2-Aminopurine (BioDeep_00000768299)

   


代谢物信息卡片


2-Aminopurine

化学式: C5H5N5 (135.054493)
中文名称: 2-氨基嘌呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C2C(=NC(=N1)N)N=CN2
InChI: InChI=1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)

描述信息

D009676 - Noxae > D000963 - Antimetabolites

同义名列表

1 个代谢物同义名

2-Aminopurine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Han Zhao, Mingjian Chen, Changbei Ma. Fluorescent Method for the Detection of Biothiols Using an Ag⁺-Mediated Conformational Switch. Sensors (Basel, Switzerland). 2019 Feb; 19(4):. doi: 10.3390/s19040934. [PMID: 30813324]
  • Fan Yang, Zhiyue Yu, Xinyi Li, Peipei Ren, Guanhong Liu, Youtao Song, Jun Wang. Design and synthesis of a novel lanthanide fluorescent probe (TbIII-dtpa-bis(2,6-diaminopurine)) and its application to the detection of uric acid in urine sample. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2018 Oct; 203(?):461-471. doi: 10.1016/j.saa.2018.06.011. [PMID: 29894961]
  • Jitka Široká, Martina Čečková, Lubor Urbánek, Vladimír Kryštof, Tomáš Gucký, Jakub Hofman, Miroslav Strnad, František Štaud. LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Jul; 1089(?):24-32. doi: 10.1016/j.jchromb.2018.04.049. [PMID: 29753211]
  • Yukiko Kamiya, Yuka Donoshita, Hiroshi Kamimoto, Keiji Murayama, Jumpei Ariyoshi, Hiroyuki Asanuma. Introduction of 2,6-Diaminopurines into Serinol Nucleic Acid Improves Anti-miRNA Performance. Chembiochem : a European journal of chemical biology. 2017 10; 18(19):1917-1922. doi: 10.1002/cbic.201700272. [PMID: 28748559]
  • Om P Mishra, Anatoliy V Popov, Ralph A Pietrofesa, Melpo Christofidou-Solomidou. Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection. Biochimica et biophysica acta. 2016 09; 1860(9):1884-97. doi: 10.1016/j.bbagen.2016.05.037. [PMID: 27261092]
  • Akbar Dastjerdi, Katharina Seilern-Moy, Karin Darpel, Falko Steinbach, Fieke Molenaar. Surviving and fatal Elephant Endotheliotropic Herpesvirus-1A infections in juvenile Asian elephants - lessons learned and recommendations on anti-herpesviral therapy. BMC veterinary research. 2016 Aug; 12(1):178. doi: 10.1186/s12917-016-0806-5. [PMID: 27567895]
  • Ashish Sachan, Muslum Ilgu, Aaron Kempema, George A Kraus, Marit Nilsen-Hamilton. Specificity and Ligand Affinities of the Cocaine Aptamer: Impact of Structural Features and Physiological NaCl. Analytical chemistry. 2016 08; 88(15):7715-23. doi: 10.1021/acs.analchem.6b01633. [PMID: 27348073]
  • Runan Qiu, Aniko Horvath, Ralf Stahlmann. Effects of four nucleoside analogues used as antiviral agents on rat Sertoli cells (SerW3) in vitro. Archives of toxicology. 2016 Aug; 90(8):1975-81. doi: 10.1007/s00204-016-1743-6. [PMID: 27224990]
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  • Darina Zouharova, Ivana Lipenska, Martina Fojtikova, Pavel Kulich, Jiri Neca, Michal Slany, Kamil Kovarcik, Pavlina Turanek-Knotigova, Frantisek Hubatka, Hana Celechovska, Josef Masek, Stepan Koudelka, Lubomir Prochazka, Ludek Eyer, Jana Plockova, Eliska Bartheldyova, Andrew D Miller, Daniel Ruzek, Milan Raska, Zlatko Janeba, Jaroslav Turanek. Antiviral activities of 2,6-diaminopurine-based acyclic nucleoside phosphonates against herpesviruses: In vitro study results with pseudorabies virus (PrV, SuHV-1). Veterinary microbiology. 2016 Feb; 184(?):84-93. doi: 10.1016/j.vetmic.2016.01.010. [PMID: 26854349]
  • Hanan Polansky, Adrian Javaherian, Edan Itzkovitz. Clinical study in genital herpes: natural Gene-Eden-VIR/Novirin versus acyclovir, valacyclovir, and famciclovir. Drug design, development and therapy. 2016; 10(?):2713-22. doi: 10.2147/dddt.s112852. [PMID: 27621592]
  • Sezin Yüksel, Lydia Schwenkbier, Sibyll Pollok, Karina Weber, Dana Cialla-May, Jürgen Popp. Label-free detection of Phytophthora ramorum using surface-enhanced Raman spectroscopy. The Analyst. 2015 Nov; 140(21):7254-62. doi: 10.1039/c5an01156f. [PMID: 26393411]
  • Allyson D Groth, Marcos T Contreras, Helen K Kado-Fong, Kyvan Q Nguyen, Sara M Thomasy, David J Maggs. In vitro cytotoxicity and antiviral efficacy against feline herpesvirus type 1 of famciclovir and its metabolites. Veterinary ophthalmology. 2014 Jul; 17(4):268-74. doi: 10.1111/vop.12094. [PMID: 24112415]
  • Cody J Peer, Jeffrey L Brown, Timothy J Martin, Jeffrey Roth, Shawn D Spencer, Patrick Brassil, Katharine A McNeill, Teri N Kreisl, Howard A Fine, William D Figg. A novel uHPLC-MS/MS method for the quantitation of AZD7451 (AZ12607092) in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Dec; 942-943(?):107-12. doi: 10.1016/j.jchromb.2013.10.023. [PMID: 24239935]
  • Fanny Schenkel, Chantal Csajka, Edoardo Baglivo, Mitsuko Kondo-Oestreicher, Pierre Dayer, Marianne Gex-Fabry, Youssef Daali. Intraocular penetration of penciclovir after oral administration of famciclovir: a population pharmacokinetic model. The Journal of antimicrobial chemotherapy. 2013 Jul; 68(7):1635-41. doi: 10.1093/jac/dkt064. [PMID: 23539240]
  • Hyonok Yoon, Ki Yon Rhew. Famciclovir as an antiviral agent for a patient with acute renal failure. International journal of clinical pharmacy. 2013 Apr; 35(2):173-5. doi: 10.1007/s11096-012-9737-9. [PMID: 23277418]
  • Mohamed S Rezk, Rasha M El Nashar. Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids. Bioelectrochemistry (Amsterdam, Netherlands). 2013 Feb; 89(?):26-33. doi: 10.1016/j.bioelechem.2012.08.006. [PMID: 23017353]
  • A Paige Brock, Ramiro Isaza, Robert P Hunter, Laura K Richman, Richard J Montali, Dennis L Schmitt, David E Koch, William A Lindsay. Estimates of the pharmacokinetics of famciclovir and its active metabolite penciclovir in young Asian elephants (Elephas maximus). American journal of veterinary research. 2012 Dec; 73(12):1996-2000. doi: 10.2460/ajvr.73.12.1996. [PMID: 23176429]
  • Sara M Thomasy, Jill C Covert, Scott D Stanley, David J Maggs. Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study. Veterinary ophthalmology. 2012 Sep; 15(5):299-306. doi: 10.1111/j.1463-5224.2011.00984.x. [PMID: 22339892]
  • Rosa M Suárez, Maria Paz Matía, José Luis Novella, Andres Molina, Antonio Cosme, Juan José Vaquero, Julio Alvarez-Builla. Synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, an impurity of acyclovir. Molecules (Basel, Switzerland). 2012 Jul; 17(8):8735-41. doi: 10.3390/molecules17088735. [PMID: 22832875]
  • Sara M Thomasy, Ted Whittem, Jerry L Bales, Marcus Ferrone, Scott D Stanley, David J Maggs. Pharmacokinetics of penciclovir in healthy cats following oral administration of famciclovir or intravenous infusion of penciclovir. American journal of veterinary research. 2012 Jul; 73(7):1092-9. doi: 10.2460/ajvr.73.7.1092. [PMID: 22738064]
  • Robert Buscaglia, David M Jameson, Jonathan B Chaires. G-quadruplex structure and stability illuminated by 2-aminopurine phasor plots. Nucleic acids research. 2012 May; 40(9):4203-15. doi: 10.1093/nar/gkr1286. [PMID: 22241767]
  • Stan L Block, Ram Yogev, Felix Waldmeier, Kamal Hamed. Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis. The Pediatric infectious disease journal. 2011 Jun; 30(6):525-8. doi: 10.1097/inf.0b013e3182067cee. [PMID: 21178655]
  • Sara M Thomasy, Christine C Lim, Christopher M Reilly, Philip H Kass, Michael R Lappin, David J Maggs. Evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1. American journal of veterinary research. 2011 Jan; 72(1):85-95. doi: 10.2460/ajvr.72.1.85. [PMID: 21194340]
  • Björn Pasternak, Anders Hviid. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA. 2010 Aug; 304(8):859-66. doi: 10.1001/jama.2010.1206. [PMID: 20736469]
  • Koji Tsujimura, Masayuki Yamada, Shun-ichi Nagata, Takashi Yamanaka, Manabu Nemoto, Takashi Kondo, Masahiko Kurosawa, Tomio Matsumura. Pharmacokinetics of penciclovir after oral administration of its prodrug famciclovir to horses. The Journal of veterinary medical science. 2010 Mar; 72(3):357-61. doi: 10.1292/jvms.09-0350. [PMID: 19959884]
  • Conor Crean, Jie Shao, Byeong Hwa Yun, Nicholas E Geacintov, Vladimir Shafirovich. The role of one-electron reduction of lipid hydroperoxides in causing DNA damage. Chemistry (Weinheim an der Bergstrasse, Germany). 2009 Oct; 15(40):10634-40. doi: 10.1002/chem.200900500. [PMID: 19746460]
  • Kayode Ogungbenro, Ivan Matthews, Michael Looby, Guenther Kaiser, Gordon Graham, Leon Aarons. Population pharmacokinetics and optimal design of paediatric studies for famciclovir. British journal of clinical pharmacology. 2009 Oct; 68(4):546-60. doi: 10.1111/j.1365-2125.2009.03479.x. [PMID: 19843058]
  • Angel García-Raso, Catalina Cabot, Juan Jesús Fiol, Lukás Spíchal, Jaroslav Nisler, Andrés Tasada, Joana Maria Luna, Francisca M Albertí, John V Sibole. Cytokinin activity of disubstituted aminopurines in Amaranthus. Journal of plant physiology. 2009 Sep; 166(14):1529-36. doi: 10.1016/j.jplph.2009.03.012. [PMID: 19450901]
  • Deborah Y Chong, Mark W Johnson, Tony H Huynh, Edward F Hall, Grant M Comer, Douglas N Fish. Vitreous penetration of orally administered famciclovir. American journal of ophthalmology. 2009 Jul; 148(1):38-42.e1. doi: 10.1016/j.ajo.2009.02.010. [PMID: 19375688]
  • Minjie Li, Yusuke Sato, Seiichi Nishizawa, Takehiro Seino, Kodai Nakamura, Norio Teramae. 2-Aminopurine-modified abasic-site-containing duplex DNA for highly selective detection of theophylline. Journal of the American Chemical Society. 2009 Feb; 131(7):2448-9. doi: 10.1021/ja8095625. [PMID: 19191489]
  • Roser Gorina, Tomàs Santalucia, Valérie Petegnief, Aroa Ejarque-Ortiz, Josep Saura, Anna M Planas. Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA. Glia. 2009 Jan; 57(1):93-107. doi: 10.1002/glia.20738. [PMID: 18709661]
  • Tin Han Htwe, Scott Bergman, Janak Koirala. Famciclovir substitution for patients with acyclovir-associated renal toxicity. The Journal of infection. 2008 Sep; 57(3):266-8. doi: 10.1016/j.jinf.2008.06.008. [PMID: 18656262]
  • Dongfang Wu, Hong Yang, Yanfeng Zhao, Chakradhari Sharan, J Shawn Goodwin, Lichun Zhou, Yang Guo, Zhongmao Guo. 2-Aminopurine inhibits lipid accumulation induced by apolipoprotein E-deficient lipoprotein in macrophages: potential role of eukaryotic initiation factor-2alpha phosphorylation in foam cell formation. The Journal of pharmacology and experimental therapeutics. 2008 Aug; 326(2):395-405. doi: 10.1124/jpet.107.134833. [PMID: 18463320]
  • Sara M Thomasy, David J Maggs, Nicole K Moulin, Scott D Stanley. Pharmacokinetics and safety of penciclovir following oral administration of famciclovir to cats. American journal of veterinary research. 2007 Nov; 68(11):1252-8. doi: 10.2460/ajvr.68.11.1252. [PMID: 17975982]
  • Jian Zong, Gregory E Chittick, Laurene H Wang, James Hui, John A Begley, M Robert Blum. Pharmacokinetic evaluation of emtricitabine in combination with other nucleoside antivirals in healthy volunteers. Journal of clinical pharmacology. 2007 Jul; 47(7):877-89. doi: 10.1177/0091270007300808. [PMID: 17526857]
  • Setu Roday, Suwipa Saen-oon, Vern L Schramm. Vinyldeoxyadenosine in a sarcin-ricin RNA loop and its binding to ricin toxin a-chain. Biochemistry. 2007 May; 46(21):6169-82. doi: 10.1021/bi0621821. [PMID: 17477546]
  • Jung-Feng Hsieh, Shih-Hsiung Wu, Yu-Liang Yang, Kee-Fong Choong, Shui-Tein Chen. The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. Bioorganic & medicinal chemistry. 2007 May; 15(10):3450-6. doi: 10.1016/j.bmc.2007.03.010. [PMID: 17379526]
  • San-Cher Chen, Jinn-Yuh Guh, Hung-Chun Chen, Yu-Lin Yang, Jau-Shyang Huang, Lea-Yea Chuang. Advanced glycation end-product-induced mitogenesis is dependent on Janus kinase 2-induced heat shock protein 70 in normal rat kidney interstitial fibroblast cells. Translational research : the journal of laboratory and clinical medicine. 2007 May; 149(5):274-81. doi: 10.1016/j.trsl.2006.08.005. [PMID: 17466927]
  • Yuji Noro, Toshiyuki Takano-Shimizu, Kunihiko Syono, Yuji Kishima, Yoshio Sano. Genetic variations in rice in vitro cultures at the EPSPs-RPS20 region. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2007 Feb; 114(4):705-11. doi: 10.1007/s00122-006-0470-4. [PMID: 17177062]
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  • Yossi Dagon, Yosefa Avraham, Elliot M Berry. AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes. Biochemical and biophysical research communications. 2006 Feb; 340(1):43-7. doi: 10.1016/j.bbrc.2005.11.159. [PMID: 16377306]
  • Philip O Scumpia, Kindra M Kelly, Westley H Reeves, Bruce R Stevens. Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes. Glia. 2005 Nov; 52(2):153-62. doi: 10.1002/glia.20234. [PMID: 15920723]
  • Zhi-yi Wang, Shu-hua Guo, Ding-feng Zhang, You-rong Zhao, Hong Ren, Xia-qiu Zhou, Dao-zhen Xu, Jing-yuan Sun, Ji-lu Yao, Wei-lun Lu. [Clinical investigation of famciclovir in chronic hepatitis B patients irresponsive to alpha interferon treatment]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 2005 Jul; 13(7):494-6. doi: NULL. [PMID: 16042882]
  • S J Dewitte-Orr, J R Zorzitto, L P Sutton, N C Bols. Preferential induction of apoptosis in the rainbow trout macrophage cell line, RTS11, by actinomycin D, cycloheximide and double stranded RNA. Fish & shellfish immunology. 2005 Apr; 18(4):279-95. doi: 10.1016/j.fsi.2004.08.001. [PMID: 15561559]
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  • Veit Hornung, Jörg Schlender, Margit Guenthner-Biller, Simon Rothenfusser, Stefan Endres, Karl-Klaus Conzelmann, Gunther Hartmann. Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. Journal of immunology (Baltimore, Md. : 1950). 2004 Nov; 173(10):5935-43. doi: 10.4049/jimmunol.173.10.5935. [PMID: 15528327]
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  • G K K Lau, A Nanji, J Hou, D Y T Fong, W-S Au, S-T Yuen, M Lin, H-F Kung, S-K Lam. Thymosin-alpha1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phase. Journal of viral hepatitis. 2002 Jul; 9(4):280-7. doi: 10.1046/j.1365-2893.2002.00361.x. [PMID: 12081605]
  • Ching-Lung Lai, Man-Fung Yuen, Chee-Kin Hui, Silvia Garrido-Lestache, Charles Tze-Kin Cheng, Yim-Ping Lai. Comparison of the efficacy of lamivudine and famciclovir in Asian patients with chronic hepatitis B: results of 24 weeks of therapy. Journal of medical virology. 2002 Jul; 67(3):334-8. doi: 10.1002/jmv.10075. [PMID: 12116023]
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