Raltegravir potassium (BioDeep_00000766002)

   


代谢物信息卡片


Raltegravir (potassium salt)

化学式: C20H20FKN6O5 (482.1116222)
中文名称: 雷特格韦钾盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NN=C(O1)C(=O)NC(C)(C)C2=NC(=C(C(=O)N2C)[O-])C(=O)NCC3=CC=C(C=C3)F.[K+]
InChI: /q

描述信息

D004791 - Enzyme Inhibitors > D019429 - Integrase Inhibitors > D019428 - HIV Integrase Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C1660 - Anti-HIV Agent

同义名列表

2 个代谢物同义名

Raltegravir (potassium salt); Raltegravir potassium



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Angelica Perna, Maria A Carleo, Silvia Mascolo, Alessandra Guida, Marcella Contieri, Carmine Sellitto, Eleonora Hay, Paolo De Blasiis, Angela Lucariello, Germano Guerra, Alfonso Baldi, Antonio De Luca, Paolo Maggi, Vincenzo Esposito. Adipocyte differentiation of 3T3-L1 cells under tenofovir alafenamide, tenofovir disoproxil fumarate, and integrase strand transfer inhibitors selective challenge: an in-vitro model. AIDS (London, England). 2023 03; 37(4):561-570. doi: 10.1097/qad.0000000000003455. [PMID: 36504092]
  • Cecilia M Shikuma, Thuy Le, Thao Vu Phuong, Glen M Chew, Van Vinh Chau Nguyen, Trieu Ly Vo, Chathura Siriwardhana, Dominic Chow, Hayk Ghukasyan, Nath Limpruttidham, Thomas Premeaux, Louie Mar Gangcuangco, Robert Paul, Lishomwa C Ndhlovu. Immunologic Change over 72 Weeks Following Raltegravir- Versus Efavirenz-Based Therapy in HIV/HCV-Coinfected Individuals in Vietnam. AIDS research and human retroviruses. 2022 06; 38(6):441-450. doi: 10.1089/aid.2021.0076. [PMID: 34861767]
  • Jen-Yu Hsu, Hsin-Yun Sun, Tan-Wen Hsieh, Sui-Yuan Chang, Yu-Chung Chuang, Yu-Shan Huang, Ching-Yu Hsiao, Yi-Ching Su, Wen-Chun Liu, Shu-Fang Chang, Chien-Ching Hung. Incidence of low-level viremia and its impact on virologic failure among people living with HIV-1 who switched to elvitegravir-based antiretroviral therapy. Journal of global antimicrobial resistance. 2022 Jun; 29(?):7-16. doi: 10.1016/j.jgar.2022.02.007. [PMID: 35172201]
  • John R Koethe, Carlee Moser, Todd T Brown, James H Stein, Theodoros Kelesidis, Michael Dube, Judith Currier, Grace A McComsey. Adipokines, Weight Gain and Metabolic and Inflammatory Markers After Antiretroviral Therapy Initiation: AIDS Clinical Trials Group (ACTG) A5260s. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 03; 74(5):857-864. doi: 10.1093/cid/ciab542. [PMID: 34117756]
  • Hannah T Baddock, Sanja Brolih, Yuliana Yosaatmadja, Malitha Ratnaweera, Marcin Bielinski, Lonnie P Swift, Abimael Cruz-Migoni, Haitian Fan, Jeremy R Keown, Alexander P Walker, Garrett M Morris, Jonathan M Grimes, Ervin Fodor, Christopher J Schofield, Opher Gileadi, Peter J McHugh. Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification. Nucleic acids research. 2022 02; 50(3):1484-1500. doi: 10.1093/nar/gkab1303. [PMID: 35037045]
  • Domagoj Segregur, James Mann, Andrea Moir, Eva M Karlsson, Jennifer Dressman. Biorelevant in vitro Tools and in silico Modeling to Assess pH-Dependent Drug-drug Interactions for Salts of Weak Acids: Case Example Potassium Raltegravir. Journal of pharmaceutical sciences. 2022 02; 111(2):517-528. doi: 10.1016/j.xphs.2021.09.037. [PMID: 34597624]
  • Nolwenn Hall, Clotilde Allavena, Christine Katlama, Alexandra Jobert, Jean-Michel Molina, Eric Cua, Firouzé Bani-Sadr, Laurent Hocqueloux, Claudine Duvivier, Dominique Merrien, Hitoto Hikombo, Elisabeth André-Garnier, Aurélie Gaultier, François Raffi. Raltegravir 1200 mg once daily as maintenance therapy in virologically suppressed HIV-1 infected adults: QDISS open-label trial. AIDS research and therapy. 2022 01; 19(1):4. doi: 10.1186/s12981-022-00428-5. [PMID: 35033092]
  • Borja Mora-Peris, Michael R Keegan, Sujan Dilly Penchala, Jaime H Vera, Jonathan Underwood, Maryam Khan, Carolina Herrera, Dietmar Fuchs, Adriano Boasso, Saye Khoo, Alan Winston. Cerebral function parameters in people with HIV switching integrase inhibitors: a randomized controlled trial. HIV research & clinical practice. 2021 12; 22(6):151-159. doi: NULL. [PMID: 34743666]
  • Lisa M Frenkel, R Leavitt Morrison, Trevon L Fuller, Maria Isabel Gouvêa, Maria de Lourdes Benamor Teixeira, Robert W Coombs, David E Shapiro, Mark Mirochnick, Roslyn Hennessey, Kyle Whitson, Nahida Chakhtoura, Esaú C João. Brief Report: Vaginal Viral Shedding With Undetectable Plasma HIV Viral Load in Pregnant Women Receiving 2 Different Antiretroviral Regimens: A Randomized Clinical Trial. Journal of acquired immune deficiency syndromes (1999). 2021 12; 88(4):361-365. doi: 10.1097/qai.0000000000002771. [PMID: 34369908]
  • Gwamaka Eliudi Mwasakifwa, Janaki Amin, Anthony Kelleher, Mark A Boyd. Inflammatory biomarkers and soft tissue changes among patients commencing second-line antiretroviral therapy after first-line virological failure. AIDS (London, England). 2021 11; 35(14):2289-2298. doi: 10.1097/qad.0000000000003014. [PMID: 34224441]
  • Margherita Bracchi, Nicole Pagani, Alessia Dalla Pria, Ana Milinkovic, Nneka Nwokolo, Lervina Thomas, Sundhyia Mandalia, Marta Boffito, Graeme Moyle. A phase IV, open-label three-arm study investigating the impact of a combination of tenofovir disoproxil fumarate/emtricitabine with raltegravir or dolutegravir or elvitegravir/cobicistat on renal function in HIV-1 antiretroviral naïve patients. HIV research & clinical practice. 2021 10; 22(5):128-139. doi: . [PMID: 34551678]
  • Anne-Genevieve Marcelin, Charlotte Charpentier, Pantxika Bellecave, Basma Abdi, Marie-Laure Chaix, Virginie Ferre, Stephanie Raymond, Djeneba Fofana, Laurence Bocket, Audrey Mirand, Helene Le Guillou-Guillemette, Brigitte Montes, Corinne Amiel, Coralie Pallier, Samira Fafi-Kremer, Anne De Monte, Elodie Alessandri-Gradt, Caroline Scholtes, Anne Maillard, Helene Jeulin, Magali Bouvier-Alias, Catherine Roussel, Georges Dos Santos, Anne Signori-Schmuck, Julia Dina, Sophie Vallet, Karl Stefic, Cathia Soulié, Vincent Calvez, Diane Descamps, Philippe Flandre. Factors associated with the emergence of integrase resistance mutations in patients failing dual or triple integrase inhibitor-based regimens in a French national survey. The Journal of antimicrobial chemotherapy. 2021 08; 76(9):2400-2406. doi: 10.1093/jac/dkab193. [PMID: 34100068]
  • Ninad S Chaudhary, Tobias Kind, Amanda L Willig, Michael S Saag, Sadeep Shrestha, Nicholas Funderburg, Howard W Wiener, E Turner Overton, Marguerite R Irvin. Changes in lipidomic profile by anti-retroviral treatment regimen: An ACTG 5257 ancillary study. Medicine. 2021 Jul; 100(30):e26588. doi: 10.1097/md.0000000000026588. [PMID: 34397689]
  • Carolina Herrera, Julianne Lwanga, Ming Lee, Suna Mantori, Alieu Amara, Laura Else, Sujan Dilly Penchala, Deirdre Egan, Elizabeth Challenger, Laura Dickinson, Marta Boffito, Robin Shattock, Saye Khoo, Julie Fox. Pharmacokinetic/pharmacodynamic investigation of raltegravir with or without lamivudine in the context of HIV-1 pre-exposure prophylaxis (PrEP). The Journal of antimicrobial chemotherapy. 2021 07; 76(8):2129-2136. doi: 10.1093/jac/dkab136. [PMID: 33993302]
  • Banda Marco, Herrera Cristina, Reynaga Cristhian, Rangel Sigfrido, Josue Del Angel, Angel Reyes, Prudente Isidoro. Dolutegravir in Mexico for special populations: A cost analysis perspective. AIDS reviews. 2021 07; 23(3):126-132. doi: 10.24875/aidsrev.m21000042. [PMID: 34198310]
  • Nathalie De Castro, Olivier Marcy, Corine Chazallon, Eugène Messou, Serge Eholié, Jean-Baptiste N'takpe, Nilesh Bhatt, Celso Khosa, Isabel Timana Massango, Didier Laureillard, Giang Do Chau, Anaïs Domergue, Valdilea Veloso, Rodrigo Escada, Sandra Wagner Cardoso, Constance Delaugerre, Xavier Anglaret, Jean-Michel Molina, Beatriz Grinsztejn. Standard dose raltegravir or efavirenz-based antiretroviral treatment for patients co-infected with HIV and tuberculosis (ANRS 12 300 Reflate TB 2): an open-label, non-inferiority, randomised, phase 3 trial. The Lancet. Infectious diseases. 2021 06; 21(6):813-822. doi: 10.1016/s1473-3099(20)30869-0. [PMID: 33667406]
  • Xiaomei I Liu, Jeremiah D Momper, Natella Y Rakhmanina, Dionna J Green, Gilbert J Burckart, Tim R Cressey, Mark Mirochnick, Brookie M Best, John N van den Anker, André Dallmann. Physiologically Based Pharmacokinetic Modeling Framework to Predict Neonatal Pharmacokinetics of Transplacentally Acquired Emtricitabine, Dolutegravir, and Raltegravir. Clinical pharmacokinetics. 2021 06; 60(6):795-809. doi: 10.1007/s40262-020-00977-w. [PMID: 33527213]
  • Zahra Molavi, Sara Razi, Seyed Amir Mirmotalebisohi, Amirjafar Adibi, Marzieh Sameni, Farshid Karami, Vahid Niazi, Zahra Niknam, Morteza Aliashrafi, Mohammad Taheri, Soudeh Ghafouri-Fard, Shabnam Jeibouei, Soodeh Mahdian, Hakimeh Zali, Mohammad Mehdi Ranjbar, Mohsen Yazdani. Identification of FDA approved drugs against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) and 3-chymotrypsin-like protease (3CLpro), drug repurposing approach. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jun; 138(?):111544. doi: 10.1016/j.biopha.2021.111544. [PMID: 34311539]
  • Prashanth Chowdary, Shraddha Shetty, John Booth, Muhammad Arslan Khurram, Magdi Yaqoob, Ismail Heyder Mohamed. Experience of SARS-CoV-2 infection in two kidney transplant recipients living with HIV-1 infection. Transplant infectious disease : an official journal of the Transplantation Society. 2021 Apr; 23(2):e13500. doi: 10.1111/tid.13500. [PMID: 33174284]
  • Yi Zheng, Gabrielle Lui, Sana Boujaafar, Radia Aboura, Naïm Bouazza, Frantz Foissac, Jean-Marc Treluyer, Sihem Benaboud, Déborah Hirt, Inès Gana. Development of a simple and rapid method to determine the unbound fraction of dolutegravir, raltegravir and darunavir in human plasma using ultrafiltration and LC-MS/MS. Journal of pharmaceutical and biomedical analysis. 2021 Mar; 196(?):113923. doi: 10.1016/j.jpba.2021.113923. [PMID: 33571728]
  • Takao Komasaka, Jennifer Dressman. Simulation of oral absorption from non-bioequivalent dosage forms of the salt of raltegravir, a poorly soluble acidic drug, using a physiologically based biopharmaceutical modeling (PBBM) approach. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Feb; 157(?):105630. doi: 10.1016/j.ejps.2020.105630. [PMID: 33122010]
  • Romain Palich, Clotilde Allavena, Gilles Peytavin, Cathia Soulie, Roland Tubiana, Laurence Weiss, Ana Montoya Ferrer, Claudine Duvivier, Olivier Bouchaud, Julie Bottero, Aurore Durand, Minh-Patrick Lê, Anne-Geneviève Marcelin, Yasmine Dudoit, Lambert Assoumou, Christine Katlama. Once-daily etravirine/raltegravir (400/800 mg q24h) dual therapy maintains viral suppression over 48 weeks in HIV-infected patients switching from a twice-daily etravirine/raltegravir (200/400 mg q12h) regimen. The Journal of antimicrobial chemotherapy. 2021 01; 76(2):477-481. doi: 10.1093/jac/dkaa423. [PMID: 33099638]
  • Himanshu G Toor, Devjani I Banerjee, Soumya Lipsa Rath, Siddhi A Darji. Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19. European journal of pharmacology. 2021 Jan; 890(?):173720. doi: 10.1016/j.ejphar.2020.173720. [PMID: 33160938]
  • Farnaz Minooei, Joel R Fried, Joshua L Fuqua, Kenneth E Palmer, Jill M Steinbach-Rankins. In vitro Study on Synergistic Interactions Between Free and Encapsulated Q-Griffithsin and Antiretrovirals Against HIV-1 Infection. International journal of nanomedicine. 2021; 16(?):1189-1206. doi: 10.2147/ijn.s287310. [PMID: 33623382]
  • Jennifer Gorwood, Christine Bourgeois, Valérie Pourcher, Guillaume Pourcher, Frédéric Charlotte, Matthieu Mantecon, Cindy Rose, Romain Morichon, Michael Atlan, Roger Le Grand, Delphine Desjardins, Christine Katlama, Bruno Fève, Olivier Lambotte, Jacqueline Capeau, Véronique Béréziat, Claire Lagathu. The Integrase Inhibitors Dolutegravir and Raltegravir Exert Proadipogenic and Profibrotic Effects and Induce Insulin Resistance in Human/Simian Adipose Tissue and Human Adipocytes. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 12; 71(10):e549-e560. doi: 10.1093/cid/ciaa259. [PMID: 32166319]
  • Diana F Clarke, Jos Lommerse, Edward P Acosta, Mae P Cababasay, Jiajia Wang, Stephen A Spector, Anne Chain, Elizabeth Smith, Hedy Teppler, Rohan Hazra, Kat Calabrese, Bobbie Graham, Stephanie Popson, Yvonne Bryson, Mark Mirochnick. Impact of Low Birth Weight and Prematurity on Neonatal Raltegravir Pharmacokinetics: Impaact P1097. Journal of acquired immune deficiency syndromes (1999). 2020 12; 85(5):626-634. doi: 10.1097/qai.0000000000002492. [PMID: 32925360]
  • Purushothaman Indu, Marimuthu Ragavan Rameshkumar, Narasingam Arunagirinathan, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Savarimuthu Ignacimuthu. Raltegravir, Indinavir, Tipranavir, Dolutegravir, and Etravirine against main protease and RNA-dependent RNA polymerase of SARS-CoV-2: A molecular docking and drug repurposing approach. Journal of infection and public health. 2020 Dec; 13(12):1856-1861. doi: 10.1016/j.jiph.2020.10.015. [PMID: 33168456]
  • Yi Zheng, Déborah Hirt, Sandrine Delmas, Gabrielle Lui, Sihem Benaboud, Jerome Lechedanec, Jean-Marc Tréluyer, Camille Chenevier-Gobeaux, Elisa Arezes, Ambre Gelley, Imane Amri, Saïk Urien, Naïm Bouazza, Frantz Foissac, Josiane Warszawski, Jade Ghosn. Effect of Pregnancy on Unbound Raltegravir Concentrations in the ANRS 160 RalFe Trial. Antimicrobial agents and chemotherapy. 2020 09; 64(10):. doi: 10.1128/aac.00759-20. [PMID: 32661003]
  • Yogesh Kumar, Harvijay Singh, Chirag N Patel. In silico prediction of potential inhibitors for the main protease of SARS-CoV-2 using molecular docking and dynamics simulation based drug-repurposing. Journal of infection and public health. 2020 Sep; 13(9):1210-1223. doi: 10.1016/j.jiph.2020.06.016. [PMID: 32561274]
  • Milan Sencanski, Vladimir Perovic, Snezana B Pajovic, Miroslav Adzic, Slobodan Paessler, Sanja Glisic. Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method. Molecules (Basel, Switzerland). 2020 Aug; 25(17):. doi: 10.3390/molecules25173830. [PMID: 32842509]
  • Harry Coleman, Luke B Snell, Rebecca Simons, Sam T Douthwaite, Ming J Lee. Coronavirus disease 2019 and Pneumocystis jirovecii pneumonia: a diagnostic dilemma in HIV. AIDS (London, England). 2020 07; 34(8):1258-1260. doi: 10.1097/qad.0000000000002571. [PMID: 32501852]
  • Cathia Soulie, Lambert Assoumou, Basma Abdi, Sophie Sayon, Thuy Nguyen, Marc-Antoine Valantin, Lydie Beniguel, Virginie Ferre, Chakib Alloui, Brigitte Montes, Véronique Avettand-Fenoel, Constance Delaugerre, Diane Descamps, Esteban Martinez, Jacques Reynes, Gilles Peytavin, Dominique Costagliola, Christine Katlama, Vincent Calvez, Anne-Geneviève Marcelin. Characterization of viral rebounds on dual etravirine/raltegravir maintenance therapy (ANRS-163 ETRAL trial). The Journal of antimicrobial chemotherapy. 2020 07; 75(7):1943-1949. doi: 10.1093/jac/dkaa090. [PMID: 32259255]
  • Letizia Santinelli, Giancarlo Ceccarelli, Cristian Borrazzo, Luigi Celani, Paolo Pavone, Giuseppe Pietro Innocenti, Ornella Spagnolello, Caterina Fimiani, Fabrizio Ceci, Fiorella Di Sora, Ivano Mezzaroma, Claudio Maria Mastroianni, Gabriella d'Ettorre. Real word outcomes associated with use of raltegravir in older people living with HIV: results from the 60 months follow-up of the RAL-age cohort. Expert review of anti-infective therapy. 2020 05; 18(5):485-492. doi: 10.1080/14787210.2020.1733415. [PMID: 32096433]
  • Esaú C João, R Leavitt Morrison, David E Shapiro, Nahida Chakhtoura, Maria Isabel S Gouvèa, Maria de Lourdes B Teixeira, Trevon L Fuller, Blandina T Mmbaga, James S Ngocho, Boniface N Njau, Avy Violari, Ruth Mathiba, Zaakirah Essack, Jose Henrique S Pilotto, Luis Felipe Moreira, Maria Jose Rolon, Pedro Cahn, Sinart Prommas, Timothy R Cressey, Kulkanya Chokephaibulkit, Peerawong Werarak, Lauren Laimon, Roslyn Hennessy, Lisa M Frenkel, Patricia Anthony, Brookie M Best, George K Siberry, Mark Mirochnick. Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial. The lancet. HIV. 2020 05; 7(5):e322-e331. doi: 10.1016/s2352-3018(20)30038-2. [PMID: 32386720]
  • Sulggi A Lee, Sushama Telwatte, Hiroyu Hatano, Angela D M Kashuba, Mackenzie L Cottrell, Rebecca Hoh, Teri J Liegler, Sophie Stephenson, Ma Somsouk, Peter W Hunt, Steven G Deeks, Steven Yukl, Radojka M Savic. Antiretroviral Therapy Concentrations Differ in Gut vs. Lymph Node Tissues and Are Associated With HIV Viral Transcription by a Novel RT-ddPCR Assay. Journal of acquired immune deficiency syndromes (1999). 2020 04; 83(5):530-537. doi: 10.1097/qai.0000000000002287. [PMID: 32168200]
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  • Aurelio Orta-Resendiz, Roberto A Rodriguez-Diaz, Luis A Angulo-Medina, Mario Hernandez-Flores, Luis E Soto-Ramirez. HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study. AIDS research and therapy. 2020 02; 17(1):6. doi: 10.1186/s12981-020-0262-y. [PMID: 32041622]
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  • Serge P Eholie, Raoul Moh, Aïda Benalycherif, Delphine Gabillard, Frédéric Ello, Eugène Messou, Jacques Zoungrana, Ismaël Diallo, Mouhamadou Diallo, Guillaume Bado, Mamadou Cisse, Almoustapha I Maiga, Amani Anzian, Thomas-d'Aquin Toni, Malika Congo-Ouedraogo, Coumba Toure-Kane, Moussa Seydi, Daouda K Minta, Adrien Sawadogo, Lassana Sangaré, Joseph Drabo, Sophie Karcher, Jérome Le Carrou, Laure-Amelie de Monteynard, Gilles Peytavin, Audrey Gabassi, Pierre-Marie Girard, Marie-Laure Chaix, Xavier Anglaret, Roland Landman. Implementation of an intensive adherence intervention in patients with second-line antiretroviral therapy failure in four west African countries with little access to genotypic resistance testing: a prospective cohort study. The lancet. HIV. 2019 11; 6(11):e750-e759. doi: 10.1016/s2352-3018(19)30228-0. [PMID: 31601544]
  • Jos Lommerse, Diana Clarke, Thomas Kerbusch, Henri Merdjan, Han Witjes, Hedy Teppler, Mark Mirochnick, Edward P Acosta, Larissa Wenning, Sharon Nachman, Anne Chain. Maternal-Neonatal Raltegravir Population Pharmacokinetics Modeling: Implications for Initial Neonatal Dosing. CPT: pharmacometrics & systems pharmacology. 2019 09; 8(9):643-653. doi: 10.1002/psp4.12443. [PMID: 31215170]
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