Betahistine mesilate (BioDeep_00000766486)

   


代谢物信息卡片


Betahistine mesilate

化学式: C10H20N2O6S2 (328.076274)
中文名称: 甲磺酸倍他司汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNCCC1=CC=CC=N1.CS(=O)(=O)O.CS(=O)(=O)O
InChI: 2*1H3,(H,2,3,4)

描述信息

D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D017442 - Histamine Agonists
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Betahistine mesylate is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine mesylate is used for the study of rheumatoid arthritis (RA)[3].

同义名列表

3 个代谢物同义名

Betahistine mesilate; Betahistine Mesylate; Betahistine (mesylate)



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Dong Wu, Bo Liu, Yunqing Wu, Yu Wang, Jingyi Sun, Jun Yang, Jinping Duan, Gang Liu, Kai Cao, Yi Zhang, Peijing Rong. Meniere Disease treated with transcutaneous auricular vagus nerve stimulation combined with betahistine Mesylate: A randomized controlled trial. Brain stimulation. 2023 Nov; 16(6):1576-1584. doi: 10.1016/j.brs.2023.10.003. [PMID: 37838094]
  • Yueqing Su, Chao Deng, Xuemei Liu, Jiamei Lian. Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia. International journal of molecular sciences. 2023 May; 24(11):. doi: 10.3390/ijms24119143. [PMID: 37298094]
  • Yu-Lin Qiao, Wen-Qiang Xiang, Fang Liu, Sheng Jin. Clinical therapeutic effects of gastrodin in combination with betahistine on vertigo: A protocol for systematic review and meta-analysis. Medicine. 2021 Mar; 100(10):e23825. doi: 10.1097/md.0000000000023825. [PMID: 33725810]
  • Azadeh Yazdi, Mohammadmahdi Doostmohammadi, Farshid Pourhossein Majarshin, Siamak Beheshti. Betahistine, prevents kindling, ameliorates the behavioral comorbidities and neurodegeneration induced by pentylenetetrazole. Epilepsy & behavior : E&B. 2020 04; 105(?):106956. doi: 10.1016/j.yebeh.2020.106956. [PMID: 32062106]
  • Xuanwei Liu, Na'na Zhao, Kexue Zeng, Peng Xiao, Pengjie Sheng, Xun Luo, Yulong Wang. Effects of nimodipine combined with betahistine on CRP and other inflammatory cytokines and vascular endothelial function in patients with hypertensive cerebral vasospasm. Clinical hemorheology and microcirculation. 2020; 75(3):279-289. doi: 10.3233/ch-190589. [PMID: 32280080]
  • Robert C Smith, Lawrence Maayan, Renrong Wu, Mary Youssef, Zhihui Jing, Henry Sershen, Victoria Szabo, Jordan Meyers, Hua Jin, Jinping Zhao, John M Davis. Betahistine effects on weight-related measures in patients treated with antipsychotic medications: a double-blind placebo-controlled study. Psychopharmacology. 2018 Dec; 235(12):3545-3558. doi: 10.1007/s00213-018-5079-1. [PMID: 30382354]
  • Michael Strupp, Ludwig Kraus, Franz Schautzer, Dan Rujescu. Menière's disease: combined pharmacotherapy with betahistine and the MAO-B inhibitor selegiline-an observational study. Journal of neurology. 2018 Oct; 265(Suppl 1):80-85. doi: 10.1007/s00415-018-8809-8. [PMID: 29532287]
  • Krunal Soni, Chandrakant Bhatt, Kanchan Singh, P C Bhuvaneshwari, Anil Jha, Palak Patel, Harilal Patel, Nuggehally R Srinivas. An LC-MS/MS assay for the quantitative determination of 2-pyridyl acetic acid, a major metabolite and key surrogate for betahistine, using low-volume human K2 EDTA plasma. Biomedical chromatography : BMC. 2017 Feb; 31(2):. doi: 10.1002/bmc.3790. [PMID: 27428039]
  • Jolene Zheng, Joseph R Vasselli, Jason F King, Michael L King, Wenqian We, Zachary Fitzpatrick, William D Johnson, John W Finley, Roy J Martin, Michael J Keenan, Frederic M Enright, Frank L Greenway. Using Caenorhabditis elegans as a Model for Obesity Pharmacology Development. American journal of therapeutics. 2016 Nov; 23(6):e1363-e1370. doi: 10.1097/mjt.0000000000000061. [PMID: 24786852]
  • Kuo-Tung Tang, Ya-Hsuan Chao, Der-Yuan Chen, Yun-Ping Lim, Yi-Ming Chen, Yi-Rong Li, Deng-Ho Yang, Chi-Chen Lin. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses. International immunopharmacology. 2016 Oct; 39(?):236-245. doi: 10.1016/j.intimp.2016.07.030. [PMID: 27494687]
  • M Nue Møller, S Kirkeby, J Vikeså, F Cilius Nielsen, P Caye-Thomasen. Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2016 Jul; 273(7):1705-10. doi: 10.1007/s00405-015-3731-5. [PMID: 26208913]
  • Richard Holy, Pavol Prazenica, Eva Stolarikova, Petr Dosel, Petra Fundova, Daniel Kovar, Jaromir Astl. Hyperbaric oxygen therapy in tinnitus with normal hearing in association with combined treatment. Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc. 2016 May; 43(3):201-5. doi: ". [PMID: 27416687]
  • Tadashi Kitahara, Hidehiko Okamoto, Munehisa Fukushima, Masaharu Sakagami, Taeko Ito, Akinori Yamashita, Ichiro Ota, Toshiaki Yamanaka. A Two-Year Randomized Trial of Interventions to Decrease Stress Hormone Vasopressin Production in Patients with Meniere's Disease-A Pilot Study. PloS one. 2016; 11(6):e0158309. doi: 10.1371/journal.pone.0158309. [PMID: 27362705]
  • Mohamed A El-Nabarawi, Adel A Ali, Heba M Aboud, Amira H Hassan, Amany H Godah. Transbuccal delivery of betahistine dihydrochloride from mucoadhesive tablets with a unidirectional drug flow: in vitro, ex vivo and in vivo evaluation. Drug design, development and therapy. 2016; 10(?):4031-4045. doi: 10.2147/dddt.s120613. [PMID: 28008227]
  • Ganesh Moorthy, Floyd Sallee, Prasad Gabbita, Frank Zemlan, Larry Sallans, Pankaj B Desai. Safety, tolerability and pharmacokinetics of 2-pyridylacetic acid, a major metabolite of betahistine, in a phase 1 dose escalation study in subjects with ADHD. Biopharmaceutics & drug disposition. 2015 Oct; 36(7):429-39. doi: 10.1002/bdd.1955. [PMID: 25904220]
  • B Acar, R M Karasen, Y Buran. Efficacy of medical therapy in the prevention of residual dizziness after successful repositioning maneuvers for Benign Paroxysmal Positional Vertigo (BPPV). B-ENT. 2015; 11(2):117-21. doi: ". [PMID: 26563011]
  • Qian Xie, Yuan-Yuan Li, Yan-Ming Xie, Wei Yang, Wei Zhao, Yan Zhuang, Yong-Yan Wang. [Characteristics and drug analysis associated with vertigo disease in real world]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Sep; 39(18):3514-8. doi: ". [PMID: 25532387]
  • Bissera A Pilicheva, Margarita I Kassarova, Plamen I Zagorchev, Yordanka I Uzunova. Formulation and performance evaluation of betahistine dihydrochloride microspheres as sustained release systems. Folia medica. 2014 Jul; 56(3):187-93. doi: 10.2478/folmed-2014-0027. [PMID: 25434076]
  • Joanna Folwarczna, Aleksandra Janas, Maria Pytlik, Leszek Śliwiński, Marek Wiercigroch, Anna Brzęczek. Modifications of histamine receptor signaling affect bone mechanical properties in rats. Pharmacological reports : PR. 2014 Feb; 66(1):93-9. doi: 10.1016/j.pharep.2013.08.010. [PMID: 24905313]
  • Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Deng. Preventing olanzapine-induced weight gain using betahistine: a study in a rat model with chronic olanzapine treatment. PloS one. 2014; 9(8):e104160. doi: 10.1371/journal.pone.0104160. [PMID: 25084453]
  • Jiamei Lian, Xu-Feng Huang, Nagesh Pai, Chao Deng. Effects of olanzapine and betahistine co-treatment on serotonin transporter, 5-HT2A and dopamine D2 receptor binding density. Progress in neuro-psychopharmacology & biological psychiatry. 2013 Dec; 47(?):62-8. doi: 10.1016/j.pnpbp.2013.08.005. [PMID: 23994047]
  • Israfil Orhan, Salih Aydın, Gökhan Altın, Fahrettin Yılmaz. [An efficacy comparison of betahistin, trimetazidine and ginkgo biloba extract in patients with tinnitus]. Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat. 2013 May; 23(3):143-7. doi: 10.5606/kbbihtisas.2013.03064. [PMID: 23682937]
  • Ligia Val, Lu Shi Chen, Gustavo Duarte Mendes, Gilberto De Nucci. Comparative bioavailability of betahistine tablet formulations administered in healthy subjects. Arzneimittel-Forschung. 2010; 60(7):440-4. doi: 10.1055/s-0031-1296309. [PMID: 20712134]
  • Ales Hahn, Lenka Radkova, Gabriela Achiemere, Vladislav Klement, Dario Alpini, Jaroslav Strouhal. Multimodal therapy for chronic tinnitus. The international tinnitus journal. 2008; 14(1):69-72. doi: ". [PMID: 18616089]
  • Maurício Malavasi Ganança, Heloisa Helena Caovilla, Mário Sérgio Lei Munhoz, Cristina Freitas Ganança, Maria Leonor Garcia da Silva, Flavio Serafini, Fernando Freitas Ganança. Optimizing the pharmacological component of integrated balance therapy. Brazilian journal of otorhinolaryngology. 2007 Jan; 73(1):12-8. doi: 10.1016/s1808-8694(15)31116-2. [PMID: 17505593]
  • Berthold Schneider, Peter Klein, Michael Weiser. Treatment of vertigo with a homeopathic complex remedy compared with usual treatments: a meta-analysis of clinical trials. Arzneimittel-Forschung. 2005; 55(1):23-9. doi: 10.1055/s-0031-1296821. [PMID: 15727161]
  • H J R Hoenders, J Wilterdink. [Delirium in a 73-year-old man after many years of unwise use of betahistine]. Nederlands tijdschrift voor geneeskunde. 2004 Nov; 148(47):2338-41. doi: NULL. [PMID: 15587054]
  • V T Pal'chun, T S Poliakova, N A Kunel'skaia, S A Bogdanets. [Pharmacological correction of cochleovestibular impairments]. Vestnik otorinolaringologii. 2004; ?(4):36-9. doi: ". [PMID: 15496841]
  • X Y Chen, D F Zhong, J L Duan, B X Yan. LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers. Xenobiotica; the fate of foreign compounds in biological systems. 2003 Dec; 33(12):1261-71. doi: 10.1080/716689336. [PMID: 14765546]
  • Wallace I Sampson. Homeopathic vs conventional treatment of vertigo. Archives of otolaryngology--head & neck surgery. 2003 Apr; 129(4):497; author reply 498. doi: 10.1001/archotol.129.4.497-b. [PMID: 12707212]
  • Xiuhua Sun, Xiurong Yang, Erkang Wang. Evaluation of a sol-gel derived carbon composite electrode as an amperometric detector for capillary electrophoresis. Journal of chromatography. A. 2003 Mar; 991(1):109-16. doi: 10.1016/s0021-9673(03)00117-1. [PMID: 12703905]
  • L Botta, E Mira, S Valli, G Zucca, C Benvenuti, A Fossati, E Soto, P Guth, P Valli. Effects of betahistine and of its metabolites on vestibular sensory organs. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale. 2001 Jun; 21(3 Suppl 66):24-30. doi: NULL. [PMID: 11677836]
  • P S Guth. The pharmacology of betahistine in the context of the vestibular system. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale. 2001 Jun; 21(3 Suppl 66):16-23. doi: NULL. [PMID: 11677835]
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  • L Botta, E Mira, S Valli, G Zucca, P Perin, C Benvenuti, A Fossati, P Valli. Effects of betahistine metabolites on frog ampullar receptors. Acta oto-laryngologica. 2000 Jan; 120(1):25-7. doi: 10.1080/000164800760370783. [PMID: 10779181]
  • T Ogiso, H Ogiso, T Paku, M Iwaki. Phase transitions of rat stratum corneum lipids by an electron paramagnetic resonance study and relationship of phase states to drug penetration. Biochimica et biophysica acta. 1996 May; 1301(1-2):97-104. doi: 10.1016/0005-2760(96)00026-4. [PMID: 8652657]
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  • H Konzett, R G Bost, F J Bowman, E R Bowman, H McKennis. Betahistine, its metabolites and vascular responses in the forelimb of the dog. The Journal of pharmacology and experimental therapeutics. 1971 Jul; 178(1):122-9. doi: NULL. [PMID: 4996589]
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