Piperazine phosphate (BioDeep_00000768394)
Volatile Flavor Compounds
代谢物信息卡片
Piperazine hydrogen phosphate 1-hydrate
化学式: C4H15N2O5P (202.071855)
中文名称: 磷酸哌嗪 一水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CNCCN1.O.OP(=O)(O)O
InChI: 1H2
描述信息
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:32006
- PubChem: 443965
- ChEMBL: CHEMBL2105892
- MeSH: Piperazine
- CAS: 18534-18-4
- PubChem: 583228
- KEGG: C12839
- KNApSAcK: 32006
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hangqi Zhang, Ming Li, Xueming Zhou, Li Tang, Guangying Chen, Yongmin Zhang. Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells.
European journal of medicinal chemistry.
2024 Jun; 272(?):116497. doi:
10.1016/j.ejmech.2024.116497. [PMID: 38759453] - Jinli Chen, Meng Zhang, Chunmei Yuan, Tao Zhang, Zhibing Wu, Tingting Li, Yonggui Robin Chi. Design, Synthesis, and Antifungal Activity of Acrylamide Derivatives Containing Trifluoromethylpyridine and Piperazine.
Journal of agricultural and food chemistry.
2024 May; 72(20):11360-11368. doi:
10.1021/acs.jafc.3c09770. [PMID: 38720533] - Guang-Long Zhang, Zhen-Chao Wang, Cheng-Peng Li, Dan-Ping Chen, Zhu-Rui Li, Yan Li, Gui-Ping Ouyang. Discovery of tryptanthrin analogues bearing F and piperazine moieties as novel phytopathogenic antibacterial and antiviral agents.
Pest management science.
2023 Oct; ?(?):. doi:
10.1002/ps.7834. [PMID: 37842924] - Fang Liu, Xiao Cao, Tao Zhang, Li Xing, Zhiling Sun, Wei Zeng, Hui Xin, Wei Xue. Synthesis and Biological Activity of Myricetin Derivatives Containing Pyrazole Piperazine Amide.
International journal of molecular sciences.
2023 Jun; 24(13):. doi:
10.3390/ijms241310442. [PMID: 37445627] - Çağrı Alkan, Cihat Çelik, Kemal Büyükgüzel, Ender Büyükgüzel. Oxidative and genotoxic effect of piperazine on Galleria mellonella (Lepidoptera: Pyralidae) hemolymph.
Environmental entomology.
2023 Jun; 52(3):399-407. doi:
10.1093/ee/nvad028. [PMID: 37043612] - Andryne R Rodrigues, Caroline R Rodrigues, Sandro A Gomes, Stefanne M Marques, Lara M Naves, Gustavo R Pedrino, Jerônimo R de Oliveira-Neto, Flávio S de Carvalho, Alessandro Cruz, Luciano M Lião, Ricardo Menegatti, Luiz Carlos da Cunha. Preclinical pharmacokinetics of a promising antineoplastic prototype piperazine-containing compound (LQFM018) in rats by a new LC-MS/MS bioanalytical method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2023 Apr; 1223(?):123710. doi:
10.1016/j.jchromb.2023.123710. [PMID: 37068313] - Seung-Hwa Kwak, C Skyler Cochrane, Jae Cho, Patrick A Dome, Amanda F Ennis, Jea Hyun Kim, Pei Zhou, Jiyong Hong. Development of LpxH inhibitors chelating the active site di-manganese metal cluster of LpxH.
ChemMedChem.
2023 Apr; ?(?):e202300023. doi:
10.1002/cmdc.202300023. [PMID: 37014664] - Hong Jiang, Jian-Hua Wei, Cui-Yan Lin, Gui-Bin Liang, Rui-Jie He, Ri-Zhen Huang, Xian-Li Ma, Guo-Bao Huang, Ye Zhang. Ursolic acid-piperazine-dithiocarbamate ruthenium(II) polypyridyl complexes induced necroptosis in MGC-803 cells.
Metallomics : integrated biometal science.
2022 10; 14(10):. doi:
10.1093/mtomcs/mfac072. [PMID: 36149330] - Zongyang Li, Xiangbao Meng, Guoxu Ma, Wenlan Liu, Weiping Li, Qian Cai, Sicen Wang, Guodong Huang, Yuan Zhang. Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice.
Alzheimer's research & therapy.
2022 10; 14(1):150. doi:
10.1186/s13195-022-01092-7. [PMID: 36217155] - Huanzhen Ni, Marine Z C Hatit, Kun Zhao, David Loughrey, Melissa P Lokugamage, Hannah E Peck, Ada Del Cid, Abinaya Muralidharan, YongTae Kim, Philip J Santangelo, James E Dahlman. Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.
Nature communications.
2022 08; 13(1):4766. doi:
10.1038/s41467-022-32281-5. [PMID: 35970837] - Ying Xu, Hongtao Wang, Xiaohua Du. Design, synthesis, and fungicidal activity of novel N-substituted piperazine-containing phenylpyridines against cucumber downy mildew.
Pest management science.
2022 May; 78(5):1806-1814. doi:
10.1002/ps.6798. [PMID: 35023277] - Ziqin Lei, Fei Luan, Xia Zhang, Lixia Peng, Bo Li, Xi Peng, Yao Liu, Rong Liu, Nan Zeng. Piperazine ferulate protects against cardiac ischemia/reperfusion injury in rat via the suppression of NLRP3 inflammasome activation and pyroptosis.
European journal of pharmacology.
2022 Apr; 920(?):174856. doi:
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Pest management science.
2022 Apr; 78(4):1749-1758. doi:
10.1002/ps.6794. [PMID: 35001496] - Qing Zhou, Xuemei Tang, Shuai Chen, Wenliang Zhan, Die Hu, Ran Zhou, Nan Sun, YongJun Wu, Wei Xue. Design, Synthesis, and Antifungal Activity of Novel Chalcone Derivatives Containing a Piperazine Fragment.
Journal of agricultural and food chemistry.
2022 Feb; 70(4):1029-1036. doi:
10.1021/acs.jafc.1c05933. [PMID: 35072471] - Yong-Yu Yang, Rong-Rong Deng, Zhuo Chen, Liang-Yuan Yao, Xi-Ding Yang, Da-Xiong Xiang. Piperazine ferulate attenuates high glucose‑induced mesangial cell injury via the regulation of p66Shc.
Molecular medicine reports.
2021 05; 23(5):. doi:
10.3892/mmr.2021.12013. [PMID: 33760157] - Fengyang Xu, Shuqi Xue, Limeng Deng, Sufen Zhang, Yaxuan Li, Xin Zhao. The piperazine compound ASP activates an auxin response in Arabidopsis thaliana.
BMC genomics.
2020 Nov; 21(1):788. doi:
10.1186/s12864-020-07203-8. [PMID: 33176686] - Martha Leyte-Lugo, Pascal Richomme, Pascal Poupard, Luis M Peña-Rodriguez. Identification and Quantification of a Phytotoxic Metabolite from Alternaria dauci.
Molecules (Basel, Switzerland).
2020 Sep; 25(17):. doi:
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Pest management science.
2020 Sep; 76(9):2959-2971. doi:
10.1002/ps.5841. [PMID: 32246577] - Seung-Hwa Kwak, C Skyler Cochrane, Amanda F Ennis, Won Young Lim, Caroline G Webster, Jae Cho, Benjamin A Fenton, Pei Zhou, Jiyong Hong. Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors.
Bioorganic chemistry.
2020 09; 102(?):104055. doi:
10.1016/j.bioorg.2020.104055. [PMID: 32663666] - Pei-Yi Wang, Meng Xiang, Min Luo, Hong-Wu Liu, Xiang Zhou, Zhi-Bing Wu, Li-Wei Liu, Zhong Li, Song Yang. Novel piperazine-tailored ursolic acid hybrids as significant antibacterial agents targeting phytopathogens Xanthomonas oryzae pv. oryzae and X. axonopodis pv. citri probably directed by activation of apoptosis.
Pest management science.
2020 Aug; 76(8):2746-2754. doi:
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Bioorganic & medicinal chemistry.
2020 06; 28(11):115497. doi:
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Natural product research.
2020 Feb; 34(4):494-502. doi:
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ACS infectious diseases.
2019 04; 5(4):641-651. doi:
10.1021/acsinfecdis.8b00364. [PMID: 30721024] - Inma García-Pereira, Riccardo Zanni, Maria Galvez-Llompart, Jorge Galvez, Ramón García-Domenech. DesMol2, an Effective Tool for the Construction of Molecular Libraries and Its Application to QSAR Using Molecular Topology.
Molecules (Basel, Switzerland).
2019 Feb; 24(4):. doi:
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Microbial pathogenesis.
2019 Feb; 127(?):106-115. doi:
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Journal of medicinal chemistry.
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Environmental science & technology.
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10.1021/acs.est.8b03512. [PMID: 30149708] - Emílio V Lage, Joana Magalhães, Marina Pinheiro, Salette Reis. Effect of the alkyl group in the piperazine N-substitution on the therapeutic action of rifamycins: A drug-membrane interaction study.
Chemico-biological interactions.
2018 Jun; 289(?):75-80. doi:
10.1016/j.cbi.2018.04.027. [PMID: 29709589] - Magdalena Kotańska, Katarzyna Kulig, Monika Marcinkowska, Marek Bednarski, Katarzyna Malawska, Paula Zaręba. Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist.
Journal of endocrinological investigation.
2018 May; 41(5):609-619. doi:
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PloS one.
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Molecules (Basel, Switzerland).
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Bioorganic & medicinal chemistry letters.
2017 09; 27(17):4066-4074. doi:
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BMC cancer.
2017 01; 17(1):51. doi:
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Bioorganic & medicinal chemistry letters.
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PloS one.
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Environmental science & technology.
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Journal of nanoscience and nanotechnology.
2014 Jun; 14(6):4639-48. doi:
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Chemistry & biology.
2013 Mar; 20(3):379-90. doi:
10.1016/j.chembiol.2013.01.012. [PMID: 23521796] - Shu Cai, Xin Li, Tianming Cai, Jian He. Degradation of piperazine by Paracoccus sp. TOH isolated from activated sludge.
Bioresource technology.
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