PD 150,606 (BioDeep_00000759395)
代谢物信息卡片
化学式: C9H7IO2S (305.9211512)
中文名称: 3-(4-碘苯基)-2-巯基-2-丙烯酸, PD150606
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C=C(C(=O)O)S)I
InChI: InChI=1S/C9H7IO2S/c10-7-3-1-6(2-4-7)5-8(13)9(11)12/h1-5,13H,(H,11,12)/b8-5-
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:130910
- PubChem: 9839500
- ChEMBL: CHEMBL366254
- CAS: 426821-41-2
- CAS: 179528-45-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Feng Wan, Emmanuel Letavernier, Shariq Abid, Amal Houssaini, Gabor Czibik, Elisabeth Marcos, Dominique Rideau, Aurélien Parpaleix, Larissa Lipskaia, Valérie Amsellem, Barnabas Gellen, Daigo Sawaki, Genevieve Derumeaux, Jean-Luc Dubois-Randé, Marion Delcroix, Rozenn Quarck, Laurent Baud, Serge Adnot. Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension.
American journal of respiratory cell and molecular biology.
2016 09; 55(3):337-51. doi:
10.1165/rcmb.2015-0257oc
. [PMID: 26974350] - Ariane Roseblade, Frederick Luk, Alison Ung, Mary Bebawy. Targeting microparticle biogenesis: a novel approach to the circumvention of cancer multidrug resistance.
Current cancer drug targets.
2015; 15(3):205-14. doi:
10.2174/1568009615666150225121508
. [PMID: 25714701] - Emmanuel Letavernier, Boris Dansou, Matthias Lochner, Joëlle Perez, Agnès Bellocq, Maja T Lindenmeyer, Clemens D Cohen, Jean-Philippe Haymann, Gérard Eberl, Laurent Baud. Critical role of the calpain/calpastatin balance in acute allograft rejection.
European journal of immunology.
2011 Feb; 41(2):473-84. doi:
10.1002/eji.201040437
. [PMID: 21268016] - Xu Cao, Ying Zhang, Liangyu Zou, Haibing Xiao, Yinghao Chu, Xiaofan Chu. Persistent oxygen-glucose deprivation induces astrocytic death through two different pathways and calpain-mediated proteolysis of cytoskeletal proteins during astrocytic oncosis.
Neuroscience letters.
2010 Jul; 479(2):118-22. doi:
10.1016/j.neulet.2010.05.040
. [PMID: 20493926] - Mathieu Peyrou, Paul E Hanna, Alastair E Cribb. Calpain inhibition but not reticulum endoplasmic stress preconditioning protects rat kidneys from p-aminophenol toxicity.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Sep; 99(1):338-45. doi:
10.1093/toxsci/kfm105
. [PMID: 17567592] - T Ohse, R Inagi, T Tanaka, T Ota, T Miyata, I Kojima, J R Ingelfinger, S Ogawa, T Fujita, M Nangaku. Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.
Kidney international.
2006 Oct; 70(8):1447-55. doi:
10.1038/sj.ki.5001704
. [PMID: 16955111] - Wing-Kee Lee, Marouan Abouhamed, Frank Thévenod. Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells.
American journal of physiology. Renal physiology.
2006 Oct; 291(4):F823-32. doi:
10.1152/ajprenal.00276.2005
. [PMID: 16597613] - K Ashizawa, G J Wishart, S Katayama, D Takano, M Maeda, E Arakawa, Y Tsuzuki. Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro.
Reproduction (Cambridge, England).
2006 Jan; 131(1):71-9. doi:
10.1530/rep.1.00588
. [PMID: 16388011] - Prabal K Chatterjee, Zoran Todorovic, Ahila Sivarajah, Helder Mota-Filipe, Paul A J Brown, Keith N Stewart, Emanuela Mazzon, Salvatore Cuzzocrea, Christoph Thiemermann. Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury.
Biochemical pharmacology.
2005 Apr; 69(7):1121-31. doi:
10.1016/j.bcp.2005.01.003
. [PMID: 15763548] - Steven M Harwood, David A Allen, Alistair M S Chesser, David I New, Martin J Raftery, Muhammad M Yaqoob. Calpain is activated in experimental uremia: is calpain a mediator of uremia-induced myocardial injury?.
Kidney international.
2003 Mar; 63(3):866-77. doi:
10.1046/j.1523-1755.2003.00823.x
. [PMID: 12631067] - Xiuli Liu, Rick G Schnellmann. Calpain mediates progressive plasma membrane permeability and proteolysis of cytoskeleton-associated paxillin, talin, and vinculin during renal cell death.
The Journal of pharmacology and experimental therapeutics.
2003 Jan; 304(1):63-70. doi:
10.1124/jpet.102.043406
. [PMID: 12490576] - X Liu, J J Rainey, J F Harriman, R G Schnellmann. Calpains mediate acute renal cell death: role of autolysis and translocation.
American journal of physiology. Renal physiology.
2001 Oct; 281(4):F728-38. doi:
10.1152/ajprenal.2001.281.4.f728
. [PMID: 11553520] - C L Edelstein, M M Yaqoob, A M Alkhunaizi, P E Gengaro, R A Nemenoff, K K Wang, R W Schrier. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules.
Kidney international.
1996 Oct; 50(4):1150-7. doi:
10.1038/ki.1996.422
. [PMID: 8887272] - J Roy, S Som, A Sen. Isolation, purification, and some properties of a lectin and abrin from Abrus precatorius linn.
Archives of biochemistry and biophysics.
1976 May; 174(1):359-61. doi:
10.1016/0003-9861(76)90357-x
. [PMID: 7206]