Selinexor (BioDeep_00000763050)
代谢物信息卡片
Selinexor
化学式: C17H11F6N7O (443.0929228)
中文名称: Selinexor
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=C(C=N1)NNC(=O)C=CN2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
InChI: InChI=1S/C17H11F6N7O/c18-16(19,20)11-5-10(6-12(7-11)17(21,22)23)15-26-9-30(29-15)4-1-14(31)28-27-13-8-24-2-3-25-13/h1-9H,(H,25,27)(H,28,31)/b4-1-
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials, Guide to PHARMACOLOGY
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D11222
- PubChem: 71481097
- DrugBank: DB11942
- ChEMBL: CHEMBL3545185
- CAS: 1393477-72-9
- CAS: 1621865-82-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Di Wang, Haiying Fu, Yimei Que, Haitao Ruan, Menglei Xu, Xiaolu Long, Qiuxia Yu, Chunhui Li, Zhe Li, Songbai Cai, Wei Chen, Cong Sun, Guang Hu, Shuai Wang, Donggou He, Jianming Mei, Wen Wang, Chunrui Li. A novel two-step administration of XPO-1 inhibitor may enhance the effect of anti-BCMA CAR-T in relapsed/refractory extramedullary multiple myeloma.
Journal of translational medicine.
2023 11; 21(1):812. doi:
10.1186/s12967-023-04655-w. [PMID: 37964302] - Lunan Jian, Robert Zscherp, Ulrike Beutling, Xiaofei Shen, Shiyang Xu, Xia Zhang, Mark Brönstrup, Philipp Klahn, Qingxiang Sun. Discovery of Aminoratjadone Derivatives as Potent Noncovalent CRM1 Inhibitors.
Journal of medicinal chemistry.
2023 Aug; ?(?):. doi:
10.1021/acs.jmedchem.3c00549. [PMID: 37595020] - Xin-Yu Tang, Yan Wang, Rui-Rong Xu. [The Latest Research Progress of Selinexor in the Treatment of Non-Hodgkin Lymphoma --Review].
Zhongguo shi yan xue ye xue za zhi.
2023 Feb; 31(1):292-296. doi:
10.19746/j.cnki.issn.1009-2137.2023.01.046. [PMID: 36765514] - Michael Cass, Andrew B McDonald, Osnat Ben-Shahar, Yosef Landesman, Trinayan Kashyap. A Case Report of a 58-Year-Old Woman with a Diagnosis of High-Risk Myeloma Refractory to Multiple Line of Therapy and Treated with Selinexor, Bortezomib, and Dexamethasone Prior to Allogeneic Stem Cell Transplantation.
The American journal of case reports.
2022 Apr; 23(?):e935353. doi:
10.12659/ajcr.935353. [PMID: 35444159] - Sosana Delimpasi, Maria Victoria Mateos, Holger W Auner, Maria Gavriatopoulou, Meletios A Dimopoulos, Hang Quach, Halyna Pylypenko, Roman Hájek, Xavier Leleu, Tuphan Kanti Dolai, Dinesh Kumar Sinha, Christopher P Venner, Reuben Benjamin, Mamta Krishnan Garg, Vadim Doronin, Yair Levy, Philippe Moreau, Yi Chai, Melina Arazy, Jatin Shah, Sharon Shacham, Michael G Kauffman, Paul G Richardson, Sebastian Grosicki. Efficacy and tolerability of once-weekly selinexor, bortezomib, and dexamethasone in comparison with standard twice-weekly bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the BOSTON study.
American journal of hematology.
2022 03; 97(3):E83-E86. doi:
10.1002/ajh.26434. [PMID: 34882831] - Liming Yu, Xuewei Yin, Yuping Si, Yan Wang, Jingyi Wang, Siyuan Cui. Efficacy and safety of selinexor in the treatment of AML: A protocol for systematic review and meta-analysis.
Medicine.
2021 Dec; 100(49):e27884. doi:
10.1097/md.0000000000027884. [PMID: 34889237] - Chrystina Castellon, Yashvin Onkarappa Mangala, Audrik Perez Rodriguez, Raymond Chaquette, Kapil S Meleveedu. First case report of tumor lysis syndrome and acute renal failure after selinexor use in multiple myeloma.
Leukemia & lymphoma.
2021 12; 62(14):3536-3539. doi:
10.1080/10428194.2021.1961230. [PMID: 34369242] - Merve Yuce, Erdem Cicek, Tugce Inan, Aslihan Basak Dag, Ozge Kurkcuoglu, Fethiye Aylin Sungur. Repurposing of FDA-approved drugs against active site and potential allosteric drug-binding sites of COVID-19 main protease.
Proteins.
2021 11; 89(11):1425-1441. doi:
10.1002/prot.26164. [PMID: 34169568] - Trinayan Kashyap, Jackelyn Murray, Christopher J Walker, Hua Chang, Sharon Tamir, Bing Hou, Sharon Shacham, Michael G Kauffman, Ralph A Tripp, Yosef Landesman. Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo.
Antiviral research.
2021 08; 192(?):105115. doi:
10.1016/j.antiviral.2021.105115. [PMID: 34157321] - Max Sauter, Kathrin I Foerster, Julia Benzel, Stefan Pfister, Kristian W Pajtler, Walter E Haefeli, Jürgen Burhenne. Bioanalysis of selinexor in mouse plasma micro-samples utilizing UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Jun; 1176(?):122781. doi:
10.1016/j.jchromb.2021.122781. [PMID: 34051651] - Yuqin Lei, Yuling Li, Yuping Tan, Zhiyong Qian, Qiao Zhou, Da Jia, Qingxiang Sun. Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
Journal of natural products.
2021 05; 84(5):1478-1488. doi:
10.1021/acs.jnatprod.0c01231. [PMID: 33890470] - Chen-Jian Zhou, Hui-Jun Wang, Chun-Yan Zhou, Chao-Fan Li, Ming-Jia Zhu, Xiang-Jun Qiu. Establishment and Verification of UPLC-MS/MS Technique for Pharmacokinetic Drug-Drug Interactions of Selinexor with Posaconazole in Rats.
Drug design, development and therapy.
2021; 15(?):1561-1568. doi:
10.2147/dddt.s303928. [PMID: 33883879] - Ashish Goyal, E Fabian Cardozo-Ojeda, Joshua T Schiffer. Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response.
Science advances.
2020 11; 6(47):. doi:
10.1126/sciadv.abc7112. [PMID: 33097472] - Jaya Kala, Omar Mamlouk, Kenar D Jhaveri. Selinexor-associated hyponatremia: single-center, real-world data.
Kidney international.
2020 09; 98(3):789-791. doi:
10.1016/j.kint.2020.06.007. [PMID: 32828243] - Tim J Peterson, Jennifer Orozco, Michael Buege. Selinexor: A First-in-Class Nuclear Export Inhibitor for Management of Multiply Relapsed Multiple Myeloma.
The Annals of pharmacotherapy.
2020 06; 54(6):577-582. doi:
10.1177/1060028019892643. [PMID: 31793336] - Cecilia Bonolo de Campos, Nathalie Meurice, Joachim L Petit, Alysia N Polito, Yuan Xiao Zhu, Panwen Wang, Laura A Bruins, Xuewei Wang, Ilsel D Lopez Armenta, Susie A Darvish, Greg J Ahmann, Kimberly J Henderson, Shulan Tian, Jonas J Kruse, William M Stewart, Jeremy T Larsen, Craig B Reeder, David Dingli, Prashant Kapoor, Shaji K Kumar, Rafael Fonseca, P Leif Bergsagel, Esteban Braggio, A Keith Stewart. 'Direct to Drug' screening as a precision medicine tool in multiple myeloma.
Blood cancer journal.
2020 05; 10(5):54. doi:
10.1038/s41408-020-0320-7. [PMID: 32393731] - Ujjawal H Gandhi, William Senapedis, Erkan Baloglu, Thaddeus J Unger, Ajai Chari, Dan Vogl, Robert F Cornell. Clinical Implications of Targeting XPO1-mediated Nuclear Export in Multiple Myeloma.
Clinical lymphoma, myeloma & leukemia.
2018 05; 18(5):335-345. doi:
10.1016/j.clml.2018.03.003. [PMID: 29610030] - Thomas B Alexander, Norman J Lacayo, John K Choi, Raul C Ribeiro, Ching-Hon Pui, Jeffrey E Rubnitz. Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2016 12; 34(34):4094-4101. doi:
10.1200/jco.2016.67.5066. [PMID: 27507877] - Shaun Rosebeck, Mattina M Alonge, Malathi Kandarpa, Anoop Mayampurath, Samuel L Volchenboum, Jagoda Jasielec, Dominik Dytfeld, Sean P Maxwell, Stephanie J Kraftson, Dilara McCauley, Sharon Shacham, Michael Kauffman, Andrzej J Jakubowiak. Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor.
Molecular cancer therapeutics.
2016 Jan; 15(1):60-71. doi:
10.1158/1535-7163.mct-15-0488. [PMID: 26637366] - Matthew Tan, Hiromi I Wettersten, Kristy Chu, David L Huso, Terry Watnick, Sharon Friedlander, Yosef Landesman, Robert H Weiss. Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.
American journal of physiology. Renal physiology.
2014 Dec; 307(11):F1179-86. doi:
10.1152/ajprenal.00406.2014. [PMID: 25234309] - Hiromi I Wettersten, Yosef Landesman, Sharon Friedlander, Sharon Shacham, Michael Kauffman, Robert H Weiss. Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth.
PloS one.
2014; 9(12):e113867. doi:
10.1371/journal.pone.0113867. [PMID: 25461627] - . .
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