Mikamycin (BioDeep_00000759414)

   

Chemicals and Drugs Antibiotics


代谢物信息卡片


Virginiamycin

化学式: C71H84N10O17 (1348.6015614)
中文名称: 弗吉尼亚霉素复合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C.CC1C=CC(=O)NCC=CC(=CC(CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)OC1C(C)C)O)C
InChI: InChI=1S/C43H49N7O10.C28H35N3O7/c1-4-29-40(56)49-21-12-17-30(49)41(57)48(3)32(23-26-13-7-5-8-14-26)42(58)50-22-19-28(51)24-31(50)37(53)47-35(27-15-9-6-10-16-27)43(59)60-25(2)34(38(54)45-29)46-39(55)36-33(52)18-11-20-44-36

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FG - Streptogramins
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06A - Antibiotics for topical use
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D025361 - Streptogramins
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors

同义名列表

2 个代谢物同义名

Virginiamycin; Mikamycin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rudramani Pokhrel, Prem Chapagain, Jessica Siltberg-Liberles. Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2. Journal of medical microbiology. 2020 Jun; 69(6):864-873. doi: 10.1099/jmm.0.001203. [PMID: 32469301]
  • Yan Chen, Jun Wang, Longfei Yu, Tianyue Xu, Nianhua Zhu. Microbiota and metabolome responses in the cecum and serum of broiler chickens fed with plant essential oils or virginiamycin. Scientific reports. 2020 03; 10(1):5382. doi: 10.1038/s41598-020-60135-x. [PMID: 32214106]
  • Marcelina Pereira da Fonseca, Ana Luiza da Costa Cruz Borges, Pedro Henrique de Araujo Carvalho, Ricardo Reis E Silva, Lúcio Carlos Gonçãlves, Iran Borges, Helena Ferreira Lage, Alexandre Lima Ferreira, Eloísa Oliveira Simões Saliba, Diogo Gonzaga Jayme, Joana Ribeiro da Glória, Décio Souza Graça, Rodrigo Melo Meneses, Antônio Último de Carvalho, Elias Jorge Facury Filho, Arthur Alves Silva. Energy partitioning in cattle fed diets based on tropical forage with the inclusion of antibiotic additives. PloS one. 2019; 14(4):e0211565. doi: 10.1371/journal.pone.0211565. [PMID: 31009472]
  • João Paulo R Costa, Raphael B De Jesus, Ivanna M Oliveira, Flávio D Resende, Gustavo R Siqueira, Euclides B Malheiros. Does virginiamycin supplementation affect the metabolism and performance of Nellore bulls grazing under low and high gain rates?. Animal science journal = Nihon chikusan Gakkaiho. 2018 Oct; 89(10):1432-1441. doi: 10.1111/asj.13052. [PMID: 30066980]
  • Qian-Qian Tong, Yue-Hui Zhou, Xiang-Song Chen, Jin-Yong Wu, Ping Wei, Li-Xia Yuan, Jian-Ming Yao. Genome shuffling and ribosome engineering of Streptomyces virginiae for improved virginiamycin production. Bioprocess and biosystems engineering. 2018 May; 41(5):729-738. doi: 10.1007/s00449-018-1906-3. [PMID: 29457193]
  • José Antonio Bessegatto, Laís Resende Paulino, Júlio Augusto Naylor Lisbôa, Amauri Alcindo Alfieri, Carlos Henrique Montemor, Leonardo Pinto Medeiros, Renata Katsuko Takayama Kobayashi, J Scott Weese, Marcio Carvalho Costa. Changes in the fecal microbiota of beef cattle caused by change in management and the use of virginiamycin as a growth promoter. Research in veterinary science. 2017 Oct; 114(?):355-362. doi: 10.1016/j.rvsc.2017.06.011. [PMID: 28675873]
  • Ali Naghi Shokri, Hossein A Ghasemi, Kamran Taherpour. Evaluation of Aloe vera and synbiotic as antibiotic growth promoter substitutions on performance, gut morphology, immune responses and blood constitutes of broiler chickens. Animal science journal = Nihon chikusan Gakkaiho. 2017 Feb; 88(2):306-313. doi: 10.1111/asj.12629. [PMID: 27255566]
  • Kenneth M Bischoff, Yanhong Zhang, Joseph O Rich. Fate of virginiamycin through the fuel ethanol production process. World journal of microbiology & biotechnology. 2016 May; 32(5):76. doi: 10.1007/s11274-016-2026-3. [PMID: 27038946]
  • Fahimeh Alipour, Ahmad Hassanabadi, Abolghasem Golian, Hassan Nassiri-Moghaddam. Effect of plant extracts derived from thyme on male broiler performance. Poultry science. 2015 Nov; 94(11):2630-4. doi: 10.3382/ps/pev220. [PMID: 26362978]
  • Farhad Rostami, Hossein A Ghasemi, Kamran Taherpour. Effect of Scrophularia striata and Ferulago angulata, as alternatives to virginiamycin, on growth performance, intestinal microbial population, immune response, and blood constituents of broiler chickens. Poultry science. 2015 Sep; 94(9):2202-9. doi: 10.3382/ps/pev198. [PMID: 26217029]
  • K G Samuel, H J Zhang, J Wang, S G Wu, H Y Yue, L L Sun, G H Qi. Effects of dietary pyrroloquinoline quinone disodium on growth performance, carcass yield and antioxidant status of broiler chicks. Animal : an international journal of animal bioscience. 2015 Mar; 9(3):409-16. doi: 10.1017/s1751731114002328. [PMID: 25229409]
  • Y D Jang, M D Lindemann, J H Agudelo-Trujillo, C S Escobar, B J Kerr, N Inocencio, G L Cromwell. Comparison of direct and indirect estimates of apparent total tract digestibility in swine with effort to reduce variation by pooling of multiple day fecal samples. Journal of animal science. 2014 Oct; 92(10):4566-76. doi: 10.2527/jas.2013-6570. [PMID: 25184842]
  • Cemil Kurekci, Rafat Al Jassim, Errol Hassan, Sharon L Bishop-Hurley, Jagadish Padmanabha, Christopher S McSweeney. Effects of feeding plant-derived agents on the colonization of Campylobacter jejuni in broiler chickens. Poultry science. 2014 Sep; 93(9):2337-46. doi: 10.3382/ps.2014-03950. [PMID: 25002548]
  • Colin A Murphree, E Patrick Heist, Luke A Moe. Antibiotic resistance among cultured bacterial isolates from bioethanol fermentation facilities across the United States. Current microbiology. 2014 Sep; 69(3):277-85. doi: 10.1007/s00284-014-0583-y. [PMID: 24748439]
  • T S Edrington, K M Bischoff, G H Loneragan, D J Nisbet. Evaluation of feeding distiller's grains, containing virginiamycin, on antimicrobial susceptibilities in fecal isolates of Enterococcus and Escherichia coli and prevalence of resistance genes in cattle. Journal of animal science. 2014 Mar; 92(3):1144-9. doi: 10.2527/jas.2013-6954. [PMID: 24492576]
  • H M Golder, P Celi, A R Rabiee, I J Lean. Effects of feed additives on rumen and blood profiles during a starch and fructose challenge. Journal of dairy science. 2014 Feb; 97(2):985-1004. doi: 10.3168/jds.2013-7166. [PMID: 24210482]
  • H M Salim, H K Kang, N Akter, D W Kim, J H Kim, M J Kim, J C Na, H B Jong, H C Choi, O S Suh, W K Kim. Supplementation of direct-fed microbials as an alternative to antibiotic on growth performance, immune response, cecal microbial population, and ileal morphology of broiler chickens. Poultry science. 2013 Aug; 92(8):2084-90. doi: 10.3382/ps.2012-02947. [PMID: 23873556]
  • Salih Cesur, Hasan Irmak, Hüsniye Simşek, Nilay Cöplü, Hasan Kılıç, Uğur Arslan, Gülçin Bayramoğlu, Betil Ozhak Baysan, Zeynep Gülay, Salih Hoşoğlu, Mustafa Berktaş, Serap Gencer, Ali Pekcan Demiröz, Berrin Esen, Nihal Karabiber, Faruk Aydın, Ata Nevzat Yalçın. [Evaluation of antibiotic susceptibilities and VISA-VRSA rates among MRSA strains isolated from hospitalized patients in intensive care units of hospitals in seven provinces of Turkey]. Mikrobiyoloji bulteni. 2012 Jul; 46(3):352-8. doi: NULL. [PMID: 22951647]
  • N J Menzies-Gow, N J Young. Antibiotic resistance in faecal bacteria isolated from horses receiving virginiamycin for the prevention of pasture-associated laminitis. Veterinary microbiology. 2011 Sep; 152(3-4):424-8. doi: 10.1016/j.vetmic.2011.05.026. [PMID: 21676560]
  • M Kalmokoff, L M Waddington, M Thomas, K-L Liang, C Ma, E Topp, U Desranleau Dandurand, A Letellier, F Matias, S P J Brooks. Continuous feeding of antimicrobial growth promoters to commercial swine during the growing/finishing phase does not modify faecal community erythromycin resistance or community structure. Journal of applied microbiology. 2011 Jun; 110(6):1414-25. doi: 10.1111/j.1365-2672.2011.04992.x. [PMID: 21395944]
  • Joseph O Rich, Timothy D Leathers, Melinda S Nunnally, Kenneth M Bischoff. Rapid evaluation of the antibiotic susceptibility of fuel ethanol contaminant biofilms. Bioresource technology. 2011 Jan; 102(2):1124-30. doi: 10.1016/j.biortech.2010.08.118. [PMID: 20855199]
  • Kimberly D Leuthner, Celine Vidaillac, Chrissy M Cheung, Michael J Rybak. In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates. Antimicrobial agents and chemotherapy. 2010 Sep; 54(9):3799-803. doi: 10.1128/aac.00452-10. [PMID: 20585126]
  • Mueen Aslam, Moussa S Diarra, Cara Service, Heidi Rempel. Characterization of antimicrobial resistance in Enterococcus spp. recovered from a commercial beef processing plant. Foodborne pathogens and disease. 2010 Mar; 7(3):235-41. doi: 10.1089/fpd.2009.0380. [PMID: 19911933]
  • Joe Boison, Stephen Lee, Ron Gedir. Analytical determination of virginiamycin drug residues in edible porcine tissues by LC-MS with confirmation by LC-MS/MS. Journal of AOAC International. 2009 Jan; 92(1):329-39. doi: 10.1093/jaoac/92.1.329. [PMID: 19382591]
  • L Drago, L Nicola, E De Vecchi. A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2008 Jun; 14(6):608-11. doi: 10.1111/j.1469-0691.2008.01993.x. [PMID: 18397336]
  • Teresita Mazzei, Andrea Novelli. [Pharmacological rationale for choice of antibiotics for intraabdominal infections]. Le infezioni in medicina. 2008 Feb; 16 Suppl 1(?):31-45. doi: NULL. [PMID: 18382149]
  • Kenneth M Bischoff, Kelly A Skinner-Nemec, Timothy D Leathers. Antimicrobial susceptibility of Lactobacillus species isolated from commercial ethanol plants. Journal of industrial microbiology & biotechnology. 2007 Nov; 34(11):739-44. doi: 10.1007/s10295-007-0250-4. [PMID: 17726620]
  • A Chaudhury, A G Kumar. In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus. Indian journal of medical microbiology. 2007 Jan; 25(1):50-2. doi: 10.4103/0255-0857.31062. [PMID: 17377353]
  • Amy L Kieke, Mark A Borchardt, Burney A Kieke, Susan K Spencer, Mary F Vandermause, Kirk E Smith, Selina L Jawahir, Edward A Belongia. Use of streptogramin growth promoters in poultry and isolation of streptogramin-resistant Enterococcus faecium from humans. The Journal of infectious diseases. 2006 Nov; 194(9):1200-8. doi: 10.1086/508189. [PMID: 17041845]
  • Thomas G Fraser, Christine Hansen, Jennifer K Long. Newer antibiotics for serious gram-positive infections. Cleveland Clinic journal of medicine. 2006 Sep; 73(9):847-53. doi: 10.3949/ccjm.73.9.847. [PMID: 16970136]
  • David T Bearden. Clinical pharmacokinetics of quinupristin/dalfopristin. Clinical pharmacokinetics. 2004; 43(4):239-52. doi: 10.2165/00003088-200443040-00003. [PMID: 15005638]
  • Susan Donabedian, Lee Ann Thal, Pamela Bozigar, Thomas Zervos, Ellie Hershberger, Marcus Zervos. Antimicrobial resistance in swine and chickens fed virginiamycin for growth promotion. Journal of microbiological methods. 2003 Dec; 55(3):739-43. doi: 10.1016/j.mimet.2003.07.002. [PMID: 14607416]
  • Robert L Thompson, Bruce Lavin, George H Talbot. Endocarditis due to vancomycin-resistant Enterococcus faecium in an immunocompromised patient: cure by administering combination therapy with quinupristin/dalfopristin and high-dose ampicillin. Southern medical journal. 2003 Aug; 96(8):818-20. doi: 10.1097/01.smj.0000047962.61701.57. [PMID: 14515928]
  • S R Bailey, A Rycroft, J Elliott. Production of amines in equine cecal contents in an in vitro model of carbohydrate overload. Journal of animal science. 2002 Oct; 80(10):2656-62. doi: 10.2527/2002.80102656x. [PMID: 12413088]
  • V Schwenger, E Mündlein, E E Dagrosa, A M Fahr, M Zeier, G Mikus, K Andrassy. Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report. Infection. 2002 Oct; 30(5):257-61. doi: 10.1007/s15010-002-2076-3. [PMID: 12382082]
  • G M Eliopoulos, C B Wennersten. Antimicrobial activity of quinupristin-dalfopristin combined with other antibiotics against vancomycin-resistant enterococci. Antimicrobial agents and chemotherapy. 2002 May; 46(5):1319-24. doi: 10.1128/aac.46.5.1319-1324.2002. [PMID: 11959562]
  • Gert Jan Timmers, Wil C van der Zwet, Ina M Simoons-Smit, Paul H M Savelkoul, Helena H M Meester, Christina M J E Vandenbroucke-Grauls, Peter C Huijgens. Outbreak of vancomycin-resistant Enterococcus faecium in a haematology unit: risk factor assessment and successful control of the epidemic. British journal of haematology. 2002 Mar; 116(4):826-33. doi: 10.1046/j.0007-1048.2002.03339.x. [PMID: 11886387]
  • Dan Ferber. Antibiotic resistance. Livestock feed ban preserves drugs' power. Science (New York, N.Y.). 2002 Jan; 295(5552):27-8. doi: 10.1126/science.295.5552.27a. [PMID: 11778017]
  • A Scanvic-Hameg, E Chachaty, J Rey, C Pousson, M L Ozoux, E Brunel, A Andremont. Impact of quinupristin/dalfopristin (RP59500) on the faecal microflora in healthy volunteers. The Journal of antimicrobial chemotherapy. 2002 Jan; 49(1):135-9. doi: 10.1093/jac/49.1.135. [PMID: 11751777]
  • M K Kim, M A Banevicius, M Zhong, X Shi, M Hu, C H Nightingale, D P Nicolau. Clearance of quinupristin-dalfopristin (Synercid) and their main metabolites during continuous veno-venous hemofiltration (CVVH) with or without dialysis. The International journal of artificial organs. 2002 Jan; 25(1):33-9. doi: 10.1177/039139880202500106. [PMID: 11853069]
  • S W Joseph, J R Hayes, L L English, L E Carr, D D Wagner. Implications of multiple antimicrobial-resistant enterococci associated with the poultry environment. Food additives and contaminants. 2001 Dec; 18(12):1118-23. doi: 10.1080/02652030110051275. [PMID: 11761123]
  • P D Walzer, A Ashbaugh, M Collins, M T Cushion. In vitro and in vivo effects of quinupristin-dalfopristin against Pneumocystis carinii. Antimicrobial agents and chemotherapy. 2001 Nov; 45(11):3234-7. doi: 10.1128/aac.45.11.3234-3237.2001. [PMID: 11600389]
  • T L Sørensen, M Blom, D L Monnet, N Frimodt-Møller, R L Poulsen, F Espersen. Transient intestinal carriage after ingestion of antibiotic-resistant Enterococcus faecium from chicken and pork. The New England journal of medicine. 2001 Oct; 345(16):1161-6. doi: 10.1056/nejmoa010692. [PMID: 11642232]
  • L C McDonald, S Rossiter, C Mackinson, Y Y Wang, S Johnson, M Sullivan, R Sokolow, E DeBess, L Gilbert, J A Benson, B Hill, F J Angulo. Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens. The New England journal of medicine. 2001 Oct; 345(16):1155-60. doi: 10.1056/nejmoa010805. [PMID: 11642231]
  • A D Frey, M Rimann, J E Bailey, P T Kallio, C J Thompson, M Fussenegger. Novel pristinamycin-responsive expression systems for plant cells. Biotechnology and bioengineering. 2001 Jul; 74(2):154-63. doi: 10.1002/bit.1105. [PMID: 11370004]
  • F M Aarestrup, A M Seyfarth, H D Emborg, K Pedersen, R S Hendriksen, F Bager. Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark. Antimicrobial agents and chemotherapy. 2001 Jul; 45(7):2054-9. doi: 10.1128/aac.45.7.2054-2059.2001. [PMID: 11408222]
  • P K Linden, F Bompart, S Gray, G H Talbot. Hyperbilirubinemia during quinupristin-dalfopristin therapy in liver transplant recipients: correlation with available liver biopsy results. Pharmacotherapy. 2001 Jun; 21(6):661-8. doi: 10.1592/phco.21.7.661.34580. [PMID: 11401179]
  • F López Fornas, F Martínez García, J Pérez Salmeron, D Roldán Conesa, R Cortés Sanchez, A García Alberola, J Ruíz Gómez, J Gómez Gómez, M Valdés Chávarri. Comparative study of treatment with penicillin, ceftriaxone, trovafloxacin, quinupristin-dalfopristin and vancomycin in experimental endocarditis due to penicillin- and ceftriaxone-resistant Streptococcus pneumoniae. The Journal of antimicrobial chemotherapy. 2001 May; 47(5):623-9. doi: 10.1093/jac/47.5.623. [PMID: 11328774]
  • P Chevalier, J Rey, O Pasquier, R Rouzier-Panis, N Harding, G Montay. Multiple-dose pharmacokinetics and safety of two regimens of quinupristin/dalfopristin (Synercid) in healthy volunteers. Journal of clinical pharmacology. 2001 Apr; 41(4):404-14. doi: 10.1177/00912700122010267. [PMID: 11304897]
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  • R W Duh, K V Singh, K Malathum, B E Murray. In vitro activity of 19 antimicrobial agents against enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification. Microbial drug resistance (Larchmont, N.Y.). 2001; 7(1):39-46. doi: 10.1089/107662901750152765. [PMID: 11310802]
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  • C A Johnson, C A Taylor, S W Zimmerman, W E Bridson, P Chevalier, O Pasquier, R I Baybutt. Pharmacokinetics of quinupristin-dalfopristin in continuous ambulatory peritoneal dialysis patients. Antimicrobial agents and chemotherapy. 1999 Jan; 43(1):152-6. doi: 10.1128/aac.43.1.152. [PMID: 9869581]
  • L Waldenstedt, A Lundén, K Elwinger, P Thebo, A Uggla. Comparison between a live, attenuated anticoccidial vaccine and an anticoccidial ionophore, on performance of broilers raised with or without a growth promoter, in an initially Eimeria-free environment. Acta veterinaria Scandinavica. 1999; 40(1):11-21. doi: 10.1186/bf03547037. [PMID: 10418192]
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