Torin 1 (BioDeep_00000759377)
代谢物信息卡片
Torin 1
化学式: C35H28F3N5O2 (607.2194984)
中文名称: 都灵1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
InChI: InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
描述信息
Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.
Torin 1 is a potent inhibitor of mTOR with an IC50 of 3 nM. Torin 1 inhibits both mTORC1/2 complexes with IC50 values between 2 and 10 nM. Torin 1 is an effective inducer of autophagy.
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:84327
- PubChem: 49836027
- ChEMBL: CHEMBL1256459
- CAS: 1222998-36-8
- medchemexpress: HY-13003
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mo-Yu Ding, Yuran Peng, Feng Li, Zheng-Qing Li, Decai Wang, Guo-Chun Zhou, Ying Wang. Andrographolide derivative as antagonist of vitamin D receptor to induce lipidation of microtubule associate protein 1 light chain 3 (LC3).
Bioorganic & medicinal chemistry.
2021 12; 51(?):116505. doi:
10.1016/j.bmc.2021.116505. [PMID: 34781081] - Chang Sook Ahn, Du-Hwa Lee, Hyun-Sook Pai. Characterization of Maf1 in Arabidopsis: function under stress conditions and regulation by the TOR signaling pathway.
Planta.
2019 Feb; 249(2):527-542. doi:
10.1007/s00425-018-3024-5. [PMID: 30293201] - Emily G Werth, Evan W McConnell, Inmaculada Couso Lianez, Zoee Perrine, Jose L Crespo, James G Umen, Leslie M Hicks. Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets.
The New phytologist.
2019 01; 221(1):247-260. doi:
10.1111/nph.15339. [PMID: 30040123] - Angela Kwok-Fung Lo, Raymond Wai-Ming Lung, Christopher W Dawson, Lawrence S Young, Chuen-Wai Ko, Walter Wai Yeung, Wei Kang, Ka-Fai To, Kwok-Wai Lo. Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma.
The Journal of pathology.
2018 10; 246(2):180-190. doi:
10.1002/path.5130. [PMID: 29968360] - Hyejin Lim, Yu-Mi Lim, Kook Hwan Kim, Young Eui Jeon, Kihyoun Park, Jinyoung Kim, Hui-Yun Hwang, Dong Jin Lee, Haushabhau Pagire, Ho Jeong Kwon, Jin Hee Ahn, Myung-Shik Lee. A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.
Nature communications.
2018 04; 9(1):1438. doi:
10.1038/s41467-018-03939-w. [PMID: 29650965] - Seda Avcioglu Barutcu, Nomeda Girnius, Santiago Vernia, Roger J Davis. Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Autophagy.
2018; 14(9):1586-1595. doi:
10.1080/15548627.2018.1466013. [PMID: 29950132] - Silvia Vega-Rubin-de-Celis, Samuel Peña-Llopis, Meghan Konda, James Brugarolas. Multistep regulation of TFEB by MTORC1.
Autophagy.
2017 Mar; 13(3):464-472. doi:
10.1080/15548627.2016.1271514. [PMID: 28055300] - Jing Zhang, Wenwen Liu, Xinhui Sun, Feifei Kong, Ye Zhu, Yue Lei, Youqiang Su, Yiping Su, Jing Li. Inhibition of mTOR Signaling Pathway Delays Follicle Formation in Mice.
Journal of cellular physiology.
2017 Mar; 232(3):585-595. doi:
10.1002/jcp.25456. [PMID: 27301841] - K R Vogel, G R Ainslie, E E W Jansen, G S Salomons, K M Gibson. Therapeutic relevance of mTOR inhibition in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism.
Biochimica et biophysica acta. Molecular basis of disease.
2017 01; 1863(1):33-42. doi:
10.1016/j.bbadis.2016.10.009. [PMID: 27760377] - Jami M Gurley, Beth A Griesel, Ann Louise Olson. Increased Skeletal Muscle GLUT4 Expression in Obese Mice After Voluntary Wheel Running Exercise Is Posttranscriptional.
Diabetes.
2016 10; 65(10):2911-9. doi:
10.2337/db16-0305. [PMID: 27411383] - Sousuke Imamura, Yasuko Kawase, Ikki Kobayashi, Mie Shimojima, Hiroyuki Ohta, Kan Tanaka. TOR (target of rapamycin) is a key regulator of triacylglycerol accumulation in microalgae.
Plant signaling & behavior.
2016; 11(3):e1149285. doi:
10.1080/15592324.2016.1149285. [PMID: 26855321] - Jinghui Zhao, Bo Zhai, Steven P Gygi, Alfred Lewis Goldberg. mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Dec; 112(52):15790-7. doi:
10.1073/pnas.1521919112. [PMID: 26669439] - Bastian Thaa, Roberta Biasiotto, Kai Eng, Maarit Neuvonen, Benjamin Götte, Lara Rheinemann, Margit Mutso, Age Utt, Finny Varghese, Giuseppe Balistreri, Andres Merits, Tero Ahola, Gerald M McInerney. Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.
Journal of virology.
2015 Nov; 89(22):11420-37. doi:
10.1128/jvi.01579-15. [PMID: 26339054] - Myriam Catalano, Giuseppina D'Alessandro, Francesca Lepore, Marco Corazzari, Sara Caldarola, Cristina Valacca, Fiorella Faienza, Vincenzo Esposito, Cristina Limatola, Francesco Cecconi, Sabrina Di Bartolomeo. Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells.
Molecular oncology.
2015 Oct; 9(8):1612-25. doi:
10.1016/j.molonc.2015.04.016. [PMID: 26022108] - Carmen Priolo, Stéphane J H Ricoult, Damir Khabibullin, Harilaos Filippakis, Jane Yu, Brendan D Manning, Clary Clish, Elizabeth P Henske. Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.
American journal of respiratory cell and molecular biology.
2015 Jul; 53(1):33-41. doi:
10.1165/rcmb.2014-0379rc. [PMID: 25780943] - Ellen L Berg, Mark A Polokoff, Alison O'Mahony, Dat Nguyen, Xitong Li. Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.
International journal of molecular sciences.
2015 Jan; 16(1):1008-29. doi:
10.3390/ijms16011008. [PMID: 25569083] - Jing Li, Jianyu Liu, Jun Song, Xiaofu Wang, Heidi L Weiss, Courtney M Townsend, Tianyan Gao, B Mark Evers. mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.
American journal of physiology. Cell physiology.
2011 Jul; 301(1):C213-26. doi:
10.1152/ajpcell.00067.2011. [PMID: 21508335] - Thomas Weichhart, Michael Haidinger, Karl Katholnig, Chantal Kopecky, Marko Poglitsch, Caroline Lassnig, Margit Rosner, Gerhard J Zlabinger, Markus Hengstschläger, Mathias Müller, Walter H Hörl, Marcus D Säemann. Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells.
Blood.
2011 Apr; 117(16):4273-83. doi:
10.1182/blood-2010-09-310888. [PMID: 21368289] - Qingsong Liu, Jinhua Wang, Seong A Kang, Carson C Thoreen, Wooyoung Hur, Tausif Ahmed, David M Sabatini, Nathanael S Gray. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Journal of medicinal chemistry.
2011 Mar; 54(5):1473-80. doi:
10.1021/jm101520v. [PMID: 21322566] - Morag K Mansley, Stuart M Wilson. Dysregulation of epithelial Na+ absorption induced by inhibition of the kinases TORC1 and TORC2.
British journal of pharmacology.
2010 Dec; 161(8):1778-92. doi:
10.1111/j.1476-5381.2010.01003.x. [PMID: 20735411]