TRICIRIBINE PHOSPHATE (BioDeep_00000769290)

   


代谢物信息卡片


1,4,5,6,8-Pentaazaacenaphthylen-3-amine

化学式: C13H17N6O7P (400.08963020000004)
中文名称: 曲西立滨磷酸酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)COP(=O)(O)O)O)O)C(=N1)N
InChI: InChI=1S/C13H17N6O7P/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(21)8(20)6(26-13)3-25-27(22,23)24/h2,4,6,8-9,13,20-21H,3H2,1H3,(H2,14,17)(H2,22,23,24)

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2087 - Inosine Monophosphate Dehydrogenase Inhibitor
C471 - Enzyme Inhibitor > C2254 - Amidophosphoribosyltransferase Inhibitor

同义名列表

3 个代谢物同义名

1,4,5,6,8-Pentaazaacenaphthylen-3-amine; Phosphate Salt of Tricyclic Nucleoside; TRICIRIBINE PHOSPHATE



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shridhar Narayanan, Radha Krishan Shandil, Vijay Kamal Ahuja, S Siva Shanmugam, Hima Mahesh K U, Niraj Ramesh, Narayanan Surendran. Development and validation of LC/MS/MS method for Triciribine and its monophosphate metabolite in plasma and RBC: Application to mice pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Jun; 1174(?):122714. doi: 10.1016/j.jchromb.2021.122714. [PMID: 33962189]
  • N Berndt, H Yang, B Trinczek, S Betzi, Z Zhang, B Wu, N J Lawrence, M Pellecchia, E Schönbrunn, J Q Cheng, S M Sebti. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane. Cell death and differentiation. 2010 Nov; 17(11):1795-804. doi: 10.1038/cdd.2010.63. [PMID: 20489726]
  • R B Schilcher, C D Haas, M K Samson, J D Young, L H Baker. Phase I evaluation and clinical pharmacology of tricyclic nucleoside 5'-phosphate using a weekly intravenous regimen. Cancer research. 1986 Jun; 46(6):3147-51. doi: NULL. [PMID: 3698029]
  • L L Wotring, G W Crabtree, N L Edwards, R E Parks, L B Townsend. Mechanism of activation of triciribine phosphate (TCN-P) as a prodrug form of TCN. Cancer treatment reports. 1986 Apr; 70(4):491-7. doi: NULL. [PMID: 3698043]
  • G Powis, P J Basseches, D M Kroschel, R L Richardson, M J O'Connell, L K Kvols. Disposition of tricyclic nucleoside-5'-monophosphate in blood and plasma of patients during phase I and II clinical trials. Cancer treatment reports. 1986 Mar; 70(3):359-62. doi: NULL. [PMID: 3955547]
  • R B Schilcher, J D Young, L H Baker. Reversed-phase high-performance liquid chromatographic determination of tricyclic nucleoside and tricyclic nucleoside 5'-phosphate in biological specimens. Journal of chromatography. 1985 Jan; 337(1):55-62. doi: 10.1016/0378-4347(85)80007-4. [PMID: 3980657]
  • L G Feun, N Savaraj, G P Bodey, K Lu, B S Yap, J A Ajani, M A Burgess, R S Benjamin, E McKelvey, I Krakoff. Phase I study of tricyclic nucleoside phosphate using a five-day continuous infusion schedule. Cancer research. 1984 Aug; 44(8):3608-12. doi: NULL. [PMID: 6744283]
  • A Mittelman, E S Casper, T A Godwin, C Cassidy, C W Young. Phase I study of tricyclic nucleoside phosphate. Cancer treatment reports. 1983 Feb; 67(2):159-62. doi: NULL. [PMID: 6825123]
  • W R Cobb, A E Bogden, S D Reich, T W Griffin, D E Kelton, D J LePage. Activity of two phase I drugs, homoharringtonine and tricyclic nucleotide, against surgical explants of human tumors in the 6-day subrenal capsule assay. Cancer treatment reports. 1983 Feb; 67(2):173-8. doi: NULL. [PMID: 6825125]
  • P J Basseches, A Durski, G Powis. High-performance liquid chromatographic assay of the antineoplastic agent tricyclic nucleoside 5'-phosphate and its disposition in rabbit. Journal of chromatography. 1982 Dec; 233(?):227-34. doi: 10.1016/s0378-4347(00)81749-1. [PMID: 7161335]
  • S Fiocca, A Basilico, G Vago. [Automatic method for determination of serum antistreptolysin]. Quaderni Sclavo di diagnostica clinica e di laboratorio. 1975 Sep; 11(3):696-702. doi: NULL. [PMID: 3821]