Cefixime trihydrate (BioDeep_00000768753)
代谢物信息卡片
Cefixime trihydrate
化学式: C16H21N5O10S2 (507.0729806)
中文名称: 头孢克肟三水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O.O.O.O
InChI: /m1.../s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sepideh Asadi, Bahar Nayeri-Fasaei, Taghi Zahraei-Salehi, Ramak Yahya-Rayat, Nemat Shams, Aram Sharifi. Antibacterial and anti-biofilm properties of carvacrol alone and in combination with cefixime against Escherichia coli.
BMC microbiology.
2023 Mar; 23(1):55. doi:
10.1186/s12866-023-02797-x. [PMID: 36864390] - Khadijeh Khoshdel, Moones Honarmand, Hassan Hassani. SnO2 and CuO anchored on zeolite as an efficient heterojunction photocatalyst for sunlight-assisted degradation of cefixime.
Environmental science and pollution research international.
2023 Mar; 30(13):36883-36903. doi:
10.1007/s11356-022-24635-9. [PMID: 36564689] - S Balasurya, Mohammad K Okla, Hamada AbdElgawad, Abdullah A Al-Ghamdi, Mostafa A Abdel-Maksoud, Saud S Al-Amri, Mahmoud M Y Madany, S Sudheer Khan. Self-propelled nanojets an interfacial Schottky junctions modulated oxygen vacancies enriched for enhanced photo-Fenton degradation of organic contaminant: Improving H2O2 generation, Fe3+/Fe2+ cycle and enhancing plant metabolism.
Chemosphere.
2023 Feb; 314(?):137516. doi:
10.1016/j.chemosphere.2022.137516. [PMID: 36521743] - Xueping Huang, Baihe Wu, Qiuzhao Chen, Yushan Chen, Xinhua Ji, Xiang Zhou, Biao Suo, Zhihui Lin, Xiaoling Zheng. Antibiotic resistance profile of Helicobacter pylori to 14 antibiotics: a multicenter study in Fujian, China.
PeerJ.
2023; 11(?):e15611. doi:
10.7717/peerj.15611. [PMID: 37456872] - Maryam Ramtin, Fariba Sharifniya, Mohaddeseh Larypoor, Mirsasan Mirpour, Saeid Zarrabi. Evaluation of the Active Ingredient of Campsis radicans Essential Oils and its Antimicrobial Evaluation Against Pathogenic Bacteria.
Current microbiology.
2022 Oct; 79(11):338. doi:
10.1007/s00284-022-03042-w. [PMID: 36201048] - Phuong Thi Thu Nguyen, Ha Viet Pham, Dung Hoang Van, Linh Van Pham, Hoi Thanh Nguyen, Hung Van Nguyen. Randomized controlled trial of the relative efficacy of high-dose intravenous ceftriaxone and oral cefixime combined with doxycycline for the treatment of Chlamydia trachomatis and Neisseria gonorrhoeae co-infection.
BMC infectious diseases.
2022 Jul; 22(1):607. doi:
10.1186/s12879-022-07595-w. [PMID: 35810277] - Fatma Ilgaz, Selin Seda Timur, Cemil Can Eylem, Emirhan Nemutlu, Çiğdem Eroğlu Erdem, Hakan Eroğlu, Hülya Gökmen-Özel. Do Thickening Agents Used in Dysphagia Diet Affect Drug Bioavailability?.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Jul; 174(?):106197. doi:
10.1016/j.ejps.2022.106197. [PMID: 35489612] - Rozhin Darabi, Mehdi Shabani-Nooshabadi. Development of an amplified nanostructured electrochemical sensor for the detection of cefixime in pharmaceuticals and biological samples.
Journal of pharmaceutical and biomedical analysis.
2022 Apr; 212(?):114657. doi:
10.1016/j.jpba.2022.114657. [PMID: 35158186] - Mahwish Kamran, Mir Azam Khan, Muhammad Shafique, Ghallab Alotaibi, Abdulaziz Al Mouslem, Maqsood Rehman, Muhammad Asghar Khan, Sumaira Gul. Formulation Design, Characterization and In-Vivo Assessment of Cefixime Loaded Binary Solid Lipid Nanoparticles to Enhance Oral Bioavailability.
Journal of biomedical nanotechnology.
2022 Apr; 18(4):1215-1226. doi:
10.1166/jbn.2022.3313. [PMID: 35854445] - Di Zhao, Xue-Fang Liu, Yan-Ge Tian, Hao-Ran Dong, Su-Xiang Feng, Jian-Sheng Li. The pharmacokinetic study of Tanreqing and the interaction with cefixime in rat model of pneumonia by validated UPLC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2022 Feb; 209(?):114484. doi:
10.1016/j.jpba.2021.114484. [PMID: 34891004] - Bushra Ahmad, Muhammad Rashid Khan, Naseer Ali Shah, Rahmat Ali Khan. In vitro antimicrobial and cytotoxic manifestations of Dicliptera roxburghiana.
Pakistan journal of pharmaceutical sciences.
2022 Jan; 35(1):29-34. doi:
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The Journal of antimicrobial chemotherapy.
2021 10; 76(11):2839-2846. doi:
10.1093/jac/dkab289. [PMID: 34453533] - Chrysovalantis Stafylis, Kori Keith, Shivani Mehta, David Tellalian, Pamela Burian, Carl Millner, Jeffrey D Klausner. Clinical Efficacy of Cefixime for the Treatment of Early Syphilis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 09; 73(5):907-910. doi:
10.1093/cid/ciab187. [PMID: 33640982] - Salim Saifullah, Tasmina Kanwal, Shafi Ullah, Muhammad Kawish, Shahida Muhammad Habib, Imdad Ali, Abubakar Munir, Muhammad Imran, Muhammad Raza Shah. Design and development of lipid modified chitosan containing muco-adhesive self-emulsifying drug delivery systems for cefixime oral delivery.
Chemistry and physics of lipids.
2021 03; 235(?):105052. doi:
10.1016/j.chemphyslip.2021.105052. [PMID: 33482099] - Shivani N Mehta, Chrysovalantis Stafylis, David M Tellalian, Pamela L Burian, Cliff M Okada, Carl E Millner, Christopher M Mejia, Jeffrey D Klausner. Clinical trial protocol to evaluate the efficacy of cefixime in the treatment of early syphilis.
Trials.
2020 Dec; 21(1):1009. doi:
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Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2020 10; 125(4):477-478. doi:
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Allergologia et immunopathologia.
2020 Sep; 48(5):424-429. doi:
10.1016/j.aller.2019.07.012. [PMID: 32653225] - Han-Ki Park, Youngwoo Choi, Dong-Hyun Lee, Sujeong Kim, Jong-Myung Lee, Sae Won Choi, Hee-Ra Lee, Mina Rho, Hae-Sim Park. Altered gut microbiota by azithromycin attenuates airway inflammation in allergic asthma.
The Journal of allergy and clinical immunology.
2020 05; 145(5):1466-1469.e8. doi:
10.1016/j.jaci.2020.01.044. [PMID: 32035985] - Kristie L Connolly, Ann E Eakin, Carolina Gomez, Blaire L Osborn, Magnus Unemo, Ann E Jerse. Pharmacokinetic Data Are Predictive of In Vivo Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Neisseria gonorrhoeae Strains in the Gonorrhea Mouse Model.
Antimicrobial agents and chemotherapy.
2019 03; 63(3):. doi:
10.1128/aac.01644-18. [PMID: 30642924] - Mohammad Dehghani, Navid Nasirizadeh, Mohammad Esmail Yazdanshenas. Determination of cefixime using a novel electrochemical sensor produced with gold nanowires/graphene oxide/electropolymerized molecular imprinted polymer.
Materials science & engineering. C, Materials for biological applications.
2019 Mar; 96(?):654-660. doi:
10.1016/j.msec.2018.12.002. [PMID: 30606577] - Muhammad Waqas Khadam, Muhammad Mudassar Ashraf, Umbreen Naz, Nadeem Irfan Bukhari, Imtiaz Mahmood Tahir, Dawood Asghar. Disposition kinetics, renal clearance and urinary excretion of cefixime in adolescent Pakistani boys - DRUG ANALYSIS REPORT.
JPMA. The Journal of the Pakistan Medical Association.
2019 Mar; 69(3):367-372. doi:
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Sexually transmitted diseases.
2018 10; 45(10):677-683. doi:
10.1097/olq.0000000000000844. [PMID: 29624558] - Shaghufta Perveen, Naila Safdar, Gul-E-Saba Chaudhry, Azra Yasmin. Antibacterial evaluation of silver nanoparticles synthesized from lychee peel: individual versus antibiotic conjugated effects.
World journal of microbiology & biotechnology.
2018 Jul; 34(8):118. doi:
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Annals of clinical microbiology and antimicrobials.
2018 Jun; 17(1):27. doi:
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Luminescence : the journal of biological and chemical luminescence.
2018 Feb; 33(1):209-218. doi:
10.1002/bio.3403. [PMID: 28976065] - Saman Naghibi, Hamed Sahebi. Employment of modified Fe3 O4 nanoparticles using thermo-sensitive polymer for extraction and pre-concentration of cefexime in biological samples.
Biomedical chromatography : BMC.
2018 Feb; 32(2):. doi:
10.1002/bmc.4082. [PMID: 28833295] - Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdul Sadiq, Imdad Ali, Farid Ahmed, Waqas Nawaz. Double-tailed acyl glycoside niosomal nanocarrier for enhanced oral bioavailability of Cefixime.
Artificial cells, nanomedicine, and biotechnology.
2017 Nov; 45(7):1440-1451. doi:
10.1080/21691401.2016.1246451. [PMID: 27822958] - Ying Shi, Qixiao Zhai, Dongyao Li, Bingyong Mao, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Wei Chen. Restoration of cefixime-induced gut microbiota changes by Lactobacillus cocktails and fructooligosaccharides in a mouse model.
Microbiological research.
2017 Jul; 200(?):14-24. doi:
10.1016/j.micres.2017.04.001. [PMID: 28527760] - Subhash Dhital, Jeevan Bahadur Sherchand, Bharat Mani Pokharel, Keshab Parajuli, Shyam Kumar Mishra, Sangita Sharma, Hari Prasad Kattel, Sundar Khadka, Sulochana Khatiwada, Basista Rijal. Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production.
BMC research notes.
2017 Jun; 10(1):192. doi:
10.1186/s13104-017-2512-1. [PMID: 28583187] - Farhad Akhgari, Naser Samadi, Khalil Farhadi. Fluorescent Carbon Dot as Nanosensor for Sensitive and Selective Detection of Cefixime Based on Inner Filter Effect.
Journal of fluorescence.
2017 May; 27(3):921-927. doi:
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BMC complementary and alternative medicine.
2016 Nov; 16(1):485. doi:
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Archives of oral biology.
2016 Nov; 71(?):122-128. doi:
10.1016/j.archoralbio.2016.07.007. [PMID: 27491082] - Tulin Demir, Mumtaz Dadali. Recurrent complicated urinary tract infection due to rare pathogen Sphingomonas paucimobilis: contamination or real deal?.
Le infezioni in medicina.
2016 Sep; 24(3):241-4. doi:
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International journal of pharmaceutics.
2016 May; 505(1-2):122-32. doi:
10.1016/j.ijpharm.2016.03.042. [PMID: 27050867] - Alexandre Malmartel, Christian Ghasarossian. Bacterial resistance in urinary tract infections in patients with diabetes matched with patients without diabetes.
Journal of diabetes and its complications.
2016 May; 30(4):705-9. doi:
10.1016/j.jdiacomp.2016.01.005. [PMID: 26851821] - Lihui Zhang, Baosheng Liu, Zhiyun Li, Ying Guo. Comparative studies on the interaction of cefixime with bovine serum albumin by fluorescence quenching spectroscopy and synchronous fluorescence spectroscopy.
Luminescence : the journal of biological and chemical luminescence.
2015 Aug; 30(5):686-92. doi:
10.1002/bio.2805. [PMID: 25351241] - Li Wang, Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Pengyuan Sun, Xiaobo Yang, Huijun Sun, Yuhong Zhen, Jinyong Peng, Xiaochi Ma, Kexin Liu. PEPT1- and OAT1/3-mediated drug-drug interactions between bestatin and cefixime in vivo and in vitro in rats, and in vitro in human.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Oct; 63(?):77-86. doi:
10.1016/j.ejps.2014.06.019. [PMID: 25016073] - Mehmet Lütfi Yola, Tanju Eren, Necip Atar. Molecularly imprinted electrochemical biosensor based on Fe@Au nanoparticles involved in 2-aminoethanethiol functionalized multi-walled carbon nanotubes for sensitive determination of cefexime in human plasma.
Biosensors & bioelectronics.
2014 Oct; 60(?):277-85. doi:
10.1016/j.bios.2014.04.045. [PMID: 24832202] - Somnath D Bhinge, Sharangouda M Malipatil, Lalit V Sonawane. Bioanalytical method development and validation for simultaneous estimation of cefixime and dicloxacillin by RP-HPLC in human plasma.
Acta chimica Slovenica.
2014; 61(3):580-6. doi:
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Urologiia (Moscow, Russia : 1999).
2013 Sep; ?(5):24, 26-8. doi:
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PloS one.
2013; 8(8):e71086. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Aug; 879(24):2423-9. doi:
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Urologiia (Moscow, Russia : 1999).
2011 Mar; ?(2):63-6. doi:
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Analytical biochemistry.
2010 Dec; 407(1):79-88. doi:
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Antimicrobial agents and chemotherapy.
2010 Jan; 54(1):164-9. doi:
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Neurology.
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