Metildigoxin (BioDeep_00000758339)

   

Chemicals and Drugs natural product


代谢物信息卡片


Metildigoxin

化学式: C42H66O14 (794.4452)
中文名称: 甲地高辛
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)OC
InChI: InChI=1S/C42H66O14/c1-20-37(49-6)29(43)16-35(51-20)55-39-22(3)53-36(18-31(39)45)56-38-21(2)52-34(17-30(38)44)54-25-9-11-40(4)24(14-25)7-8-27-28(40)15-32(46)41(5)26(10-12-42(27,41)48)23-13-33(47)50-19-23/h13,20-22,24-32,34-39,43-46,48H,7-12,14-19H2,1-6H3/t20-,21-,22-,24-,25+,26-,27-,28+,29+,30+,31+,32-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m1/s1

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01A - Cardiac glycosides > C01AA - Digitalis glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D004071 - Digitalis Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C823 - Saponin
C78274 - Agent Affecting Cardiovascular System > C78322 - Cardiotonic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
C1907 - Drug, Natural Product
D004791 - Enzyme Inhibitors

同义名列表

1 个代谢物同义名

Metildigoxin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Cornelius Hess, Christopher Brockmann, Elke Doberentz, Burkhard Madea, Frank Musshoff. Unintentional lethal overdose with metildigoxin in a 36-week-old infant--post mortem tissue distribution of metildigoxin and its metabolites by liquid chromatography tandem mass spectrometry. Forensic science international. 2014 Aug; 241(?):e23-7. doi: 10.1016/j.forsciint.2014.05.013. [PMID: 24889325]
  • Florian Eyer, Werner Steimer, Christine Müller, Thomas Zilker. Free and total digoxin in serum during treatment of acute digoxin poisoning with Fab fragments: case study. American journal of critical care : an official publication, American Association of Critical-Care Nurses. 2010 Jul; 19(4):391-87. doi: 10.4037/ajcc2009227. [PMID: 19875723]
  • Mateusz Kurzawski, Lilianna Bartnicka, Marcin Florczak, Wanda Górnik, Marek Droździk. Impact of ABCB1 (MDR1) gene polymorphism and P-glycoprotein inhibitors on digoxin serum concentration in congestive heart failure patients. Pharmacological reports : PR. 2007 Jan; 59(1):107-11. doi: NULL. [PMID: 17377214]
  • A Horvat, T Momić, S Petrović, G Nikezić, M Demajo. Selective inhibition of brain Na,K-ATPase by drugs. Physiological research. 2006; 55(3):325-338. doi: 10.33549/physiolres.930696. [PMID: 16083303]
  • Sachiyo Funakoshi, Teruo Murakami, Ryoko Yumoto, Yoshie Kiribayashi, Mikihisa Takano. Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and beta-methyldigoxin in rats. Journal of pharmaceutical sciences. 2005 Jun; 94(6):1196-203. doi: 10.1002/jps.20346. [PMID: 15858844]
  • Yasuhiko Higashi, Naomi Watanabe, Toshiyuki Sasaki, Youichi Fujii. Measurement of beta-methyldigoxin level in serum from patients by enzyme immunoassay using novel specific antiserum with a phenyl boric acid column. Therapeutic drug monitoring. 2003 Aug; 25(4):452-6. doi: 10.1097/00007691-200308000-00006. [PMID: 12883228]
  • Sachiyo Funakoshi, Teruo Murakami, Ryoko Yumoto, Yoshie Kiribayashi, Mikihisa Takano. Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats. Journal of pharmaceutical sciences. 2003 Jul; 92(7):1455-63. doi: 10.1002/jps.10416. [PMID: 12820149]
  • Yasuhiko Higashi, Naomi Watanabe, Toshiyuki Sasaki, Youichi Fujii. Pharmacokinetic study of beta-methyldigoxin by enzyme immunoassay using a novel specific antiserum in rats. Biological & pharmaceutical bulletin. 2003 Feb; 26(2):247-51. doi: 10.1248/bpb.26.247. [PMID: 12576688]
  • Mariusz Scisłowski, Sebastian Rojek, Małgorzata Kłys, Krzysztof Woźniak, Franciszek Trela. [Application of HPLC/MS for evaluation of fatal poisoning with digoxin in the aspect of medico-legal evidence]. Archiwum medycyny sadowej i kryminologii. 2003 Jan; 53(1):19-31. doi: NULL. [PMID: 14669547]
  • Yasuhiko Higashi, Naomi Watanabe, Toshiyuki Sasaki, Youichi Fujii. Establishment of enzyme immunoassay for measuring beta-methyldigoxin levels in human serum by specific antiserum. Biological & pharmaceutical bulletin. 2002 Oct; 25(10):1251-7. doi: 10.1248/bpb.25.1251. [PMID: 12392073]
  • C Pauli-Magnus, T Mürdter, A Godel, T Mettang, M Eichelbaum, U Klotz, M F Fromm. P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin. Naunyn-Schmiedeberg's archives of pharmacology. 2001 Mar; 363(3):337-43. doi: 10.1007/s002100000354. [PMID: 11284449]
  • M Janion, D Bakowski, H Brzyźkiewicz. [Disturbances of rhythm and atrio-ventricular conduction in digitalis overdose. Case reports]. Przeglad lekarski. 2001; 58(1):54-7. doi: NULL. [PMID: 11450159]
  • T Murakawa, T Kubota, A Matsuki. [Therapeutic drug monitoring in perioperative period--management of atrial fibrillation in a patient with bradycardia due to relative overdose of digitalis]. Masui. The Japanese journal of anesthesiology. 1997 Apr; 46(4):521-4. doi: NULL. [PMID: 9128025]
  • W Tadeusiak, E Marcinowska-Suchowierska, J Podleśny, A Andrzejewski. [Possibility of using saliva for therapeutic monitoring of digoxin]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 1997 Feb; 2(8):116-9. doi: NULL. [PMID: 9538655]
  • J Schmolling, S Jung, J Reinsberg, H Schlebusch. Digoxin transfer across the isolated placenta is influenced by maternal and fetal albumin concentrations. Reproduction, fertility, and development. 1996; 8(6):969-74. doi: 10.1071/rd9960969. [PMID: 8896031]
  • E Yukawa. New and simple method for estimating metildigoxin dosing regimens by multiple trough screen analysis. International journal of clinical pharmacology and therapeutics. 1995 Nov; 33(11):605-11. doi: NULL. [PMID: 8688985]
  • M A Rodriguez, M Padrón-Nieves, M Pérez-González, V Lamanna. [Effect of the in vivo administration of beta-methyldigoxin on the Na, K-ATPase measured in different tissues of guinea pigs]. Acta cientifica venezolana. 1994; 45(2):112-9. doi: NULL. [PMID: 8731295]
  • H R Heise, P Vorwerk, K Fritsche, R Richter. [Digoxin-like immunoreactivity in newborn infants--a pitfall of digoxin therapy?]. Kinderarztliche Praxis. 1993 May; 61(3):108-11. doi: NULL. [PMID: 8326698]
  • K Tsutsumi, H Nakashima, T Tateishi, M Imagawa, S Nakano. Pharmacokinetics of beta-methyldigoxin in subjects with normal and impaired renal function. Journal of clinical pharmacology. 1993 Feb; 33(2):154-60. doi: 10.1002/j.1552-4604.1993.tb03937.x. [PMID: 8440765]
  • Z Duraković, F Plavsić, A Smalcelj, V Grgić. [Blue color vision as a sign of digitalis poisoning]. Lijecnicki vjesnik. 1992 May; 114(5-8):132-4. doi: NULL. [PMID: 1343044]
  • K Tsutsumi, H Nakashima, T Kotegawa, S Nakano. Influence of food on the absorption of beta-methyldigoxin. Journal of clinical pharmacology. 1992 Feb; 32(2):157-62. doi: 10.1002/j.1552-4604.1992.tb03821.x. [PMID: 1613126]
  • Z Duraković, B Vucelić, F Plavsić. [Acute psychoses caused by digitalis poisoning]. Lijecnicki vjesnik. 1991 Nov; 113(11-12):417-9. doi: NULL. [PMID: 1669614]
  • P Soler, Y García, R Zilleruelo, G Enríquez, F Eimbcke, D Vicuña, H Jaeger. [Serum digoxin in children treated with beta methyl digoxin]. Revista chilena de pediatria. 1991 Nov; 62(6):350-4. doi: NULL. [PMID: 1845639]
  • G Das. Beta-methyl digoxin: a better absorbable digoxin. International journal of clinical pharmacology, therapy, and toxicology. 1989 Nov; 27(11):521-5. doi: . [PMID: 2693372]
  • H Nakashima, K Tsutsumi, M Hashiguchi, Y Kumagai, A Ebihara. Determination of beta-methyldigoxin and its metabolites by high-performance liquid chromatography and fluorescence polarization immunoassay. Journal of chromatography. 1989 Apr; 489(2):425-31. doi: 10.1016/s0378-4347(00)82925-4. [PMID: 2666425]
  • R Cristodorescu, G Deutsch, S Drăgan. Clinical utility of plasma digoxin measurements. Medecine interne. 1989 Jan; 27(1):25-32. doi: NULL. [PMID: 2749155]
  • G Seghieri, G C Bartolomei, L A De Giorgio, F Innocenti, A Gironi, M Mian, F Franconi. Serum digoxin and beta-methyldigoxin in elderly patients on hospital admission: correlation with home compliance and clinical variables. European journal of clinical pharmacology. 1989; 37(4):401-4. doi: 10.1007/bf00558509. [PMID: 2598974]
  • G Staudacher. [Individual glycoside therapy using serum concentration determination in heart insufficiency of horses]. Berliner und Munchener tierarztliche Wochenschrift. 1989 Jan; 102(1):1-3. doi: NULL. [PMID: 2923617]
  • W Koenig, N Rietbrock, B G Woodcock, W Lehmacher. [Determinants of plasma digoxin and digitoxin concentrations in elderly patients. A multivariate analysis]. Klinische Wochenschrift. 1987 Nov; 65(22):1073-80. doi: 10.1007/bf01736113. [PMID: 3695294]
  • M Goto, A Suzuki, T Terashima, I Johno, S Kitazawa. Variances in pharmacokinetic parameters due to assay methods for beta-methyldigoxin. Journal of pharmacobio-dynamics. 1987 May; 10(5):209-14. doi: 10.1248/bpb1978.10.209. [PMID: 3305859]
  • R Todorova, D Baltadzhieva, D Staneva. [Clinical importance of determining the digoxin level in the serum in long-term beta-methyldigoxin treatment]. Vutreshni bolesti. 1987; 26(6):26-9. doi: NULL. [PMID: 3439149]
  • R Cristodorescu, D Roşu, G Deutsch, A Verdeş, C Luca. The heart rate slowing effect of pindolol in patients with digitalis resistant atrial fibrillation and heart failure. Medecine interne. 1986 Jul; 24(3):207-15. doi: NULL. [PMID: 3775215]
  • K Bachmayer, R Wytek. [What value do body weight, age and drug anamnesis have as an index of elevated digoxin level?]. Wiener klinische Wochenschrift. 1986 Mar; 98(6):165-70. doi: NULL. [PMID: 3705594]
  • Z Durakovic. Poisoning with a large dose of digitalis. Indian heart journal. 1985 Mar; 37(2):113-5. doi: NULL. [PMID: 4029988]
  • G Fornaro, P Rossi, R Padrini, D Piovan, M Ferrari, A Fortina, G Tomassini, C Aquili. [Pharmacological and clinical research on the interaction of digitalis and amiodarone in heart disease patients with varying degrees of cardiac insufficiency]. Giornale italiano di cardiologia. 1984 Dec; 14(12):990-8. doi: NULL. [PMID: 6532895]
  • J Kuhlmann. Use of cholestyramine in three patients with beta-acetyldigoxin, beta-methyldigoxin and digitoxin intoxication. International journal of clinical pharmacology, therapy, and toxicology. 1984 Oct; 22(10):543-8. doi: . [PMID: 6511130]
  • V C Ohri, J C Chatterji, Y R Sachdev, B K Das, M Akhtar, S C Tiwari, P Bhattacharji, A Behl, S K Dutta. Effect of digoxin on serum and urinary cation changes on acute induction to high altitude. Aviation, space, and environmental medicine. 1984 Apr; 55(4):287-90. doi: NULL. [PMID: 6732679]
  • H Rameis, B Woodcock, J Bonelli, H Waginger. Changes in metildigoxin pharmacokinetics in cirrhosis of the liver: a comparison with beta-acetyldigoxin. International journal of clinical pharmacology, therapy, and toxicology. 1984 Mar; 22(3):145-51. doi: NULL. [PMID: 6715083]
  • A Smolarz, E Roesch, H Lenz, P Neubert, U Abshagen. [Report of experiences in the treatment of 16 cases of severe glycoside poisoning with digitalis antibody fragments (Fab)]. Zeitschrift fur Kardiologie. 1984 Feb; 73(2):113-9. doi: NULL. [PMID: 6719984]
  • G G Belz, R Wintrich. [Cardiac effects of a single daily dose of 0.15 mg and 0.20 mg of beta-methyldigoxin]. Zeitschrift fur Kardiologie. 1984 Jan; 73(1):29-33. doi: NULL. [PMID: 6367246]
  • T Risler. [Renal and extracorporeal elimination of digoxin and its methylated and acetylated derivatives]. Fortschritte der Medizin. 1983 Dec; 101(47-48):2185-8. doi: NULL. [PMID: 6671635]
  • R De Cesaris, M Balestrazzi, R Chiarappa, G Ranieri. [Increased digitalis-like activity in combined administration of calcium antagonists and digitalis preparations]. Giornale italiano di cardiologia. 1983 Sep; 13(9):188-91. doi: NULL. [PMID: 6662312]
  • M G Terzano, M R Salati, F Gemignani. Asterixis associated with carbamazepine. Acta neurologica Belgica. 1983 May; 83(3):158-65. doi: NULL. [PMID: 6613518]
  • E Ferranti, S Latini, M Liberatore, F Scopinaro, P Iacovoni. [Serum digoxin levels and echocardiographic indices of myocardial contractility in acute ischemic heart disease]. La Clinica terapeutica. 1983 Mar; 104(6):473-7. doi: NULL. [PMID: 6851448]
  • G Salvadè, R Tartini, T Moccetti. [Digitalization without saturation dose using methyldigoxin. Experiences with 29 patients]. Schweizerische medizinische Wochenschrift. 1982 Dec; 112(50):1825-8. doi: NULL. [PMID: 7156964]
  • W Emser. Hypermagnesemic periodic paralysis: treatment with digitalis and lithium carbonate. Archives of neurology. 1982 Nov; 39(11):727-30. doi: 10.1001/archneur.1982.00510230053017. [PMID: 6812556]
  • T Hess, A Bütler, P Stucki. [Bioavailability of digoxin and beta-methyl-digoxin in patients with liver and gastro-intestinal diseases ]. Wiener klinische Wochenschrift. 1982 May; 94(10):251-8. doi: NULL. [PMID: 7123952]
  • F Yoshimura, T Nakazaki, S Hamada. [Radioimmunoassay of digoxin and methyldigoxin in serum by Amerlex Digoxin RIA kit (author's transl)]. Radioisotopes. 1982 Apr; 31(4):199-201. doi: 10.3769/radioisotopes.31.4_199. [PMID: 7111773]
  • B Kaufmann, A Olcay, W Schaumann, W Teufel, W Weib. Pharmacokinetics of metildigoxin and digoxin in geriatric patients with normal and elevated serum creatinine levels. Clinical pharmacokinetics. 1981 Nov; 6(6):463-8. doi: 10.2165/00003088-198106060-00004. [PMID: 7318305]
  • H Rameis, J Bonelli, H Waginger, K Hruby. [Pharmacokinetics of beta-methyldigoxin and beta-acetyldigoxin in patients with cirrhosis of the liver (author's transl)]. Wiener klinische Wochenschrift. 1981 Oct; 93(18):572-6. doi: NULL. [PMID: 7303703]
  • T Hess, A Krähenbühl, J Luisier, M Weiss. [Biological availability of digoxin and beta-methyl-digoxin administered in the fasting state or after meals]. Schweizerische medizinische Wochenschrift. 1981 Sep; 111(39):1434-40. doi: NULL. [PMID: 7291961]
  • R Baczynski, F Kokot. [Influence of azosemide on renal metildigoxin excretion (author's transl)]. Deutsche medizinische Wochenschrift (1946). 1981 Aug; 106(34):1065-6. doi: 10.1055/s-2008-1070454. [PMID: 7261931]
  • H R Ochs, D J Greenblatt, J S Harmatz, G Bodem, H J Dengler. Clinical implications of serum digoxin concentrations. Klinische Wochenschrift. 1981 May; 59(10):501-7. doi: 10.1007/bf01696212. [PMID: 7241950]
  • W R Smith, E M Rodgers, P W Nicholson, R P Humm, D A Gettins, S M Dobbs, A A Deshmukh. Evaluation of medigoxin in outpatients. European journal of clinical pharmacology. 1981 Mar; 19(4):251-8. doi: 10.1007/bf00562801. [PMID: 7286028]
  • J Bonelli, H Rameis, H Waginger. Digoxin concentration in cerebrospinal fluid-a study carried out after 9 days of treatment of beta-methyldigoxin or beta-acetyldigoxin. International journal of clinical pharmacology, therapy, and toxicology. 1981 Mar; 19(3):93-5. doi: NULL. [PMID: 7228456]
  • B Modrić, B Kovarbasić. [Pharmacokinetics of beta-methyl-digoxin in patients on dialysis]. Vojnosanitetski pregled. 1981 Mar; 38(2):88-92. doi: NULL. [PMID: 7257229]
  • G Pelosi, G Bracchi, S Orazio, A Cereda. [Serum levels of beta-methyldigoxin and contractile efficiency of the myocardium evaluated with systolic polygraphy and determination of cardiac output]. Minerva medica. 1981 Feb; 72(4-5):225-31. doi: . [PMID: 7010220]
  • F Furlanello, G Inama, M Ferrari, R Padrini, M Guarnerio, G Vergara, P Dal Forno, R Bettini, M Disertori. [Another type of interaction between blood levels of digitalis and anti-arrhythmic drugs: digoxin and amiodarone. Experience with long-term therapy]. Giornale italiano di cardiologia. 1981; 11(11):1725-8. doi: NULL. [PMID: 7343376]
  • N Rietbrock, R G Alken. [Disorders of the ability to distinguish colors during digitalis therapy (author's transl)]. MMW, Munchener medizinische Wochenschrift. 1980 Nov; 122(46):1624-6. doi: NULL. [PMID: 6780853]
  • R Haasis. [Glycoside therapy in elderly patients (author's transl)]. Aktuelle Gerontologie. 1980 Oct; 10(10):435-8. doi: NULL. [PMID: 6110348]
  • A Gobbi, G C Tabacchi, A Giangrande, G Crespi. [Radioimmunological determination of digitalis in the blood during treatment with beta-methyldigoxin in patients with different degrees of renal function]. Minerva cardioangiologica. 1980 Jun; 28(6):445-51. doi: NULL. [PMID: 7242930]
  • H Thiele. [Latent cardiac insufficiency. Experimental digitalization with Lanitop and Lanitop mite. A study in general practice. 2. Experimental digitalization with Lanitop mite with regard to kidney function and serum glycoside concentration]. ZFA. Zeitschrift fur Allgemeinmedizin. 1980 Mar; 56(9):637-45. doi: NULL. [PMID: 7376702]
  • G Hennersdorf, H Leithäuser. [Digoxin therapy in patients with long-term digitalis therapy. Comparison of the digoxin blood level after oral administration of digoxin and beta-methyldigoxin]. Fortschritte der Medizin. 1980 Mar; 98(11):(410-2). doi: . [PMID: 7372228]
  • W Arnold, K Püschel. [Forensic aspects of digoxin-poisoning: toxicological and morphological findings (author's transl)]. Zeitschrift fur Rechtsmedizin. Journal of legal medicine. 1979 Aug; 83(3):265-72. doi: 10.1007/bf02333330. [PMID: 494825]
  • P Coburn, G M Kongola, G E Mawer. Comparison of medigoxin and digoxin in the control of atrial fibrillation. British journal of clinical pharmacology. 1979 Jul; 8(1):53-8. doi: 10.1111/j.1365-2125.1979.tb05909.x. [PMID: 552298]
  • F Kokot, J Pietrek, M Seredyński. Influence of hemoperfusion on the concentration of beta-methyldigoxin and hormones in plasma. Kidney international. 1979 Apr; 15(4):404-10. doi: 10.1038/ki.1979.52. [PMID: 513497]
  • P F Angelino, F Matta, P Ladetto. [Kinetics of beta-methyl-digoxin in different degrees of renal function (author's transl)]. Medicina clinica. 1979 Mar; 72(5):210-6. doi: NULL. [PMID: 431186]
  • J Kuhlmann, N Rietbrock, B Schnieders. Tissue distribution and elimination of digoxin and methyldigoxin after single and multiple doses in dogs. Journal of cardiovascular pharmacology. 1979 Mar; 1(2):219-34. doi: 10.1097/00005344-197903000-00005. [PMID: 94391]
  • L Padeletti, M C Porciani, G Scimone. Placental transfer of digoxin (beta-methyl-digoxin) in man. International journal of clinical pharmacology and biopharmacy. 1979 Feb; 17(2):82-3. doi: NULL. [PMID: 422306]
  • F Kokot, J Pietrek, M Seredyński. Influence of haemoperfusion on plasma levels of hormones and beta-methyldigoxin. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association. 1978; 15(?):604-6. doi: NULL. [PMID: 740697]
  • K E Andersson, B W Johansson, H Ledermann, H von Schenck, J I Thorell. The effects of digoxin and beta-methyldigoxin on the heart rate of decompensated patients with atrial fibrillation. European journal of clinical investigation. 1977 Feb; 7(1):3-6. doi: 10.1111/j.1365-2362.1977.tb01562.x. [PMID: 402273]
  • P F Angelino, F Matta, S Bartolozzi, P Ladetto, M Rotunno. [Kinetics of betamethyl-digoxin in various degrees of renal function]. Bollettino della Societa italiana di cardiologia. 1977; 22(6):773-8. doi: NULL. [PMID: 618218]