Calpain Inhibitor III (BioDeep_00000759408)

   


代谢物信息卡片


Calpain Inhibitor III

化学式: C22H26N2O4 (382.18924760000004)
中文名称: 钙蛋白酶抑制剂III
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
InChI: InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors

同义名列表

1 个代谢物同义名

Calpain Inhibitor III



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ying-Da Chen, Po-Yuan Huang, Chien-Sung Chiang, Yi-Shuian Huang, Sung-Chun Tang. Generation and Role of Calpain-Cleaved 17-kDa Tau Fragment in Acute Ischemic Stroke. Molecular neurobiology. 2021 Nov; 58(11):5814-5825. doi: 10.1007/s12035-021-02519-2. [PMID: 34414533]
  • Vítor Ennes-Vidal, Bianca da Silva Vitório, Rubem Figueiredo Sadok Menna-Barreto, André Nóbrega Pitaluga, Silvia Amaral Gonçalves-da-Silva, Marta Helena Branquinha, André Luis Souza Santos, Claudia Masini d'Avila-Levy. Calpains of Leishmania braziliensis: genome analysis, differential expression, and functional analysis. Memorias do Instituto Oswaldo Cruz. 2019; 114(?):e190147. doi: 10.1590/0074-02760190147. [PMID: 31553371]
  • Dimitrios Giakoumettis, Chryssa Pourzitaki, Theofanis Vavilis, Anastasia Tsingotjidou, Anastasia Kyriakoudi, Maria Tsimidou, Marina Boziki, Antonia Sioga, Nikolaos Foroglou, Aristeidis Kritis. Crocus sativus L. Causes a Non Apoptotic Calpain Dependent Death in C6 Rat Glioma Cells, Exhibiting a Synergistic Effect with Temozolomide. Nutrition and cancer. 2019; 71(3):491-507. doi: 10.1080/01635581.2018.1506493. [PMID: 30273051]
  • J S Pierre, D Giblot-Ducray, A C McKay, D M Hartley, J M Perroux, A L Rae. DNA based diagnostic for the quantification of sugarcane root DNA in the field. Scientific reports. 2018 11; 8(1):16720. doi: 10.1038/s41598-018-34844-3. [PMID: 30425256]
  • Cécile Brocard, Vanessa Plantier, Pascale Boulenguez, Sylvie Liabeuf, Mouloud Bouhadfane, Annelise Viallat-Lieutaud, Laurent Vinay, Frédéric Brocard. Cleavage of Na(+) channels by calpain increases persistent Na(+) current and promotes spasticity after spinal cord injury. Nature medicine. 2016 Apr; 22(4):404-11. doi: 10.1038/nm.4061. [PMID: 26974309]
  • Shivsharan B Kharatmal, Jitendra N Singh, Shyam S Sharma. Calpain inhibitor, MDL 28170 confer electrophysiological, nociceptive and biochemical improvement in diabetic neuropathy. Neuropharmacology. 2015 Oct; 97(?):113-21. doi: 10.1016/j.neuropharm.2015.05.040. [PMID: 26087461]
  • Mounira Krifa, Antonio Pizzi, Marc Mousli, Leila Chekir-Ghedira, Ludovic Leloup, Kamel Ghedira. Limoniastrum guyonianum aqueous gall extract induces apoptosis in colorectal cancer cells by inhibiting calpain activity. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2014 Aug; 35(8):7877-85. doi: 10.1007/s13277-014-1993-y. [PMID: 24828012]
  • Fernanda A Marinho, Keyla C S Gonçalves, Simone S C Oliveira, Diego S Gonçalves, Filipe P Matteoli, Sergio H Seabra, Ana Carolina S Oliveira, Maria Bellio, Selma S Oliveira, Thaïs Souto-Padrón, Claudia M d'Avila-Levy, André L S Santos, Marta H Branquinha. The calpain inhibitor MDL28170 induces the expression of apoptotic markers in Leishmania amazonensis promastigotes. PloS one. 2014; 9(1):e87659. doi: 10.1371/journal.pone.0087659. [PMID: 24498160]
  • Eduard Sarró, Conxita Jacobs-Cachá, Emilio Itarte, Anna Meseguer. A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. Toxicology and applied pharmacology. 2012 Jan; 258(2):275-87. doi: 10.1016/j.taap.2011.11.007. [PMID: 22155090]
  • Vítor Ennes-Vidal, Rubem F S Menna-Barreto, André L S Santos, Marta H Branquinha, Claudia M d'Avila-Levy. MDL28170, a calpain inhibitor, affects Trypanosoma cruzi metacyclogenesis, ultrastructure and attachment to Rhodnius prolixus midgut. PloS one. 2011 Apr; 6(4):e18371. doi: 10.1371/journal.pone.0018371. [PMID: 21483751]
  • Caitlin E Hill, Yelena Guller, Scott J Raffa, Andres Hurtado, Mary Bartlett Bunge. A calpain inhibitor enhances the survival of Schwann cells in vitro and after transplantation into the injured spinal cord. Journal of neurotrauma. 2010 Sep; 27(9):1685-95. doi: 10.1089/neu.2010.1272. [PMID: 20568964]
  • Declan P McKernan, Marc B Guerin, Colm J O'Brien, Thomas G Cotter. A key role for calpains in retinal ganglion cell death. Investigative ophthalmology & visual science. 2007 Dec; 48(12):5420-30. doi: 10.1167/iovs.07-0287. [PMID: 18055788]
  • William J Pottorf, Tanner M Johanns, Stephen M Derrington, Emanuel E Strehler, Agnes Enyedi, Stanley A Thayer. Glutamate-induced protease-mediated loss of plasma membrane Ca2+ pump activity in rat hippocampal neurons. Journal of neurochemistry. 2006 Sep; 98(5):1646-56. doi: 10.1111/j.1471-4159.2006.04063.x. [PMID: 16923173]
  • Teng-Man Chen, Harlan K Jones. Epimerization study of the L,L- and L,D-diastereoisomers of the calpain inhibitor MDL 28170 by capillary electrophoresis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Sep; 809(1):31-5. doi: 10.1016/j.jchromb.2004.05.031. [PMID: 15282090]
  • Cheng-Haung Wang, Yann-Jang Chen, Tsung-Hsing Lee, Yi-Shen Chen, Bruno Jawan, Kuo-Sheng Hung, Cheng-Nan Lu, Jong-Kang Liu. Protective effect of MDL28170 against thioacetamide-induced acute liver failure in mice. Journal of biomedical science. 2004 Sep; 11(5):571-8. doi: 10.1007/bf02256121. [PMID: 15316131]
  • Pallavi B Limaye, Udayan M Apte, Kartik Shankar, Thomas J Bucci, Alan Warbritton, Harihara M Mehendale. Calpain released from dying hepatocytes mediates progression of acute liver injury induced by model hepatotoxicants. Toxicology and applied pharmacology. 2003 Sep; 191(3):211-26. doi: 10.1016/s0041-008x(03)00250-3. [PMID: 13678654]
  • D Seiffert, T Mitchell, A M Stern, A Roach, Y Zhan, R Grzanna. Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing. Brain research. Molecular brain research. 2000 Dec; 84(1-2):115-26. doi: 10.1016/s0169-328x(00)00230-8. [PMID: 11113538]
  • J J Briedé, J W Heemskerk, H C Hemker, T Lindhout. Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets. Biochimica et biophysica acta. 1999 Aug; 1451(1):163-72. doi: 10.1016/s0167-4889(99)00085-3. [PMID: 10446398]