Guanethidine sulfate (BioDeep_00000767938)
代谢物信息卡片
Guanethidine sulfate
化学式: C20H46N8O4S (494.3362556)
中文名称: 胍乙啶硫酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCCN(CCC1)CCN=C(N)N.C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O
InChI: (H2,1,2,3,4)
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:51017
- PubChem: 65328
- ChEMBL: CHEMBL2051958
- MeSH: Guanethidine
- CAS: 60-02-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anna Vavřínová, Michal Behuliak, Michal Bencze, Martin Vodička, Peter Ergang, Ivana Vaněčková, Josef Zicha. Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 12; 42(12):1872-1882. doi:
10.1038/s41440-019-0319-2. [PMID: 31527789] - Tod Turner, Xian Chen, Matthew Zahner, Alan Opsahl, George DeMarco, Magalie Boucher, Bryan Goodwin, Mylène Perreault. FGF21 increases water intake, urine output and blood pressure in rats.
PloS one.
2018; 13(8):e0202182. doi:
10.1371/journal.pone.0202182. [PMID: 30106981] - Matthew R Zahner, Chang-Ning Liu, Vincent Bernardo, Carrie Northcott, Cheryl Tyszkiewicz, Carlin Okerberg, Magalie Boucher, Ingrid Pardo, Chris J Somps. Physiological approaches to assess diminished sympathetic activity in the conscious rat.
Journal of pharmacological and toxicological methods.
2017 Nov; 88(Pt 1):64-71. doi:
10.1016/j.vascn.2017.06.002. [PMID: 28658603] - Patrick Freyhardt, Ricardo Donners, Alex Riemert, Jörg Schnorr, Nicola Stolzenburg, Jan L Rinnenthal, Ulrich Bernhardt, Bernd Hamm, Rolf W Günther, Florian Streitparth. Renal denervation by CT-guided periarterial injection of hyperosmolar saline, vincristine, paclitaxel and guanethidine in a pig model.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
2017 Apr; 12(18):e2262-e2270. doi:
10.4244/eij-d-15-00354. [PMID: 27890860] - Matthew R Zahner, Chang-Ning Liu, Carlin V Okerberg, Alan C Opsahl, Walter F Bobrowski, Chris J Somps. Neurophysiological assessment of sympathetic cardiovascular activity after loss of postganglionic neurons in the anesthetized rat.
Journal of pharmacological and toxicological methods.
2016 Jul; 80(?):59-67. doi:
10.1016/j.vascn.2016.04.010. [PMID: 27085835] - Rafik Hachani, Houcine Dab, Anouar Feriani, Sami Saber, Mohsen Sakly, Eric Vicaut, Jacques Callebert, Richard Sercombe, Kamel Kacem. Hypercholesterolemic diet induces vascular smooth muscle cell apoptosis in sympathectomized rats via intrinsic pathway.
Autonomic neuroscience : basic & clinical.
2014 Jul; 183(?):49-57. doi:
10.1016/j.autneu.2014.02.007. [PMID: 24708922] - Paul M Consigny, Dariush Davalian, Rosy Donn, Jie Hu, Matthew Rieser, Deanne Stolarik. Chemical renal denervation in the rat.
Cardiovascular and interventional radiology.
2014 Feb; 37(1):218-23. doi:
10.1007/s00270-013-0796-7. [PMID: 24305982] - Younes Filali-Zegzouti, Jean-Louis Rouanet, Toufiq Fechtali, Damien Roussel. Mitochondrial oxidative energy metabolism in guanethidine-induced sympathectomized ducklings.
General physiology and biophysics.
2014; 33(1):91-7. doi:
10.4149/gpb_2013072. [PMID: 24334534] - Robert A Augustyniak, Maria M Picken, David Leonard, Xin J Zhou, Weiguo Zhang, Ronald G Victor. Sympathetic nerves and the progression of chronic kidney disease during 5/6 nephrectomy: studies in sympathectomized rats.
Clinical and experimental pharmacology & physiology.
2010 Jan; 37(1):12-8. doi:
10.1111/j.1440-1681.2009.05253.x. [PMID: 19566818] - Ju-Hyun Jeon, Hyung-Wook Kim, Min-Gi Kim, Hoi-Seon Lee. Mite-control activities of active constituents isolated from Pelargonium graveolens against house dust mites.
Journal of microbiology and biotechnology.
2008 Oct; 18(10):1666-71. doi:
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Journal of cellular biochemistry.
2008 Aug; 104(6):2155-64. doi:
10.1002/jcb.21775. [PMID: 18449939] - Amanda Martins Baviera, Neusa Maria Zanon, Luiz Carlos C Navegantes, Renato Hélios Migliorini, Isis C Kettelhut. Chemical sympathectomy further increases muscle protein degradation of acutely diabetic rats.
Muscle & nerve.
2008 Aug; 38(2):1027-35. doi:
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Life sciences.
2008 Apr; 82(15-16):862-8. doi:
10.1016/j.lfs.2008.01.020. [PMID: 18343456] - E D Bruder, L M Henderson, H Raff. Adrenal lipid profiles of chemically sympathectomized normoxic and hypoxic neonatal rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2006 Dec; 38(12):807-11. doi:
10.1055/s-2006-956183. [PMID: 17163355] - Nga Cao, John M Haynes, Sabatino Ventura. Saw palmetto is an indirectly acting sympathomimetic in the rat-isolated prostate gland.
The Prostate.
2006 Feb; 66(2):115-23. doi:
10.1002/pros.20322. [PMID: 16114061] - Margarita Franco-Colín, Iván Villanueva, Manuel Piñón, Radu Racotta. The effects of sympathectomy and dexamethasone in rats ingesting sucrose.
International journal of biological sciences.
2006; 2(1):17-22. doi:
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Journal of neural transmission (Vienna, Austria : 1996).
2005 Apr; 112(4):481-9. doi:
10.1007/s00702-004-0199-7. [PMID: 15480854] - Milan Holecek, Marcela Bielavská, Ludek Sprongl. Protein metabolism in guanethidine-treated rats.
International journal of experimental pathology.
2004 Oct; 85(5):257-64. doi:
10.1111/j.0959-9673.2004.00400.x. [PMID: 15379958] - Kelley W Dwyer, Paolo P Provenzano, Peter Muir, Wilmot B Valhmu, Ray Vanderby. Blockade of the sympathetic nervous system degrades ligament in a rat MCL model.
Journal of applied physiology (Bethesda, Md. : 1985).
2004 Feb; 96(2):711-8. doi:
10.1152/japplphysiol.00307.2003. [PMID: 14527964] - Hershel Raff, Julie J Lee, Eric P Widmaier, Martin K Oaks, William C Engeland. Basal and adrenocorticotropin-stimulated corticosterone in the neonatal rat exposed to hypoxia from birth: modulation by chemical sympathectomy.
Endocrinology.
2004 Jan; 145(1):79-86. doi:
10.1210/en.2003-1130. [PMID: 14525916] - Rodrigo Bastos Fóscolo, Mauricio Gustavo Bravim de Castro, Umeko Marubayashi, Adelina Martha dos Reis, Cândido Celso Coimbra. Medial preoptic area adrenergic receptors modulate glycemia and insulinemia in freely moving rats.
Brain research.
2003 Sep; 985(1):56-64. doi:
10.1016/s0006-8993(03)03158-5. [PMID: 12957368] - Akihiko Igawa, Takashi Nozawa, Nozomu Fujii, Bun-ichi Kato, Hidetsugu Asanoi, Hiroshi Inoue. Long-term treatment with low-dose, but not high-dose, guanethidine improves ventricular function and survival of rats with heart failure after myocardial infarction.
Journal of the American College of Cardiology.
2003 Aug; 42(3):541-8. doi:
10.1016/s0735-1097(03)00650-8. [PMID: 12906986] - Olaf Grisk, Hans-Joachim Rose, Gerd Lorenz, Rainer Rettig. Sympathetic-renal interaction in chronic arterial pressure control.
American journal of physiology. Regulatory, integrative and comparative physiology.
2002 Aug; 283(2):R441-50. doi:
10.1152/ajpregu.00669.2001. [PMID: 12121857] - Iván Villanueva, Manuel Piñón, Lucía Quevedo-Corona, Rubén Martínez-Olivares, Radu Racotta. Chemical sympathectomy alters food intake and thermogenic responses to catecholamines in rats.
Life sciences.
2002 Jul; 71(7):789-801. doi:
10.1016/s0024-3205(02)01739-3. [PMID: 12074938] - A Trujillo, L Riboni. Effects of functional peripheral sympathetic denervation induced by guanethidine on follicular development and ovulation of the adult female guinea pig.
General and comparative endocrinology.
2002 Jul; 127(3):273-8. doi:
10.1016/s0016-6480(02)00062-x. [PMID: 12225769] - G E Demas, T J Bartness. Novel method for localized, functional sympathetic nervous system denervation of peripheral tissue using guanethidine.
Journal of neuroscience methods.
2001 Nov; 112(1):21-8. doi:
10.1016/s0165-0270(01)00452-6. [PMID: 11640954] - J T Cheng, I M Liu, T C Chi, T F Tzeng. Release of beta-endorphin by prostaglandin E2 to lower plasma glucose in streptozotocin-induced diabetic rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2001 Jul; 33(7):439-43. doi:
10.1055/s-2001-16236. [PMID: 11507683] - D H Wang, W Wu, K J Lookingland. Degeneration of capsaicin-sensitive sensory nerves leads to increased salt sensitivity through enhancement of sympathoexcitatory response.
Hypertension (Dallas, Tex. : 1979).
2001 Feb; 37(2 Pt 2):440-3. doi:
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Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology.
2000 Sep; 170(5-6):379-86. doi:
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European journal of pharmacology.
2000 Jul; 399(2-3):251-8. doi:
10.1016/s0014-2999(00)00341-1. [PMID: 10884527] - J Qiu, S H Nelson, R C Speth, D H Wang. Regulation of adrenal angiotensin receptor subtypes: a possible mechanism for sympathectomy-induced adrenal hypertrophy.
Journal of hypertension.
1999 Jul; 17(7):933-40. doi:
10.1097/00004872-199917070-00009. [PMID: 10419066] - J L Berfield, L C Wang, M E Reith. Which form of dopamine is the substrate for the human dopamine transporter: the cationic or the uncharged species?.
The Journal of biological chemistry.
1999 Feb; 274(8):4876-82. doi:
10.1074/jbc.274.8.4876. [PMID: 9988729] - C J Chang, J S Wu, F H Lu, I M Liu, T C Chi, J T Cheng. Sympathetic hyperactivity in Wistar rats with insulin-resistance.
Journal of the autonomic nervous system.
1998 Dec; 74(2-3):116-9. doi:
10.1016/s0165-1838(98)00143-x. [PMID: 9915626] - W D Kempinas, J D Suarez, N L Roberts, L F Strader, J Ferrell, J M Goldman, M G Narotsky, S D Perreault, D P Evenson, D D Ricker, G R Klinefelter. Fertility of rat epididymal sperm after chemically and surgically induced sympathectomy.
Biology of reproduction.
1998 Oct; 59(4):897-904. doi:
10.1095/biolreprod59.4.897. [PMID: 9746741] - W D Kempinas, J D Suarez, N L Roberts, L Strader, J Ferrell, J M Goldman, G R Klinefelter. Rat epididymal sperm quantity, quality, and transit time after guanethidine-induced sympathectomy.
Biology of reproduction.
1998 Oct; 59(4):890-6. doi:
10.1095/biolreprod59.4.890. [PMID: 9746740] - P Sántha, F K Pierau, G Jancsó. Evidence for an inhibition by endogenous galanin of neurogenic cutaneous vasodilatation in the pigeon.
Neuroscience letters.
1998 Feb; 243(1-3):101-4. doi:
10.1016/s0304-3940(98)00098-6. [PMID: 9535123] - A Delaunois, P Segura, C Dessy-Doizé, M Ansay, L M Montaño, M H Vargas, P Gustin. Ozone-induced stimulation of pulmonary sympathetic fibers: a protective mechanism against edema.
Toxicology and applied pharmacology.
1997 Nov; 147(1):71-82. doi:
10.1006/taap.1997.8266. [PMID: 9356309] - A Aneman, A Pettersson, G Eisenhofer, P Friberg, M Holm, C von Bothmer, L Fändriks. Sympathetic and renin-angiotensin activation during graded hypovolemia in pigs: impact on mesenteric perfusion and duodenal mucosal function.
Shock (Augusta, Ga.).
1997 Nov; 8(5):378-84. doi:
10.1097/00024382-199711000-00011. [PMID: 9361350] - R A Krasnoperov. [The bioavailability of endogenous calcitonin under selective pharmacological sympathectomy].
Patologicheskaia fiziologiia i eksperimental'naia terapiia.
1997 Apr; ?(2):11-3. doi:
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Journal of ethnopharmacology.
1996 Dec; 55(1):13-8. doi:
10.1016/s0378-8741(96)01465-1. [PMID: 9121162] - R C Komorowski, C D Torneck, J W Hu. Neurogenic inflammation and tooth pulp innervation pattern in sympathectomized rats.
Journal of endodontics.
1996 Aug; 22(8):414-7. doi:
10.1016/s0099-2399(96)80242-1. [PMID: 8941750] - I Mihessen-Neto, A M Reis, U Marubayashi, C C Coimbra. Effect of sympathoadrenal blockade on the hyperglycemic action of angiotensin II.
Neuropeptides.
1996 Jun; 30(3):303-8. doi:
10.1016/s0143-4179(96)90076-1. [PMID: 8819154] - L J Machado, U Marubayashi, A M Reis, C C Coimbra. Effect of [1-Sar,8-Thr]-angiotensin II on the hyperglycemic response to hemorrhage in adrenodemedullated and guanethidine-treated rats.
Regulatory peptides.
1995 Dec; 60(1):69-77. doi:
10.1016/0167-0115(95)00126-1. [PMID: 8747786] - R L Chevalier, B A Thornhill. Ureteral obstruction in the neonatal guinea pig: interaction of sympathetic nerves and angiotensin.
Pediatric nephrology (Berlin, Germany).
1995 Aug; 9(4):441-6. doi:
10.1007/bf00866723. [PMID: 7577406] - C D Walker. Chemical sympathectomy and maternal separation affect neonatal stress responses and adrenal sensitivity to ACTH.
The American journal of physiology.
1995 May; 268(5 Pt 2):R1281-8. doi:
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Archives of physiology and biochemistry.
1995 Apr; 103(1):109-13. doi:
10.3109/13813459509007572. [PMID: 8574767] - W G Kempinas, S O Petenusci, A A Rosa e Silva, A L Favaretto, T L Carvalho. The hypophyseal-testicular axis and sex accessory glands following chemical sympathectomy with guanethidine of pre-pubertal to mature rats.
Andrologia.
1995 Mar; 27(2):121-5. doi:
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The Journal of endocrinology.
1994 Jul; 142(1):19-28. doi:
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Brain research.
1994 May; 644(2):251-6. doi:
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Kidney international.
1994 May; 45(5):1333-9. doi:
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1993 Aug; 618(2):238-45. doi:
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Journal of the autonomic nervous system.
1993 Aug; 44(2-3):109-17. doi:
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1993 Jun; 26(6):639-46. doi:
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The Journal of endocrinology.
1992 Dec; 135(3):415-20. doi:
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Acta physiologica Scandinavica.
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British journal of pharmacology.
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The American journal of physiology.
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Journal of applied physiology (Bethesda, Md. : 1985).
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The Journal of clinical investigation.
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Pain.
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Neuroscience.
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Sleep.
1990 Jun; 13(3):218-31. doi:
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The Journal of pharmacology and experimental therapeutics.
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Experientia.
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Journal of hypertension.
1990 May; 8(5):423-8. doi:
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
1990; 23(11):1181-4. doi:
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Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova.
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Naunyn-Schmiedeberg's archives of pharmacology.
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Neuroscience letters.
1989 Jul; 102(2-3):349-54. doi:
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1989 Jul; 25(4):481-6. doi:
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Voprosy meditsinskoi khimii.
1989 May; 35(3):117-20. doi:
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Biulleten' eksperimental'noi biologii i meditsiny.
1989 Mar; 107(3):283-5. doi:
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Fiziologicheskii zhurnal.
1989 Mar; 35(2):104-7. doi:
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The American journal of physiology.
1989 Feb; 256(2 Pt 1):E231-5. doi:
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1989 Jan; 11(1):45-54. doi:
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Agents and actions.
1988 Dec; 25(3-4):237-9. doi:
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1988 Apr; 398(?):361-70. doi:
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Journal of ethnopharmacology.
1988 Jan; 22(1):33-44. doi:
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The American journal of physiology.
1987 Dec; 253(6 Pt 2):F1223-31. doi:
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Hepatology (Baltimore, Md.).
1987 Nov; 7(6):1189-94. doi:
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Japanese journal of pharmacology.
1987 Oct; 45(2):197-201. doi:
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Journal of developmental physiology.
1987 Aug; 9(4):347-67. doi:
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Canadian journal of physiology and pharmacology.
1987 Jun; 65(6):1136-41. doi:
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British journal of pharmacology.
1987 Jun; 91(2):333-46. doi:
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Journal of neural transmission.
1987; 70(1-2):19-37. doi:
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The American journal of physiology.
1987 Jan; 252(1 Pt 2):H40-6. doi:
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Journal of neurochemistry.
1986 Oct; 47(4):1286-93. doi:
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1986 Oct; 4(3):S321-4. doi:
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The Journal of pharmacology and experimental therapeutics.
1986 Sep; 238(3):1014-20. doi:
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Journal of medicinal chemistry.
1986 Aug; 29(8):1499-504. doi:
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1986 Mar; 367(1-2):258-64. doi:
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1986 Feb; 332(2):163-8. doi:
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Acta physiologica Scandinavica.
1986 Feb; 126(2):231-8. doi:
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Clinical and experimental hypertension. Part A, Theory and practice.
1986; 8(6):919-39. doi:
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