R-1479 (BioDeep_00000760374)

   


代谢物信息卡片


4-Azidocytidine

化学式: C9H12N6O5 (284.0869142)
中文名称: 盐酸茚罗西生
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O
InChI: InChI=1S/C9H12N6O5/c10-4-1-2-15(8(19)12-4)7-5(17)6(18)9(3-16,20-7)13-14-11/h1-2,5-7,16-18H,3H2,(H2,10,12,19)/t5-,6+,7-,9-/m1/s1

描述信息

R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM)[1][2][3]. R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

同义名列表

3 个代谢物同义名

4-Azidocytidine; R-1479; 4'-Azidocytidine



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Youmei Peng, Tiefeng Cheng, Lihong Dong, Yuhai Zhang, Xiaojing Chen, Jinhua Jiang, Jingmin Zhang, Xiaohe Guo, Mintong Guo, Junbiao Chang, Qingduan Wang. Quantification of 2'-deoxy-2'-β-fluoro-4'-azidocytidine in rat and dog plasma using liquid chromatography-quadrupole time-of-flight and liquid chromatography-triple quadrupole mass spectrometry: Application to bioavailability and pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2014 Sep; 98(?):379-86. doi: 10.1016/j.jpba.2014.06.019. [PMID: 24999865]
  • Yen-Liang Chen, Nahdiyah Abdul Ghafar, Ratna Karuna, Yilong Fu, Siew Pheng Lim, Wouter Schul, Feng Gu, Maxime Herve, Fumiaki Yokohama, Gang Wang, Daniela Cerny, Katja Fink, Francesca Blasco, Pei-Yong Shi. Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir. Journal of virology. 2014 Feb; 88(3):1740-7. doi: 10.1128/jvi.02841-13. [PMID: 24257621]
  • Lotte Coelmont, Suzanne Kaptein, Jan Paeshuyse, Inge Vliegen, Jean-Maurice Dumont, Grégoire Vuagniaux, Johan Neyts. Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors. Antimicrobial agents and chemotherapy. 2009 Mar; 53(3):967-76. doi: 10.1128/aac.00939-08. [PMID: 19104013]
  • Klaus Klumpp, Genadiy Kalayanov, Han Ma, Sophie Le Pogam, Vincent Leveque, Wen-Rong Jiang, Nicole Inocencio, Anniek De Witte, Sonal Rajyaguru, Ezra Tai, Sushmita Chanda, Michael R Irwin, Christian Sund, Anna Winqist, Tatiana Maltseva, Staffan Eriksson, Elena Usova, Mark Smith, Andre Alker, Isabel Najera, Nick Cammack, Joseph A Martin, Nils Gunnar Johansson, David B Smith. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. The Journal of biological chemistry. 2008 Jan; 283(4):2167-75. doi: 10.1074/jbc.m708929200. [PMID: 18003608]