Succinylcholine Chloride Dihydrate (BioDeep_00000757911)
代谢物信息卡片
Succinylcholine Chloride Dihydrate
化学式: C14H34Cl2N2O6 (396.1793804)
中文名称: 氯化琥珀酰胆碱二水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C.O.O.[Cl-].[Cl-]
InChI: /p-2
描述信息
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:61225
- KEGGdrug: D02275
- PubChem: 656867
- MeSH: Succinylcholine
- CAS: 6101-15-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sachiko Otsuki, Hirotsugu Miyoshi, Keiko Mukaida, Toshimichi Yasuda, Ryuji Nakamura, Yasuo M Tsutsumi. Age-Specific Clinical Features of Pediatric Malignant Hyperthermia: A Review of 187 Cases Over 60 Years in Japan.
Anesthesia and analgesia.
2022 07; 135(1):128-135. doi:
10.1213/ane.0000000000005837. [PMID: 34962895] - Dongyue Lin, Yao He, Ronglu Dong, Wei Li, Fanli Meng, Yunfeng Zhang, Liangbao Yang. The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Dec; 263(?):120172. doi:
10.1016/j.saa.2021.120172. [PMID: 34273893] - Jaelin J Otta, Lisa Ohden, Douglas G Bell. Malignant Hyperthermia-Associated Rhabdomyolysis After Succinylcholine: A Case Report.
South Dakota medicine : the journal of the South Dakota State Medical Association.
2021 Jan; 74(1):17-20. doi:
. [PMID: 33691052] - Bryant W Cornelius, Todd M Jacobs. Pseudocholinesterase Deficiency Considerations: A Case Study.
Anesthesia progress.
2020 09; 67(3):177-184. doi:
10.2344/anpr-67-03-16. [PMID: 32992329] - Douglas C Crockett, Matthew C Frise, Jamie M Strachan. Cardiac arrest precipitated by succinylcholine in a patient with COVID-19. Comment on Br J Anaesth 2020; 125: e255-7.
British journal of anaesthesia.
2020 09; 125(3):e336-e337. doi:
10.1016/j.bja.2020.06.014. [PMID: 32624186] - Theodor S Sigurdsson, Asgeir P Þorvaldsson, Sigrun Asgeirsdottir, Kristinn Sigvaldason. Cardiac arrest in a COVID-19 patient after receiving succinylcholine for tracheal reintubation.
British journal of anaesthesia.
2020 08; 125(2):e255-e257. doi:
10.1016/j.bja.2020.04.073. [PMID: 32423609] - Durriya Raza, Fauzia Anis Khan. Anaesthetic management for hiatal hernia repair in a child with Bartter's syndrome: A case report.
JPMA. The Journal of the Pakistan Medical Association.
2020 Apr; 70(4):737-739. doi:
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Journal of anesthesia history.
2019 07; 5(3):65-84. doi:
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Der Anaesthesist.
2018 04; 67(4):275-279. doi:
10.1007/s00101-018-0419-4. [PMID: 29480319] - Karim Nasseri, Shoaleh Shami, Mousa Shirmohammadi, Farzad Sarshivi, Negin Ghadami. The Effect of Remifentanil on Succinylcholine Induced Changes in Serum Potassium and Creatine Kinase: A Prospective Randomized Double blind Study.
Acta bio-medica : Atenei Parmensis.
2017 10; 88(3):276-280. doi:
10.23750/abm.v88i3.4845. [PMID: 29083331] - Thomas Hackmann, David L Skidmore, Brian MacManus. Case Report of Cardiac Arrest After Succinylcholine in a Child With Muscle-Eye-Brain Disease.
A & A case reports.
2017 Oct; 9(8):244-247. doi:
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European journal of anaesthesiology.
2017 09; 34(9):623-627. doi:
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The journal of ECT.
2017 Jun; 33(2):e14-e16. doi:
10.1097/yct.0000000000000371. [PMID: 28009618] - NULL. JSA guideline for the management of malignant hyperthermia crisis 2016.
Journal of anesthesia.
2017 Apr; 31(2):307-317. doi:
10.1007/s00540-016-2305-z. [PMID: 28246924] - Jingjun Xing, Wenhe Li, Fang Tong, Yue Liang, Guanglong He, Yiwu Zhou. Three homicides with darts tainted with succinylcholine: autopsy and toxicology.
International journal of legal medicine.
2016 Nov; 130(6):1541-1545. doi:
10.1007/s00414-016-1374-8. [PMID: 27179645] - Gabrielle Jacknin, Michael C Overbeck. Succinylcholine in an ED patient with unanticipated hyperkalemia.
The American journal of emergency medicine.
2016 Oct; 34(10):2054.e3-2054.e5. doi:
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The journal of ECT.
2016 Jun; 32(2):136-8. doi:
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Journal of affective disorders.
2016 May; 196(?):109-16. doi:
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Pregnancy hypertension.
2016 Jan; 6(1):26-9. doi:
10.1016/j.preghy.2016.01.004. [PMID: 26955768] - Hong Wang, Wei Fu, Gang Liu, Shi-Tong Li. Effects of skeletal muscle denervation on the potency of succinylcholine.
Molecular medicine reports.
2015 Nov; 12(5):7796-800. doi:
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European journal of internal medicine.
2015 Mar; 26(2):106-11. doi:
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Biotechnology and applied biochemistry.
2015 Mar; 62(2):154-63. doi:
10.1002/bab.1252. [PMID: 24863940] - Herve Delacour, Sofya Lushchekina, Isabelle Mabboux, Franck Ceppa, Patrick Masson, Lawrence M Schopfer, Oksana Lockridge. Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), "silent" with mivacurium.
Biochemical pharmacology.
2014 Dec; 92(3):476-83. doi:
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Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2014 May; 61(5):423-32. doi:
10.1007/s12630-014-0128-7. [PMID: 24710957] - G Jurkolow, T Fuchs-Buder, A Lemoine, J Raft, N Rocq, C Meistelman. [Prolonged phase II neuromuscular blockade following succinylcholine administration].
Annales francaises d'anesthesie et de reanimation.
2014 Mar; 33(3):176-7. doi:
10.1016/j.annfar.2013.12.017. [PMID: 24440731] - Kulsoom Farhat, Anwar Kamal Pasha, Nusrat Jaffery. Biochemical changes following succinylcholine administration after pretreatment with rocuronium at different intervals.
JPMA. The Journal of the Pakistan Medical Association.
2014 Feb; 64(2):146-50. doi:
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PloS one.
2014; 9(7):e101552. doi:
10.1371/journal.pone.0101552. [PMID: 25054547] - Marc Zoller, Stefan Walther. [Residual relaxant block due to pseudocholinesterase deficiency - First manifestation in an elderly patient].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.
2014 Jan; 49(1):8-11. doi:
10.1055/s-0033-1363907. [PMID: 24446003] - Azize Bestas, Hulya Goksu, Omer Lutfi Erhan. The effect of preoperative consumption of potatoes on succinylcholine-induced block and recovery from anesthesia.
Journal of clinical monitoring and computing.
2013 Dec; 27(6):609-12. doi:
10.1007/s10877-013-9476-z. [PMID: 23700201] - D Dillon, P Lee. Patient information sheet for plasma cholinesterase deficiency.
Anaesthesia.
2013 Oct; 68(10):1085. doi:
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Drug testing and analysis.
2013 Sep; 5(9-10):741-4. doi:
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Pakistan journal of pharmaceutical sciences.
2013 Sep; 26(5):939-42. doi:
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Annales francaises d'anesthesie et de reanimation.
2013 May; 32(5):372-4. doi:
10.1016/j.annfar.2013.03.007. [PMID: 23648013] - K Y Yoo, D H Kang, H Jeong, C W Jeong, Y Y Choi, J Lee. A dose-response study of remifentanil for attenuation of the hypertensive response to laryngoscopy and tracheal intubation in severely preeclamptic women undergoing caesarean delivery under general anaesthesia.
International journal of obstetric anesthesia.
2013 Jan; 22(1):10-8. doi:
10.1016/j.ijoa.2012.09.010. [PMID: 23182608] - Brian C Geyer, Katherine E Larrimore, Jacquelyn Kilbourne, Latha Kannan, Tsafrir S Mor. Reversal of succinylcholine induced apnea with an organophosphate scavenging recombinant butyrylcholinesterase.
PloS one.
2013; 8(3):e59159. doi:
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Annales francaises d'anesthesie et de reanimation.
2012 Dec; 31(12):972-3. doi:
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Annales francaises d'anesthesie et de reanimation.
2012 Oct; 31(10):788-92. doi:
10.1016/j.annfar.2012.06.024. [PMID: 22925939] - Uta Kuepper, Frank Herbstreit, Jürgen Peters, Burkhard Madea, Frank Musshoff. Degradation and elimination of succinylcholine and succinylmonocholine and definition of their respective detection windows in blood and urine for forensic purposes.
International journal of legal medicine.
2012 Mar; 126(2):259-69. doi:
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Proteomics. Clinical applications.
2011 Dec; 5(11-12):644-9. doi:
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Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2011 Aug; 58(8):751-63. doi:
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Anesthesiology.
2011 Jul; 115(1):28-35. doi:
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Journal of analytical toxicology.
2011 Jun; 35(5):302-11. doi:
10.1093/anatox/35.5.302. [PMID: 21619725] - Uta Kuepper, Frank Musshoff, Burkhard Madea. Applicability of succinylmonocholine as a marker for succinylcholine administration--comparative analysis of samples from a fatal succinylcholine-intoxication versus postmortem control specimens.
Forensic science international.
2011 Apr; 207(1-3):84-90. doi:
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The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2011 Mar; 12(2):149-55. doi:
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Yonsei medical journal.
2010 Jul; 51(4):585-9. doi:
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Annals of clinical biochemistry.
2010 May; 47(Pt 3):217-22. doi:
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Revista espanola de anestesiologia y reanimacion.
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Annales francaises d'anesthesie et de reanimation.
2009 Sep; 28(9):787-9. doi:
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2008 Dec; 55(12):860-68. doi:
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Revista espanola de anestesiologia y reanimacion.
2008 Dec; 55(10):645-6. doi:
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Journal of mass spectrometry : JMS.
2008 Oct; 43(10):1344-52. doi:
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2008 Jun; 22(12):1965-70. doi:
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2007 Dec; 62(12):1445-50. doi:
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2007 Nov; 62(11):1326-30. doi:
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2007 Jun; 40(9-10):629-33. doi:
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2007 Mar; 36(1):43-7. doi:
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Allergy.
2005 Oct; 60(10):1312-5. doi:
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Journal of clinical anesthesia.
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Annales francaises d'anesthesie et de reanimation.
2005 Apr; 24(4):425-7. doi:
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Acta anaesthesiologica Scandinavica.
2005 Apr; 49(4):437-44. doi:
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2004 Nov; 32(6):352-60. doi:
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Anesthesia and analgesia.
2004 Jun; 98(6):1676-1679. doi:
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Anesthesiology.
2004 Apr; 100(4):768-73. doi:
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Revista espanola de anestesiologia y reanimacion.
2004 Apr; 51(4):184-9. doi:
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Annals of clinical biochemistry.
2004 Mar; 41(Pt 2):98-110. doi:
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Collegium antropologicum.
2004; 28 Suppl 2(?):297-304. doi:
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Anaesthesia.
2004 Jan; 59(1):89; author reply 89-90. doi:
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Acta anaesthesiologica Scandinavica.
2003 Nov; 47(10):1211-8. doi:
10.1046/j.1399-6576.2003.00237.x. [PMID: 14616317] - J C Norris. Prolonged succinylcholine apnoea resulting from acquired deficiency of plasma cholinesterase.
Anaesthesia.
2003 Nov; 58(11):1137. doi:
10.1046/j.1365-2044.2003.03503.x. [PMID: 14616624] - Donald Schwartz, Neil Roy Connelly, P Manikantan, J H Nichols. Hyperkalemia and pyloric stenosis.
Anesthesia and analgesia.
2003 Aug; 97(2):355-357. doi:
10.1213/01.ane.0000070233.40151.ce. [PMID: 12873916] - Tina Yen, Brian N Nightingale, Jennifer C Burns, David R Sullivan, Peter M Stewart. Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population.
Clinical chemistry.
2003 Aug; 49(8):1297-308. doi:
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Anaesthesia.
2003 Aug; 58(8):815-6. doi:
10.1046/j.1365-2044.2003.03295_19.x. [PMID: 12859495] - Kenji Shigematsu, Shinjiro Shono, Koichi Tanigawa, Keiko Mukaida, Kiyoshi Katori, Takamitsu Hamada, Kazuo Higa. [Malignant hyperthermia during emergency craniotomy: a case report].
Masui. The Japanese journal of anesthesiology.
2003 Jul; 52(7):773-6. doi:
NULL. [PMID: 12910983] - Zohar A Dotan, Rene Hana, Daniel Simon, Daniel Geva, Reuven A Pfeffermann, Tiberiu Ezri. The effect of vecuronium is enhanced by a large rather than a modest dose of gentamicin as compared with no preoperative gentamicin.
Anesthesia and analgesia.
2003 Mar; 96(3):750-754. doi:
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Clinical chemistry and laboratory medicine.
2003 Mar; 41(3):317-22. doi:
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Der Anaesthesist.
2003 Feb; 52(2):127-31. doi:
10.1007/s00101-002-0434-2. [PMID: 12624697] - Neville I Pitts, Graham Mitchell. In vitro succinylcholine hydrolysis in plasma of the African elephant (Loxodonta africana) and impala (Aepyceros melampus).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2003 Jan; 134(1):123-9. doi:
10.1016/s1532-0456(02)00216-8. [PMID: 12524024] - Haolin Ma, Xinliang Zhuang. Selection of neuromuscular blocking agents in patients undergoing renal transplantation under general anesthesia.
Chinese medical journal.
2002 Nov; 115(11):1692-6. doi:
NULL. [PMID: 12609090] - Julie J Roy, François Donati, Daniel Boismenu, France Varin. Concentration-effect relation of succinylcholine chloride during propofol anesthesia.
Anesthesiology.
2002 Nov; 97(5):1082-92. doi:
10.1097/00000542-200211000-00009. [PMID: 12411790] - E B Sener, E Ustun, S Kocamanoglu, A Tur. Prolonged apnea following succinylcholine administration in undiagnosed acute organophosphate poisoning.
Acta anaesthesiologica Scandinavica.
2002 Sep; 46(8):1046-8. doi:
10.1034/j.1399-6576.2002.460821.x. [PMID: 12190811] - Franck Ceppa, Stephane Gidenne, Alain Benois, Eleonore Fontan, Pascal Burnat. Rapid identification of atypical variant of plasma butyrylcholinesterase by PCR.
Clinical chemistry and laboratory medicine.
2002 Aug; 40(8):799-801. doi:
10.1515/cclm.2002.138. [PMID: 12392308] - Bhiken Naik, Steven Hirshhorn, Vikas R Dharnidharka. Prolonged neuromuscular block due to cholinesterase depletion by plasmapheresis.
Journal of clinical anesthesia.
2002 Aug; 14(5):381-4. doi:
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Anesthesia and analgesia.
2002 Jul; 95(1):119-22, table of contents. doi:
10.1097/00000539-200207000-00021. [PMID: 12088954] - Neville Iain Pitts, Graham Mitchell. Pharmacokinetics and effects of succinylcholine in African elephant (Loxodonta africana) and impala (Aepyceros melampus).
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2002 Apr; 15(3):251-60. doi:
10.1016/s0928-0987(01)00215-9. [PMID: 11923057] - Andreea Ticu Boeck, Debra L Fry, Antonio Sastre, Oksana Lockridge. Naturally occurring mutation, Asp70his, in human butyrylcholinesterase.
Annals of clinical biochemistry.
2002 Mar; 39(Pt 2):154-6. doi:
10.1258/0004563021901775. [PMID: 11928765] - C Lang, P Lukasewitz, H Wulf, G Geldner. [Plasma cholinesterase variations as a result of prolonged neuromuscular blockade. Review and problems encountered in two cases of prolonged neuromuscular blockade after muscle relaxation with succinylcholine as compared to mivacurium].
Der Anaesthesist.
2002 Feb; 51(2):134-41. doi:
10.1007/s00101-001-0276-3. [PMID: 11963306] - Onur Ozlü, Senay Eris, Ali Mert. Effects of rocuronium pretreatment on muscle enzyme levels following suxamethonium.
Paediatric anaesthesia.
2002 Feb; 12(2):151-5. doi:
10.1046/j.1460-9592.2002.00817.x. [PMID: 11882227] - C H M Kerskes, K J Lusthof, P G M Zweipfenning, J P Franke. The detection and identification of quaternary nitrogen muscle relaxants in biological fluids and tissues by ion-trap LC-ESI-MS.
Journal of analytical toxicology.
2002 Jan; 26(1):29-34. doi:
10.1093/jat/26.1.29. [PMID: 11890177] - M C Theroux, J B Rose, S Iyengar, M S Katz. Succinylcholine pretreatment using gallamine or mivacurium during rapid sequence induction in children: a randomized, controlled study.
Journal of clinical anesthesia.
2001 Jun; 13(4):287-92. doi:
10.1016/s0952-8180(01)00267-7. [PMID: 11435054] - A H Al-Khafaji, W E Dewhirst, C J Cornell, T J Quill. Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy.
Critical care medicine.
2001 Jun; 29(6):1274-6. doi:
10.1097/00003246-200106000-00040. [PMID: 11414270] - K Nishiyama, A Kitahara, H Natsume, A Matsushita, K Nakano, S Sasaki, R Genma, Y Yamamoto, H Nakamura. Malignant hyperthermia in a patient with Graves' disease during subtotal thyroidectomy.
Endocrine journal.
2001 Apr; 48(2):227-32. doi:
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Analytical biochemistry.
2001 Mar; 290(2):238-44. doi:
10.1006/abio.2000.4956. [PMID: 11237325] - E P Melillo, D J Hawkins, L Lynch, A Macnamara. Difficult airway management of a child impaled through the neck.
Paediatric anaesthesia.
2001; 11(5):615-7. doi:
10.1046/j.1460-9592.2001.00725.x. [PMID: 11696129] - N I Pitts, D Deftereos, G Mitchell. Determination of succinylcholine in plasma by high-pressure liquid chromatography with electrochemical detection.
British journal of anaesthesia.
2000 Oct; 85(4):592-8. doi:
10.1093/bja/85.4.592. [PMID: 11064619]