Fenobam (BioDeep_00000767740)
Chemicals and Drugs
代谢物信息卡片
化学式: C11H11ClN4O2 (266.05704959999997)
中文名称: 非诺班
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CC(=O)NC1=NC(=O)NC2=CC(=CC=C2)Cl
InChI: InChI=1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
描述信息
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction[1][2][3].
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:92728
- PubChem: 135659063
- DrugBank: DB12931
- ChEMBL: CHEMBL239800
- CAS: 57653-26-6
- medchemexpress: HY-101478
分类词条
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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文献列表
- Laura F Cavallone, Michael C Montana, Karen Frey, Dorina Kallogjeri, James M Wages, Thomas L Rodebaugh, Tina Doshi, Evan D Kharasch, Robert W Gereau. The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects.
Pain.
2020 01; 161(1):135-146. doi:
10.1097/j.pain.0000000000001695. [PMID: 31568235] - Thomas M Keck, Hong-Ju Yang, Guo-Hua Bi, Yong Huang, Hai-Ying Zhang, Ratika Srivastava, Eliot L Gardner, Amy Hauck Newman, Zheng-Xiong Xi. Fenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans.
Psychopharmacology.
2013 Sep; 229(2):253-65. doi:
10.1007/s00213-013-3106-9. [PMID: 23615919] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Michael C Montana, Laura F Cavallone, Kristi K Stubbert, Andrei D Stefanescu, Evan D Kharasch, Robert W Gereau. The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.
The Journal of pharmacology and experimental therapeutics.
2009 Sep; 330(3):834-43. doi:
10.1124/jpet.109.154138. [PMID: 19515968] - W N Wu, L A McKown, P J O'Neill. In vitro and in vivo metabolism of the antianxiolytic agent fenobam in the rat.
Journal of pharmaceutical sciences.
1995 Feb; 84(2):185-9. doi:
10.1002/jps.2600840212. [PMID: 7738798]