Trospium Chloride (BioDeep_00000765994)

   


代谢物信息卡片


Trospium Chloride

化学式: C25H30ClNO3 (427.19141)
中文名称: 曲司氯胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC[N+]2(C1)C3CCC2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O.[Cl-]
InChI: 1H/q+1

描述信息

C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
D000089162 - Genitourinary Agents > D064804 - Urological Agents
Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors[1][2].

同义名列表

2 个代谢物同义名

Trospium Chloride; Trospium (chloride)



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Matthias Gorecki, Simon F Müller, Regina Leidolf, Joachim Geyer. Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families. International journal of molecular sciences. 2020 Dec; 22(1):. doi: 10.3390/ijms22010022. [PMID: 33375004]
  • Bayew Tsega Abebe, Michael Weiss, Christiane Modess, Tarek Roustom, Tobias Tadken, Danilo Wegner, Ulrich Schwantes, Claudia Neumeister, Hans-Ulrich Schulz, Eberhard Scheuch, Werner Siegmund. Effects of the P-Glycoprotein Inhibitor Clarithromycin on the Pharmacokinetics of Intravenous and Oral Trospium Chloride: A 4-Way Crossover Drug-Drug Interaction Study in Healthy Subjects. Journal of clinical pharmacology. 2019 10; 59(10):1319-1330. doi: 10.1002/jcph.1421. [PMID: 30973998]
  • Birgit Deutsch, Claudia Neumeister, Ulrich Schwantes, Martin F Fromm, Jörg König. Interplay of the Organic Cation Transporters OCT1 and OCT2 with the Apically Localized Export Protein MATE1 for the Polarized Transport of Trospium. Molecular pharmaceutics. 2019 02; 16(2):510-517. doi: 10.1021/acs.molpharmaceut.8b00779. [PMID: 30656943]
  • O Iatsyna, S Vernygorodskyi, F Kostyev. MORPHOLOGICAL ASSESSMENT OF NO-SYNTHASE DISTRIBUTION IN OVERACTIVE BLADDER AND STRESS URINE INCONTINENCE IN ANIMAL MODELS ADMINISTERED WITH EXPERIMENTAL PHARMACOCORRECTION REGIMENS. Georgian medical news. 2018 Jun; ?(279):143-150. doi: NULL. [PMID: 30035737]
  • Miao Yan, Peng Xue, Kunpeng Wang, Guojun Gao, Wei Zhang, Fanghu Sun. Does combination therapy with tamsulosin and trospium chloride improve lower urinary tract symptoms after SEEDS brachytherapy for prostate cancer compared with tamsulosin alone? : A prospective, randomized, controlled trial. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 2017 Sep; 193(9):714-721. doi: 10.1007/s00066-017-1162-5. [PMID: 28612083]
  • Mohamed H Abdelhamid, Ahmed S Zayed, Waleed E Ghoneima, Akrm A Elmarakbi, Mohamed S El Sheemy, Ahmed Aref, Ahmed Abdelbary, Hani H Nour. Randomized, double-blind, placebo-controlled trial to compare solifenacin versus trospium chloride in the relief of double-J stent-related symptoms. World journal of urology. 2017 Aug; 35(8):1261-1268. doi: 10.1007/s00345-016-1988-y. [PMID: 28050642]
  • Yoshihiko Ito, Michishi Kashiwabara, Akira Yoshida, Eriko Hikiyama, Satomi Onoue, Shizuo Yamada. Muscarinic Receptor Binding in Rat Bladder Urothelium and Detrusor Muscle by Intravesical Solifenacin. Biological & pharmaceutical bulletin. 2016; 39(7):1167-71. doi: 10.1248/bpb.b16-00194. [PMID: 27374291]
  • Maria Bexten, Stefan Oswald, Markus Grube, Jia Jia, Tanja Graf, Uwe Zimmermann, Kathrin Rodewald, Oliver Zolk, Ulrich Schwantes, Werner Siegmund, Markus Keiser. Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Molecular pharmaceutics. 2015 Jan; 12(1):171-8. doi: 10.1021/mp500532x. [PMID: 25466967]
  • M Haupt, M Thommes, A Heidenreich, J Breitkreutz. Lipid-based intravesical drug delivery systems with controlled release of trospium chloride for the urinary bladder. Journal of controlled release : official journal of the Controlled Release Society. 2013 Sep; 170(2):161-6. doi: 10.1016/j.jconrel.2013.05.018. [PMID: 23732944]
  • C Heinen, S Reuss, S Saaler-Reinhardt, P Langguth. Mechanistic basis for unexpected bioavailability enhancement of polyelectrolyte complexes incorporating BCS class III drugs and carrageenans. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2013 Sep; 85(1):26-33. doi: 10.1016/j.ejpb.2013.03.010. [PMID: 23958316]
  • Abdurrahman Karaman, Emine Samdancı, Sadegül Sayın, Ismail Karabulut, Ersin Fadıllıoglu. Effects of tolterodine and trospium chloride on renal damage induced by partial upper urinary tract obstruction. Urology. 2013 Jul; 82(1):194-200. doi: 10.1016/j.urology.2013.01.030. [PMID: 23453648]
  • Mark D Harnett, James Shipley, Laura MacLean, Ute Schwiderski, Bobby W Sandage. Study of the population pharmacokinetic characteristics of once-daily trospium chloride 60 mg extended-release capsules in patients with overactive bladder and in healthy subjects. Clinical drug investigation. 2013 Feb; 33(2):133-41. doi: 10.1007/s40261-012-0039-8. [PMID: 23203138]
  • Michael G Oefelein, Warren Tong, Sam Kerr, Kavitha Bhasi, Rina K Patel, Dale Yu. Effect of concomitant administration of trospium chloride extended release on the steady-state pharmacokinetics of metformin in healthy adults. Clinical drug investigation. 2013 Feb; 33(2):123-31. doi: 10.1007/s40261-012-0049-6. [PMID: 23325481]
  • Jasmin Kranz, Ernst Petzinger, Joachim Geyer. Brain penetration of the OAB drug trospium chloride is not increased in aged mice. World journal of urology. 2013 Feb; 31(1):219-24. doi: 10.1007/s00345-011-0803-z. [PMID: 22120415]
  • H-J Notz, B Hautumm, D Werdier, R Groves, K P Odenthal. [Trospium chloride once daily for overactive bladder syndrome: results of a multicenter observational study]. Der Urologe. Ausg. A. 2013 Jan; 52(1):65-70. doi: 10.1007/s00120-012-2989-0. [PMID: 23052979]
  • Asma Radwan, Gordon L Amidon, Peter Langguth. Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity. Biopharmaceutics & drug disposition. 2012 Oct; 33(7):403-16. doi: 10.1002/bdd.1798. [PMID: 22782559]
  • Serap Kaya, Türkan Akbayrak, Sinan Beksaç. Comparison of different treatment protocols in the treatment of idiopathic detrusor overactivity: a randomized controlled trial. Clinical rehabilitation. 2011 Apr; 25(4):327-38. doi: 10.1177/0269215510385481. [PMID: 20943711]
  • David A Ginsberg, Michael G Oefelein, Pamela I Ellsworth. Once-daily administration of trospium chloride extended release provides 24-hr coverage of nocturnal and diurnal symptoms of overactive bladder: an integrated analysis of two phase III trials. Neurourology and urodynamics. 2011 Apr; 30(4):563-7. doi: 10.1002/nau.21018. [PMID: 21268101]
  • Birger Wenge, Joachim Geyer, Heinz Bönisch. Oxybutynin and trospium are substrates of the human organic cation transporters. Naunyn-Schmiedeberg's archives of pharmacology. 2011 Feb; 383(2):203-8. doi: 10.1007/s00210-010-0590-x. [PMID: 21212936]
  • D Staskin, G Kay, C Tannenbaum, H B Goldman, K Bhashi, J Ling, M G Oefelein. Trospium chloride has no effect on memory testing and is assay undetectable in the central nervous system of older patients with overactive bladder. International journal of clinical practice. 2010 Aug; 64(9):1294-300. doi: 10.1111/j.1742-1241.2010.02433.x. [PMID: 20561092]
  • Kishore Kumar Hotha, D Vijaya Bharathi, Sanagapati Sirish Kumar, Y Narasimha Reddy, Pankaj K Chatki, L K Ravindranath, K N Jayaveera. Determination of the quaternary ammonium compound trospium in human plasma by LC-MS/MS: application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Apr; 878(13-14):981-6. doi: 10.1016/j.jchromb.2010.02.028. [PMID: 20303326]
  • Nova Silver, Bobby Sandage, LuAnn Sabounjian, Ute Schwiderski, James Shipley, Mark Harnett. Pharmacokinetics of once-daily trospium chloride 60 mg extended release and twice-daily trospium chloride 20 mg in healthy adults. Journal of clinical pharmacology. 2010 Feb; 50(2):143-50. doi: 10.1177/0091270009345498. [PMID: 19948948]
  • D R Staskin, M T Rosenberg, P K Sand, N R Zinner, R R Dmochowski. Trospium chloride once-daily extended release is effective and well tolerated for the treatment of overactive bladder syndrome: an integrated analysis of two randomised, phase III trials. International journal of clinical practice. 2009 Dec; 63(12):1715-23. doi: 10.1111/j.1742-1241.2009.02189.x. [PMID: 19930332]
  • Joachim Geyer, Olga Gavrilova, Ernst Petzinger. The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride. Drug metabolism and disposition: the biological fate of chemicals. 2009 Jul; 37(7):1371-4. doi: 10.1124/dmd.109.027144. [PMID: 19389858]
  • Kelly Biastre, Thomas Burnakis. Trospium chloride treatment of overactive bladder. The Annals of pharmacotherapy. 2009 Feb; 43(2):283-95. doi: 10.1345/aph.1l160. [PMID: 19193592]
  • M e Shkol'nikov, E B Mazo, G G Krivoborodov, Iu E Dobrokhotova, M M Kaĭfadzhan, L V Fandeeva, R F Nurullin, M S Zhdanova. [Trospium chloride in combined treatment of females with genital prolapse and overactive urinary bladder]. Urologiia (Moscow, Russia : 1999). 2008 Sep; ?(5):16-9. doi: NULL. [PMID: 19069489]
  • Nathan Bittner, Gregory S Merrick, Sarah Brammer, Angela Niehaus, Kent E Wallner, Wayne M Butler, Zachariah A Allen, Robert W Galbreath. Role of trospium chloride in brachytherapy-related detrusor overactivity. Urology. 2008 Mar; 71(3):460-4. doi: 10.1016/j.urology.2007.10.023. [PMID: 18342187]
  • V V Danilov, T I Danilova. [M-cholinolytic spasmex and its role in preoperative preparation of patients with urine incontinence]. Urologiia (Moscow, Russia : 1999). 2007 Jan; ?(1):33-6. doi: NULL. [PMID: 17471995]
  • M Menarini, G Del Popolo, P Di Benedetto, J Haselmann, R H Bödeker, U Schwantes, H Madersbacher. Trospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients?. International journal of clinical pharmacology and therapeutics. 2006 Dec; 44(12):623-32. doi: 10.5414/cpp44623. [PMID: 17190372]
  • B Sandage, L Sabounjian, J Shipley, A Profy, K Lasseter, L Fox, M Harnett. Predictive power of an in vitro system to assess drug interactions of an antimuscarinic medication: a comparison of in vitro and in vivo drug-drug interaction studies of trospium chloride with digoxin. Journal of clinical pharmacology. 2006 Jul; 46(7):776-84. doi: 10.1177/0091270006289481. [PMID: 16809803]
  • E V Kul'chavenia, E V Brizhatiuk. [Tuberculosis of the urinary bladder: diagnosis and treatment]. Urologiia (Moscow, Russia : 1999). 2006 May; ?(3):61-4, 66. doi: NULL. [PMID: 16889095]
  • E B Mazo, G G Krivoborodov, M E Shkol'nikov, G A Babanina, S V Kozyrev, E S Korshunov. [Trospium chloride in the treatment of idiopathic and neurogenic detrusor overactivity]. Urologiia (Moscow, Russia : 1999). 2005 Jul; ?(4):56-9. doi: NULL. [PMID: 16158750]
  • YongTae Kim, Naoki Yoshimura, Hitoshi Masuda, Fernando de Miguel, Michael B Chancellor. Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways. Urology. 2005 Feb; 65(2):238-42. doi: 10.1016/j.urology.2004.11.021. [PMID: 15708029]
  • Oxana Doroshyenko, Alexander Jetter, Karl P Odenthal, Uwe Fuhr. Clinical pharmacokinetics of trospium chloride. Clinical pharmacokinetics. 2005; 44(7):701-20. doi: 10.2165/00003088-200544070-00003. [PMID: 15966754]
  • Mitchell R Humphreys, Yuri E Reinberg. Contemporary and emerging drug treatments for urinary incontinence in children. Paediatric drugs. 2005; 7(3):151-62. doi: 10.2165/00148581-200507030-00002. [PMID: 15977961]
  • S Schröder, A Jetter, M Zaigler, R Weyhenmeyer, G Krumbiegel, W Wächter, U Fuhr. Absorption pattern of trospium chloride along the human gastrointestinal tract assessed using local enteral administration. International journal of clinical pharmacology and therapeutics. 2004 Oct; 42(10):543-9. doi: 10.5414/cpp42543. [PMID: 15516023]
  • Eric S Rovner. Trospium chloride in the management of overactive bladder. Drugs. 2004; 64(21):2433-46. doi: 10.2165/00003495-200464210-00005. [PMID: 15482001]
  • S Beckmann-Knopp, S Rietbrock, R Weyhenmeyer, R H Böcker, K T Beckurts, W Lang, U Fuhr. Inhibitory effects of trospium chloride on cytochrome P450 enzymes in human liver microsomes. Pharmacology & toxicology. 1999 Dec; 85(6):299-304. doi: 10.1111/j.1600-0773.1999.tb02026.x. [PMID: 10628907]
  • G Fröhlich, S Burmeister, A Wiedemann, M Bulitta. [Intravesical instillation of trospium chloride, oxybutynin and verapamil for relaxation of the bladder detrusor muscle. A placebo controlled, randomized clinical test]. Arzneimittel-Forschung. 1998 May; 48(5):486-91. doi: . [PMID: 9638316]
  • H Madersbacher, M Stöhrer, R Richter, H Burgdörfer, H J Hachen, G Mürtz. Trospium chloride versus oxybutynin: a randomized, double-blind, multicentre trial in the treatment of detrusor hyper-reflexia. British journal of urology. 1995 Apr; 75(4):452-6. doi: 10.1111/j.1464-410x.1995.tb07264.x. [PMID: 7788255]
  • H Madersbacher, M Stöhrer, R Richter, B M Giannetti, G Mürtz. [High-dose trospium chloride in therapy of detrusor hyperreflexia]. Der Urologe. Ausg. A. 1991 Jul; 30(4):260-3. doi: NULL. [PMID: 1926674]
  • M Stöhrer, P Bauer, B M Giannetti, R Richter, H Burgdörfer, G Mürtz. Effect of trospium chloride on urodynamic parameters in patients with detrusor hyperreflexia due to spinal cord injuries. A multicentre placebo-controlled double-blind trial. Urologia internationalis. 1991; 47(3):138-43. doi: 10.1159/000282207. [PMID: 1771701]
  • T Suzuki, O Nishizawa, K Sugaya, T Kohama, A Matsuzaki, T Fukuda, T Tsukada, T Harada, S Tsuchida. [Effects of trospium chloride on the lower urinary tract function]. Hinyokika kiyo. Acta urologica Japonica. 1990 Sep; 36(9):1047-51. doi: NULL. [PMID: 2239610]
  • T Lehtola, O Lavikainen, A Huhtikangas. Radioimmunoassay of trospiumchloride, a quaternary tropane derivative. Journal of immunoassay. 1988; 9(3-4):297-307. doi: 10.1080/01971528808053218. [PMID: 3235686]
  • P Langguth, E Mutschler. Lipophilisation of hydrophilic compounds. Consequences on transepidermal and intestinal transport of trospium chloride. Arzneimittel-Forschung. 1987 Dec; 37(12):1362-6. doi: ". [PMID: 3449063]
  • G Schladitz-Keil, H Spahn, E Mutschler. Determination of the bioavailability of the quaternary compound trospium chloride in man from urinary excretion data. Arzneimittel-Forschung. 1986 Jun; 36(6):984-7. doi: NULL. [PMID: 3741535]
  • G Schladitz-Keil, H Spahn, E Mutschler. Fluorimetric determination of the quaternary compound trospium and its metabolite in biological material after derivatization with benoxaprofen chloride. Journal of chromatography. 1985 Nov; 345(1):99-110. doi: 10.1016/0378-4347(85)80139-0. [PMID: 4086592]
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