Poziotinib (BioDeep_00000765145)

   


代谢物信息卡片


Poziotinib

化学式: C23H21Cl2FN4O3 (490.0974668)
中文名称: 波齐奥替尼(HM781-36B)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C
InChI: InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C163952 - EGFR-targeting Agent
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor

同义名列表

1 个代谢物同义名

Poziotinib



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Haizhen Hui, Mengxin Wang, Hongxing Guo, Yingjun Wang, Bingjun Shi. Poziotinib-induced cutaneous adverse reactions in the treatment of non-small cell lung cancer: A case report. International journal of dermatology. 2022 06; 61(6):769-770. doi: 10.1111/ijd.16205. [PMID: 35394067]
  • Ying Fan, Jing Qin, Na Han, Hongyang Lu. HER2 exon 20 insertion mutations in lung adenocarcinoma with leptomeningeal metastasis: a case report and response to poziotinib. Annals of palliative medicine. 2022 Apr; 11(4):1582-1588. doi: 10.21037/apm-21-213. [PMID: 34118831]
  • Weiping Ji, Jiquan Shen, Bo Wang, Feifei Chen, Deru Meng, Shuanghu Wang, Dapeng Dai, Yunfang Zhou, Changxiong Wang, Quan Zhou. Effects of dacomitinib on the pharmacokinetics of poziotinib in vivo and in vitro. Pharmaceutical biology. 2021 Dec; 59(1):457-464. doi: 10.1080/13880209.2021.1914114. [PMID: 33899675]
  • Seema Zargar, Salman Alamery, Ahmed H Bakheit, Tanveer A Wani. Poziotinib and bovine serum albumin binding characterization and influence of quercetin, rutin, naringenin and sinapic acid on their binding interaction. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Jul; 235(?):118335. doi: 10.1016/j.saa.2020.118335. [PMID: 32278151]
  • Tae-Yong Kim, Hye Sook Han, Keun-Wook Lee, Dae Young Zang, Sun Young Rha, Young Iee Park, Jin-Soo Kim, Kyung-Hun Lee, Se Hoon Park, Eun-Kee Song, Soo-A Jung, NaMi Lee, Yeul Hong Kim, Jae Yong Cho, Yung-Jue Bang. A phase I/II study of poziotinib combined with paclitaxel and trastuzumab in patients with HER2-positive advanced gastric cancer. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 2019 11; 22(6):1206-1214. doi: 10.1007/s10120-019-00958-4. [PMID: 30945121]
  • Ji-Youn Han, Ki Hyeong Lee, Sang-We Kim, Young Joo Min, Eunkyung Cho, Youngjoo Lee, Soo-Hyun Lee, Hyae Young Kim, Geon Kook Lee, Byung Ho Nam, Hyesun Han, Jina Jung, Jin Soo Lee. A Phase II Study of Poziotinib in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma Who Have Acquired Resistance to EGFR-Tyrosine Kinase Inhibitors. Cancer research and treatment. 2017 Jan; 49(1):10-19. doi: 10.4143/crt.2016.058. [PMID: 27188206]
  • Eunyoung Kim, Hankyong Kim, Kweehyun Suh, Sechang Kwon, Gwansun Lee, Na Hyun Park, Jongki Hong. Metabolite identification of a new tyrosine kinase inhibitor, HM781-36B, and a pharmacokinetic study by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2013 Jun; 27(11):1183-95. doi: 10.1002/rcm.6559. [PMID: 23650031]