi: 10.1523/jneurosci.4493-05.2006. [PMID: 16407558]
  • Kimiyasu Kato, Norio Yasui-Furukori, Takashi Fukasawa, Toshiaki Aoshima, Akihito Suzuki, Muneaki Kanno, Koichi Otani. Effects of itraconazole on the plasma kinetics of quazepam and its two active metabolites after a single oral dose of the drug. Therapeutic drug monitoring. 2003 Aug; 25(4):473-7. doi: 10.1097/00007691-200308000-00010. [PMID: 12883232]
  • Ahmed Ahmed Omran, Keisuke Kitamura, Shigehiko Takegami, Tatsuya Kitade, Abdel-Aziz Youssef El-Sayed, Mahmoud Hamed Mohamed, Mohamed Abdel-Mottaleb. Effect of phosphatidylserine content on the partition coefficients of diazepam and flurazepam between phosphatidylcholine-phosphatidylserine bilayer of small unilamellar vesicles and water studied by second derivative spectrophotometry. Chemical & pharmaceutical bulletin. 2002 Mar; 50(3):312-5. doi: 10.1248/cpb.50.312. [PMID: 11911192]
  • A A Omran, K Kitamura, S Takegami, A A El-Sayed, M Abdel-Mottaleb. Determination of partition coefficients of diazepam and flurazepam between phosphatidylcholine bilayer vesicles and water by second derivative spectrophotometric method. Journal of pharmaceutical and biomedical analysis. 2001 May; 25(2):319-24. doi: 10.1016/s0731-7085(00)00503-3. [PMID: 11275439]
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  • M Tomita, T Okuyama. Application of capillary electrophoresis to the simultaneous screening and quantitation of benzodiazepines. Journal of chromatography. B, Biomedical applications. 1996 Apr; 678(2):331-7. doi: 10.1016/0378-4347(95)00512-9. [PMID: 8738039]
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