Tecovirimat (BioDeep_00000763411)
代谢物信息卡片
N-((3aR,4R,4aR,5aS,6S,6aS)-1,3-Dioxo-3,3a,4,4a,5,5a,6,6a-octahydro-4,6-ethenocyclopropa(f)isoindol-2(1H)-yl)-4-(trifluoromethyl)benzamide
化学式: C19H15F3N2O3 (376.10347160000003)
中文名称: 特考韦瑞
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2C1C3C=CC2C4C3C(=O)N(C4=O)NC(=O)C5=CC=C(C=C5)C(F)(F)F
InChI: InChI=1S/C19H15F3N2O3/c20-19(21,22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6,10-15H,7H2,(H,23,25)
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
C254 - Anti-Infective Agent > C281 - Antiviral Agent
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 25101755
- PubChem: 16124688
- DrugBank: DB12020
- ChEMBL: CHEMBL1257073
- ChEMBL: CHEMBL485653
- CAS: 816458-31-8
- CAS: 869572-92-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Galina A Oleinik, Vladimir V Koval, Svetlana V Usova, Larisa N Shishkina, Alexander A Chernonosov. Development and Validation of a Method of Liquid Chromatography Coupled with Tandem Mass Spectrometry for Quantification of ST-246 (Tecovirimat) in Human Plasma.
Molecules (Basel, Switzerland).
2022 Jun; 27(11):. doi:
10.3390/molecules27113577. [PMID: 35684513] - Scott Parker, June D'Angelo, R Mark Buller, Donald F Smee, Johan Lantto, Henriette Nielsen, Allan Jensen, Mark Prichard, Sarah L George. A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge.
Antiviral research.
2021 11; 195(?):105179. doi:
10.1016/j.antiviral.2021.105179. [PMID: 34530009] - Christina L Hutson, Ashley V Kondas, Mathew R Mauldin, Jeffrey B Doty, Irma M Grossi, Clint N Morgan, Sharon Dietz Ostergaard, Christine M Hughes, Yoshinori Nakazawa, Chantal Kling, Brock E Martin, James A Ellison, Darin S Carroll, Nadia F Gallardo-Romero, Victoria A Olson. Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model.
mSphere.
2021 02; 6(1):. doi:
10.1128/msphere.00927-20. [PMID: 33536322] - Adams Amantana, Yali Chen, Shanthakumar R Tyavanagimatt, Kevin F Jones, Robert Jordan, Jarasvech Chinsangaram, Tove C Bolken, Janet M Leeds, Dennis E Hruby. Pharmacokinetics and interspecies allometric scaling of ST-246, an oral antiviral therapeutic for treatment of orthopoxvirus infection.
PloS one.
2013; 8(4):e61514. doi:
10.1371/journal.pone.0061514. [PMID: 23637845] - Jarasvech Chinsangaram, Kady M Honeychurch, Shanthakumar R Tyavanagimatt, Janet M Leeds, Tove' C Bolken, Kevin F Jones, Robert Jordan, Thomas Marbury, Jon Ruckle, Denis Mee-Lee, Eric Ross, Israel Lichtenstein, Margaret Pickens, Michael Corrado, Jean M Clarke, Annie M Frimm, Dennis E Hruby. Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers.
Antimicrobial agents and chemotherapy.
2012 Sep; 56(9):4900-5. doi:
10.1128/aac.00904-12. [PMID: 22777041] - Jarasvech Chinsangaram, Kady M Honeychurch, Shanthakumar R Tyavanagimatt, Tove' C Bolken, Robert Jordan, Kevin F Jones, Thomas Marbury, Israel Lichtenstein, Margaret Pickens, Michael Corrado, Patrick Landis, Jean M Clarke, Annie M Frimm, Dennis E Hruby. Pharmacokinetic comparison of a single oral dose of polymorph form i versus form V capsules of the antiorthopoxvirus compound ST-246 in human volunteers.
Antimicrobial agents and chemotherapy.
2012 Jul; 56(7):3582-6. doi:
10.1128/aac.06090-11. [PMID: 22526314] - Scott Parker, Nanhai G Chen, Scott Foster, Hollyce Hartzler, Ed Hembrador, Dennis Hruby, Robert Jordan, Randall Lanier, George Painter, Wesley Painter, John E Sagartz, Jill Schriewer, R Mark Buller. Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox.
Antiviral research.
2012 Apr; 94(1):44-53. doi:
10.1016/j.antiviral.2012.02.005. [PMID: 22381921] - Yali Chen, Adams Amantana, Shanthakumar R Tyavanagimatt, Daniela Zima, X Steven Yan, Gopi Kasi, Morgan Weeks, Melialani A Stone, William C Weimers, Peter Samuel, Ying Tan, Kevin F Jones, Daniel R Lee, Shirley S Kickner, Bradley M Saville, Martin Lauzon, Alan McIntyre, Kady M Honeychurch, Robert Jordan, Dennis E Hruby, Janet M Leeds. Comparison of the safety and pharmacokinetics of ST-246® after i.v. infusion or oral administration in mice, rabbits and monkeys.
PloS one.
2011; 6(8):e23237. doi:
10.1371/journal.pone.0023237. [PMID: 21858040] - Robert Jordan, Jarasvech Chinsangaram, Tove' C Bolken, Shanthakumar R Tyavanagimatt, Deborah Tien, Kevin F Jones, Annie Frimm, Michael L Corrado, Margaret Pickens, Patrick Landis, Jean Clarke, Thomas C Marbury, Dennis E Hruby. Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects.
Antimicrobial agents and chemotherapy.
2010 Jun; 54(6):2560-6. doi:
10.1128/aac.01689-09. [PMID: 20385870] - Earl R Kern, Mark N Prichard, Debra C Quenelle, Kathy A Keith, Kamal N Tiwari, Joseph A Maddry, John A Secrist. Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
Antimicrobial agents and chemotherapy.
2009 Feb; 53(2):572-9. doi:
10.1128/aac.01257-08. [PMID: 19029322] - Surabhi Vora, Inger Damon, Vincent Fulginiti, Stephen G Weber, Madelyn Kahana, Sarah L Stein, Susan I Gerber, Sylvia Garcia-Houchins, Edith Lederman, Dennis Hruby, Limone Collins, Dorothy Scott, Kenneth Thompson, John V Barson, Russell Regnery, Christine Hughes, Robert S Daum, Yu Li, Hui Zhao, Scott Smith, Zach Braden, Kevin Karem, Victoria Olson, Whitni Davidson, Giliane Trindade, Tove Bolken, Robert Jordan, Debbie Tien, John Marcinak. Severe eczema vaccinatum in a household contact of a smallpox vaccinee.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2008 May; 46(10):1555-61. doi:
10.1086/587668. [PMID: 18419490] - Donald F Smee. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models.
Antiviral chemistry & chemotherapy.
2008; 19(3):115-24. doi:
10.1177/095632020801900302. [PMID: 19024628] - Debra C Quenelle, R M L Buller, Scott Parker, Kathy A Keith, Dennis E Hruby, Robert Jordan, Earl R Kern. Efficacy of delayed treatment with ST-246 given orally against systemic orthopoxvirus infections in mice.
Antimicrobial agents and chemotherapy.
2007 Feb; 51(2):689-95. doi:
10.1128/aac.00879-06. [PMID: 17116683] - R C Foster. Renal hydromineral metabolism in starry flounder, Platichthys stellatus.
Comparative biochemistry and physiology. A, Comparative physiology.
1976; 55(2a):135-40. doi:
10.1016/0300-9629(76)90081-5. [PMID: 7410]