Predonine (BioDeep_00000767733)
Secondary id: BioDeep_00001899868
代谢物信息卡片
Prednisolone Sodium Succinate
化学式: C25H31NaO8 (482.1916526)
中文名称: 泼尼松龙21-半琥珀酸钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CC(C3C(C1CCC2(C(=O)COC(=O)CCC(=O)[O-])O)CCC4=CC(=O)C=CC34C)O.[Na+]
InChI: /q
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:32044
- PubChem: 23680518
- ChEMBL: CHEMBL1412530
- CAS: 1715-33-9
- KEGG: C12666
- PubChem: 583056
- NIKKAJI: J7.571J
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hiraku Onishi, Yuta Saito, Masanaho Sasatsu, Yoshiharu Machida. Kinetic analysis of in vitro and in vivo release of prednisolone from the conjugate of glycol-chitosan and succinyl-prednisolone.
International journal of pharmaceutics.
2011 May; 410(1-2):17-22. doi:
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Deutsche medizinische Wochenschrift (1946).
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10.1055/s-0029-1244828. [PMID: 20101555] - Kouji Higashi, Masaru Terai, Hiromichi Hamada, Takafumi Honda, Masaki Kanazawa, Yoichi Kohno. Impairment of angiogenic activity in the serum from patients with coronary aneurysms due to Kawasaki disease.
Circulation journal : official journal of the Japanese Circulation Society.
2007 Jul; 71(7):1052-9. doi:
10.1253/circj.71.1052. [PMID: 17587710] - K Miyanishi, T Yamamoto, T Irisa, G Motomura, S Jingushi, K Sueishi, Y Iwamoto. Effects of different corticosteroids on the development of osteonecrosis in rabbits.
Rheumatology (Oxford, England).
2005 Mar; 44(3):332-6. doi:
10.1093/rheumatology/keh505. [PMID: 15598709] - K Sugiyama, T Kawada, H Sato, T Hirano. Comparison of suppressive potency between prednisolone and prednisolone sodium succinate against mitogen-induced blastogenesis of human peripheral blood mononuclear cells in-vitro.
The Journal of pharmacy and pharmacology.
2001 May; 53(5):727-33. doi:
10.1211/0022357011775857. [PMID: 11370712] - E P Zhang, F Schulte, S Bulfone-Paus, F Hoffmann. The effect of corticosteroid and cyclosporin A on murine corneal allograft rejection.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2000 Jun; 238(6):525-30. doi:
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Laryngo- rhino- otologie.
1999 Oct; 78(10):573-8. doi:
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Archives of otolaryngology--head & neck surgery.
1998 Nov; 124(11):1260-4. doi:
10.1001/archotol.124.11.1260. [PMID: 9821930] - K Frenzel, G Burda, G Fürst, J Golej, M Hermon, G Trittenwein, A Pollak. [Therapy refractory arterial hypotension after heart operation].
Klinische Padiatrie.
1997 Jan; 209(1):36-8. doi:
10.1055/s-2008-1043925. [PMID: 9121076] - K A Mathews, D L Holmberg, K Johnston, C M Miller, A G Binnington, G Maxie, M Atilola, G Smith. Renal allograft survival in outbred mongrel dogs using rabbit anti-dog thymocyte serum in combination with immunosuppressive drug therapy with or without donor bone marrow.
Veterinary surgery : VS.
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Endocrinologia japonica.
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10.1507/endocrj1954.38.167. [PMID: 1752235] - M F Chen, F Shimada, H Kato, S Yano, M Kanaoka. Effect of glycyrrhizin on the pharmacokinetics of prednisolone following low dosage of prednisolone hemisuccinate.
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10.1507/endocrj1954.37.331. [PMID: 2253583] - M C Castle. Alteration of hepatic carboxylesterase activity by soman: inhibition in vitro and enhancement in vivo.
Xenobiotica; the fate of foreign compounds in biological systems.
1989 Jan; 19(1):115-21. doi:
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Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete.
1988 May; 43(9):250-2. doi:
NULL. [PMID: 3407239] - V P Rohdewald, J Rehder, H Möllmann, J Barth, H Derendorf. [Pharmacokinetics and pharmacodynamics of prednisolone following extremely high dosage as prednisolone hemisuccinate].
Arzneimittel-Forschung.
1987 Feb; 37(2):194-8. doi:
NULL. [PMID: 3580023] - A Tsuji, I Tamai, K Sasaki. Hydrolysis of prednisolone succinate by esterase in rabbit ocular tissue.
Ophthalmic research.
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10.1159/000265516. [PMID: 3441354] - F D Boudinot, W J Jusko. Dose-dependent pharmacokinetics of prednisolone in normal and adrenalectomized rats.
Journal of pharmacokinetics and biopharmaceutics.
1986 Oct; 14(5):453-67. doi:
10.1007/bf01059655. [PMID: 3806371] - H Derendorf, P Rohdewald, H Möllmann, J Rehder, J Barth, D Neveling. Pharmacokinetics of prednisolone after high doses of prednisolone hemisuccinate.
Biopharmaceutics & drug disposition.
1985 Oct; 6(4):423-32. doi:
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10.1111/j.1471-4159.1985.tb08755.x. [PMID: 3882888] - P L Toutain, G D Koritz, M Alvinerie, H de Pomyers, Y Ruckebusch. Prednisolone succinate and prednisolone acetate in cattle: pharmacokinetics and action on the adrenal gland.
American journal of veterinary research.
1985 Mar; 46(3):719-25. doi:
NULL. [PMID: 3994138] - G H Hankes, L R Lazenby, W R Ravis, A A Belmonte. Pharmacokinetics of prednisolone sodium succinate and its metabolites in normovolemic and hypovolemic dogs.
American journal of veterinary research.
1985 Feb; 46(2):476-8. doi:
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1984 Oct; 45(10):2077-83. doi:
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10.1001/archsurg.1984.01390140022004. [PMID: 6320765] - H Bergrem. Pharmacokinetics and protein binding of prednisolone in patients with nephrotic syndrome and patients undergoing hemodialysis.
Kidney international.
1983 Jun; 23(6):876-81. doi:
10.1038/ki.1983.110. [PMID: 6887699] - K Yanagibashi, A Mizuchi, H Yotsumoto, Y Miyachi. Separation of serum prednisolone and prednisolone-21-hemisuccinate by extraction and their concurrent determination by radioimmunoassay.
Clinical chemistry.
1980 Aug; 26(9):1301-3. doi:
10.1093/clinchem/26.9.1301. [PMID: 7398044] - J TAMM, K D VOIGT. Free and bound 17-hydroxycorticosteroids in plasma and urine following a rapid intravenous injection of prednisolone-hemisuccinate and prednisone-glycinate.
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