Mibefradil dihydrochloride (BioDeep_00000763846)
代谢物信息卡片
Mibefradil dihydrochloride
化学式: C29H40Cl2FN3O3 (567.2430602)
中文名称: 盐酸米贝拉地尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)C1C2=C(CCC1(CCN(C)CCCC3=NC4=CC=CC=C4N3)OC(=O)COC)C=C(C=C2)F.Cl.Cl
InChI: /m0../s1
描述信息
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065609 - Cytochrome P-450 CYP1A2 Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D05024
- PubChem: 60662
- ChEMBL: CHEMBL1534525
- MeSH: Mibefradil
- CAS: 116666-63-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J Wu, Y Wu, Y Yang, J Yu, R Fu, Y Sun, Q Xiao. [Mibefradil improves skeletal muscle mass, function and structure in obese mice].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2022 Jul; 42(7):1032-1037. doi:
10.12122/j.issn.1673-4254.2022.07.10. [PMID: 35869766] - Sudha Priya Soundara Pandi, Michael J Shattock, Bruce M Hendry, Claire C Sharpe. Stimulated phosphorylation of ERK in mouse kidney mesangial cells is dependent upon expression of Cav3.1.
BMC nephrology.
2022 06; 23(1):211. doi:
10.1186/s12882-022-02844-1. [PMID: 35710406] - Mohammed Sedeeq, Ahmed Maklad, Taush Dutta, Zikai Feng, Richard Wilson, Nuri Gueven, Iman Azimi. T-Type Calcium Channel Inhibitors Induce Apoptosis in Medulloblastoma Cells Associated with Altered Metabolic Activity.
Molecular neurobiology.
2022 May; 59(5):2932-2945. doi:
10.1007/s12035-022-02771-0. [PMID: 35243582] - Heng Zhang, Chen Chen, Yue Liu, Lu Ren, Jing Qi, Yang Yang, Wei Chen, Yingjia Yao, Xintong Cai, Zhuang Liu, Miao Hao, Lingkang Li, Zisu Deng, Mingyu Sun, Yongping Lu, Keyan Chen, Ping Hou. NRF-2/HO-1 Pathway-Mediated SHOX2 Activation Is a Key Switch for Heart Rate Acceleration by Yixin-Fumai Granules.
Oxidative medicine and cellular longevity.
2022; 2022(?):8488269. doi:
10.1155/2022/8488269. [PMID: 36199421] - Matthias Holdhoff, Xiaobu Ye, Jeffrey G Supko, Louis B Nabors, Arati S Desai, Tobias Walbert, Glenn J Lesser, William L Read, Frank S Lieberman, Martin A Lodge, Jeffrey Leal, Joy D Fisher, Serena Desideri, Stuart A Grossman, Richard L Wahl, David Schiff. Timed sequential therapy of the selective T-type calcium channel blocker mibefradil and temozolomide in patients with recurrent high-grade gliomas.
Neuro-oncology.
2017 06; 19(6):845-852. doi:
10.1093/neuonc/nox020. [PMID: 28371832] - Rasmus Hassing Frandsen, Max Salomonsson, Pernille B L Hansen, Lars J Jensen, Thomas Hartig Braunstein, Niels-Henrik Holstein-Rathlou, Charlotte Mehlin Sorensen. No apparent role for T-type Ca²⁺ channels in renal autoregulation.
Pflugers Archiv : European journal of physiology.
2016 Apr; 468(4):541-50. doi:
10.1007/s00424-015-1770-9. [PMID: 26658945] - Pernille B Hansen, Christian B Poulsen, Steen Walter, Niels Marcussen, Leanne L Cribbs, Ole Skøtt, Boye L Jensen. Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.
Hypertension (Dallas, Tex. : 1979).
2011 Sep; 58(3):464-70. doi:
10.1161/hypertensionaha.111.170845. [PMID: 21788606] - Christian B Poulsen, Rozh H Al-Mashhadi, Leanne L Cribbs, Ole Skøtt, Pernille B Hansen. T-type voltage-gated calcium channels regulate the tone of mouse efferent arterioles.
Kidney international.
2011 Feb; 79(4):443-51. doi:
10.1038/ki.2010.429. [PMID: 21068717] - Zhong Zhang, Hai Lin, Chunhua Cao, Sandeep Khurana, Thomas L Pallone. Voltage-gated divalent currents in descending vasa recta pericytes.
American journal of physiology. Renal physiology.
2010 Oct; 299(4):F862-71. doi:
10.1152/ajprenal.00321.2010. [PMID: 20630935] - Chun Zhou, Hairu Chen, Judy A King, Hassan Sellak, Wolfgang M Kuebler, Jun Yin, Mary I Townsley, Hee-Sup Shin, Songwei Wu. Alpha1G T-type calcium channel selectively regulates P-selectin surface expression in pulmonary capillary endothelium.
American journal of physiology. Lung cellular and molecular physiology.
2010 Jul; 299(1):L86-97. doi:
10.1152/ajplung.00331.2009. [PMID: 20435690] - N Sekiguchi, M Kato, M Takada, H Watanabe, A Higashida, S Sakai, M Ishigai, Y Aso. In vivo approach for the evaluation of mechanism-based inhibition of cytochrome P450 3A in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2008 Apr; 38(4):368-81. doi:
10.1080/00498250701851891. [PMID: 18340562] - Larissa Lipskaia, Caroline Pinet, Yves Fromes, Stéphane Hatem, Isabelle Cantaloube, Alain Coulombe, Anne-Marie Lompré. Mutation of delta-sarcoglycan is associated with Ca(2+) -dependent vascular remodeling in the Syrian hamster.
The American journal of pathology.
2007 Jul; 171(1):162-71. doi:
10.2353/ajpath.2007.070054. [PMID: 17591963] - Jung Hwan Park, Jin Kyu Choi, Eunjung Lee, Jae Kyun Lee, Hyewhon Rhim, Seon Hee Seo, Yoonjee Kim, Munikumar Reddy Doddareddy, Ae Nim Pae, Jahyo Kang, Eun Joo Roh. Lead discovery and optimization of T-type calcium channel blockers.
Bioorganic & medicinal chemistry.
2007 Feb; 15(3):1409-19. doi:
10.1016/j.bmc.2006.11.004. [PMID: 17150365] - Hayrettin Ozturk, Hulya Ozturk, Hatun Duran, Ali Kemal Uzunlar. Mibefradil, a T-type Ca2+ channel blocker, protects against mesenteric ischemia-reperfusion-induced oxidative injury and histologic alterations in intestinal mucosa in rats.
Digestive diseases and sciences.
2006 Aug; 51(8):1454-60. doi:
10.1007/s10620-005-9060-6. [PMID: 16868826] - Walter Raasch, Christian Wittmershaus, Andreas Dendorfer, Inga Voges, Friedrich Pahlke, Christoph Dodt, Peter Dominiak, Olaf Jöhren. Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats.
Endocrinology.
2006 Jul; 147(7):3539-46. doi:
10.1210/en.2006-0198. [PMID: 16574788] - Florian Gackière, Gabriel Bidaux, Philippe Lory, Natalia Prevarskaya, Pascal Mariot. A role for voltage gated T-type calcium channels in mediating "capacitative" calcium entry?.
Cell calcium.
2006 Apr; 39(4):357-66. doi:
10.1016/j.ceca.2005.12.003. [PMID: 16442617] - Sachar Lambert, Johannes Oberwinkler. Characterization of a proton-activated, outwardly rectifying anion channel.
The Journal of physiology.
2005 Aug; 567(Pt 1):191-213. doi:
10.1113/jphysiol.2005.089888. [PMID: 15961423] - Peter R Strege, Cheryl E Bernard, Yijun Ou, Simon J Gibbons, Gianrico Farrugia. Effect of mibefradil on sodium and calcium currents.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Aug; 289(2):G249-53. doi:
10.1152/ajpgi.00022.2005. [PMID: 15790762] - Koichi Hayashi, Shu Wakino, Yuri Ozawa, Koichiro Homma, Takeshi Kanda, Ken Okubo, Ichiro Takamatsu, Satoru Tatematsu, Hiroo Kumagai, Takao Saruta. Role of protein kinase C in Ca channel blocker-induced renal arteriolar dilation in spontaneously hypertensive rats--studies in the isolated perfused hydronephrotic kidney.
The Keio journal of medicine.
2005 Jun; 54(2):102-8. doi:
10.2302/kjm.54.102. [PMID: 16077260] - David M Rodman, Katherine Reese, Julie Harral, Brian Fouty, Songwei Wu, James West, Marloes Hoedt-Miller, Yuji Tada, Kai-Xun Li, Carlyne Cool, Karen Fagan, Leanne Cribbs. Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes.
Circulation research.
2005 Apr; 96(8):864-72. doi:
10.1161/01.res.0000163066.07472.ff. [PMID: 15774856] - Lioubov I Brueggemann, Beverly L Martin, John Barakat, Kenneth L Byron, Leanne L Cribbs. Low voltage-activated calcium channels in vascular smooth muscle: T-type channels and AVP-stimulated calcium spiking.
American journal of physiology. Heart and circulatory physiology.
2005 Feb; 288(2):H923-35. doi:
10.1152/ajpheart.01126.2003. [PMID: 15498818] - Amith Panner, Leanne L Cribbs, Gina M Zainelli, Thomas C Origitano, Sanjay Singh, Robert D Wurster. Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells.
Cell calcium.
2005 Feb; 37(2):105-19. doi:
10.1016/j.ceca.2004.07.002. [PMID: 15589991] - Ayten Gezici, Hayrettin Ozturk, Hulya Ozturk. The effects of mibefradil, a T-type Ca2+ channels blocker, on the renal dysfunction and injury caused by ischemia-reperfusion of the rat kidney.
Renal failure.
2005; 27(6):775-81. doi:
10.1080/08860220500244831. [PMID: 16350833] - Ming Li, J Bondo Hansen, Luping Huang, Brian M Keyser, James T Taylor. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396.
Cardiovascular drug reviews.
2005; 23(2):173-96. doi:
10.1111/j.1527-3466.2005.tb00164.x. [PMID: 16007233] - Megan M McNulty, Dorothy A Hanck. State-dependent mibefradil block of Na+ channels.
Molecular pharmacology.
2004 12; 66(6):1652-61. doi:
10.1124/mol.66.6.1652. [PMID: 15562257] - Taehyun Kim, Juhyun Choi, Sunoh Kim, Ohyeun Kwon, Seung-Yeol Nah, Ye Sun Han, Hyewhon Rhim. The biochemical activation of T-type Ca2+ channels in HEK293 cells stably expressing alpha1G and Kir2.1 subunits.
Biochemical and biophysical research communications.
2004 Nov; 324(1):401-8. doi:
10.1016/j.bbrc.2004.09.069. [PMID: 15465033] - Terry A Jacobson. Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.
The American journal of cardiology.
2004 Nov; 94(9):1140-6. doi:
10.1016/j.amjcard.2004.07.080. [PMID: 15518608] - Guorong Ma, Terri J Allen, Mark E Cooper, Zemin Cao. Calcium channel blockers, either amlodipine or mibefradil, ameliorate renal injury in experimental diabetes.
Kidney international.
2004 Sep; 66(3):1090-8. doi:
10.1111/j.1523-1755.2004.00859.x. [PMID: 15327403] - Kosmas Kosmidis, Vangelis Karalis, Panos Argyrakis, Panos Macheras. Michaelis-Menten kinetics under spatially constrained conditions: application to mibefradil pharmacokinetics.
Biophysical journal.
2004 Sep; 87(3):1498-506. doi:
10.1529/biophysj.104.042143. [PMID: 15345531] - Denis Couchourel, Marie Leclerc, Janos Filep, Michèle G Brunette. Testosterone enhances calcium reabsorption by the kidney.
Molecular and cellular endocrinology.
2004 Jul; 222(1-2):71-81. doi:
10.1016/j.mce.2004.05.001. [PMID: 15249127] - Karen A Griffin, Rifat Hacioglu, Isam Abu-Amarah, Rodger Loutzenhiser, Geoffrey A Williamson, Anil K Bidani. Effects of calcium channel blockers on "dynamic" and "steady-state step" renal autoregulation.
American journal of physiology. Renal physiology.
2004 Jun; 286(6):F1136-43. doi:
10.1152/ajprenal.00401.2003. [PMID: 14996672] - Luping Huang, Brian M Keyser, Tina M Tagmose, J Bondo Hansen, James T Taylor, Hean Zhuang, Min Zhang, David S Ragsdale, Ming Li. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels.
The Journal of pharmacology and experimental therapeutics.
2004 Apr; 309(1):193-9. doi:
10.1124/jpet.103.060814. [PMID: 14718587] - Cvetka Grasic Kuhar, Metka V Budihna, Ruda Zorc Pleskovic. Mibefradil is more effective than verapamil for restoring post-ischemic function of isolated hearts of guinea pigs with acute renal failure.
European journal of pharmacology.
2004 Mar; 488(1-3):137-46. doi:
10.1016/j.ejphar.2004.02.013. [PMID: 15044045] - M Martínez-Sánchez, F Striggow, U H Schröder, S Kahlert, K G Reymann, G Reiser. Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures.
Neuroscience.
2004; 128(4):729-40. doi:
10.1016/j.neuroscience.2004.06.074. [PMID: 15464281] - Koichi Hayashi, Yuri Ozawa, Shu Wakino, Takeshi Kanda, Koichiro Homma, Ichiro Takamatsu, Satoru Tatematsu, Takao Saruta. Cellular mechanism for mibefradil-induced vasodilation of renal microcirculation: studies in the isolated perfused hydronephrotic kidney.
Journal of cardiovascular pharmacology.
2003 Dec; 42(6):697-702. doi:
10.1097/00005344-200312000-00001. [PMID: 14639089] - Maria L Veronese, Lisa P Gillen, Ellen P Dorval, Walter W Hauck, Scott A Waldman, Howard E Greenberg. Effect of mibefradil on CYP3A4 in vivo.
Journal of clinical pharmacology.
2003 Oct; 43(10):1091-100. doi:
10.1177/0091270003256687. [PMID: 14517191] - Pascal Benquet, Janine Le Guen, Yves Pichon, François Tiaho. Differential involvement of Ca(2+) channels in survival and neurite outgrowth of cultured embryonic cockroach brain neurons.
Journal of neurophysiology.
2002 Sep; 88(3):1475-90. doi:
10.1152/jn.2002.88.3.1475. [PMID: 12205168] - Mark G Devlin, James A Angus, Kathryn M Wilson, Christine E Wright. Acute effects of L- and T-type calcium channel antagonists on cardiovascular reflexes in conscious rabbits.
Clinical and experimental pharmacology & physiology.
2002 May; 29(5-6):372-80. doi:
10.1046/j.1440-1681.2002.03670.x. [PMID: 12010178] - Guido Michels, Jan Matthes, Renate Handrock, Ute Kuchinke, Ferdi Groner, Leanne L Cribbs, Alexey Pereverzev, Toni Schneider, Edward Perez-Reyes, Stefan Herzig. Single-channel pharmacology of mibefradil in human native T-type and recombinant Ca(v)3.2 calcium channels.
Molecular pharmacology.
2002 Mar; 61(3):682-94. doi:
10.1124/mol.61.3.682. [PMID: 11854450] - C Baylis, C Qiu, K Engels. Comparison of L-type and mixed L- and T-type calcium channel blockers on kidney injury caused by deoxycorticosterone-salt hypertension in rats.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2001 Dec; 38(6):1292-7. doi:
10.1053/ajkd.2001.29227. [PMID: 11728963] - M Honda, K Hayashi, H Matsuda, E Kubota, H Tokuyama, K Okubo, I Takamatsu, Y Ozawa, T Saruta. Divergent renal vasodilator action of L- and T-type calcium antagonists in vivo.
Journal of hypertension.
2001 Nov; 19(11):2031-7. doi:
10.1097/00004872-200111000-00014. [PMID: 11677369] - M Honda, K Hayashi, H Matsuda, E Kubota, H Tokuyama, K Okubo, Y Ozawa, T Saruta. Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis.
Clinical science (London, England : 1979).
2001 Oct; 101(4):421-7. doi:
NULL. [PMID: 11566080] - Y Ozawa, K Hayashi, T Nagahama, K Fujiwara, T Saruta. Effect of T-type selective calcium antagonist on renal microcirculation: studies in the isolated perfused hydronephrotic kidney.
Hypertension (Dallas, Tex. : 1979).
2001 Sep; 38(3):343-7. doi:
10.1161/01.hyp.38.3.343. [PMID: 11566902] - K A Griffin, M Picken, G L Bakris, A K Bidani. Comparative effects of selective T- and L-type calcium channel blockers in the remnant kidney model.
Hypertension (Dallas, Tex. : 1979).
2001 May; 37(5):1268-72. doi:
10.1161/01.hyp.37.5.1268. [PMID: 11358939] - I Ragueneau, A B Sao, J L Démolis, B Darné, C Funck-Brentano, P Jaillon. Comparison of sympathetic modulation induced by single oral doses of mibefradil, amlodipine, and nifedipine in healthy volunteers.
Clinical pharmacology and therapeutics.
2001 Mar; 69(3):122-9. doi:
10.1067/mcp.2001.113406. [PMID: 11240976] - W Y Son, J H Lee, J H Lee, C T Han. Acrosome reaction of human spermatozoa is mainly mediated by alpha1H T-type calcium channels.
Molecular human reproduction.
2000 Oct; 6(10):893-7. doi:
10.1093/molehr/6.10.893. [PMID: 11006317] - L Lacinová, N Klugbauer, F Hofmann. Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers.
Neuropharmacology.
2000 Apr; 39(7):1254-66. doi:
10.1016/s0028-3908(99)00202-6. [PMID: 10760367] - H Wang, J A Joseph. Mechanisms of hydrogen peroxide-induced calcium dysregulation in PC12 cells.
Free radical biology & medicine.
2000 Apr; 28(8):1222-31. doi:
10.1016/s0891-5849(00)00241-0. [PMID: 10889452] - A Monteil, J Chemin, E Bourinet, G Mennessier, P Lory, J Nargeot. Molecular and functional properties of the human alpha(1G) subunit that forms T-type calcium channels.
The Journal of biological chemistry.
2000 Mar; 275(9):6090-100. doi:
10.1074/jbc.275.9.6090. [PMID: 10692398] - T Varis, J T Backman, K T Kivistö, P J Neuvonen. Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone.
Clinical pharmacology and therapeutics.
2000 Mar; 67(3):215-21. doi:
10.1067/mcp.2000.104611. [PMID: 10741623] - P du Souich, J G Besner, J P Clozel, H A Welker, M Lefebvre, G Caillé. Nonlinear kinetics and pharmacologic response to mibefradil.
Clinical pharmacology and therapeutics.
2000 Mar; 67(3):249-57. doi:
10.1067/mcp.2000.104616. [PMID: 10741628] - T B Levine, P J Bernink, A Caspi, U Elkayam, E M Geltman, B Greenberg, W J McKenna, J K Ghali, T D Giles, A Marmor, L H Reisin, S Ammon, E Lindberg. Effect of mibefradil, a T-type calcium channel blocker, on morbidity and mortality in moderate to severe congestive heart failure: the MACH-1 study. Mortality Assessment in Congestive Heart Failure Trial.
Circulation.
2000 Feb; 101(7):758-64. doi:
10.1161/01.cir.101.7.758. [PMID: 10683349] - B Ma, T Prueksaritanont, J H Lin. Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A.
Drug metabolism and disposition: the biological fate of chemicals.
2000 Feb; 28(2):125-30. doi:
. [PMID: 10640508] - V G Manolopoulos, S Liekens, P Koolwijk, T Voets, E Peters, G Droogmans, P I Lelkes, E De Clercq, B Nilius. Inhibition of angiogenesis by blockers of volume-regulated anion channels.
General pharmacology.
2000 Feb; 34(2):107-16. doi:
10.1016/s0306-3623(00)00052-5. [PMID: 10974418] - P V Avdonin, F R Buhler, V A Tkachuk. Ca2+-agonistic effect of a T-type Ca-channel blocker mibefradil (Ro 40-5967).
Membrane & cell biology.
2000; 13(5):645-55. doi:
NULL. [PMID: 10987388] - C Grasic Kuhar, M V Budihna. Effects of mibefradil and verapamil on ischemic-reperfusion in the hearts of guinea pigs with acute renal failure.
Pflugers Archiv : European journal of physiology.
2000; 440(5 Suppl):R141-2. doi:
NULL. [PMID: 11005645] - S Fareh, A Bénardeau, B Thibault, S Nattel. The T-type Ca(2+) channel blocker mibefradil prevents the development of a substrate for atrial fibrillation by tachycardia-induced atrial remodeling in dogs.
Circulation.
1999 Nov; 100(21):2191-7. doi:
10.1161/01.cir.100.21.2191. [PMID: 10571979] - C Wagner, M Hinder, B K Krämer, A Kurtz. Role of renal nerves in the stimulation of the renin system by reduced renal arterial pressure.
Hypertension (Dallas, Tex. : 1979).
1999 Nov; 34(5):1101-5. doi:
10.1161/01.hyp.34.5.1101. [PMID: 10567189] - J T Backman, J S Wang, X Wen, K T Kivistö, P J Neuvonen. Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam.
Clinical pharmacology and therapeutics.
1999 Oct; 66(4):401-7. doi:
10.1053/cp.1999.v66.a101461. [PMID: 10546924] - H Karam, J P Clozel, P Bruneval, M F Gonzalez, J Ménard. Contrasting effects of selective T- and L-type calcium channel blockade on glomerular damage in DOCA hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
1999 Oct; 34(4 Pt 1):673-8. doi:
10.1161/01.hyp.34.4.673. [PMID: 10523345] - Y Nakamura, H Ono, E D Frohlich. Differential effects of T- and L-type calcium antagonists on glomerular dynamics in spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
1999 Aug; 34(2):273-8. doi:
10.1161/01.hyp.34.2.273. [PMID: 10454453] - P F Blackmore, S Eisoldt. The neoglycoprotein mannose-bovine serum albumin, but not progesterone, activates T-type calcium channels in human spermatozoa.
Molecular human reproduction.
1999 Jun; 5(6):498-506. doi:
10.1093/molehr/5.6.498. [PMID: 10340995] - J Peters, H A Welker, R Bullingham. Pharmacokinetic and pharmacodynamic aspects of concomitant mibefradil-digoxin therapy at therapeutic doses.
European journal of drug metabolism and pharmacokinetics.
1999 Apr; 24(2):133-40. doi:
10.1007/bf03190358. [PMID: 10510740] - D G Wombolt, A Jackson, R Punn, S Smith, T R McCune, P B Williams. Case report: rhabdomyolysis induced by mibefradil in a patient treated with cyclosporine and simvastatin.
Journal of clinical pharmacology.
1999 Mar; 39(3):310-2. doi:
. [PMID: 10073331] - T Prueksaritanont, B Ma, C Tang, Y Meng, C Assang, P Lu, P J Reider, J H Lin, T A Baillie. Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: an in vitro investigation with human liver preparations.
British journal of clinical pharmacology.
1999 Mar; 47(3):291-8. doi:
10.1046/j.1365-2125.1999.00903.x. [PMID: 10215754] - M E Williams, M S Washburn, M Hans, A Urrutia, P F Brust, P Prodanovich, M M Harpold, K A Stauderman. Structure and functional characterization of a novel human low-voltage activated calcium channel.
Journal of neurochemistry.
1999 Feb; 72(2):791-9. doi:
10.1046/j.1471-4159.1999.0720791.x. [PMID: 9930755] - L Becquemont, C Funck-Brentano, P Jaillon. Mibefradil, a potent CYP3A inhibitor, does not alter pravastatin pharmacokinetics.
Fundamental & clinical pharmacology.
1999; 13(2):232-6. doi:
10.1111/j.1472-8206.1999.tb00344.x. [PMID: 10226769] - H A Welker, H Wiltshire, R Bullingham. Clinical pharmacokinetics of mibefradil.
Clinical pharmacokinetics.
1998 Dec; 35(6):405-23. doi:
10.2165/00003088-199835060-00001. [PMID: 9884814] - S Krähenbühl, A Menafoglio, E Giostra, A Gallino. Serious interaction between mibefradil and tacrolimus.
Transplantation.
1998 Oct; 66(8):1113-5. doi:
10.1097/00007890-199810270-00026. [PMID: 9808502] - J Greven. Effect of the novel T-selective calcium channel antagonist mibefradil on kidney function in comparison with amlodipine.
Arzneimittel-Forschung.
1998 Aug; 48(8):806-10. doi:
. [PMID: 9748707] - L L Cribbs, J H Lee, J Yang, J Satin, Y Zhang, A Daud, J Barclay, M P Williamson, M Fox, M Rees, E Perez-Reyes. Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family.
Circulation research.
1998 Jul; 83(1):103-9. doi:
10.1161/01.res.83.1.103. [PMID: 9670923] - M Spoendlin, J Peters, H Welker, A Bock, G Thiel. Pharmacokinetic interaction between oral cyclosporin and mibefradil in stabilized post-renal-transplant patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1998 Jul; 13(7):1787-91. doi:
10.1093/ndt/13.7.1787. [PMID: 9681729] - R P Mason, I T Mak, M F Walter, T N Tulenko, P E Mason. Antioxidant and cytoprotective activities of the calcium channel blocker mibefradil.
Biochemical pharmacology.
1998 Jun; 55(11):1843-52. doi:
10.1016/s0006-2952(98)00070-7. [PMID: 9714303] - C Wagner, B K Krämer, M Hinder, M Kieninger, A Kurtz. T-type and L-type calcium channel blockers exert opposite effects on renin secretion and renin gene expression in conscious rats.
British journal of pharmacology.
1998 Jun; 124(3):579-85. doi:
10.1038/sj.bjp.0701861. [PMID: 9647484] - W Huang, F Alhenc Gelas, M J Osborne-Pellegrin. Protection of the arterial internal elastic lamina by inhibition of the renin-angiotensin system in the rat.
Circulation research.
1998 May; 82(8):879-90. doi:
10.1161/01.res.82.8.879. [PMID: 9576107] - M E Ernst, M W Kelly. Mibefradil, a pharmacologically distinct calcium antagonist.
Pharmacotherapy.
1998 May; 18(3):463-85. doi:
. [PMID: 9620098] - C C Silliman, N F Voelkel, J D Allard, D J Elzi, R M Tuder, J L Johnson, D R Ambruso. Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model.
The Journal of clinical investigation.
1998 Apr; 101(7):1458-67. doi:
10.1172/jci1841. [PMID: 9525989] - A J Woittiez, F T Huysmans, R Bailey, R A Robson, D Mion Júnior, G Villa, I Kobrin. A comparison of the safety and efficacy of mibefradil and nifedipine SR in patients with renal disease and hypertension.
Clinical nephrology.
1998 Mar; 49(3):160-6. doi:
. [PMID: 9543597] - P Lacolley, P Poitevin, R Koen, B I Levy. Different effects of calcium antagonists on fluid filtration of large arteries and albumin permeability in spontaneously hypertensive rats.
Journal of hypertension.
1998 Mar; 16(3):349-55. doi:
10.1097/00004872-199816030-00012. [PMID: 9557928] - R Pordy, A Woittiez. Steady-state trough plasma mibefradil concentrations and correlation to blood pressure response in hypertensive patients with chronic renal disease.
International journal of clinical pharmacology research.
1998; 18(3):105-8. doi:
. [PMID: 9825266] - H A Welker, L Banken. Mibefradil pharmacokinetic and pharmacodynamic population analysis.
International journal of clinical pharmacology research.
1998; 18(2):63-71. doi:
NULL. [PMID: 9675623] - J P Clozel, E A Ertel, S I Ertel. Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension.
1997 Dec; 15(5):S17-25. doi:
10.1097/00004872-199715055-00004. [PMID: 9481612] - H R Wiltshire, B M Sutton, G Heeps, A M Betty, D W Angus, S R Harris, E Worth, H A Welker. Metabolism of the calcium antagonist, mibefradil (POSICOR, Ro 40-5967). Part III. Comparative pharmacokinetics of mibefradil and its major metabolites in rat, marmoset, cynomolgus monkey and man.
Xenobiotica; the fate of foreign compounds in biological systems.
1997 Jun; 27(6):557-71. doi:
10.1080/004982597240343. [PMID: 9211656] - B Cremers, M Flesch, M Südkamp, M Böhm. Effects of the novel T-type calcium channel antagonist mibefradil on human myocardial contractility in comparison with nifedipine and verapamil.
Journal of cardiovascular pharmacology.
1997 May; 29(5):692-6. doi:
10.1097/00005344-199705000-00019. [PMID: 9213214] - S Verma, S Bhanot, A Hicke, J H McNeill. Chronic T-type Ca2+ channel blockade with mibefradil in hyperinsulinemic, insulin-resistant and hypertensive rats.
Cardiovascular research.
1997 Apr; 34(1):121-8. doi:
10.1016/s0008-6363(97)00032-1. [PMID: 9217881] - M Rosenquist, B Brembilla-Perrot, T Meinertz, A Neugebauer, H J Crijns, J L Smeets, J A van der Vring, M Fromer, I Kobrin. The acute effects of intravenously administered mibefradil, a new calcium antagonist, on the electrophysiologic characteristics of the human heart.
European journal of clinical pharmacology.
1997; 52(1):7-12. doi:
10.1007/s002280050241. [PMID: 9143860] - B Pitt. Diversity of calcium antagonists.
Clinical therapeutics.
1997; 19 Suppl A(?):3-17. doi:
10.1016/s0149-2918(97)80033-1. [PMID: 9385501] - M F Rousseau, W Hayashida, C van Eyll, O M Hess, C R Benedict, S Ahn, F Chapelle, I Kobrin, H Pouleur. Hemodynamic and cardiac effects of the selective T-type and L-type calcium channel blocking agent mibefradil in patients with varying degrees of left ventricular systolic dysfunction.
Journal of the American College of Cardiology.
1996 Oct; 28(4):972-9. doi:
10.1016/s0735-1097(96)00261-6. [PMID: 8837576] - H Karam, D Heudes, P Bruneval, M F Gonzales, B M Löffler, M Clozel, J P Clozel. Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism.
Hypertension (Dallas, Tex. : 1979).
1996 Sep; 28(3):379-85. doi:
10.1161/01.hyp.28.3.379. [PMID: 8794820] - K Skov, J Fenger-Grøn, M J Mulvany. Effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist, and an endothelin receptor antagonist on renal afferent arteriolar structure.
Hypertension (Dallas, Tex. : 1979).
1996 Sep; 28(3):464-71. doi:
10.1161/01.hyp.28.3.464. [PMID: 8794834] - A Skerjanec, S Tawfik, Y K Tam. Nonlinear pharmacokinetics of mibefradil in the dog.
Journal of pharmaceutical sciences.
1996 Feb; 85(2):189-92. doi:
10.1021/js9501775. [PMID: 8683447] - J R Petrie, S K Glen, M MacMahon, R Crome, P A Meredith, H L Elliott, J L Reid. Haemodynamics, cardiac conduction and pharmacokinetics of mibefradil (Ro 40-5967), a novel calcium antagonist.
Journal of hypertension.
1995 Dec; 13(12 Pt 2):1842-6. doi:
. [PMID: 8903664] - A L Bakx, E E van der Wall, S Braun, H Emanuelsson, A V Bruschke, I Kobrin. Effects of the new calcium antagonist mibefradil (Ro 40-5967) on exercise duration in patients with chronic stable angina pectoris: a multicenter, placebo-controlled study. Ro 40-5967 International Study Group.
American heart journal.
1995 Oct; 130(4):748-57. doi:
10.1016/0002-8703(95)90073-x. [PMID: 7572582] - R Schmitt, J P Clozel, N Iberg, F R Bühler. Mibefradil prevents neointima formation after vascular injury in rats. Possible role of the blockade of the T-type voltage-operated calcium channel.
Arteriosclerosis, thrombosis, and vascular biology.
1995 Aug; 15(8):1161-5. doi:
10.1161/01.atv.15.8.1161. [PMID: 7627710] - A Skerjanec, Y K Tam. High-performance liquid chromatographic analysis of mibefradil in dog plasma and urine.
Journal of chromatography. B, Biomedical applications.
1995 Jul; 669(2):377-82. doi:
10.1016/0378-4347(95)00102-o. [PMID: 7581915] - M Véniant, G A Gray, D Heudes, J Ménard, J P Clozel. Structural changes and cyclic GMP content of the aorta after calcium antagonism or angiotensin converting enzyme inhibition in renovascular hypertensive rats.
Journal of hypertension.
1995 Jul; 13(7):731-7. doi:
. [PMID: 7594436] - C H Kleinbloesem, M Siepmann, W Kirch. Hemolysis on intravenous administration of a new calcium antagonist.
Journal of cardiovascular pharmacology.
1995 Jun; 25(6):855-8. doi:
10.1097/00005344-199506000-00001. [PMID: 7564328] - M Siepmann, C Kleinbloesem, W Kirch. The interaction of the calcium antagonist RO 40-5967 with digoxin.
British journal of clinical pharmacology.
1995 May; 39(5):491-6. doi:
10.1111/j.1365-2125.1995.tb04485.x. [PMID: 7669484] - J Su, N Renaud, A Carayon, B Crozatier, L Hittinger. Effects of the calcium channel blockers, diltiazem and Ro 40-5967, on systemic haemodynamics and plasma noradrenaline levels in conscious dogs with pacing-induced heart failure.
British journal of pharmacology.
1994 Oct; 113(2):395-402. doi:
10.1111/j.1476-5381.1994.tb17002.x. [PMID: 7834190]