Ethylestrenol (BioDeep_00000769304)

   


代谢物信息卡片


19-Norpregn-4-en-17-ol, (17alpha)-

化学式: C20H32O (288.24530219999997)
中文名称: 乙基雌烯醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1(CCC2C1(CCC3C2CCC4=CCCCC34)C)O
InChI: InChI=1S/C20H32O/c1-3-20(21)13-11-18-17-9-8-14-6-4-5-7-15(14)16(17)10-12-19(18,20)2/h6,15-18,21H,3-5,7-13H2,1-2H3

描述信息

A - Alimentary tract and metabolism > A14 - Anabolic agents for systemic use > A14A - Anabolic steroids > A14AB - Estren derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid

同义名列表

2 个代谢物同义名

Ethylestrenol; 19-Norpregn-4-en-17-ol, (17alpha)-



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • Ihsan Ergün, M Cenk Akbostanci, Başol Canbakan, Bilge Koçer, Arzu Ensari, Gökhan Nergizoglu, Kenan Keven. Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2005 Jul; 46(1):e11-4. doi: 10.1053/j.ajkd.2005.03.009. [PMID: 15983949]
  • M Van Puymbroeck, M E Kuilman, R F Maas, R F Witkamp, L Leyssens, A S Van Miert, L Hendriks, D Vanderzande, P Adriaensens, M P Jacobs, J Raus. 17alpha-ethyl-5beta-estrane-3alpha, 17beta-diol, a biological marker for the abuse of norethandrolone and ethylestrenol in slaughter cattle. Journal of chromatography. B, Biomedical sciences and applications. 1999 May; 728(2):217-32. doi: 10.1016/s0378-4347(99)00091-2. [PMID: 10406207]
  • H A Verheul, E V Tittes, J Kelder, A H Schuurs. Effects of steroids with different endocrine profiles on the development, morphology and function of the bursa of Fabricius in chickens. Journal of steroid biochemistry. 1986 Nov; 25(5A):665-75. doi: 10.1016/0022-4731(86)90009-9. [PMID: 3795945]
  • K P Lone, B W Ince. Cellular growth responses of rainbow trout (Salmo gairdneri) fed different levels of dietary protein, and an anabolic steroid ethylestrenol. General and comparative endocrinology. 1983 Jan; 49(1):32-49. doi: 10.1016/0016-6480(83)90005-9. [PMID: 6186574]
  • I Björkhem, H Ek, O Lantto. Assay of ethylestrenol in urine by isotope dilution--mass spectrometry. Journal of chromatography. 1982 Oct; 232(1):154-9. doi: 10.1016/s0378-4347(00)86018-1. [PMID: 6754754]
  • B W Ince, K P Lone, A J Matty. Effect of dietary protein level, and an anabolic steroid, ethylestrenol, on the growth, food conversion efficiency and protein efficiency ratio of rainbow trout (Salmo gairdneri). The British journal of nutrition. 1982 May; 47(3):615-24. doi: 10.1079/bjn19820073. [PMID: 7082629]
  • J W Steele, L J Boux, R C Audette. Anabolic steroids. Part 2: the disposition of ethylestrenol in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1981 Feb; 11(2):103-15. doi: 10.3109/00498258109045280. [PMID: 7233967]
  • I M Nilsson, U Hedner. [Non-enzymatic fibrinolytic agents]. Annales de l'anesthesiologie francaise. 1978; 19(8):697-702. doi: . [PMID: 31113]
  • C P Robinson, P W Smith, C R Crane, J K McConnell, L V Allen, B R Endecott. The protective effects of ethylestrenol against acute poisoning by organophosphorus cholinesterase inhibitors in rats. Archives internationales de pharmacodynamie et de therapie. 1978 Jan; 231(1):168-76. doi: NULL. [PMID: 637620]
  • R J Ward, A M Lawson, C H Shackleton. Metabolism of anabolic steroid drugs in man and the marmoset monkey (Callithrix jacchus)--I. Nilevar and Orabolin. Journal of steroid biochemistry. 1977 Oct; 8(10):1057-63. doi: 10.1016/0022-4731(77)90274-6. [PMID: 410996]
  • J S Dericks-Tan, H D Taubert. Elevation of serum prolactin during application of oral contraceptives. Contraception. 1976 Jul; 14(1):1-8. doi: 10.1016/s0010-7824(76)80002-9. [PMID: 975808]
  • I D Walker, J F Davidson, P Young, J A Conkie. Effect of anabolic steroids on plasma antithrombin III. alpha2 macroglobulin and alpha1 antitrypsin levels. Thrombosis et diathesis haemorrhagica. 1975 Sep; 34(1):106-14. doi: . [PMID: 52896]
  • M Tsushima, E Asano, Y Hata. Primary prevention of atherosclerotic vascular disease with ethylnandrol. An interim report of four-year observations. Japanese circulation journal. 1975 Mar; 39(3):285-92. doi: 10.1253/jcj.39.285. [PMID: 1090769]
  • H D Bruhn, P Jipp, S Okoye, A Oltmann. [Hypofibrinolysis in acute myocardial infarction (author's transl)]. Medizinische Klinik. 1974 Nov; 69(47):1951-5. doi: NULL. [PMID: 4444662]
  • B Tuchweber, K Kovacs, M V Jago, T Beaulieu. Effect of steroidal and nonsteroidal microsomal enzyme inducers on the hepatotoxicity of pyrrolizidine alkaloids in rats. Research communications in chemical pathology and pharmacology. 1974 Feb; 7(2):459-80. doi: NULL. [PMID: 4818386]
  • O H Bolch, J C Warren. Induction of premature menstruation with anabolic steroids. American journal of obstetrics and gynecology. 1973 Sep; 117(1):121-5. doi: 10.1016/0002-9378(73)90738-2. [PMID: 4722368]
  • M H Tabacchi, A Kirksey. Influence of dietary lipids on plasma and hepatic lipids and on blood clotting properties in rats fed oral contraceptives. The Journal of nutrition. 1973 Sep; 103(9):1270-8. doi: 10.1093/jn/103.9.1270. [PMID: 4725717]
  • B Dodman, W J Cunliffe, B E Roberts, R Sibbald. Clinical and laboratory double-blind investigation on effect of fibrinolytic therapy in patients with cutaneous vasculitis. British medical journal. 1973 Apr; 2(5858):82-4. doi: 10.1136/bmj.2.5858.82. [PMID: 4573315]
  • S K Banerjee, R K Roy, P K Majumder, G C Chatterjee. Effect of sulphur containing amino acids and anabolic steroid on the metabolism of ascorbic acid in rats fed on necrogenic diets. Indian journal of biochemistry & biophysics. 1973 Mar; 10(1):27-30. doi: NULL. [PMID: 4778112]
  • P T Rao, A M Khan, K Anjaiah. Comparative trial of Liv 52 and Orabolin in marasmus. Indian journal of pediatrics. 1972 Jul; 39(294):227-30. doi: 10.1007/bf02752466. [PMID: 4644287]
  • H Selye. Protection by glucocorticoids against allopurinol nephropathy. Acta endocrinologica. 1972 Feb; 69(2):347-54. doi: 10.1530/acta.0.0690347. [PMID: 4400740]
  • S D Kulkarni, G V Joglekar, J H Balwani. Anabolic activity of buclizine on rats. European journal of pharmacology. 1972 Feb; 17(2):312-4. doi: 10.1016/0014-2999(72)90179-3. [PMID: 4402100]
  • G A MacGregor, P A Poole-Wilson, N F Jones. Phenformin and metabolic acidosis. Lancet (London, England). 1972 Jan; 1(7741):69-71. doi: 10.1016/s0140-6736(72)90065-7. [PMID: 4108948]
  • B Solymoss, S Toth, S Varga, M Krajny. Influence of spironolactone and other steroids on the plasma level of digitoxin. Recent advances in studies on cardiac structure and metabolism. 1972; 1(?):605-11. doi: NULL. [PMID: 4681488]
  • H L Krüskemper. [Androgens, anabolic steroids and lipid metabolism]. Zeitschrift fur Ernahrungswissenschaft. Journal of nutritional sciences. Supplementa. 1972; 12(?):Suppl 12:16-21. doi: ". [PMID: 4505202]
  • B K Mandal, M McNulty. Treatment of haemolytic-uraemic syndrome with phenformin and ethyloestrenol. Lancet (London, England). 1971 Nov; 2(7732):1036. doi: 10.1016/s0140-6736(71)90352-7. [PMID: 4108091]
  • J Barbosa, U S Seal, R P Doe. Effects of anabolic steroids on haptoglobin, orosomucoid, plasminogen, fibrinogen, transferrin, ceruloplasmin, alpha-1-antitrypsin, beta-glucuronidase and total serum proteins. The Journal of clinical endocrinology and metabolism. 1971 Sep; 33(3):388-98. doi: 10.1210/jcem-33-3-388. [PMID: 4105857]
  • J Barbosa, U S Seal, R P Doe. Effects of anabolic steroids on hormone-binding proteins, serum cortisol and serum nonprotein-bound cortisol. The Journal of clinical endocrinology and metabolism. 1971 Feb; 32(2):232-40. doi: 10.1210/jcem-32-2-232. [PMID: 4992507]
  • W J Cunliffe, I S Menon. The association between cutaneous vasculitis and decreased blood fibrinolytic activity. The British journal of dermatology. 1971 Feb; 84(2):99-105. doi: 10.1111/j.1365-2133.1971.tb06850.x. [PMID: 4396169]
  • S Isacson. Low fibrinolytic activity of blood and vein walls in venous thrombosis. Scandinavian journal of haematology. Supplementum. 1971; 16(?):1-29. doi: 10.1111/j.1600-0609.1971.tb02062.x. [PMID: 5285936]
  • J A Hickman. Pharmacological enhancement of fibrinolytic activity and 125I-fibrinogen survival. Journal of clinical pathology. 1970 Dec; 23(9):797-800. doi: 10.1136/jcp.23.9.797. [PMID: 5504373]
  • B Solymoss, M Krajny, S Varga. Independence of antimineralocorticoid and catatoxic effects of various steroids. Journal of pharmaceutical sciences. 1970 May; 59(5):712-4. doi: 10.1002/jps.2600590532. [PMID: 4392820]
  • G R Fearnley, R Chakrabarti, J F Evans. Effect of ethyloestrenol combined with phenformin or with metformin on platelet stickiness and serum-cholesterol in patients with occlusive vascular disease. Lancet (London, England). 1968 Nov; 2(7576):1004-7. doi: 10.1016/s0140-6736(68)91297-x. [PMID: 4176859]
  • R G van Wayjen. [Determination of nitrogen-saving effect of anabolic hormones by means of balance studies. IV. After administration of 5,6-dimethyl-benzimidazole-cobamide-coenzyme]. Arzneimittel-Forschung. 1968 Jul; 18(7):872-6. doi: NULL. [PMID: 5755834]
  • T Saito, M Saito. [Studies on the mechanism of action of anabolic steroids. 2. Effect on serum glycoproteins]. Iryo. 1966 Nov; 20(11):1154-61. doi: NULL. [PMID: 5982058]
  • G Fiegel, R Bargheer, D Kukwa. [The behavior of lipid metabolism under the effect of simultaneous administration of anabolics and essential phospholipids]. Arzneimittel-Forschung. 1966 Mar; 16(3):443-6. doi: ". [PMID: 6013856]
  • G Fiegel, R Bargheer, D Kukwa. [Modification of lipid metabolism by anabolic agents]. Arzneimittel-Forschung. 1966 Feb; 16(2):202-6. doi: ". [PMID: 6014014]
  • G Fanconi. [Appearance of diabetes mellitus in primordial dwarfism during long continued therapy with anabolic steroids]. Helvetica paediatrica acta. 1965 Dec; 20(6):643-5. doi: NULL. [PMID: 5869819]
  • Y YOSHITOSHI. [THE METABOLIC EFFECT OF ANABOLIC STEROIDS AND THEIR CLINICAL APPLICATION]. Nihon Naibunpi Gakkai zasshi. 1964 Dec; 40(?):1155-65. doi: NULL. [PMID: 14267839]
  • A WALSER, G SCHOENENBERGER. [Metabolic research on ethylestrenol]. Schweizerische medizinische Wochenschrift. 1962 Jul; 92(?):897-901. doi: ". [PMID: 14004722]