Rilapladib (BioDeep_00000763388)
代谢物信息卡片
化学式: C40H38F5N3O3S (735.2553898000001)
中文名称: 瑞拉帕地
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COCCN1CCC(CC1)N(CC2=CC=C(C=C2)C3=CC=C(C=C3)C(F)(F)F)C(=O)CN4C5=CC=CC=C5C(=O)C=C4SCC6=C(C(=CC=C6)F)F
InChI: InChI=1S/C40H38F5N3O3S/c1-51-22-21-46-19-17-32(18-20-46)47(24-27-9-11-28(12-10-27)29-13-15-31(16-14-29)40(43,44)45)37(50)25-48-35-8-3-2-6-33(35)36(49)23-38(48)52-26-30-5-4-7-34(41)39(30)42/h2-16,23,32H,17-22,24-26H2,1H3
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM[1]. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist[2].
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D05728
- PubChem: 9918381
- DrugBank: DB05119
- ChEMBL: CHEMBL2104981
- CAS: 412950-08-4
- medchemexpress: HY-102004
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Annette L Fitzpatrick, Michael C Irizarry, Mary Cushman, Nancy S Jenny, Gloria C Chi, Carol Koro. Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study.
Atherosclerosis.
2014 Aug; 235(2):384-91. doi:
10.1016/j.atherosclerosis.2014.04.032. [PMID: 24929287] - Bonnie C Shaddinger, Yanmei Xu, James H Roger, Colin H Macphee, Malcolm Handel, Charlotte A Baidoo, Mindy Magee, John J Lepore, Dennis L Sprecher. Platelet aggregation unchanged by lipoprotein-associated phospholipase A₂ inhibition: results from an in vitro study and two randomized phase I trials.
PloS one.
2014; 9(1):e83094. doi:
10.1371/journal.pone.0083094. [PMID: 24475026] - Julie E Davidson, Andrew Lockhart, Leslie Amos, Heide A Stirnadel-Farrant, Vincent Mooser, Marc Sollberger, Axel Regeniter, Andreas U Monsch, Michael C Irizarry. Plasma lipoprotein-associated phospholipase A2 activity in Alzheimer's disease, amnestic mild cognitive impairment, and cognitively healthy elderly subjects: a cross-sectional study.
Alzheimer's research & therapy.
2012; 4(6):51. doi:
10.1186/alzrt154. [PMID: 23217243] - Robert L Wilensky, Colin H Macphee. Lipoprotein-associated phospholipase A(2) and atherosclerosis.
Current opinion in lipidology.
2009 Oct; 20(5):415-20. doi:
10.1097/mol.0b013e3283307c16. [PMID: 19667981] - L W Tjoelker, C Wilder, C Eberhardt, D M Stafforini, G Dietsch, B Schimpf, S Hooper, H Le Trong, L S Cousens, G A Zimmerman, Y Yamada, T M McIntyre, S M Prescott, P W Gray. Anti-inflammatory properties of a platelet-activating factor acetylhydrolase.
Nature.
1995 Apr; 374(6522):549-53. doi:
10.1038/374549a0. [PMID: 7700381]