Isoetharine mesylate (BioDeep_00000767863)
代谢物信息卡片
化学式: C14H25NO6S (335.14025100000003)
中文名称: 异丙甲磺酸异噻嗪盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C(C1=CC(=C(C=C1)O)O)O)NC(C)C.CS(=O)(=O)O
InChI: 1H3,(H,2,3,4)
描述信息
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
Isoetharine (Isoetarine) mesylate is an orally active selective agonist of β-adrenergic receptors. Isoetharine mesylate is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine mesylate can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator[1][2].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D04626
- PubChem: 23702
- ChEMBL: CHEMBL1201153
- MeSH: Isoetharine
- CAS: 7279-75-6
- medchemexpress: HY-B1481
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - D M Gelmont, J R Balmes, A Yee. Hypokalemia induced by inhaled bronchodilators.
Chest.
1988 Oct; 94(4):763-6. doi:
10.1378/chest.94.4.763. [PMID: 3168573] - G P Zaloga, U R Hierlwimmer, R J Engler. Anaphylaxis following psyllium ingestion.
The Journal of allergy and clinical immunology.
1984 Jul; 74(1):79-80. doi:
10.1016/0091-6749(84)90091-5. [PMID: 6736485] - G P Berezuk, S W Schondelmeyer, J J Seidenfeld, W N Jones, J L Bootman. Clinical comparison of albuterol, isoetharine, and metaproterenol given by aerosol inhalation.
Clinical pharmacy.
1983 Mar; 2(2):129-34. doi:
. [PMID: 6349905] - G B Park, R F Koss, J Utter, B A Mayes, J Edelson. Determination of isoetharine in plasma by reversed-phase chromatography with amperometric detection.
Journal of pharmaceutical sciences.
1982 Aug; 71(8):932-4. doi:
10.1002/jps.2600710824. [PMID: 7120101] - A Arnold, J P McAuliff. Relative lipolytic activities of selected catecholamines in the mouse.
Pharmacology.
1976; 14(2):158-65. doi:
10.1159/000136591. [PMID: 959317]