Torin 2 (BioDeep_00000759394)
代谢物信息卡片
化学式: C24H15F3N4O (432.1197896)
中文名称: 9-(6-氨基-3-吡啶基)-1-[3-(三氟甲基)苯基]苯并[H]-1,6-萘啶-2(1H)-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F
InChI: InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
描述信息
Torin 2 is an mTOR inhibitor with EC50 of 0.25 nM for inhibiting cellular mTOR activity, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM). Torin 2 also inhibits DNA-PK with an IC50 of 0.5 nM in the cell free assay. Torin 2 can suppress both mTORC1 and mTORC2.
Torin 2 is an mTOR inhibitor with EC50 of 0.25 nM for inhibiting cellular mTOR activity, and exhibits 800-fold selectivity over PI3K (EC50: 200 nM). Torin 2 also inhibits DNA-PK with an IC50 of 0.5 nM in the cell free assay. Torin 2 can suppress both mTORC1 and mTORC2.
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:90682
- PubChem: 51358113
- ChEMBL: CHEMBL1765602
- CAS: 1223001-51-1
- medchemexpress: HY-13002
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Peter J Mullen, Gustavo Garcia, Arunima Purkayastha, Nedas Matulionis, Ernst W Schmid, Milica Momcilovic, Chandani Sen, Justin Langerman, Arunachalam Ramaiah, David B Shackelford, Robert Damoiseaux, Samuel W French, Kathrin Plath, Brigitte N Gomperts, Vaithilingaraja Arumugaswami, Heather R Christofk. SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Nature communications.
2021 03; 12(1):1876. doi:
10.1038/s41467-021-22166-4. [PMID: 33767183] - Dan Song, Yu Chen, Binran Wang, Diana Li, Chao Xu, Hong Huang, Saifei Huang, Rong Liu. Bisphenol A inhibits autophagosome-lysosome fusion and lipid droplet degradation.
Ecotoxicology and environmental safety.
2019 Nov; 183(?):109492. doi:
10.1016/j.ecoenv.2019.109492. [PMID: 31421534] - Sara J Holditch, Carolyn N Brown, Daniel J Atwood, Andrew M Lombardi, Khoa N Nguyen, Harrison W Toll, Katharina Hopp, Charles L Edelstein. A study of sirolimus and mTOR kinase inhibitor in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease.
American journal of physiology. Renal physiology.
2019 07; 317(1):F187-F196. doi:
10.1152/ajprenal.00051.2019. [PMID: 31042058] - Qi Wang, Zhenquan Hu, Xixiang Li, Aoli Wang, Hong Wu, Jing Liu, Shugeng Cao, Qingsong Liu. Salviachinensines A-F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis.
Journal of natural products.
2018 11; 81(11):2531-2538. doi:
10.1021/acs.jnatprod.8b00638. [PMID: 30370766] - Angela Kwok-Fung Lo, Raymond Wai-Ming Lung, Christopher W Dawson, Lawrence S Young, Chuen-Wai Ko, Walter Wai Yeung, Wei Kang, Ka-Fai To, Kwok-Wai Lo. Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma.
The Journal of pathology.
2018 10; 246(2):180-190. doi:
10.1002/path.5130. [PMID: 29968360] - Yoshihiko Kuchitsu, Yuta Homma, Naonobu Fujita, Mitsunori Fukuda. Rab7 knockout unveils regulated autolysosome maturation induced by glutamine starvation.
Journal of cell science.
2018 04; 131(7):. doi:
10.1242/jcs.215442. [PMID: 29514857] - K R Vogel, G R Ainslie, E E W Jansen, G S Salomons, K M Gibson. Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.
Biochimica et biophysica acta. Molecular basis of disease.
2017 01; 1863(1):33-42. doi:
10.1016/j.bbadis.2016.10.009. [PMID: 27760377] - Ellen L Berg, Mark A Polokoff, Alison O'Mahony, Dat Nguyen, Xitong Li. Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.
International journal of molecular sciences.
2015 Jan; 16(1):1008-29. doi:
10.3390/ijms16011008. [PMID: 25569083] - Marie-Hélène Montané, Benoît Menand. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Journal of experimental botany.
2013 Nov; 64(14):4361-74. doi:
10.1093/jxb/ert242. [PMID: 23963679] - Qingsong Liu, Jinhua Wang, Seong A Kang, Carson C Thoreen, Wooyoung Hur, Tausif Ahmed, David M Sabatini, Nathanael S Gray. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Journal of medicinal chemistry.
2011 Mar; 54(5):1473-80. doi:
10.1021/jm101520v. [PMID: 21322566]