Arbidol (BioDeep_00000763889)
代谢物信息卡片
Arbidol
化学式: C22H25BrN2O3S (476.076916)
中文名称: 阿比朵尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3
InChI: InChI=1S/C22H25BrN2O3S/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3/h6-11,26H,5,12-13H2,1-4H3
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals
COVID info from DrugBank, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C254 - Anti-Infective Agent > C281 - Antiviral Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:134730
- KEGGdrug: D10558
- PubChem: 131411
- DrugBank: DB13609
- ChEMBL: CHEMBL1214598
- CAS: 131707-25-0
- CAS: 5674-91-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ziwei Guo, Huan He, Gui Yang, Kunqian Liu, Yanting Xi, Zihui Li, Yu Luo, Zhicheng Liao, Guohua Dao, Xiaomin Ren, Bin Huang, Xuejun Pan. The environmental risks of antiviral drug arbidol in eutrophic lake: Interactions with Microcystis aeruginosa.
Journal of hazardous materials.
2024 Mar; 466(?):133609. doi:
10.1016/j.jhazmat.2024.133609. [PMID: 38310846] - Ziwei Guo, Huan He, Kunqian Liu, Shicheng Yang, Zihui Li, Chaochao Lai, Zhicheng Liao, Xiaomin Ren, Bin Huang, Xuejun Pan. Sunlight-induced degradation of COVID-19 antivirals arbidol in natural aquatic environments: Mechanisms, pathways and toxicity.
Journal of environmental management.
2023 Dec; 347(?):119113. doi:
10.1016/j.jenvman.2023.119113. [PMID: 37769471] - Xinfeng Bai, Suya Xi, Guiyan Chen, Xiaoying Fan, Kaiwei Wang, Yong Li, Yang Zhao, Weizhan Wang, Yingping Tian. Multicenter, randomized controlled, open label evaluation of the efficacy and safety of arbidol hydrochloride tablets in the treatment of influenza-like cases.
BMC infectious diseases.
2023 Sep; 23(1):585. doi:
10.1186/s12879-023-08570-9. [PMID: 37674112] - Dexin Jin, Yihan Lv, Dongyang He, Dongmei Zhang, Yue Liu, Tingting Zhang, Fangyuan Cheng, Ya-Nan Zhang, Jiaqiong Sun, Jiao Qu. Photocatalytic degradation of COVID-19 related drug arbidol hydrochloride by Ti3C2 MXene/supramolecular g-C3N4 Schottky junction photocatalyst.
Chemosphere.
2022 Dec; 308(Pt 3):136461. doi:
10.1016/j.chemosphere.2022.136461. [PMID: 36122752] - Ping Jiang, Shuang-Hua Wu, Ting Zhu, Yuan Guo, Yi He. A rare case of drug-induced bradycardia associated with the just low dose use of methylprednisolone in a child with COVID-19.
Journal of medical virology.
2022 04; 94(4):1745-1747. doi:
10.1002/jmv.27525. [PMID: 34911144] - Miao Yu, Deng-Chao Wang, Sheng Li, Yue-Hua Lei, Jian Wei, Li-Yan Huang. Meta-analysis of arbidol versus lopinavir/ritonavir in the treatment of coronavirus disease 2019.
Journal of medical virology.
2022 04; 94(4):1513-1522. doi:
10.1002/jmv.27481. [PMID: 34837230] - Ravishankar Ramachandran, Vivek Bhosale, Himanshu Reddy, Virendra Atam, Mma Faridi, Jalees Fatima, Vaibhav Shukla, Zaw A Khan, Hana Khan, Vikram Singh, Mahendra Pal Singh Negi, Mukesh Srivastava, Ajay Kumar Srivastava, Chandra Bhushan Tripathi, Nayan Ghosh, Nilanjana Majumdar, Raj Kamal Tripathi, Srikanta Kumar Rath, Prabhat Ranjan Mishra, Sharad Sharma, Tapas K Kundu. Phase III, Randomized, Double-blind, Placebo controlled trial of Efficacy, Safety and Tolerability of Antiviral drug Umifenovir vs Standard care of therapy in non-severe COVID-19 patients.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Feb; 115(?):62-69. doi:
10.1016/j.ijid.2021.11.025. [PMID: 34801738] - Nikolay V Ul'yanovskii, Dmitry S Kosyakov, Sergey A Sypalov, Ilya S Varsegov, Irina S Shavrina, Albert T Lebedev. Antiviral drug Umifenovir (Arbidol) in municipal wastewater during the COVID-19 pandemic: Estimated levels and transformation.
The Science of the total environment.
2022 Jan; 805(?):150380. doi:
10.1016/j.scitotenv.2021.150380. [PMID: 34818770] - Jing-Ze Lu, Dan Ye, Long Chen, Bing-Liang Ma. Pharmacokinetic comparison of four arbidol hydrochloride preparations in beagle dogs.
Biomedical chromatography : BMC.
2022 Jan; 36(1):e5245. doi:
10.1002/bmc.5245. [PMID: 34532879] - Akbar Dadras, Mohammad Amin Rezvanfar, Abolghasem Beheshti, Sedigheh Sadat Naeimi, Seyyed Amir Siadati. An Urgent Industrial Scheme Both for Total Synthesis, and for Pharmaceutical Analytical Analysis of Umifenovir as an Anti-viral API for Treatment of COVID-19.
Combinatorial chemistry & high throughput screening.
2022; 25(5):838-846. doi:
10.2174/1386207324666210203175631. [PMID: 33538665] - Matthew R Freidel, Roger S Armen. Modeling the Structure-Activity Relationship of Arbidol Derivatives and Other SARS-CoV-2 Fusion Inhibitors Targeting the S2 Segment of the Spike Protein.
Journal of chemical information and modeling.
2021 12; 61(12):5906-5922. doi:
10.1021/acs.jcim.1c01061. [PMID: 34898207] - Anton Shuster, Dany Pechalrieu, Cody B Jackson, Daniel Abegg, Hyeryun Choe, Alexander Adibekian. Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein.
ACS chemical biology.
2021 12; 16(12):2845-2851. doi:
10.1021/acschembio.1c00756. [PMID: 34792325] - Yingfu Lin, Zirong Zhang, Babak Mahjour, Di Wang, Rui Zhang, Eunjae Shim, Andrew McGrath, Yuning Shen, Nadia Brugger, Rachel Turnbull, Sarah Trice, Shashi Jasty, Tim Cernak. Reinforcing the supply chain of umifenovir and other antiviral drugs with retrosynthetic software.
Nature communications.
2021 12; 12(1):7327. doi:
10.1038/s41467-021-27547-3. [PMID: 34916512] - Behnam Amani, Bahman Amani, Sara Zareei, Mahsa Zareei. Efficacy and safety of arbidol (umifenovir) in patients with COVID-19: A systematic review and meta-analysis.
Immunity, inflammation and disease.
2021 12; 9(4):1197-1208. doi:
10.1002/iid3.502. [PMID: 34347937] - Xin-Liang He, Ya-Ya Zhou, Wei Fu, Yu-E Xue, Meng-Yuan Liang, Bo-Han Yang, Wan-Li Ma, Qiong Zhou, Long Chen, Jian-Chu Zhang, Xiao-Rong Wang. Prolonged SARS-CoV-2 Viral Shedding in Patients with COVID-19 was Associated with Delayed Initiation of Arbidol Treatment and Consulting Doctor Later: A Retrospective Cohort Study.
Current medical science.
2021 Dec; 41(6):1096-1104. doi:
10.1007/s11596-021-2434-y. [PMID: 34515914] - Hormat Rahimzadeh, Mohammad Keykhaei, Effat Razeghi, Ensieh Zivari, Ensieh Sadat Mansouri. COVID-19 progression in kidney transplant recipients: a single-center case series.
CEN case reports.
2021 11; 10(4):494-499. doi:
10.1007/s13730-021-00584-z. [PMID: 33770414] - Nida Bokharee, Yusra Habib Khan, Aisha Khokhar, Tauqeer Hussain Mallhi, Nasser Hadal Alotaibi, Maria Rasheed. Pharmacological interventions for COVID-19: a systematic review of observational studies and clinical trials.
Expert review of anti-infective therapy.
2021 Oct; 19(10):1219-1244. doi:
10.1080/14787210.2021.1902805. [PMID: 33719819] - Ilad Alavi Darazam, Shervin Shokouhi, Masoud Mardani, Mohamad Amin Pourhoseingholi, Mohammad Mahdi Rabiei, Firouze Hatami, Minoosh Shabani, Omid Moradi, Farid Javandoust Gharehbagh, Seyed Sina Naghibi Irvani, Mahdi Amirdosara, Mohammadreza Hajiesmaeili, Omidvar Rezaei, Ali Khoshkar, Legha Lotfollahi, Latif Gachkar, Hadiseh Shabanpour Dehbsneh, Negar Khalili, Azam Soleymaninia, Akram Hoseyni Kusha, Maryam Taleb Shoushtari, Parham Torabinavid. Umifenovir in hospitalized moderate to severe COVID-19 patients: A randomized clinical trial.
International immunopharmacology.
2021 Oct; 99(?):107969. doi:
10.1016/j.intimp.2021.107969. [PMID: 34273635] - Nanjin Chen, Xiaodan Wang, Sheng Zhang, Ronghai Lin, Yongpo Jiang. Efficacy analysis of Arbidol treatment in patients with 2019 novel coronavirus pneumonia: a retrospective cohort study.
Annals of palliative medicine.
2021 10; 10(10):10626-10632. doi:
10.21037/apm-21-2397. [PMID: 34763510] - Chih-Cheng Lai, Chien-Ming Chao, Po-Ren Hsueh. Clinical efficacy of antiviral agents against coronavirus disease 2019: A systematic review of randomized controlled trials.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2021 Oct; 54(5):767-775. doi:
10.1016/j.jmii.2021.05.011. [PMID: 34253490] - Irina Leneva, Nadezhda Kartashova, Artem Poromov, Anastasiia Gracheva, Ekaterina Korchevaya, Ekaterina Glubokova, Olga Borisova, Anna Shtro, Svetlana Loginova, Veronika Shchukina, Ravil Khamitov, Evgeny Faizuloev. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus.
Viruses.
2021 08; 13(8):. doi:
10.3390/v13081665. [PMID: 34452529] - Xuejin Zhao, Lianzhong Zhao, Ya Zhao, Kun Huang, Wenxiao Gong, Ying Yang, Li Zhao, Xiaohan Xia, Zaiyun Li, Feng Sheng, Xuezhu Du, Meilin Jin. 3-Indoleacetonitrile Is Highly Effective in Treating Influenza A Virus Infection In Vitro and In Vivo.
Viruses.
2021 07; 13(8):. doi:
10.3390/v13081433. [PMID: 34452298] - Jiaxing Ding, Wei Liu, Hongquan Guan, Yu Feng, Yintu Bao, Huili Li, Xuehua Wang, Zihua Zhou, Zhijian Chen. Corrected QT interval in hospitalized patients with coronavirus disease 2019: Focus on drugs therapy.
Medicine.
2021 Jul; 100(28):e26538. doi:
10.1097/md.0000000000026538. [PMID: 34260531] - Yunzhen Hu, Minjuan Zuo, Xiaojuan Wang, Rongrong Wang, Lu Li, Xiaoyang Lu, Saiping Jiang. Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats.
Journal of Zhejiang University. Science. B.
2021 Jul; 22(7):599-602. doi:
10.1631/jzus.b2000728. [PMID: 34269012] - Peng Yin, Juan Meng, Jincheng Chen, Junxiao Gao, Dongqi Wang, Shuyan Liu, Qinglong Guo, Muchun Zhu, Gengwei Zhang, Yingxia Liu, Ye Li, Guoliang Zhang. Antiviral drugs arbidol and interferon alpha-1b contribute to reducing the severity of COVID-19 patients: a retrospective cohort study.
Virology journal.
2021 07; 18(1):142. doi:
10.1186/s12985-021-01617-w. [PMID: 34238341] - Qi Xia, Wanrong Dai, Kaijin Xu, Qin Ni, Yongtao Li, Jun Liu, Hong Zhao, Yongzheng Guo, Liang Yu, Ping Yi, Junwei Su, Guanjing Lang, Jingjing Tao, Ding Shi, Wenrui Wu, Xiaoxin Wu, Yan Xu, Min Xu, Ling Yu, Xiaoyan Wang, Hongliu Cai, Qiang Fang, Jianying Zhou, Yunqing Qiu, Lanjuan Li. Clinical efficacy of methylprednisolone and the combined use of lopinavir/ritonavir with arbidol in treatment of coronavirus disease 2019.
Journal of medical virology.
2021 07; 93(7):4446-4453. doi:
10.1002/jmv.26798. [PMID: 33448426] - Jie Ma, Hua-Yang Wu, Yu-Zhu Chen, Mao Huang, Li-Shan Zhang. Thoughts on Traditional Chinese Medicine Treatment of Novel Coronavirus Pneumonia Based on Two Cases.
Chinese journal of integrative medicine.
2021 May; 27(5):375-378. doi:
10.1007/s11655-020-3485-9. [PMID: 33528745] - Lu Xia, Yujing Shi, Jie Su, Thomas Friedemann, Zhenggang Tao, Yunfei Lu, Yun Ling, Ying Lv, Ronghua Zhao, Zihan Geng, Xiaolan Cui, Hongzhou Lu, Sven Schröder. Shufeng Jiedu, a promising herbal therapy for moderate COVID-19:Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153390. doi:
10.1016/j.phymed.2020.153390. [PMID: 33158717] - Xiu Lan, Chuxiao Shao, Xu Zeng, Zhenbo Wu, Yanyan Xu. Lopinavir-ritonavir alone or combined with arbidol in the treatment of 73 hospitalized patients with COVID-19: A pilot retrospective study.
International journal of clinical pharmacology and therapeutics.
2021 May; 59(5):378-385. doi:
10.5414/cp203861. [PMID: 33624583] - Xiong Jie, Yuan Hongmei, Fan Ping, Zhu Kuikui, Yang Bohan, Meng Rui. Beneficial effect of Arbidol in the management of COVID-19 infection.
Aging.
2021 04; 13(7):9253-9264. doi:
10.18632/aging.202867. [PMID: 33811756] - Liyang Cai, Xi Guo, Yuchen Cao, Peixi Ying, Libing Hong, Yuxi Zhang, Guoguo Yi, Min Fu. Determining available strategies for prevention and therapy: Exploring COVID‑19 from the perspective of ACE2 (Review).
International journal of molecular medicine.
2021 04; 47(4):. doi:
10.3892/ijmm.2021.4876. [PMID: 33576441] - T A Ruzhentsova, D A Khavkina, P V Chukhliaev, A A Garbuzov, A A Ploskireva. [Effect of anticoagulant therapy on the course of COVID-19 in comorbid patients].
Voprosy virusologii.
2021 03; 66(1):40-46. doi:
10.36233/0507-4088-14. [PMID: 33683064] - Aditya K Padhi, Aniruddha Seal, Javed Masood Khan, Maqusood Ahamed, Timir Tripathi. Unraveling the mechanism of arbidol binding and inhibition of SARS-CoV-2: Insights from atomistic simulations.
European journal of pharmacology.
2021 Mar; 894(?):173836. doi:
10.1016/j.ejphar.2020.173836. [PMID: 33387467] - Jiahong Tan, Yuan Yuan, Cheng Xu, Chunyan Song, Dan Liu, Ding Ma, Qinglei Gao. A retrospective comparison of drugs against COVID-19.
Virus research.
2021 03; 294(?):198262. doi:
10.1016/j.virusres.2020.198262. [PMID: 33333102] - Meng Wang, Ting Wu, Zhihong Zuo, Yaxian You, Xinyuan Yang, Liangyu Pan, Ying Hu, Xuan Luo, Liping Jiang, Zanxian Xia, Meichun Deng. Evaluation of current medical approaches for COVID-19: a systematic review and meta-analysis.
BMJ supportive & palliative care.
2021 Mar; 11(1):45-52. doi:
10.1136/bmjspcare-2020-002554. [PMID: 32958501] - Ming Li, Tongya Yu, Jinghua Zhu, Yinjia Wang, Yanxia Yang, Kaiwu Zhao, Yongning Yi, Juan He, Chao Li, Jian He. Comparison of the antiviral effect of Arbidol and Chloroquine in treating COVID-19.
Annals of palliative medicine.
2021 Mar; 10(3):3307-3312. doi:
10.21037/apm-21-400. [PMID: 33849115] - Xinjia Ruan, Xiaofan Lu, Kangyi Wang, Bing Zhang, Jun Wang, Yongsheng Li, Jiashuo Wang, Zhengbao Xu, Fangrong Yan. Liver injury after antiviral treatment of critically ill patients with COVID-19: a single-centered retrospective cohort study.
Annals of palliative medicine.
2021 Mar; 10(3):2429-2438. doi:
10.21037/apm-20-1581. [PMID: 33440980] - Jing Chen, Shaowu Lin, Conway Niu, Qi Xiao. Clinical evaluation of Shufeng Jiedu Capsules combined with umifenovir (Arbidol) in the treatment of common-type COVID-19: a retrospective study.
Expert review of respiratory medicine.
2021 02; 15(2):257-265. doi:
10.1080/17476348.2020.1822741. [PMID: 32941741] - Sanjay Kumar Mishra, Timir Tripathi. One year update on the COVID-19 pandemic: Where are we now?.
Acta tropica.
2021 Feb; 214(?):105778. doi:
10.1016/j.actatropica.2020.105778. [PMID: 33253656] - Weiyin Lin, Zhiwei Xie, Yueping Li, Liya Li, Chunyan Wen, Yi Cao, Xiaoting Chen, Xu Ou, Fengyu Hu, Feng Li, Xiaoping Tang, Weiping Cai, Linghua Li. Association between detectable SARS-COV-2 RNA in anal swabs and disease severity in patients with coronavirus disease 2019.
Journal of medical virology.
2021 02; 93(2):794-802. doi:
10.1002/jmv.26307. [PMID: 32672840] - Lei Liu, Feng Shi, Pei Tu, Chen Chen, Ming Zhang, Xiaoguang Li, Chang Li. Arbidol combined with the Chinese medicine Lianhuaqingwen capsule versus arbidol alone in the treatment of COVID-19.
Medicine.
2021 Jan; 100(4):e24475. doi:
10.1097/md.0000000000024475. [PMID: 33530261] - Lichao Fan, Huan Liu, Na Li, Chang Liu, Ye Gu, Yongyu Liu, Yu Chen. Medical treatment of 55 patients with COVID-19 from seven cities in northeast China who fully recovered: A single-center, retrospective, observational study.
Medicine.
2021 Jan; 100(2):e23923. doi:
10.1097/md.0000000000023923. [PMID: 33466134] - Alexander Simonis, Sebastian J Theobald, Gerd Fätkenheuer, Jan Rybniker, Jakob J Malin. A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2.
EMBO molecular medicine.
2021 01; 13(1):e13105. doi:
10.15252/emmm.202013105. [PMID: 33015938] - Liwen Wei, Yuqi Shang, Xi Liu, Xinghua Li, Gongqi Chen, Siping Liang, Zhengyu Zou, Tao Ding, Zhongsi Hong, Minhao Wu, Jinyu Xia. Antibody Responses and the Effects of Clinical Drugs in COVID-19 Patients.
Frontiers in immunology.
2021; 12(?):580989. doi:
10.3389/fimmu.2021.580989. [PMID: 34177879] - Xianlong Zhou, Haifeng Hou, Luyu Yang, Guoyong Ding, Tao Wei, Cancan Li, Yuanyuan Heng, Ruining Liu, Min Ma, Zhuanzhuan Hu, Lei Huang, Xizhu Xu, Quan Hu, Yan Zhao, Weijia Xing, Zhigang Zhao. Arbidol is associated with increased in-hospital mortality among 109 patients with severe COVID-19: A multicenter, retrospective study.
Journal of global health.
2021; 11(?):05017. doi:
10.7189/jogh.11.05017. [PMID: 34326998] - Dong Huang, He Yu, Ting Wang, Huan Yang, Rong Yao, Zongan Liang. Efficacy and safety of umifenovir for coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Journal of medical virology.
2021 01; 93(1):481-490. doi:
10.1002/jmv.26256. [PMID: 32617989] - Ambedkar Kumar Yadav, Siwan Wen, Xianghuai Xu, Li Yu. Antiviral treatment in COVID-19: which is the most promising?-a narrative review.
Annals of palliative medicine.
2021 Jan; 10(1):707-720. doi:
10.21037/apm-20-1755. [PMID: 33440983] - Jun Chen, Danping Liu, Lin Yin, Lijun Zhang, Hongzhou Lu. Can we use hydroxychloroquine to treat COVID-19 now?.
International journal of antimicrobial agents.
2021 Jan; 57(1):106173. doi:
10.1016/j.ijantimicag.2020.106173. [PMID: 33408016] - Qiong Zhou, Michael R MacArthur, Xinliang He, Xiaoshan Wei, Payam Zarin, Bola S Hanna, Zi-Hao Wang, Xuan Xiang, Eleanor N Fish. Interferon-α2b Treatment for COVID-19 Is Associated with Improvements in Lung Abnormalities.
Viruses.
2020 12; 13(1):. doi:
10.3390/v13010044. [PMID: 33396578] - I A Leneva, N Y Pshenichnaya, V A Bulgakova. [Umifenovir and coronavirus infections: a review of research results and clinical practice].
Terapevticheskii arkhiv.
2020 Dec; 92(11):91-97. doi:
10.26442/00403660.2020.11.000713. [PMID: 33720612] - Yanyan Li, Kaishu Li, Wei Xiong, Xinan Wang, Chaowu Liu, Chun Liu, Weiping Tan, Baowei Luo, Yongfeng Zhu, Yanbin Wu, Huiming Yin, Xueqin Li, Zunchang Li. Clinical characteristics and viral shedding kinetics of 38 asymptomatic patients with coronavirus disease 2019: A retrospective observational study.
Medicine.
2020 Dec; 99(51):e23547. doi:
10.1097/md.0000000000023547. [PMID: 33371079] - Yueping Li, Zhiwei Xie, Weiyin Lin, Weiping Cai, Chunyan Wen, Yujuan Guan, Xiaoneng Mo, Jian Wang, Yaping Wang, Ping Peng, Xudan Chen, Wenxin Hong, Guangming Xiao, Jinxin Liu, Lieguang Zhang, Fengyu Hu, Feng Li, Fuchun Zhang, Xilong Deng, Linghua Li. Efficacy and Safety of Lopinavir/Ritonavir or Arbidol in Adult Patients with Mild/Moderate COVID-19: An Exploratory Randomized Controlled Trial.
Med (New York, N.Y.).
2020 12; 1(1):105-113.e4. doi:
10.1016/j.medj.2020.04.001. [PMID: 32838353] - Marzieh Nojomi, Zeynab Yassin, Hossein Keyvani, Mahin Jamshidi Makiani, Maryam Roham, Azadeh Laali, Nasir Dehghan, Mehrnaz Navaei, Mitra Ranjbar. Effect of Arbidol (Umifenovir) on COVID-19: a randomized controlled trial.
BMC infectious diseases.
2020 Dec; 20(1):954. doi:
10.1186/s12879-020-05698-w. [PMID: 33317461] - Panpan Liu, Zhijun Huang, Mingzhu Yin, Chun Liu, Xiang Chen, Pinhua Pan, Yehong Kuang. Safety and Efficacy of Ixekizumab and Antiviral Treatment for Patients with COVID-19: A structured summary of a study protocol for a Pilot Randomized Controlled Trial.
Trials.
2020 Dec; 21(1):999. doi:
10.1186/s13063-020-04925-8. [PMID: 33276811] - N Trivedi, A Verma, D Kumar. Possible treatment and strategies for COVID-19: review and assessment.
European review for medical and pharmacological sciences.
2020 12; 24(23):12593-12608. doi:
10.26355/eurrev_202012_24057. [PMID: 33336780] - Fang-Fang Chen, Ming Zhong, Ya Liu, Yi Zhang, Kai Zhang, De-Zhen Su, Xiao Meng, Yun Zhang. The characteristics and outcomes of 681 severe cases with COVID-19 in China.
Journal of critical care.
2020 12; 60(?):32-37. doi:
10.1016/j.jcrc.2020.07.003. [PMID: 32736197] - Shaojia Lu, Ning Wei, Jiajun Jiang, Lingling Wu, Jifang Sheng, Jianying Zhou, Qiang Fang, Yu Chen, Shufa Zheng, Feng Chen, Tingbo Liang, Shaohua Hu. First report of manic-like symptoms in a COVID-19 patient with no previous history of a psychiatric disorder.
Journal of affective disorders.
2020 12; 277(?):337-340. doi:
10.1016/j.jad.2020.08.031. [PMID: 32858315] - Yong-Zheng Guo, Kai-Jin Xu, Yong-Tao Li, Jia-Dan Fu, Min Xu, Ling Yu, Ji-Fang Sheng, Biao Zhu. Safety of protease inhibitors and Arbidol for SARS-CoV-2 pneumonia in Zhejiang Province, China.
Journal of Zhejiang University. Science. B.
2020 Dec; 21(12):948-954. doi:
10.1631/jzus.b2000204. [PMID: 33843160] - Fuying Hu, Gang Yin, Youping Chen, Jiangqin Song, Maosong Ye, Jie Liu, Cuicui Chen, Yuanlin Song, Xinjun Tang, Yong Zhang. Corticosteroid, oseltamivir and delayed admission are independent risk factors for prolonged viral shedding in patients with Coronavirus Disease 2019.
The clinical respiratory journal.
2020 Nov; 14(11):1067-1075. doi:
10.1111/crj.13243. [PMID: 32750201] - Shalki Choudhary, Om Silakari. Scaffold morphing of arbidol (umifenovir) in search of multi-targeting therapy halting the interaction of SARS-CoV-2 with ACE2 and other proteases involved in COVID-19.
Virus research.
2020 11; 289(?):198146. doi:
10.1016/j.virusres.2020.198146. [PMID: 32866534] - Saba Shamim, Maryam Khan, Zelal Jaber Kharaba, Munazza Ijaz, Ghulam Murtaza. Potential strategies for combating COVID-19.
Archives of virology.
2020 Nov; 165(11):2419-2438. doi:
10.1007/s00705-020-04768-3. [PMID: 32778950] - Lu Zheng, Lina Zhang, Jiamin Huang, Kutty Selva Nandakumar, Shuwen Liu, Kui Cheng. Potential treatment methods targeting 2019-nCoV infection.
European journal of medicinal chemistry.
2020 Nov; 205(?):112687. doi:
10.1016/j.ejmech.2020.112687. [PMID: 32771797] - Wenyu Chen, Ming Yao, Zhixian Fang, Xiaodong Lv, Min Deng, Zhen Wu. A study on clinical effect of Arbidol combined with adjuvant therapy on COVID-19.
Journal of medical virology.
2020 11; 92(11):2702-2708. doi:
10.1002/jmv.26142. [PMID: 32510169] - Wei Gao, Si Chen, Kun Wang, Rongzhang Chen, Qian Guo, Jingjing Lu, Xiaodong Wu, Yanan He, Qiaoyun Yan, Shengyun Wang, Feilong Wang, Li Jin, Jing Hua, Qiang Li. Clinical features and efficacy of antiviral drug, Arbidol in 220 nonemergency COVID-19 patients from East-West-Lake Shelter Hospital in Wuhan: a retrospective case series.
Virology journal.
2020 10; 17(1):162. doi:
10.1186/s12985-020-01428-5. [PMID: 33097047] - Dongyuan Wang, Zigang Li, Yihui Liu. An overview of the safety, clinical application and antiviral research of the COVID-19 therapeutics.
Journal of infection and public health.
2020 Oct; 13(10):1405-1414. doi:
10.1016/j.jiph.2020.07.004. [PMID: 32684351] - Zita-Rose Manjaly Thomas, Anne Leuppi-Taegtmeyer, Dagmar Jamiolkowski, Esther Steveling-Klein, Felicitas Bellutti-Enders, Kathrin Scherer Hofmeier, Karin Hartmann. Emerging treatments in COVID-19: Adverse drug reactions including drug hypersensitivities.
The Journal of allergy and clinical immunology.
2020 10; 146(4):786-789. doi:
10.1016/j.jaci.2020.07.008. [PMID: 32710973] - Nan Wang, Yan Zhan, Linyu Zhu, Zhibing Hou, Feng Liu, Pinhong Song, Feng Qiu, Xiaolin Wang, Xiafei Zou, Deyun Wan, Xiaosong Qian, Shanshan Wang, Yabi Guo, Hao Yu, Miao Cui, Gangling Tong, Yunsheng Xu, Zhihua Zheng, Yingying Lu, Peng Hong. Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients.
Cell host & microbe.
2020 09; 28(3):455-464.e2. doi:
10.1016/j.chom.2020.07.005. [PMID: 32707096] - Chang Li, Lin Wang, Linzhu Ren. Antiviral mechanisms of candidate chemical medicines and traditional Chinese medicines for SARS-CoV-2 infection.
Virus research.
2020 09; 286(?):198073. doi:
10.1016/j.virusres.2020.198073. [PMID: 32592817] - Xiaoqi Pan, Lan Dong, Lian Yang, Dayi Chen, Cheng Peng. Potential drugs for the treatment of the novel coronavirus pneumonia (COVID-19) in China.
Virus research.
2020 09; 286(?):198057. doi:
10.1016/j.virusres.2020.198057. [PMID: 32531236] - Siyi Xin, Xueqi Cheng, Bo Zhu, Xiaolong Liao, Feng Yang, Lina Song, Yan Shi, Xuefeng Guan, Renyi Su, Jian Wang, Limin Xing, Xiping Xu, Lin Jin, Yanping Liu, Wei Zhou, Dongwei Zhang, Liang Liang, You Yu, Rui Yu. Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Sep; 129(?):110500. doi:
10.1016/j.biopha.2020.110500. [PMID: 32768975] - Shahamah Jomah, Syed Mohammed Basheeruddin Asdaq, Mohammed Jaber Al-Yamani. Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review.
Journal of infection and public health.
2020 Sep; 13(9):1187-1195. doi:
10.1016/j.jiph.2020.07.013. [PMID: 32773212] - Andrés Pizzorno, Blandine Padey, Julia Dubois, Thomas Julien, Aurélien Traversier, Victoria Dulière, Pauline Brun, Bruno Lina, Manuel Rosa-Calatrava, Olivier Terrier. In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2.
Antiviral research.
2020 09; 181(?):104878. doi:
10.1016/j.antiviral.2020.104878. [PMID: 32679055] - Richard A Giovane, Shadi Rezai, Ellen Cleland, Cassandra E Henderson. Current pharmacological modalities for management of novel coronavirus disease 2019 (COVID-19) and the rationale for their utilization: A review.
Reviews in medical virology.
2020 09; 30(5):e2136. doi:
10.1002/rmv.2136. [PMID: 32644275] - Kui Zhang, Maolu Tian, Yang Zeng, Linwen Wang, Sha Luo, Wei Xia, Xiangyan Zhang, Yan Zha. The combined therapy of a traditional Chinese medicine formula and Western medicine for a critically ill case infected with COVID-19.
Complementary therapies in medicine.
2020 Aug; 52(?):102473. doi:
10.1016/j.ctim.2020.102473. [PMID: 32951723] - Naveen Vankadari. Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein.
International journal of antimicrobial agents.
2020 Aug; 56(2):105998. doi:
10.1016/j.ijantimicag.2020.105998. [PMID: 32360231] - C Y Wen, Z W Xie, Y P Li, X L Deng, X T Chen, Y Cao, X Ou, W Y Lin, F Li, W P Cai, L H Li. [The efficacy and safety of lopinavir/ritonavir and arbidol in patients with coronavirus disease 2019].
Zhonghua nei ke za zhi.
2020 Aug; 59(8):605-609. doi:
10.3760/cma.j.cn112138-20200227-00147. [PMID: 32388937] - Junwei Su, Xiaomin Shen, Qin Ni, Hong Zhao, Jieru Cai, Biao Zhu, Wenrui Wu, Guanjing Lang, Kaijin Xu, Jifang Sheng. Infection of severe acute respiratory syndrome coronavirus 2 in a patient with AIDS.
AIDS (London, England).
2020 08; 34(10):1575-1576. doi:
10.1097/qad.0000000000002553. [PMID: 32675569] - Xuemei Wang, Ping Xie, Guojuan Sun, Min Zhao, Zhumei Deng, Yunxia Zhou, Shuting Bao. A systematic review and meta-analysis of the efficacy and safety of arbidol in the treatment of coronavirus disease 2019.
Medicine.
2020 Jul; 99(30):e21402. doi:
10.1097/md.0000000000021402. [PMID: 32791753] - Xiaoxi Zhou, Jianfeng Zhou, Jianping Zhao. Recurrent pneumonia in a patient with new coronavirus infection after discharge from hospital for insufficient antibody production: a case report.
BMC infectious diseases.
2020 Jul; 20(1):500. doi:
10.1186/s12879-020-05231-z. [PMID: 32652938] - Guangwei Wu, Guihong Yu, Yunjia Yu, Shuang Yang, Zhongwei Duan, Wei Wang, Yankai Liu, Rilei Yu, Jing Li, Tianjiao Zhu, Qianqun Gu, Dehai Li. Chemoreactive-Inspired Discovery of Influenza A Virus Dual Inhibitor to Block Hemagglutinin-Mediated Adsorption and Membrane Fusion.
Journal of medicinal chemistry.
2020 07; 63(13):6924-6940. doi:
10.1021/acs.jmedchem.0c00312. [PMID: 32520560] - Wei Liu, Pengxiang Zhou, Ken Chen, Zhikang Ye, Fang Liu, Xiaotong Li, Na He, Ziyang Wu, Qi Zhang, Xuepeng Gong, Qiyu Tang, Xin Du, Yingqiu Ying, Xiaohan Xu, Yahui Zhang, Jinyu Liu, Yun Li, Ning Shen, Rachel J Couban, Quazi I Ibrahim, Gordon Guyatt, Suodi Zhai. Efficacy and safety of antiviral treatment for COVID-19 from evidence in studies of SARS-CoV-2 and other acute viral infections: a systematic review and meta-analysis.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
2020 07; 192(27):E734-E744. doi:
10.1503/cmaj.200647. [PMID: 32493740] - Zhen Zhu, Zhaohui Lu, Tianmin Xu, Cong Chen, Gang Yang, Tao Zha, Jianchun Lu, Yuan Xue. Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19.
The Journal of infection.
2020 07; 81(1):e21-e23. doi:
10.1016/j.jinf.2020.03.060. [PMID: 32283143] - Ling Wang, Xiaopeng Xu, Junshan Ruan, Saijin Lin, Jinhua Jiang, Hong Ye. Quadruple therapy for asymptomatic COVID-19 infection patients.
Expert review of anti-infective therapy.
2020 07; 18(7):617-624. doi:
10.1080/14787210.2020.1758066. [PMID: 32362193] - Lisi Deng, Chunna Li, Qi Zeng, Xi Liu, Xinghua Li, Haitang Zhang, Zhongsi Hong, Jinyu Xia. Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study.
The Journal of infection.
2020 07; 81(1):e1-e5. doi:
10.1016/j.jinf.2020.03.002. [PMID: 32171872] - N Lian, H Xie, S Lin, J Huang, J Zhao, Q Lin. Umifenovir treatment is not associated with improved outcomes in patients with coronavirus disease 2019: a retrospective study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 Jul; 26(7):917-921. doi:
10.1016/j.cmi.2020.04.026. [PMID: 32344167] - Yaxiong Huang, Chunlin Cai, Jinglei Zang, Jun Xie, Dan Xu, Fang Zheng, Tao Zhan, Kang Huang, Yikai Wang, Xiao Wang, Zhe-Yu Hu, Yapeng Deng, Yuanlin Xie. Treatment strategies of hospitalized patients with coronavirus disease-19.
Aging.
2020 06; 12(12):11224-11237. doi:
10.18632/aging.103370. [PMID: 32554861] - Aleksandr Ianevski, Rouan Yao, Mona Høysæter Fenstad, Svetlana Biza, Eva Zusinaite, Tuuli Reisberg, Hilde Lysvand, Kirsti Løseth, Veslemøy Malm Landsem, Janne Fossum Malmring, Valentyn Oksenych, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Caroline H Pettersen, Tanel Tenson, Jan Egil Afset, Svein Arne Nordbø, Magnar Bjørås, Denis E Kainov. Potential Antiviral Options against SARS-CoV-2 Infection.
Viruses.
2020 06; 12(6):. doi:
10.3390/v12060642. [PMID: 32545799] - Jin-Nong Zhang, Wen-Jing Wang, Bo Peng, Wei Peng, Yi-Sheng Zhang, Ya-Ling Wang, Yan Wan, Jiang Chang, Ling Mao, Xiao-Ping Miao, Ya-Nan Li, Yi-Fan Zhou, Bo Hu. Potential of Arbidol for Post-exposure Prophylaxis of COVID-19 Transmission: A Preliminary Report of a Retrospective Cohort Study.
Current medical science.
2020 Jun; 40(3):480-485. doi:
10.1007/s11596-020-2203-3. [PMID: 32474860] - Junyao Li, Lin Zhang, Baihui Liu, Debiao Song. Case Report: Viral Shedding for 60 Days in a Woman with COVID-19.
The American journal of tropical medicine and hygiene.
2020 06; 102(6):1210-1213. doi:
10.4269/ajtmh.20-0275. [PMID: 32342849] - Chen Chen, Moxian Chen, Cong Cheng, Yun Chi, Zhiliang Hu, Yuan Liu, Shan Huang, Yanling Lv, Chongfeng Liang, Damin Jiao, Yongxiang Yi, Xia Zhang, Wenkui Sun, Hongxia Wei. A special symptom of olfactory dysfunction in coronavirus disease 2019: report of three cases.
Journal of neurovirology.
2020 06; 26(3):456-458. doi:
10.1007/s13365-020-00849-w. [PMID: 32424616] - Sabrina Bimonte, Anna Crispo, Alfonso Amore, Egidio Celentano, Arturo Cuomo, Marco Cascella. Potential Antiviral Drugs for SARS-Cov-2 Treatment: Preclinical Findings and Ongoing Clinical Research.
In vivo (Athens, Greece).
2020 Jun; 34(3 Suppl):1597-1602. doi:
10.21873/invivo.11949. [PMID: 32503817] - Yan Wang, Li-Qin Zhu. Pharmaceutical care recommendations for antiviral treatments in children with coronavirus disease 2019.
World journal of pediatrics : WJP.
2020 Jun; 16(3):271-274. doi:
10.1007/s12519-020-00353-5. [PMID: 32166483] - James M Sanders, Marguerite L Monogue, Tomasz Z Jodlowski, James B Cutrell. Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review.
JAMA.
2020 May; 323(18):1824-1836. doi:
10.1001/jama.2020.6019. [PMID: 32282022] - Waquar Ahsan, Shamama Javed, Mohammed Al Bratty, Hassan A Alhazmi, Asim Najmi. Treatment of SARS-CoV-2: How far have we reached?.
Drug discoveries & therapeutics.
2020 May; 14(2):67-72. doi:
10.5582/ddt.2020.03008. [PMID: 32336723] - Yongtao Duan, Hai-Liang Zhu, Chongchen Zhou. Advance of promising targets and agents against COVID-19 in China.
Drug discovery today.
2020 05; 25(5):810-812. doi:
10.1016/j.drudis.2020.02.011. [PMID: 32198066] - Ping Xu, Jianping Huang, Zhao Fan, Wendi Huang, Minghua Qi, Xuwen Lin, Weidong Song, Li Yi. Arbidol/IFN-α2b therapy for patients with corona virus disease 2019: a retrospective multicenter cohort study.
Microbes and infection.
2020 May; 22(4-5):200-205. doi:
10.1016/j.micinf.2020.05.012. [PMID: 32445881] - Hongzhou Lu. Drug treatment options for the 2019-new coronavirus (2019-nCoV).
Bioscience trends.
2020 Mar; 14(1):69-71. doi:
10.5582/bst.2020.01020. [PMID: 31996494] - Zhenwei Wang, Xiaorong Chen, Yunfei Lu, Feifei Chen, Wei Zhang. Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment.
Bioscience trends.
2020 Mar; 14(1):64-68. doi:
10.5582/bst.2020.01030. [PMID: 32037389] - Michele Costanzo, Maria Anna Rachele De Giglio, Giovanni Nicola Roviello. SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus.
Current medicinal chemistry.
2020; 27(27):4536-4541. doi:
10.2174/0929867327666200416131117. [PMID: 32297571]