Pyripyropene A (BioDeep_00000767880)
代谢物信息卡片
化学式: C31H37NO10 (583.2417342)
中文名称: 啶南平A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OCC1(C(CCC2(C1CC(C3(C2C(C4=C(O3)C=C(OC4=O)C5=CN=CC=C5)O)C)OC(=O)C)C)OC(=O)C)C
InChI: InChI=1S/C31H37NO10/c1-16(33)38-15-30(5)22-13-24(40-18(3)35)31(6)27(29(22,4)10-9-23(30)39-17(2)34)26(36)25-21(42-31)12-20(41-28(25)37)19-8-7-11-32-14-19/h7-8,11-12,14,22-24,26-27,36H,9-10,13,15H2,1-6H3/t22-,23+,24+,26+,27-,29+,30+,31-/m1/s1
描述信息
A sesquiterpenoid that consists of (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diol in which the hydrogens of the 3- and 6-hydroxy functions are substituted by acetyl groups.
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:64695
- PubChem: 11828024
- ChEMBL: CHEMBL4518651
- CAS: 147444-03-9
- MetaboLights: MTBLC64695
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 36630 Aspergillus fischeri: 10.7164/ANTIBIOTICS.46.1168
- 746128 Aspergillus fumigatus:
- 75750 Aspergillus sydowii: 10.1021/NP700737G
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Renjian Zou, Chengwen Wei, Xuexia Zhang, Dongdong Zhou, Jing Xu. Alkaloids from endophytic fungus Aspergillus fumigatus HQD24 isolated from the Chinese mangrove plant Rhizophora mucronata.
Natural product research.
2022 Oct; 36(19):5069-5073. doi:
10.1080/14786419.2021.1916017. [PMID: 34180322] - Kyeong-Ryoon Lee, Song-Hee Chae, Min Ju Kim, Yoon-Jee Chae, Myung Yeol Lee, Chang Woo Lee, Jong Soon Kang, Won-Kee Yoon, Young-Suk Won, Kihoon Lee, Og-Sung Moon, Young-Kook Kim, Hyoung-Chin Kim. Determination of Penicillium griseofulvum-oriented pyripyropene A, a selective inhibitor of acyl-coenzyme A:cholesterol acyltransferase 2, in mouse plasma using liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies.
Biomedical chromatography : BMC.
2019 Feb; 33(2):e4388. doi:
10.1002/bmc.4388. [PMID: 30238481] - Taichi Ohshiro, Masaki Ohtawa, Tohru Nagamitsu, Daisuke Matsuda, Hiroaki Yagyu, Matthew A Davis, Lawrence L Rudel, Shun Ishibashi, Hiroshi Tomoda. New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.
The Journal of pharmacology and experimental therapeutics.
2015 Nov; 355(2):299-307. doi:
10.1124/jpet.115.227348. [PMID: 26338984] - Daisuke Matsuda, Taichi Ohshiro, Masaki Ohtawa, Hiroyuki Yamazaki, Tohru Nagamitsu, Hiroshi Tomoda. In vitro metabolism of pyripyropene A and ACAT inhibitory activity of its metabolites.
The Journal of antibiotics.
2015 Jan; 68(1):27-34. doi:
10.1038/ja.2014.91. [PMID: 25005817] - Taichi Ohshiro, Daisuke Matsuda, Kent Sakai, Chiara Degirolamo, Hiroaki Yagyu, Lawrence L Rudel, Satoshi Omura, Shun Ishibashi, Hiroshi Tomoda. Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.
Arteriosclerosis, thrombosis, and vascular biology.
2011 May; 31(5):1108-15. doi:
10.1161/atvbaha.111.223552. [PMID: 21393580] - Akash Das, Matthew A Davis, Hiroshi Tomoda, Satoshi Omura, Lawrence L Rudel. Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A.
The Journal of biological chemistry.
2008 Apr; 283(16):10453-60. doi:
10.1074/jbc.m709460200. [PMID: 18285335] - Aaron T Lada, Matthew Davis, Carol Kent, James Chapman, Hiroshi Tomoda, Satoshi Omura, Lawrence L Rudel. Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay: individual ACAT uniqueness.
Journal of lipid research.
2004 Feb; 45(2):378-86. doi:
10.1194/jlr.d300037-jlr200. [PMID: 14617738] - Hye Young Song, Mun-Chual Rho, Seung Woong Lee, Oh Eok Kwon, Young-Duck Chang, Hyun Sun Lee, Young-Kook Kim. Isolation of Acyl-CoA:cholesterol acyltransferase inhibitor from Persicaria vulgaris.
Planta medica.
2002 Sep; 68(9):845-7. doi:
10.1055/s-2002-34395. [PMID: 12357403]