Forodesine (BioDeep_00000763334)

   


代谢物信息卡片


Forodesine

化学式: C11H14N4O4 (266.1015004)
中文名称: 7-[(2S,3S,4R,5R)-3,4-二羟基-5-(羟甲基)-2-吡咯烷基]-3,5-二氢-4H-吡咯并[3,2-D]嘧啶-4-酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C2=C(N1)C(=O)NC=N2)C3C(C(C(N3)CO)O)O
InChI: InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1

描述信息

C471 - Enzyme Inhibitor > C2151 - Purine Nucleoside Phosphorylase Inhibitor

同义名列表

1 个代谢物同义名

Forodesine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kumudha Balakrishnan, Farhad Ravandi, Shanta Bantia, Anna Franklin, Varsha Gandhi. Preclinical and clinical evaluation of forodesine in pediatric and adult B-cell acute lymphoblastic leukemia. Clinical lymphoma, myeloma & leukemia. 2013 Aug; 13(4):458-66. doi: 10.1016/j.clml.2013.04.009. [PMID: 23773454]
  • Michinori Ogura, Kunihiro Tsukasaki, Hirokazu Nagai, Toshiki Uchida, Takashi Oyama, Tatsuya Suzuki, Jun Taguchi, Dai Maruyama, Tomomitsu Hotta, Kensei Tobinai. Phase I study of BCX1777 (forodesine) in patients with relapsed or refractory peripheral T/natural killer-cell malignancies. Cancer science. 2012 Jul; 103(7):1290-5. doi: 10.1111/j.1349-7006.2012.02287.x. [PMID: 22448814]
  • Kumudha Balakrishnan, Dushyant Verma, Susan O'Brien, John Michael Kilpatrick, Yuling Chen, Brenita F Tyler, Susan Bickel, Shanta Bantia, Michael J Keating, Hagop Kantarjian, Varsha Gandhi, Farhad Ravandi. Phase 2 and pharmacodynamic study of oral forodesine in patients with advanced, fludarabine-treated chronic lymphocytic leukemia. Blood. 2010 Aug; 116(6):886-92. doi: 10.1182/blood-2010-02-272039. [PMID: 20427701]
  • Aref Al-Kali, Varsha Gandhi, Mohamad Ayoubi, Michael Keating, Farhad Ravandi. Forodesine: review of preclinical and clinical data. Future oncology (London, England). 2010 Aug; 6(8):1211-7. doi: 10.2217/fon.10.83. [PMID: 20799866]
  • Paul M Riegelhaupt, María B Cassera, Richard F G Fröhlich, Keith Z Hazleton, Jonathan J Hefter, Vern L Schramm, Myles H Akabas. Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Molecular and biochemical parasitology. 2010 Jan; 169(1):40-9. doi: 10.1016/j.molbiopara.2009.10.001. [PMID: 19818813]
  • Varsha Gandhi, Kumudha Balakrishnan. Pharmacology and mechanism of action of forodesine, a T-cell targeted agent. Seminars in oncology. 2007 Dec; 34(6 Suppl 5):S8-12. doi: 10.1053/j.seminoncol.2007.11.003. [PMID: 18086347]
  • Anna Korycka, Jerzy Z Błoński, Tadeusz Robak. Forodesine (BCX-1777, Immucillin H)--a new purine nucleoside analogue: mechanism of action and potential clinical application. Mini reviews in medicinal chemistry. 2007 Sep; 7(9):976-83. doi: 10.2174/138955707781662636. [PMID: 17897085]
  • Farhad Ravandi, Varsha Gandhi. Novel purine nucleoside analogues for T-cell-lineage acute lymphoblastic leukaemia and lymphoma. Expert opinion on investigational drugs. 2006 Dec; 15(12):1601-13. doi: 10.1517/13543784.15.12.1601. [PMID: 17107284]
  • Carlos M Galmarini. Drug evaluation: forodesine - PNP inhibitor for the treatment of leukemia, lymphoma and solid tumor. IDrugs : the investigational drugs journal. 2006 Oct; 9(10):712-22. doi: . [PMID: 17016779]
  • Varsha Gandhi, John M Kilpatrick, William Plunkett, Mary Ayres, Leigh Harman, Min Du, Shanta Bantia, Jan Davisson, William G Wierda, Stefan Faderl, Hagop Kantarjian, Deborah Thomas. A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine). Blood. 2005 Dec; 106(13):4253-60. doi: 10.1182/blood-2005-03-1309. [PMID: 16131572]
  • J Michael Kilpatrick, Philip E Morris, David G Serota, Deborah Phillips, D Ray Moore, J Claude Bennett, Y S Babu. Intravenous and oral pharmacokinetic study of BCX-1777, a novel purine nucleoside phosphorylase transition-state inhibitor. In vivo effects on blood 2'-deoxyguanosine in primates. International immunopharmacology. 2003 Apr; 3(4):541-8. doi: 10.1016/s1567-5769(03)00044-4. [PMID: 12689658]