Iclaprim (BioDeep_00000763380)
代谢物信息卡片
化学式: C19H22N4O3 (354.1691822)
中文名称: 艾拉普林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C2=C(C=CC(O2)C3CC3)C(=C1)CC4=CN=C(N=C4N)N)OC
InChI: InChI=1S/C19H22N4O3/c1-24-15-8-11(7-12-9-22-19(21)23-18(12)20)13-5-6-14(10-3-4-10)26-16(13)17(15)25-2/h5-6,8-10,14H,3-4,7H2,1-2H3,(H4,20,21,22,23)
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01EA - Trimethoprim and derivatives
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:131751
- KEGGdrug: D08337
- PubChem: 213043
- DrugBank: DB06358
- ChEMBL: CHEMBL134561
- CAS: 192314-93-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Stephanie Noviello, David B Huang, G Ralph Corey. Iclaprim: a differentiated option for the treatment of skin and skin structure infections.
Expert review of anti-infective therapy.
2018 11; 16(11):793-803. doi:
10.1080/14787210.2018.1536545
. [PMID: 30317894] - Nimish Patel, David Huang, Thomas Lodise. Potential for Cost Saving with Iclaprim Owing to Avoidance of Vancomycin-Associated Acute Kidney Injury in Hospitalized Patients with Acute Bacterial Skin and Skin Structure Infections.
Clinical drug investigation.
2018 Oct; 38(10):935-943. doi:
10.1007/s40261-018-0686-5
. [PMID: 30105549] - Heike Laue, Tiziana Valensise, Aurélie Seguin, Sergio Lociuro, Khalid Islam, Stephen Hawser. In vitro bactericidal activity of iclaprim in human plasma.
Antimicrobial agents and chemotherapy.
2009 Oct; 53(10):4542-4. doi:
10.1128/aac.00766-09
. [PMID: 19651909] - José M Entenza, Andreas Haldimann, Marlyse Giddey, Sergio Lociuro, Stephen Hawser, Philippe Moreillon. Efficacy of iclaprim against wild-type and thymidine kinase-deficient methicillin-resistant Staphylococcus aureus isolates in an in vitro fibrin clot model.
Antimicrobial agents and chemotherapy.
2009 Sep; 53(9):3635-41. doi:
10.1128/aac.00325-09
. [PMID: 19564362] - H Laue, T Valensise, A Seguin, S Hawser, S Lociuro, K Islam. Effect of human plasma on the antimicrobial activity of iclaprim in vitro.
The Journal of antimicrobial chemotherapy.
2007 Dec; 60(6):1388-90. doi:
10.1093/jac/dkm392
. [PMID: 17951265] - J Andrews, D Honeybourne, J Ashby, G Jevons, A Fraise, P Fry, S Warrington, S Hawser, R Wise. Concentrations in plasma, epithelial lining fluid, alveolar macrophages and bronchial mucosa after a single intravenous dose of 1.6 mg/kg of iclaprim (AR-100) in healthy men.
The Journal of antimicrobial chemotherapy.
2007 Sep; 60(3):677-80. doi:
10.1093/jac/dkm242
. [PMID: 17623694]