Bucillamine (BioDeep_00000765996)
代谢物信息卡片
Bucillamine
化学式: C7H13NO3S2 (223.0337)
中文名称: 布西拉明
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(=O)NC(CS)C(=O)O)S
InChI: InChI=1S/C7H13NO3S2/c1-7(2,13)6(11)8-4(3-12)5(9)10/h4,12-13H,3H2,1-2H3,(H,8,11)(H,9,10)/t4-/m0/s1
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01C - Specific antirheumatic agents > M01CC - Penicillamine and similar agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31312
- KEGGdrug: D01809
- PubChem: 656604
- DrugBank: DB12160
- ChEMBL: CHEMBL80830
- CAS: 65002-17-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Michael Frank. Bucillamine in the treatment of patients with mild to moderate COVID-19: an interview with Michael Frank.
Future microbiology.
2022 02; 17(?):157-159. doi:
10.2217/fmb-2021-0277. [PMID: 35044238] - Yasuo Suzuki. [Anti-rheumatic drugs].
Nihon rinsho. Japanese journal of clinical medicine.
2012 Aug; 70 Suppl 6(?):185-9. doi:
NULL. [PMID: 23156506] - Takeshi Kuroda, Yoko Wada, Daisuke Kobayashi, Hiroe Sato, Syuichi Murakami, Masaaki Nakano, Ichiei Narita. Effect of etanercept and entecavil in a patient with rheumatoid arthritis who is a hepatitis B carrier: a review of the literature.
Rheumatology international.
2012 Apr; 32(4):1059-63. doi:
10.1007/s00296-009-1344-2. [PMID: 20062998] - Yoko Fujiwara, Hiroyoshi Tsuchiya, Nobuya Sakai, Katsushi Shibata, Akio Fujimura, Taka-aki Koshimizu. Proximal tubules and podocytes are toxicity targets of bucillamine in a mouse model of drug-induced kidney injury.
European journal of pharmacology.
2011 Nov; 670(1):208-15. doi:
10.1016/j.ejphar.2011.08.051. [PMID: 21933671] - Sameer P Junnarkar, Niteen Tapuria, Alireza Mani, Sas Dijk, Barry Fuller, Alexander M Seifalian, Brian R Davidson. Attenuation of warm ischemia-reperfusion injury in the liver by bucillamine through decreased neutrophil activation and Bax/Bcl-2 modulation.
Journal of gastroenterology and hepatology.
2010 Dec; 25(12):1891-9. doi:
10.1111/j.1440-1746.2010.06312.x. [PMID: 21092002] - Chikako Setoguchi, Fumio Tsuji, Osamu Katsuta, Masahiro Okamoto, Hiroyuki Aono. Combined effects of bucillamine and etanercept on a rat type II collagen-induced arthritis model.
Modern rheumatology.
2010 Aug; 20(4):381-8. doi:
10.1007/s10165-010-0292-8. [PMID: 20379758] - Kang Choon Lee, Young Goo Chun, Insoo Kim, Beom Soo Shin, Eun-Seok Park, Sun Dong Yoo, Yu Seok Youn. Development and validation of a reversed-phase fluorescence HPLC method for determination of bucillamine in human plasma using pre-column derivatization with monobromobimane.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jul; 877(22):2130-4. doi:
10.1016/j.jchromb.2009.06.010. [PMID: 19546034] - Sameer P Junnarkar, Niteen Tapuria, Neelanjana Dutt, Barry Fuller, Alexander M Seifalian, Brian R Davidson. Bucillamine improves hepatic microcirculation and reduces hepatocellular injury after liver warm ischaemia-reperfusion injury.
HPB : the official journal of the International Hepato Pancreato Biliary Association.
2009 May; 11(3):264-73. doi:
10.1111/j.1477-2574.2009.00054.x. [PMID: 19590658] - Elisabetta Albi, Samuela Cataldi, Maristella Villani, Giuseppina Perrella. Nuclear phosphatidylcholine and sphingomyelin metabolism of thyroid cells changes during stratospheric balloon flight.
Journal of biomedicine & biotechnology.
2009; 2009(?):125412. doi:
10.1155/2009/125412. [PMID: 20011661] - Hiroko Ogasawara, Kyoko Hayashi, Hatsuko Toi, Michio Hagihara, Shuji Tohda, Nobuyuki Miyasaka, Naoko Tojo. [False-positive reaction of urinary ketone bodies caused by bucillamine].
Rinsho byori. The Japanese journal of clinical pathology.
2008 Jul; 56(7):584-8. doi:
NULL. [PMID: 18709990] - Yasuo Suzuki, Eiko Saito, Takayuki Wakabayashi, Akira Suwa. [Adverse effects of conventional DMARDs and biologic DMARDs].
Nihon rinsho. Japanese journal of clinical medicine.
2007 Oct; 65 Suppl 8(?):209-17. doi:
NULL. [PMID: 18074541] - Yoshinobu Saito, Takahito Nei, Shinji Abe, Jiro Usuki, Arata Azuma, Tomoko Nakayama, Yuh Fukuda, Shoji Kudoh. A case of bucillamine-induced interstitial pneumonia with positive lymphocyte stimulation test for bucillamine using bronchoalveolar lavage lymphocytes.
Internal medicine (Tokyo, Japan).
2007; 46(20):1739-43. doi:
10.2169/internalmedicine.46.0139. [PMID: 17938531] - Luc Mouthon, Alice Berezné, Serge Poiraudeau, Loïc Guillevin. [Therapeutic management of systemic sclerosis].
Presse medicale (Paris, France : 1983).
2006 Dec; 35(12 Pt 2):1975-82. doi:
10.1016/s0755-4982(06)74932-6. [PMID: 17159724] - Junichi Hoshino, Yoshifumi Ubara, Shigeo Hara, Tatsuya Suwabe, Naoki Sawa, Tetsuo Tagami, Hideyuki Katori, Fumi Takemoto, Shigeko Hara, Kenmei Takaichi. Outcome and treatment of bucillamine-induced nephropathy.
Nephron. Clinical practice.
2006; 104(1):c15-9. doi:
10.1159/000093254. [PMID: 16685139] - Yoo Seob Shin, Jeong Hee Choi, Dong Ho Nahm, Hae Sim Park, Jae Hyun Cho, Chang Hee Suh. Rheumatoid factor is a marker of disease severity in Korean rheumatoid arthritis.
Yonsei medical journal.
2005 Aug; 46(4):464-70. doi:
10.3349/ymj.2005.46.4.464. [PMID: 16127769] - Takahiro Takeda, Yuko Shimizu, Megumi Takeuchi, Shiori Hashimoto, Chiyoko Nagai, Shinichiro Uchiyama, Makoto Iwata. [Bucillamine-induced dermatomyositis-like clinical features in a patient with rheumatoid arthritis].
Rinsho shinkeigaku = Clinical neurology.
2005 Jan; 45(1):45-8. doi:
NULL. [PMID: 15715001] - Iwao Ohno. [Drug induced nephrotic syndrome].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Oct; 62(10):1919-24. doi:
NULL. [PMID: 15500140] - Natsuko Kusunoki, Ryuta Yamazaki, Hidero Kitasato, Moroe Beppu, Haruhito Aoki, Shinichi Kawai. Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.
BMC pharmacology.
2004 Feb; 4(?):2. doi:
10.1186/1471-2210-4-2. [PMID: 15040811] - Mie Obayashi, Takashi Uzu, Tamaki Harada, Masafumi Yamato, Ken Takahara, Atsushi Yamauchi. Clinical course of bucillamine-induced nephropathy in patients with rheumatoid arthritis.
Clinical and experimental nephrology.
2003 Dec; 7(4):275-8. doi:
10.1007/s10157-003-0252-0. [PMID: 14712356] - Mitsuhiro Kawano, Kanae Okada, Hiroaki Muramoto, Hajime Morishita, Takayo Omura, Ryo Inoue, Susumu Kitajima, Kenichi Katano, Ichiro Koni, Hiroshi Mabuchi, Akihiro Yachie. Simultaneous, clonally identical T cell expansion in tonsil and synovium in a patient with rheumatoid arthritis and chronic tonsillitis.
Arthritis and rheumatism.
2003 Sep; 48(9):2483-8. doi:
10.1002/art.11212. [PMID: 13130467] - Yuji Akiyama, Toshihisa Fujimaki, Yusei Sakurai. [Pharmacokinetics of salazosulfapyridine in a hemodialysis patient].
Ryumachi. [Rheumatism].
2003 Jun; 43(3):569-76. doi:
NULL. [PMID: 12910967] - Hiroomi Kasumoto, Masaaki Izumi, Kenichi Shirai, Koji Miyagawa, Reiko Itahana, Hirofumi Nishikage, Keisuke Hiraoka, Takeshi Nakanishi, Yoshihiro Takamitsu. [A case of sarcoidosis overlapping with rheumatoid arthritis].
Nihon Jinzo Gakkai shi.
2003; 45(4):381-6. doi:
NULL. [PMID: 12806976] - M Funauchi, M Ohno, Y Nozaki, K Kinoshita, M Sugiyama, A Kanamaru. Two injections of interferon-alpha could trigger the development of rheumatoid arthritis.
Clinical and experimental rheumatology.
2002 Nov; 20(6):871. doi:
NULL. [PMID: 12508785] - Kiyotaka Nagahama, Hiroshi Matsushita, Mitsuru Hara, Yoshifumi Ubara, Shigeko Hara, Akira Yamada. Bucillamine induces membranous glomerulonephritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2002 Apr; 39(4):706-12. doi:
10.1053/ajkd.2002.31987. [PMID: 11920335] - Michael J Whitekus, Ning Li, Min Zhang, Meiying Wang, Marcus A Horwitz, Sally K Nelson, Lawrence D Horwitz, Nicholas Brechun, David Diaz-Sanchez, Andre E Nel. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization.
Journal of immunology (Baltimore, Md. : 1950).
2002 Mar; 168(5):2560-7. doi:
10.4049/jimmunol.168.5.2560. [PMID: 11859152] - Yusuke Miwa, Shuji Kaga, Ryosuke Hanaoka, Fumitaka Shiozawa, Michio Hanyuda, Tsuyoshi Kasama, Masao Negishi, Hirotsugu Ide. [A case of rheumatoid arthritis complicated with a pneumonitis during concomitant treatment with methotrexate and bucillamine].
Ryumachi. [Rheumatism].
2002 Feb; 42(1):70-5. doi:
NULL. [PMID: 11925909] - Peter C Taylor. VEGF and imaging of vessels in rheumatoid arthritis.
Arthritis research.
2002; 4 Suppl 3(?):S99-107. doi:
10.1186/ar582. [PMID: 12110128] - K Kishimoto, K Iwatsuki, H Akiba, Y Motoki, F Kaneko. Subcorneal pustular dermatosis-type IgA pemphigus induced by thiol drugs.
European journal of dermatology : EJD.
2001 Jan; 11(1):41-4. doi:
NULL. [PMID: 11174137] - M Nagashima, K Wauke, D Hirano, S Ishigami, H Aono, M Takai, M Sasano, S Yoshino. Effects of combinations of anti-rheumatic drugs on the production of vascular endothelial growth factor and basic fibroblast growth factor in cultured synoviocytes and patients with rheumatoid arthritis.
Rheumatology (Oxford, England).
2000 Nov; 39(11):1255-62. doi:
10.1093/rheumatology/39.11.1255. [PMID: 11085806] - Y Kawasaki, J Suzuki, T Sike, M Isome, R Nozawa, S Suzuki, K Suyama, H Suzuki. Bucillamine-induced nephropathy in a child with juvenile rheumatoid arthritis and Kartagener's syndrome.
Pediatrics international : official journal of the Japan Pediatric Society.
2000 Jun; 42(3):316-8. doi:
10.1046/j.1442-200x.2000.01211.x. [PMID: 10881595] - N Sawa, Y Ubara, S Hara, K Hideyuki, T Tagami, K Yokoyama, F Takemoto, A Yamada, T Mori, A Mikami, S Tachibana, K Nakase. [A case of rheumatoid arthritis with bucillamine-induced myasthenia gravis treated by immunoadsorption therapy].
Ryumachi. [Rheumatism].
1999 Feb; 39(1):33-8. doi:
NULL. [PMID: 10332215] - H Matsuno, E Sugiyama, A Muraguchi, T Nezuka, T Kubo, K Matsuura, H Tsuji. Pharmacological effects of SA96 (bucillamine) and its metabolites as immunomodulating drugs--the disulfide structure of SA-96 metabolites plays a critical role in the pharmacological action of the drug.
International journal of immunopharmacology.
1998 Jun; 20(6):295-304. doi:
10.1016/s0192-0561(98)00012-5. [PMID: 9754677] - M Nakano, S Nishi, M Ueno, T Saito, H Hasegawa, M Arakawa. [Drug-induced renal disorders in patients with rheumatoid arthritis].
Ryumachi. [Rheumatism].
1996 Oct; 36(5):775-82. doi:
NULL. [PMID: 8969558] - M Koda, S Yoshino, H Nakamura, G Asano. [Effects of disease modifying antirheumatic drugs (DMARDs) and DEX on IL-1 beta and IL-6 production by IL-1 beta stimulated synovial culture cells].
Nihon Ika Daigaku zasshi.
1996 Oct; 63(5):419-23. doi:
10.1272/jnms1923.63.419. [PMID: 8937133] - R Narazaki, M Hamada, K Harada, M Otagiri. Covalent binding between bucillamine derivatives and human serum albumin.
Pharmaceutical research.
1996 Sep; 13(9):1317-21. doi:
10.1023/a:1016057513490. [PMID: 8893268] - S Inokuma, M Sakata, A Yoshida, K Shiratori, H Kiyosawa. Bucillamine induced pulmonary injury occurs with immunoglobulin decrease.
The Journal of rheumatology.
1996 Jul; 23(7):1282-5. doi:
NULL. [PMID: 8823707] - S Inokuma, T Ikoma, S Inoue, A Ueda, Y Urano, T Satou, T Sayama, H Shimizu, M Hayakawa, M Negishi. [Bucillamin induced lung injury in rheumatoid arthritis].
Ryumachi. [Rheumatism].
1996 Feb; 36(1):34-42. doi:
NULL. [PMID: 8711536] - Y Takahashi, T Funakoshi, H Shimada, S Kojima. The utility of chelating agents as antidotes for nephrotoxicity of gold sodium thiomalate in adjuvant-arthritic rats.
Toxicology.
1995 Mar; 97(1-3):151-7. doi:
10.1016/0300-483x(94)02944-p. [PMID: 7716781] - K Hiramatsu, Y Matsuzaki, K Shiratori, Y Miyakuni, J Ando, S Inokuma. [Immunoglobulin and LST in RA patients treated with bucillamine].
Ryumachi. [Rheumatism].
1995 Feb; 35(1):38-45. doi:
NULL. [PMID: 7732489] - M Negishi, J Yamazaki, M Hosaka, H Iwabuchi, A Matsuda, H Kanemitsu, K Hiramatsu, S Kaga, M Hashimoto, T Kasama. [A case of rheumatoid arthritis associated with agranulocytosis during bucillamine treatment].
Ryumachi. [Rheumatism].
1994 Jun; 34(3):651-5. doi:
NULL. [PMID: 8052932] - L Girgis, P G Conaghan, P Brooks. Disease-modifying antirheumatic drugs, including methotrexate, sulfasalazine, gold, antimalarials, and penicillamine.
Current opinion in rheumatology.
1994 May; 6(3):252-61. doi:
10.1097/00002281-199405000-00003. [PMID: 7914739] - K Sawa, M Mochizuki. Effects of bucillamine, a new anti-rheumatic drug, on the experimental autoimmune uveitis in rats.
Experimental eye research.
1994 Apr; 58(4):431-8. doi:
10.1006/exer.1994.1036. [PMID: 7925680] - M Kikuchi, T Saeki, S Ito, H In, T Saito, M Ueno, T Sato, S Suzuki, M Nakano, T Ozawa. [Clinicopathological evaluation and treatment of bucillamine induced membranous nephropathy].
Ryumachi. [Rheumatism].
1993 Jun; 33(3):215-22. doi:
NULL. [PMID: 8346463] - S Hirohata, C Kawashima, S Shinohara, T Sawada, Y Nishioka, S Tohma, T Kisaki, T Inoue, S Iwamoto, K Ito. [Analysis of the state of patients with rheumatoid arthritis using a personal computer].
Ryumachi. [Rheumatism].
1993 Apr; 33(2):131-41. doi:
NULL. [PMID: 8316903] - A Yoshida, K Morozumi, A Takeda, K Koyama, T Oikawa, T Fujinami. A case of rapidly progressive glomerulonephritis associated with bucillamine-treated rheumatoid arthritis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1992 Oct; 20(4):411-3. doi:
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Toxicology.
1992 Aug; 74(1):1-8. doi:
10.1016/0300-483x(92)90038-g. [PMID: 1325079] - M Negishi, S Kaga, T Kasama, M Hashimoto, T Fukushima, N Yamagata, M Tabata, K Kobayashi, H Ide, T Takahashi. [Lung injury associated with bucillamine therapy].
Ryumachi. [Rheumatism].
1992 Apr; 32(2):135-9. doi:
NULL. [PMID: 1595005] - H Tanaka, K Nakahara, K Goto. [A case of bucillamine-induced pneumonitis].
Nihon Kyobu Shikkan Gakkai zasshi.
1992 Apr; 30(4):695-701. doi:
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Biochemical pharmacology.
1991 Jul; 42(4):847-52. doi:
10.1016/0006-2952(91)90045-7. [PMID: 1867640] - N Baba, T Nomura, T Sakemi, M Uchida, T Watanabe. [Membranous glomerulonephritis probably related to bucillamine therapy in two patients with rheumatoid arthritis].
Nihon Jinzo Gakkai shi.
1991 Jun; 33(6):629-34. doi:
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Ryumachi. [Rheumatism].
1991 Feb; 31(1):14-21. doi:
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Archives of toxicology.
1991; 65(7):532-6. doi:
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American journal of nephrology.
1991; 11(4):284-8. doi:
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International journal of tissue reactions.
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1985 Apr; 85(4):243-8. doi:
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Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
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