Semapimod (BioDeep_00000763391)
代谢物信息卡片
化学式: C34H52N18O2 (744.4520411999999)
中文名称: 塞马莫德
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=NN=C(N)N)C1=CC(=CC(=C1)NC(=O)CCCCCCCCC(=O)NC2=CC(=CC(=C2)C(=NN=C(N)N)C)C(=NN=C(N)N)C)C(=NN=C(N)N)C
InChI: InChI=1S/C34H52N18O2/c1-19(45-49-31(35)36)23-13-24(20(2)46-50-32(37)38)16-27(15-23)43-29(53)11-9-7-5-6-8-10-12-30(54)44-28-17-25(21(3)47-51-33(39)40)14-26(18-28)22(4)48-52-34(41)42/h13-18H,5-12H2,1-4H3,(H,43,53)(H,44,54)(H4,35,36,49)(H4,37,38,50)(H4,39,40,51)(H4,41,42,52)/b45-19+,46-20+,47-21+,48-22+
描述信息
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2149 - Mitogen-Activated Protein Kinase Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mayada Woriedh, Ilona Hauber, Ana Lilia Martinez-Rocha, Christian Voigt, Frank J Maier, Marcus Schröder, Chris Meier, Joachim Hauber, Wilhelm Schäfer. Preventing Fusarium head blight of wheat and cob rot of maize by inhibition of fungal deoxyhypusine synthase.
Molecular plant-microbe interactions : MPMI.
2011 May; 24(5):619-27. doi:
10.1094/mpmi-03-10-0068. [PMID: 21463208] - Claudia C dos dos Santos, Yuexin Shan, Ali Akram, Arthur S Slutsky, Jack J Haitsma. Neuroimmune regulation of ventilator-induced lung injury.
American journal of respiratory and critical care medicine.
2011 Feb; 183(4):471-82. doi:
10.1164/rccm.201002-0314oc. [PMID: 20870758] - I K Vlachakis, G A Pitoulias, K E Kontopoulou, R E Kotakidou, E K Kosmidou, M E Kallaitzopoulou, D K Papadimitriou. Semapimod a new pretreatment modality of acute intestinal ischemia-reperfusion syndrome: experimental study in rabbits.
International angiology : a journal of the International Union of Angiology.
2011 Feb; 30(1):35-42. doi:
NULL. [PMID: 21248671] - Iris Dotan, Daniel Rachmilewitz, Stefan Schreiber, Rami Eliakim, C Janneke van der Woude, Asher Kornbluth, Alan L Buchman, Shimon Bar-Meir, Bernd Bokemeyer, Eran Goldin, Christian Maaser, Uma Mahadevan, Ursula Seidler, Jörg C Hoffman, Douglas Homoky, Terry Plasse, Barbara Powers, Paul Rutgeerts, Daniel Hommes. A randomised placebo-controlled multicentre trial of intravenous semapimod HCl for moderate to severe Crohn's disease.
Gut.
2010 Jun; 59(6):760-6. doi:
10.1136/gut.2009.179994. [PMID: 20551461] - Sabine Specht, Salem Ramadan Sarite, Ilona Hauber, Joachim Hauber, Ulf F Görbig, Chris Meier, Dorian Bevec, Achim Hoerauf, Annette Kaiser. The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase.
Parasitology research.
2008 May; 102(6):1177-84. doi:
10.1007/s00436-008-0891-x. [PMID: 18256853] - Ping Chen, Yongping Zhang, Minmin Qiao, Yaozong Yuan. Activated protein C, an anticoagulant polypeptide, ameliorates severe acute pancreatitis via regulation of mitogen-activated protein kinases.
Journal of gastroenterology.
2007 Nov; 42(11):887-96. doi:
10.1007/s00535-007-2104-2. [PMID: 18008033] - E Larsson, H E Harris, K Palmblad, B Månsson, T Saxne, L Klareskog. CNI-1493, an inhibitor of proinflammatory cytokines, retards cartilage destruction in rats with collagen induced arthritis.
Annals of the rheumatic diseases.
2005 Mar; 64(3):494-6. doi:
10.1136/ard.2004.021550. [PMID: 15708902] - Aftab R Kherani, Garrett W Moss, Hua Zhou, Anguo Gu, Geping Zhang, Allison R Schulman, Jennifer M Fal, Robert Sorabella, Terry Plasse, Liu Rui, Shunichi Homma, Daniel Burkhoff, Mehmet C Oz, Jie Wang. Macrophage inhibitor, semapimod, reduces tumor necrosis factor-alpha in myocardium in a rat model of ischemic heart failure.
Journal of cardiovascular pharmacology.
2004 Dec; 44(6):665-71. doi:
10.1097/00005344-200412000-00007. [PMID: 15550785] - Paul Rutgeerts, Gert Van Assche, Séverine Vermeire. Optimizing anti-TNF treatment in inflammatory bowel disease.
Gastroenterology.
2004 May; 126(6):1593-610. doi:
10.1053/j.gastro.2004.02.070. [PMID: 15168370] - Thomas R Bernik, Steven G Friedman, Mahendar Ochani, Robert DiRaimo, Luis Ulloa, Huan Yang, Samridhi Sudan, Christopher J Czura, Svetlana M Ivanova, Kevin J Tracey. Pharmacological stimulation of the cholinergic antiinflammatory pathway.
The Journal of experimental medicine.
2002 Mar; 195(6):781-8. doi:
10.1084/jem.20011714. [PMID: 11901203] - M B Atkins, B Redman, J Mier, J Gollob, J Weber, J Sosman, B L MacPherson, T Plasse. A phase I study of CNI-1493, an inhibitor of cytokine release, in combination with high-dose interleukin-2 in patients with renal cancer and melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2001 Mar; 7(3):486-92. doi:
NULL. [PMID: 11297238] - W Denham, J Yang, H Wang, G Botchkina, K J Tracey, J Norman. Inhibition of p38 mitogen activate kinase attenuates the severity of pancreatitis-induced adult respiratory distress syndrome.
Critical care medicine.
2000 Jul; 28(7):2567-72. doi:
10.1097/00003246-200007000-00064. [PMID: 10921596] - C Jaffray, J Yang, J Norman. Elastase mimics pancreatitis-induced hepatic injury via inflammatory mediators.
The Journal of surgical research.
2000 May; 90(2):95-101. doi:
10.1006/jsre.2000.5832. [PMID: 10792947] - A A Kramer, G Postler, K F Salhab, C Mendez, L C Carey, H Rabb. Renal ischemia/reperfusion leads to macrophage-mediated increase in pulmonary vascular permeability.
Kidney international.
1999 Jun; 55(6):2362-7. doi:
10.1046/j.1523-1755.1999.00460.x. [PMID: 10354283] - J Yang, W Denham, G Carter, K J Tracey, J Norman. Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor alpha and interleukin-1beta.
Hepatology (Baltimore, Md.).
1998 Nov; 28(5):1282-8. doi:
10.1002/hep.510280517. [PMID: 9794913] - J Yang, W Denham, K J Tracey, H Wang, A A Kramer, K F Salhab, J Norman. The physiologic consequences of macrophage pacification during severe acute pancreatitis.
Shock (Augusta, Ga.).
1998 Sep; 10(3):169-75. doi:
10.1097/00024382-199809000-00004. [PMID: 9744644] - M M Kemeny, G I Botchkina, M Ochani, M Bianchi, C Urmacher, K J Tracey. The tetravalent guanylhydrazone CNI-1493 blocks the toxic effects of interleukin-2 without diminishing antitumor efficacy.
Proceedings of the National Academy of Sciences of the United States of America.
1998 Apr; 95(8):4561-6. doi:
10.1073/pnas.95.8.4561. [PMID: 9539777] - W Denham, G Fink, J Yang, P Ulrich, K Tracey, J Norman. Small molecule inhibition of tumor necrosis factor gene processing during acute pancreatitis prevents cytokine cascade progression and attenuates pancreatitis severity.
The American surgeon.
1997 Dec; 63(12):1045-9; discussion 1049. doi:
NULL. [PMID: 9393251]