Torate (BioDeep_00000767749)

   


代谢物信息卡片


Butorphanol tartrate

化学式: C25H35NO8 (477.2363)
中文名称: 酒石酸布托诺啡
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC2(C3CC4=C(C2(C1)CCN3CC5CCC5)C=C(C=C4)O)O.C(C(C(=O)O)O)(C(=O)O)O
InChI: 1-,2-/m10/s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

3 个代谢物同义名

Butorphanol tartrate; Torate; Torbugesic



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Shylo R Johnson, Christine K Ellis, Chad K Wickham, Molly R Selleck, Amy T Gilbert. Comparison of Ketamine-Xylazine, Butorphanol-Azaperone-Medetomidine, and Nalbuphine-Medetomidine-Azaperone for Raccoon (Procyon Lotor) Immobilization. Journal of wildlife diseases. 2023 Nov; ?(?):. doi: 10.7589/jwd-d-23-00060. [PMID: 37924235]
  • Marta Tikhomirov, Paweł Jajor, Tomasz Śniegocki, Błażej Poźniak. Predicting the efficacy of opioid sequestration by intravenous lipid emulsion using biologically relevant in vitro models of drug distribution. Scientific reports. 2022 11; 12(1):18683. doi: 10.1038/s41598-022-21790-4. [PMID: 36333363]
  • Mizuho Tashiro, Atsushi Tohei. Recommended doses of medetomidine-midazolam-butorphanol with atipamezole for preventing hypothermia in mice. The Journal of veterinary medical science. 2022 Mar; 84(3):445-453. doi: 10.1292/jvms.21-0479. [PMID: 35135936]
  • Minna Guo, Shijiang Liu, Jian Gao, Chuanbao Han, Chun Yang, Cunming Liu. The effects of fentanyl, oxycodone, and butorphanol on gastrointestinal function in patients undergoing laparoscopic hysterectomy: a prospective, double-blind, randomized controlled trial. BMC anesthesiology. 2022 02; 22(1):53. doi: 10.1186/s12871-022-01594-9. [PMID: 35209847]
  • Bruno H Pypendop, Yael Shilo-Benjamini. Pharmacokinetics of butorphanol in male neutered cats anesthetized with isoflurane. Journal of veterinary pharmacology and therapeutics. 2021 Nov; 44(6):883-887. doi: 10.1111/jvp.13014. [PMID: 34558086]
  • E L Oberhaus, D L Thompson, L E Kerrigan, A M Chapman. Plasma prolactin, thyroid-stimulating hormone, melanocyte-stimulating hormone, and adrenocorticotropin responses to thyrotropin-releasing hormone in mares treated with detomidine and butorphanol. Domestic animal endocrinology. 2021 01; 74(?):106536. doi: 10.1016/j.domaniend.2020.106536. [PMID: 32871339]
  • Tanya Duke-Novakovski, Carolina Palacios Jimenez, Masako Fujiyama, Shannon G Beazley. Plasma histamine concentrations in horses administered sodium penicillin, guaifenesin-xylazine-ketamine and isoflurane with morphine or butorphanol. Veterinary anaesthesia and analgesia. 2021 Jan; 48(1):17-25. doi: 10.1016/j.vaa.2020.10.003. [PMID: 33229232]
  • Qin Cai, Hanlin Gong, Mingbo Fan, Wen Chen, Lun Cai. The analgesic effect of tramadol combined with butorphanol on uterine cramping pain after repeat caesarean section: a randomized, controlled, double-blind study. Journal of anesthesia. 2020 12; 34(6):825-833. doi: 10.1007/s00540-020-02820-9. [PMID: 32627064]
  • Lisa L Wolfe, Travis Mays, Mark C Fisher, Michael W Miller. Tissue Residue Levels of the Tranquilizer Combination of Butorphanol, Azaperone, and Medetomidine, and the Antagonists, Naltrexone, Atipamezole, and Tolazoline, in Black Bears (Ursus americanus) Postimmobilization. Journal of wildlife diseases. 2020 10; 56(4):933-936. doi: 10.7589/jwd-d-19-00012. [PMID: 32348204]
  • Jiafu Ji, Wenzhen Lin, Amey Vrudhula, Jin Xi, Alexei Yeliseev, John R Grothusen, Weiming Bu, Renyu Liu. Molecular Interaction Between Butorphanol and κ-Opioid Receptor. Anesthesia and analgesia. 2020 09; 131(3):935-942. doi: 10.1213/ane.0000000000005017. [PMID: 32701545]
  • Stuart W Paine, Jane Bright, James P Scarth, Pamela R Hincks, Clive M Pearce, Colette Hannan, Marc Machnik, Lynn Hillyer. The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses. Journal of veterinary pharmacology and therapeutics. 2020 Mar; 43(2):162-170. doi: 10.1111/jvp.12838. [PMID: 32012314]
  • H Wang, J-L Wang, H-W Ren, W-F He, M Sun. Butorphanol protects on myocardial ischemia/reperfusion injury in rats through MAPK signaling pathway. European review for medical and pharmacological sciences. 2019 Dec; 23(23):10541-10548. doi: 10.26355/eurrev_201912_19695. [PMID: 31841210]
  • Naomi E Crabtree, Cathleen A Mochal-King, Pearce B Sloan, Alison L Eddy, Robert W Wills, Ashley N Meredith, Robin L Fontenot. Synovial butorphanol concentrations and mechanical nociceptive thresholds after intravenous regional limb perfusion in standing sedated horses. Veterinary surgery : VS. 2019 Nov; 48(8):1473-1482. doi: 10.1111/vsu.13309. [PMID: 31513300]
  • J Meng, S-J Jiang, D Jiang, Y Zhao. Butorphanol attenuates inflammation via targeting NF-κB in septic rats with brain injury. European review for medical and pharmacological sciences. 2019 Aug; 23(3 Suppl):161-170. doi: 10.26355/eurrev_201908_18643. [PMID: 31389587]
  • Daisy J X Liu, Myriam Hesta, Emmelie Stock, Evelien Bogaerts, Bart J G Broeckx, Jimmy H Saunders, Katrien Vanderperren. Renal perfusion parameters measured by contrast-enhanced ultrasound in healthy dogs demonstrate a wide range of variability in the long-term. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 2019 Mar; 60(2):201-209. doi: 10.1111/vru.12690. [PMID: 30276919]
  • I J Kallio-Kujala, H A Turunen, M R Raekallio, J M Honkavaara, K M Salla, D Casoni, H J Hautajärvi, O M Vainio. Peripherally acting α-adrenoceptor antagonist MK-467 with intramuscular medetomidine and butorphanol in dogs: A prospective, randomised, clinical trial. Veterinary journal (London, England : 1997). 2018 Oct; 240(?):22-26. doi: 10.1016/j.tvjl.2018.08.007. [PMID: 30268328]
  • Ira J Kallio-Kujala, Marja R Raekallio, Juhana Honkavaara, Rachel C Bennett, Heta Turunen, Mika Scheinin, Heidi Hautajärvi, Outi Vainio. Peripheral α2-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs. Veterinary anaesthesia and analgesia. 2018 Jul; 45(4):405-413. doi: 10.1016/j.vaa.2018.01.008. [PMID: 29891212]
  • L-H Huang, J Li, J-P Gu, M-X Qu, J Yu, Z-Y Wang. Butorphanol attenuates myocardial ischemia reperfusion injury through inhibiting mitochondria-mediated apoptosis in mice. European review for medical and pharmacological sciences. 2018 03; 22(6):1819-1824. doi: 10.26355/eurrev_201803_14601. [PMID: 29630131]
  • Teppei Nakamura, Naoya Karakida, Ai Dantsuka, Osamu Ichii, Yaser Hosny Ali Elewa, Yasuhiro Kon, Ken-Ichi Nagasaki, Hideki Hattori, Tomoji Yoshiyasu. Effects of a mixture of medetomidine, midazolam and butorphanol on anesthesia and blood biochemistry and the antagonizing action of atipamezole in hamsters. The Journal of veterinary medical science. 2017 Jul; 79(7):1230-1235. doi: 10.1292/jvms.17-0210. [PMID: 28603217]
  • Delphine Laniesse, David Sanchez-Migallon Guzman, Heather K Knych, Dale A Smith, Cornelia Mosley, Joanne R Paul-Murphy, Hugues Beaufrère. Pharmacokinetics of butorphanol tartrate in a long-acting poloxamer 407 gel formulation administered to Hispaniolan Amazon parrots (Amazona ventralis). American journal of veterinary research. 2017 Jun; 78(6):688-694. doi: 10.2460/ajvr.78.6.688. [PMID: 28541145]
  • Lisa L Wolfe, Mary E Wood, Pauline Nol, Matthew P McCollum, Mark C Fisher, William R Lance. THE EFFICACY OF NALBUPHINE, MEDETOMIDINE, AND AZAPERONE IN IMMOBILIZING AMERICAN BISON (BISON BISON). Journal of wildlife diseases. 2017 04; 53(2):304-310. doi: 10.7589/2016-05-107. [PMID: 28051569]
  • Christina A Gerlach, Maya S Kummrow, Leith C Meyer, Gareth E Zeiler, George F Stegmann, Roxanne K Buck, Geoffrey T Fosgate, Sabine B Kästner. CONTINUOUS INTRAVENOUS INFUSION ANESTHESIA WITH MEDETOMIDINE, KETAMINE, AND MIDAZOLAM AFTER INDUCTION WITH A COMBINATION OF ETORPHINE, MEDETOMIDINE, AND MIDAZOLAM OR WITH MEDETOMIDINE, KETAMINE, AND BUTORPHANOL IN IMPALA (AEPYCEROS MELAMPUS). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2017 Mar; 48(1):62-71. doi: 10.1638/2016-0010.1. [PMID: 28363076]
  • B Santangelo, F Micieli, F Marino, F Reynaud, P Cassandro, A Carfora, R Petrella, R Borriello, M Cataldi, G Vesce. Plasma concentrations and sedative effects of a dexmedetomidine, midazolam, and butorphanol combination after transnasal administration in healthy rabbits. Journal of veterinary pharmacology and therapeutics. 2016 Aug; 39(4):408-11. doi: 10.1111/jvp.12282. [PMID: 26687556]
  • Luca Bellini, Marta Vadori, Giulia Maria De Benedictis, Roberto Busetto. Effects of opioids on proximal renal tubular cells undergoing ATP depletion. Journal of pharmacological sciences. 2016 Aug; 131(4):288-91. doi: 10.1016/j.jphs.2016.08.002. [PMID: 27569459]
  • Yasuhiro Tsubokura, Toshio Kobayashi, Yutaka Oshima, Naoki Hashizume, Makoto Nakai, Shozo Ajimi, Nobuya Imatanaka. Effects of pentobarbital, isoflurane, or medetomidine-midazolam-butorphanol anesthesia on bronchoalveolar lavage fluid and blood chemistry in rats. The Journal of toxicological sciences. 2016; 41(5):595-604. doi: 10.2131/jts.41.595. [PMID: 27665769]
  • Meredith M Clancy, Butch KuKanich, John M Sykes. Pharmacokinetics of butorphanol delivered with an osmotic pump during a seven-day period in common peafowl (Pavo cristatus). American journal of veterinary research. 2015 Dec; 76(12):1070-6. doi: 10.2460/ajvr.76.12.1070. [PMID: 26618732]
  • L Chiavaccini, A K Claude, J H Lee, M K Ross, R E Meyer, V C Langston. Pharmacokinetics and pharmacodynamics comparison between subcutaneous and intravenous butorphanol administration in horses. Journal of veterinary pharmacology and therapeutics. 2015 Aug; 38(4):365-74. doi: 10.1111/jvp.12191. [PMID: 25484250]
  • Adriano B Carregaro, Gabrielle C Freitas, Martina H Ribeiro, Nathalia V Xavier, Renata G S Dória. Physiological and analgesic effects of continuous-rate infusion of morphine, butorphanol, tramadol or methadone in horses with lipopolysaccharide (LPS)-induced carpal synovitis. BMC veterinary research. 2014 Dec; 10(?):966. doi: 10.1186/s12917-014-0299-z. [PMID: 25528353]
  • Bianca Paludeto Dias, Marcelo Augusto de Araújo, Maurício Deschk, Thomas Alexander Trein, Nirmem Carlos Pinheiro, Silvia Helena Venturolli Perri, Celso Antônio Rodrigues, Paulo Sergio Patto dos Santos. Effects of a continuous rate infusion of butorphanol in isoflurane-anesthetized horses on cardiorespiratory parameters, recovery quality, gastrointestinal motility and serum cortisol concentrations. Acta cirurgica brasileira. 2014 Dec; 29(12):801-6. doi: 10.1590/s0102-86502014001900006. [PMID: 25517493]
  • Emmelie Stock, Katrien Vanderperren, Elke Van der Vekens, Hendrik Haers, Luc Duchateau, Ingeborgh Polis, Myriam Hesta, Jimmy H Saunders. The effect of anesthesia with propofol and sedation with butorphanol on quantitative contrast-enhanced ultrasonography of the healthy feline kidney. Veterinary journal (London, England : 1997). 2014 Dec; 202(3):637-9. doi: 10.1016/j.tvjl.2014.10.008. [PMID: 25458879]
  • Lon V Kendall, Ryan J Hansen, Kathryn Dorsey, Sooah Kang, Paul J Lunghofer, Daniel L Gustafson. Pharmacokinetics of sustained-release analgesics in mice. Journal of the American Association for Laboratory Animal Science : JAALAS. 2014 Sep; 53(5):478-84. doi: . [PMID: 25255070]
  • Takehiro Ochi, Ippei Nishiura, Mitsuyoshi Tatsumi, Yoshimi Hirano, Kouichi Yahagi, Yasuhiro Sakurai, Kanako Matsuyama-Fujiwara, Yuji Sudo, Noriko Nishina, Hironari Koyama. Anesthetic effect of a combination of medetomidine-midazolam-butorphanol in cynomolgus monkeys (Macaca fascicularis). The Journal of veterinary medical science. 2014 Jun; 76(6):917-21. doi: 10.1292/jvms.13-0589. [PMID: 24584083]
  • Yun Wu, Jing Wan, Wen-Zhon Zhen, Liu-Fang Chen, Jia Zhan, Jian-Juan Ke, Zong-Ze Zhang, Yan-Lin Wang. The effect of butorphanol postconditioning on myocardial ischaemia reperfusion injury in rats. Interactive cardiovascular and thoracic surgery. 2014 Mar; 18(3):308-12. doi: 10.1093/icvts/ivt516. [PMID: 24336785]
  • Johanna R Elfenbein, Sheilah A Robertson, Robert J MacKay, Butch KuKanich, L Sanchez. Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses. BMC veterinary research. 2014; 10 Suppl 1(?):S6. doi: 10.1186/1746-6148-10-s1-s6. [PMID: 25238633]
  • H K Knych, H C Casbeer, D S McKemie, R M Arthur. Pharmacokinetics and pharmacodynamics of butorphanol following intravenous administration to the horse. Journal of veterinary pharmacology and therapeutics. 2013 Feb; 36(1):21-30. doi: 10.1111/j.1365-2885.2012.01385.x. [PMID: 22339417]
  • Wendy Goodwin, Helen Keates, Kirby Pasloske, Martin Pearson, Ben Sauer, Millagahamada G Ranasinghe. Plasma pharmacokinetics and pharmacodynamics of alfaxalone in neonatal foals after an intravenous bolus of alfaxalone following premedication with butorphanol tartrate. Veterinary anaesthesia and analgesia. 2012 Sep; 39(5):503-10. doi: 10.1111/j.1467-2995.2012.00734.x. [PMID: 22642499]
  • Akari Kamine, Michito Shimozuru, Haruki Shibata, Toshio Tsubota. Effects of intramuscular administration of tiletamine-zolazepam with and without sedative pretreatment on plasma and serum biochemical values and glucose tolerance test results in Japanese black bears (Ursus thibetanus japonicus). American journal of veterinary research. 2012 Aug; 73(8):1282-9. doi: 10.2460/ajvr.73.8.1282. [PMID: 22849689]
  • D C Williams, M Aleman, B Tharp, D J Fletcher, P H Kass, E P Steffey, R A LeCouteur, T A Holliday. Qualitative and quantitative characteristics of the electroencephalogram in normal horses after sedation. Journal of veterinary internal medicine. 2012 May; 26(3):645-53. doi: 10.1111/j.1939-1676.2012.00921.x. [PMID: 22489924]
  • Kirsten Biermann, Stephan Hungerbühler, Reinhard Mischke, Sabine B R Kästner. Sedative, cardiovascular, haematologic and biochemical effects of four different drug combinations administered intramuscularly in cats. Veterinary anaesthesia and analgesia. 2012 Mar; 39(2):137-50. doi: 10.1111/j.1467-2995.2011.00699.x. [PMID: 22356415]
  • Simone K Ringer, Karine G Portier, Isabelle Fourel, Regula Bettschart-Wolfensberger. Development of a xylazine constant rate infusion with or without butorphanol for standing sedation of horses. Veterinary anaesthesia and analgesia. 2012 Jan; 39(1):1-11. doi: 10.1111/j.1467-2995.2011.00653.x. [PMID: 22103355]
  • Simone K Ringer, Karine G Portier, Isabelle Fourel, Regula Bettschart-Wolfensberger. Development of a romifidine constant rate infusion with or without butorphanol for standing sedation of horses. Veterinary anaesthesia and analgesia. 2012 Jan; 39(1):12-20. doi: 10.1111/j.1467-2995.2011.00681.x. [PMID: 22151873]
  • Sarah L Baldridge, Johann F Coetzee, Steve S Dritz, James B Reinbold, Ronette Gehring, James Havel, Butch Kukanich. Pharmacokinetics and physiologic effects of intramuscularly administered xylazine hydrochloride-ketamine hydrochloride-butorphanol tartrate alone or in combination with orally administered sodium salicylate on biomarkers of pain in Holstein calves following castration and dehorning. American journal of veterinary research. 2011 Oct; 72(10):1305-17. doi: 10.2460/ajvr.72.10.1305. [PMID: 21962272]
  • D Groppetti, A M Pecile, P Sacerdote, V Bronzo, G Ravasio. Effectiveness of electroacupuncture analgesia compared with opioid administration in a dog model: a pilot study. British journal of anaesthesia. 2011 Oct; 107(4):612-8. doi: 10.1093/bja/aer199. [PMID: 21749999]
  • David Sanchez-Migallon Guzman, Keven Flammer, Joanne R Paul-Murphy, Steven A Barker, Thomas N Tully. Pharmacokinetics of butorphanol after intravenous, intramuscular, and oral administration in Hispaniolan Amazon parrots (Amazona ventralis). Journal of avian medicine and surgery. 2011 Sep; 25(3):185-91. doi: 10.1647/2009-054.1. [PMID: 22216718]
  • Matthew D Winter, Kristina G Miles, Dean H Riedesel. Effect of sedation protocol on glomerular filtration rate in cats as determined by use of quantitative renal scintigraphy. American journal of veterinary research. 2011 Sep; 72(9):1222-5. doi: 10.2460/ajvr.72.9.1222. [PMID: 21879980]
  • P M Singh, C Johnson, B Gartrell, S Mitchinson, P Chambers. Pharmacokinetics of butorphanol in broiler chickens. The Veterinary record. 2011 Jun; 168(22):588. doi: 10.1136/vr.d1191. [PMID: 21628341]
  • B P S Thakur, S K Sharma, Arvind Sharma, Adarsh Kumar. Clinical evaluation of detomidine-butorphanol-guaifenesin-ketamine as short term TIVA in Spiti ponies. Pakistan journal of biological sciences : PJBS. 2011 Jun; 14(11):647-52. doi: 10.3923/pjbs.2011.647.652. [PMID: 22235506]
  • Jordyn M Boesch, Jason R Boulanger, Paul D Curtis, Hollis N Erb, John W Ludders, Marc S Kraus, Robin D Gleed. Biochemical variables in free-ranging white-tailed deer (Odocoileus virginianus) after chemical immobilization in clover traps or via ground-darting. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2011 Mar; 42(1):18-28. doi: 10.1638/2009-0146.1. [PMID: 22946365]
  • Gretchen E Singletary, Ashley B Saunders, W Brian Saunders, Jan S Suchodolski, Jörg M Steiner, Geoffery T Fosgate, Sandee M Hartsfield. Cardiac troponin I concentrations following medetomidine-butorphanol sedation in dogs. Veterinary anaesthesia and analgesia. 2010 Jul; 37(4):342-6. doi: 10.1111/j.1467-2995.2010.00540.x. [PMID: 20636565]
  • Macarena G Sanz, Debra C Sellon, Julie A Cary, Melissa T Hines, Kelly D Farnsworth. Analgesic effects of butorphanol tartrate and phenylbutazone administered alone and in combination in young horses undergoing routine castration. Journal of the American Veterinary Medical Association. 2009 Nov; 235(10):1194-203. doi: 10.2460/javma.235.10.1194. [PMID: 19912042]
  • G Schöffmann, P Winter, R Palme, A Pollak, G Trittenwein, J Golej. Haemodynamic changes and stress responses of piglets to surgery during total intravenous anaesthesia with propofol and fentanyl. Laboratory animals. 2009 Jul; 43(3):243-8. doi: 10.1258/la.2008.0080026. [PMID: 19246504]
  • D C Sellon, M G Papich, L Palmer, B Remund. Pharmacokinetics of butorphanol in horses after intramuscular injection. Journal of veterinary pharmacology and therapeutics. 2009 Feb; 32(1):62-5. doi: 10.1111/j.1365-2885.2008.01004.x. [PMID: 19161457]
  • Mette G Olesen, Mads F Bertelsen, Steve F Perry, Tobias Wang. Effects of preoperative administration of butorphanol or meloxicam on physiologic responses to surgery in ball pythons. Journal of the American Veterinary Medical Association. 2008 Dec; 233(12):1883-8. doi: 10.2460/javma.233.12.1883. [PMID: 19072601]
  • Sean M Wells, Leigh E Glerum, Mark G Papich. Pharmacokinetics of butorphanol in cats after intramuscular and buccal transmucosal administration. American journal of veterinary research. 2008 Dec; 69(12):1548-54. doi: 10.2460/ajvr.69.12.1548. [PMID: 19045999]
  • Shannon M Riggs, Michelle G Hawkins, Arthur L Craigmill, Philip H Kass, Scott D Stanley, Ian T Taylor. Pharmacokinetics of butorphanol tartrate in red-tailed hawks (Buteo jamaicensis) and great horned owls (Bubo virginianus). American journal of veterinary research. 2008 May; 69(5):596-603. doi: 10.2460/ajvr.69.5.596. [PMID: 18447789]
  • A V Kireeva, A B Zelentsova, N V Saĭgushkin, A A Vatalev, S V Volchenko, V N Kuklin. [Chemical-toxicological analysis of butorphanol]. Sudebno-meditsinskaia ekspertiza. 2008 Mar; 51(2):23-6. doi: NULL. [PMID: 18450095]
  • S L Walsh, A E Chausmer, E C Strain, G E Bigelow. Evaluation of the mu and kappa opioid actions of butorphanol in humans through differential naltrexone blockade. Psychopharmacology. 2008 Jan; 196(1):143-55. doi: 10.1007/s00213-007-0948-z. [PMID: 17909753]
  • Grace J Lim, Yozo Ishiuji, Aerlyn Dawn, Benjamin Harrison, Do Won Kim, Anthony Atala, Gil Yosipovitch. In vitro and in vivo characterization of a novel liposomal butorphanol formulation for treatment of pruritus. Acta dermato-venereologica. 2008; 88(4):327-30. doi: 10.2340/00015555-0480. [PMID: 18709299]
  • Gary N W Leung, David K K Leung, Terence S M Wan, Colton H F Wong. High throughput screening of sub-ppb levels of basic drugs in equine plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2007 Jul; 1156(1-2):271-9. doi: 10.1016/j.chroma.2006.10.006. [PMID: 17054971]
  • Rosa Novellas, Rafael Ruiz de Gopegui, Yvonne Espada. Effects of sedation with midazolam and butorphanol on resistive and pulsatility indices in healthy dogs. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 2007 May; 48(3):276-80. doi: 10.1111/j.1740-8261.2007.00242.x. [PMID: 17508517]
  • Tomohito Inoue, Jeff C Ko, Ronald E Mandsager, Mark E Payton, David S Galloway, Douglas N Lange. Efficacy and safety of preoperative etodolac and butorphanol administration in dogs undergoing ovariohysterectomy. Journal of the American Animal Hospital Association. 2006 May; 42(3):178-88. doi: 10.5326/0420178. [PMID: 16611929]
  • Kurt K Sladky, Lisa Krugner-Higby, Elizabeth Meek-Walker, Timothy D Heath, Joanne Paul-Murphy. Serum concentrations and analgesic effects of liposome-encapsulated and standard butorphanol tartrate in parrots. American journal of veterinary research. 2006 May; 67(5):775-81. doi: 10.2460/ajvr.67.5.775. [PMID: 16649909]
  • Allison J Stewart. Clostridial myositis and collapse in a standardbred filly. The Veterinary clinics of North America. Equine practice. 2006 Apr; 22(1):127-43. doi: 10.1016/j.cveq.2005.12.019. [PMID: 16627111]
  • Craig A Harms, Gregory A Lewbart, Clifford R Swanson, Jennifer M Kishimori, Shane M Boylan. Behavioral and clinical pathology changes in koi carp (Cyprinus carpio) subjected to anesthesia and surgery with and without intra-operative analgesics. Comparative medicine. 2005 Jun; 55(3):221-6. doi: . [PMID: 16089168]
  • Tamas D Ambrisko, Yoshiaki Hikasa, Kota Sato. Influence of medetomidine on stress-related neurohormonal and metabolic effects caused by butorphanol, fentanyl, and ketamine administration in dogs. American journal of veterinary research. 2005 Mar; 66(3):406-12. doi: 10.2460/ajvr.2005.66.406. [PMID: 15822583]
  • Debra C Sellon, Malcolm C Roberts, Anthony T Blikslager, Catherine Ulibarri, Mark G Papich. Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy. Journal of veterinary internal medicine. 2004 Jul; 18(4):555-63. doi: 10.1892/0891-6640(2004)18<555:eocrii>2.0.co;2. [PMID: 15320598]
  • Deborah V Wilson, A Thomas Evans, Rachael A Carpenter, David R Mullineaux. The effect of four anesthetic protocols on splenic size in dogs. Veterinary anaesthesia and analgesia. 2004 Apr; 31(2):102-8. doi: 10.1111/j.1467-2987.2004.00152.x. [PMID: 15053748]
  • Luc R Borer, John E Peel, Wolfgang Seewald, Peter Schawalder, David E Spreng. Effect of carprofen, etodolac, meloxicam, or butorphanol in dogs with induced acute synovitis. American journal of veterinary research. 2003 Nov; 64(11):1429-37. doi: 10.2460/ajvr.2003.64.1429. [PMID: 14620781]
  • Steven C Budsberg, Alan R Cross, Jane E Quandt, Luisito S Pablo, Alice R Runk. Evaluation of intravenous administration of meloxicam for perioperative pain management following stifle joint surgery in dogs. American journal of veterinary research. 2002 Nov; 63(11):1557-63. doi: 10.2460/ajvr.2002.63.1557. [PMID: 12428667]
  • G F Leskova, Iu V Arkhipenko. [Comparative effect of partial opiate agonists buprenorphine and butorphanol on the phospholipid composition of hepatocytes plasma membranes during hemorrhagic shock in cats]. Voprosy meditsinskoi khimii. 2002 Sep; 48(5):497-502. doi: NULL. [PMID: 12498093]
  • David W Boulton, Glenn F Duncan, Nimish N Vachharajani. Validation and application of a sensitive assay for butorphanol in human plasma by high-performance liquid chromatography with tandem mass spectrometry detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2002 Jul; 775(1):57-62. doi: 10.1016/s1570-0232(02)00277-5. [PMID: 12101060]
  • Misse Väisänen, Marja Raekallio, Erja Kuusela, Pirkko Huttunen, Juhani Leppäluoto, Petra Kirves, Outi Vainio. Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic medication. American journal of veterinary research. 2002 Jul; 63(7):969-75. doi: 10.2460/ajvr.2002.63.969. [PMID: 12118677]
  • N N Vachharajani, W-C Shyu, P S Nichola, D W Boulton. A pharmacokinetic interaction study between butorphanol and sumatriptan nasal sprays in healthy subjects: importance of the timing of butorphanol administration. Cephalalgia : an international journal of headache. 2002 May; 22(4):282-7. doi: 10.1046/j.1468-2982.2002.00359.x. [PMID: 12100090]
  • Kelly L Gellasch, Kris T Kruse-Elliott, Christian S Osmond, Andre N C Shih, Dale E Bjorling. Comparison of transdermal administration of fentanyl versus intramuscular administration of butorphanol for analgesia after onychectomy in cats. Journal of the American Veterinary Medical Association. 2002 Apr; 220(7):1020-4. doi: 10.2460/javma.2002.220.1020. [PMID: 12420780]
  • G L Carroll, D M Boothe, S M Hartsfield, E A Martinez, A C Spann, A Hernandez. Pharmacokinetics and pharmacodynamics of butorphanol in llamas after intravenous and intramuscular administration. Journal of the American Veterinary Medical Association. 2001 Nov; 219(9):1263-7. doi: 10.2460/javma.2001.219.1263. [PMID: 11697372]
  • J B Grimm, K A Grimm, S K Kneller, W J Tranquilli, S S Crochik, M G Bischoff, J L Podolski. The effect of a combination of medetomidine-butorphanol and medetomidine, butorphanol, atropine on glomerular filtration rate in dogs. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 2001 Sep; 42(5):458-62. doi: 10.1111/j.1740-8261.2001.tb00970.x. [PMID: 11678570]
  • D C Sellon, V L Monroe, M C Roberts, M G Papich. Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses. American journal of veterinary research. 2001 Feb; 62(2):183-9. doi: 10.2460/ajvr.2001.62.183. [PMID: 11212025]
  • J N Franks, H W Boothe, L Taylor, S Geller, G L Carroll, V Cracas, D M Boothe. Evaluation of transdermal fentanyl patches for analgesia in cats undergoing onychectomy. Journal of the American Veterinary Medical Association. 2000 Oct; 217(7):1013-20. doi: 10.2460/javma.2000.217.1013. [PMID: 11019707]
  • A J Cambridge, K M Tobias, R C Newberry, D K Sarkar. Subjective and objective measurements of postoperative pain in cats. Journal of the American Veterinary Medical Association. 2000 Sep; 217(5):685-90. doi: 10.2460/javma.2000.217.685. [PMID: 10976300]
  • T J Doherty, F M Andrews, M K Provenza, D L Frazier. The effect of sedation on gastric emptying of a liquid marker in ponies. Veterinary surgery : VS. 1999 Sep; 28(5):375-9. doi: 10.1111/j.1532-950x.1999.00375.x. [PMID: 10493642]
  • C Grondahl-Nielsen, H B Simonsen, J D Lund, M Hesselholt. Behavioural, endocrine and cardiac responses in young calves undergoing dehorning without and with use of sedation and analgesia. Veterinary journal (London, England : 1997). 1999 Jul; 158(1):14-20. doi: 10.1053/tvjl.1998.0284. [PMID: 10409412]
  • J A Vivian, M B DeYoung, T L Sumpter, J R Traynor, J W Lewis, J H Woods. kappa-Opioid receptor effects of butorphanol in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. 1999 Jul; 290(1):259-65. doi: NULL. [PMID: 10381785]
  • S M Fox, D J Mellor, C R Lawoko, H Hodge, E C Firth. Changes in plasma cortisol concentrations in bitches in response to different combinations of halothane and butorphanol, with or without ovariohysterectomy. Research in veterinary science. 1998 Sep; 65(2):125-33. doi: 10.1016/s0034-5288(98)90163-1. [PMID: 9839890]
  • M H Andraus, M E Siqueira. Determination of butorphanol in horse race urine by immunoassay and gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1997 Dec; 704(1-2):143-50. doi: 10.1016/s0378-4347(97)00473-8. [PMID: 9518143]
  • N N Vachharajani, W C Shyu, R H Barbhaiya. Pharmacokinetic interaction between butorphanol nasal spray and oral metoclopramide in healthy women. Journal of clinical pharmacology. 1997 Oct; 37(10):979-85. doi: 10.1002/j.1552-4604.1997.tb04273.x. [PMID: 9505990]
  • G L Carroll, S M Hartsfield, R Hambleton. Anesthetic effects of tiletamine-zolazepam, alone or in combination with butorphanol, in goats. Journal of the American Veterinary Medical Association. 1997 Sep; 211(5):593-7. doi: NULL. [PMID: 9290827]
  • P Pibarot, J Dupuis, E Grisneaux, S Cuvelliez, J Planté, G Beauregard, N H Bonneau, J Bouffard, D Blais. Comparison of ketoprofen, oxymorphone hydrochloride, and butorphanol in the treatment of postoperative pain in dogs. Journal of the American Veterinary Medical Association. 1997 Aug; 211(4):438-44. doi: NULL. [PMID: 9267504]
  • S M Newell, J C Ko, P E Ginn, T G Heaton-Jones, D A Hyatt, A L Cardwell, D F Mauragis, J M Harrison. Effects of three sedative protocols on glomerular filtration rate in clinically normal dogs. American journal of veterinary research. 1997 May; 58(5):446-50. doi: NULL. [PMID: 9140548]
  • N N Vachharajani, W C Shyu, D S Greene, R H Barbhaiya. The pharmacokinetics of butorphanol and its metabolites at steady state following nasal administration in humans. Biopharmaceutics & drug disposition. 1997 Apr; 18(3):191-202. doi: 10.1002/(sici)1099-081x(199704)18:3<191::aid-bdd9>3.0.co;2-6. [PMID: 9113342]
  • W C Shyu, R H Barbhaiya. Lack of pharmacokinetic interaction between butorphanol nasal spray and cimetidine. British journal of clinical pharmacology. 1996 Oct; 42(4):513-7. doi: 10.1046/j.1365-2125.1996.459/2.x. [PMID: 8904627]
  • K A Mathews, D M Paley, R A Foster, A E Valliant, S S Young. A comparison of ketorolac with flunixin, butorphanol, and oxymorphone in controlling postoperative pain in dogs. The Canadian veterinary journal = La revue veterinaire canadienne. 1996 Sep; 37(9):557-67. doi: . [PMID: 8877043]
  • N N Vachharajani, W C Shyu, W R Garnett, E A Morgenthien, R H Barbhaiya. The absolute bioavailability and pharmacokinetics of butorphanol nasal spray in patients with hepatic impairment. Clinical pharmacology and therapeutics. 1996 Sep; 60(3):283-94. doi: 10.1016/s0009-9236(96)90055-7. [PMID: 8841151]
  • E Troncy, J G Besner, R Charbonneau, S G Cuvelliez, D Blais. Pharmacokinetics of epidural butorphanol in isoflurane-anaesthetized dogs. Journal of veterinary pharmacology and therapeutics. 1996 Aug; 19(4):268-73. doi: 10.1111/j.1365-2885.1996.tb00048.x. [PMID: 8866454]
  • D E Mulvana, G F Duncan, W C Shyu, L K Tay, R H Barbhaiya. Quantitative determination of butorphanol and its metabolites in human plasma by gas chromatography-electron capture negative-ion chemical ionization mass spectrometry. Journal of chromatography. B, Biomedical applications. 1996 Jul; 682(2):289-300. doi: 10.1016/0378-4347(96)00084-9. [PMID: 8844422]
  • W C Shyu, E A Morgenthien, R H Barbhaiya. Pharmacokinetics of butorphanol nasal spray in patients with renal impairment. British journal of clinical pharmacology. 1996 May; 41(5):397-402. doi: 10.1046/j.1365-2125.1996.03327.x. [PMID: 8735680]
  • J C Ko, J E Bailey, L S Pablo, T G Heaton-Jones. Comparison of sedative and cardiorespiratory effects of medetomidine and medetomidine-butorphanol combination in dogs. American journal of veterinary research. 1996 Apr; 57(4):535-40. doi: NULL. [PMID: 8712521]
  • E S el Daly. Influence of acute and chronic morphine or stadol on the secretion of adrenocorticotrophin and its hypothalamic releasing hormone in the rat. Life sciences. 1996; 59(22):1881-90. doi: 10.1016/s0024-3205(96)00535-8. [PMID: 8950285]
  • H J Lemmens, T D Egan, P Fiset, D R Stanski. Pharmacokinetic/dynamic assessment in drug development: application to the investigational opioid mirfentanil. Anesthesia and analgesia. 1995 Jun; 80(6):1206-11. doi: 10.1097/00000539-199506000-00024. [PMID: 7762853]
  • N R Srinivas, W C Shyu, D Upmalis, J S Lee, R H Barbhaiya. Lack of pharmacokinetic interaction between butorphanol tartrate nasal spray and sumatriptan succinate. Journal of clinical pharmacology. 1995 Apr; 35(4):432-7. doi: 10.1002/j.1552-4604.1995.tb04085.x. [PMID: 7650235]