2-Deoxy-2-fluoro-5-iodouridine (BioDeep_00000764868)
代谢物信息卡片
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodouracil
化学式: C9H10FIN2O5 (371.9618492)
中文名称: 5-碘-2-氟-脱氧尿苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)F)I
InChI: InChI=1S/C9H10FIN2O5/c10-5-6(15)4(2-14)18-8(5)13-1-3(11)7(16)12-9(13)17/h1,4-6,8,14-15H,2H2,(H,12,16,17)
描述信息
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
2'-Deoxy-2'-fluoro-5-iodouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
同义名列表
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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Nuclear medicine and biology.
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World journal of microbiology & biotechnology.
2014 Nov; 30(11):3003-10. doi:
10.1007/s11274-014-1709-x. [PMID: 25085723] - Dan Xu, Toshi Nishimura, Sachiko Nishimura, Haili Zhang, Ming Zheng, Ying-Ying Guo, Marylin Masek, Sara A Michie, Jeffrey Glenn, Gary Peltz. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.
PLoS medicine.
2014 Apr; 11(4):e1001628. doi:
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2008 Jan; 49(1):94-102. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2007 Apr; 48(4):655-60. doi:
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The Journal of biological chemistry.
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The Journal of biological chemistry.
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10.1074/jbc.m307938200. [PMID: 14607828] - Juri Gelovani Tjuvajev, Mikhail Doubrovin, Timothy Akhurst, Shangde Cai, Julius Balatoni, Mian M Alauddin, Ronald Finn, William Bornmann, Howard Thaler, Peter S Conti, Ronald G Blasberg. Comparison of radiolabeled nucleoside probes (FIAU, FHBG, and FHPG) for PET imaging of HSV1-tk gene expression.
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