5FUR-144 (BioDeep_00000759319)
代谢物信息卡片
(1-(5-Fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
化学式: C21H28FNO (329.215481)
中文名称: [1-(5-氟戊基)吲哚-3-基]-(2,2,3,3-四甲基环丙基)甲酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(C(C1(C)C)C(=O)C2=CN(C3=CC=CC=C32)CCCCCF)C
InChI: InChI=1S/C21H28FNO/c1-20(2)19(21(20,3)4)18(24)16-14-23(13-9-5-8-12-22)17-11-7-6-10-15(16)17/h6-7,10-11,14,19H,5,8-9,12-13H2,1-4H3
描述信息
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Bree A Humburg, Chloe J Jordan, Hai-Ying Zhang, Hui Shen, Xiao Han, Guo-Hua Bi, Briana Hempel, Ewa Galaj, Michael H Baumann, Zheng-Xiong Xi. Optogenetic brain-stimulation reward: A new procedure to re-evaluate the rewarding versus aversive effects of cannabinoids in dopamine transporter-Cre mice.
Addiction biology.
2021 07; 26(4):e13005. doi:
10.1111/adb.13005. [PMID: 33538103] - David Fabregat-Safont, María Ibáñez, Abel Baquero, Juan Vicente Sancho, Félix Hernández, Gonzalo Haro. Investigation on the consumption of synthetic cannabinoids among teenagers by the analysis of herbal blends and urine samples.
Journal of pharmaceutical and biomedical analysis.
2020 Jul; 186(?):113298. doi:
10.1016/j.jpba.2020.113298. [PMID: 32325401] - Shivani Sachdev, Samuel D Banister, Marina Santiago, Chris Bladen, Michael Kassiou, Mark Connor. Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists.
Pharmacology research & perspectives.
2020 04; 8(2):e00566. doi:
10.1002/prp2.566. [PMID: 32101383] - João P Silva, Helena Carmo, Félix Carvalho. The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis.
Toxicology letters.
2018 May; 287(?):59-69. doi:
10.1016/j.toxlet.2018.01.023. [PMID: 29410032] - Payal Sud, Miles Gordon, Laura Tortora, Matthew Stripp, Damon Borg, Adam Berman. Retrospective Chart Review of Synthetic Cannabinoid Intoxication with Toxicologic Analysis.
The western journal of emergency medicine.
2018 May; 19(3):567-572. doi:
10.5811/westjem.2017.12.36968. [PMID: 29760857] - Melanie Hutter, Sebastian Broecker, Stefan Kneisel, Florian Franz, Simon D Brandt, Volker Auwarter. Metabolism of Nine Synthetic Cannabinoid Receptor Agonists Encountered in Clinical Casework: Major in vivo Phase I Metabolites of AM-694, AM-2201, JWH-007, JWH-019, JWH-203, JWH-307, MAM-2201, UR-144 and XLR-11 in Human Urine Using LC-MS/MS.
Current pharmaceutical biotechnology.
2018; 19(2):144-162. doi:
10.2174/1389201019666180509163114. [PMID: 29745330] - Lilian H J Richter, Hans H Maurer, Markus R Meyer. New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine.
Toxicology letters.
2017 Oct; 280(?):142-150. doi:
10.1016/j.toxlet.2017.07.901. [PMID: 28782580] - Katherine N Moore, Demetra Garvin, Brian F Thomas, Megan Grabenauer. Identification of Eight Synthetic Cannabinoids, Including 5F-AKB48 in Seized Herbal Products Using DART-TOF-MS and LC-QTOF-MS as Nontargeted Screening Methods.
Journal of forensic sciences.
2017 Sep; 62(5):1151-1158. doi:
10.1111/1556-4029.13367. [PMID: 28597943] - Brian F Thomas, Timothy W Lefever, Ricardo A Cortes, Megan Grabenauer, Alexander L Kovach, Anderson O Cox, Purvi R Patel, Gerald T Pollard, Julie A Marusich, Richard C Kevin, Thomas F Gamage, Jenny L Wiley. Thermolytic Degradation of Synthetic Cannabinoids: Chemical Exposures and Pharmacological Consequences.
The Journal of pharmacology and experimental therapeutics.
2017 04; 361(1):162-171. doi:
10.1124/jpet.116.238717. [PMID: 28087785] - Moonhee Jang, In Sook Kim, Yu Na Park, Jihyun Kim, Inhoi Han, Seungkyung Baeck, Wonkyung Yang, Hye Hyun Yoo. Determination of urinary metabolites of XLR-11 by liquid chromatography-quadrupole time-of-flight mass spectrometry.
Analytical and bioanalytical chemistry.
2016 Jan; 408(2):503-16. doi:
10.1007/s00216-015-9116-1. [PMID: 26514671] - Tatsuyuki Kanamori, Koji Kanda, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Yuko Togawa Iwata, Hiroyuki Inoue. Detection of main metabolites of XLR-11 and its thermal degradation product in human hepatoma HepaRG cells and human urine.
Drug testing and analysis.
2015 Apr; 7(4):341-5. doi:
10.1002/dta.1765. [PMID: 25600155] - M Takematsu, R S Hoffman, L S Nelson, J M Schechter, J H Moran, S W Wiener. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid.
Clinical toxicology (Philadelphia, Pa.).
2014 Nov; 52(9):973-5. doi:
10.3109/15563650.2014.958614. [PMID: 25241766] - Amanda L A Mohr, Bill Ofsa, Alyssa Marie Keil, John R Simon, Matthew McMullin, Barry K Logan. Enzyme-linked immunosorbent assay (ELISA) for the detection of use of the synthetic cannabinoid agonists UR-144 and XLR-11 in human urine.
Journal of analytical toxicology.
2014 Sep; 38(7):427-31. doi:
10.1093/jat/bku049. [PMID: 24908262] - G L Buser, R R Gerona, B Z Horowitz, K P Vian, M L Troxell, R G Hendrickson, D C Houghton, D Rozansky, S W Su, R F Leman. Acute kidney injury associated with smoking synthetic cannabinoid.
Clinical toxicology (Philadelphia, Pa.).
2014 Aug; 52(7):664-73. doi:
10.3109/15563650.2014.932365. [PMID: 25089722] - Jenny L Wiley, Julie A Marusich, Timothy W Lefever, Megan Grabenauer, Katherine N Moore, Brian F Thomas. Cannabinoids in disguise: Δ9-tetrahydrocannabinol-like effects of tetramethylcyclopropyl ketone indoles.
Neuropharmacology.
2013 Dec; 75(?):145-54. doi:
10.1016/j.neuropharm.2013.07.022. [PMID: 23916483] - Ariane Wohlfarth, Shaokun Pang, Mingshe Zhu, Adarsh S Gandhi, Karl B Scheidweiler, Hua-fen Liu, Marilyn A Huestis. First metabolic profile of XLR-11, a novel synthetic cannabinoid, obtained by using human hepatocytes and high-resolution mass spectrometry.
Clinical chemistry.
2013 Nov; 59(11):1638-48. doi:
10.1373/clinchem.2013.209965. [PMID: 24014837]