Deramciclane (BioDeep_00000756593)

   


代谢物信息卡片


Deramciclane

化学式: C20H31NO (301.2405516)
中文名称: 德伦环烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)[C@]2(C)[C@@](OCCN(C)C)(C3=CC=CC=C3)C[C@@]1([H])CC2
InChI: InChI=1S/C20H31NO/c1-18(2)17-11-12-19(18,3)20(15-17,22-14-13-21(4)5)16-9-7-6-8-10-16/h6-10,17H,11-15H2,1-5H3/t17-,19-,20+/m1/s1

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
Deramciclane has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist.

同义名列表

2 个代谢物同义名

Deramciclane; EGIS-3886



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Masayuki Hiramatsu. [Functional role for GABA transporters in the CNS]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2014 Apr; 143(4):187-92. doi: 10.1254/fpj.143.187. [PMID: 24717607]
  • Ilona Fitos, Júlia Visy, Miklós Simonyi, György Mády, Ferenc Zsila. Selective binding interactions of deramciclane to the genetic variants of human alpha(1)-acid glycoprotein. Biochimica et biophysica acta. 2010 Mar; 1800(3):367-72. doi: 10.1016/j.bbagen.2009.08.006. [PMID: 19720112]
  • Sándor Drabant, Katalin Balogh Nemes, Viola Horváth, Antal Tolokán, Gyula Grézal, Markku Anttila, Béla Gachályi, Harri Kanerva, Samar Al-Behaisi, George Horvai, Imre Klebovich. Influence of food on the oral bioavailability of deramciclane from film-coated tablet in healthy male volunteers. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2004 Nov; 58(3):689-95. doi: 10.1016/j.ejpb.2004.03.036. [PMID: 15451546]
  • R Huupponen, M Anttila, J Rouru, H Kanerva, T Miettinen, M Scheinin. Pharmacokinetics of deramciclane and N-desmethylderamciclane after single and repeated oral doses in healthy volunteers. International journal of clinical pharmacology and therapeutics. 2004 Aug; 42(8):449-55. doi: 10.5414/cpp42449. [PMID: 15366325]
  • Kari Laine, Outi Ahokoski, Risto Huupponen, Jutta Hänninen, Sanna Palovaara, Jori Ruuskanen, Harry Björklund, Markku Anttila, Juha Rouru. Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone. European journal of clinical pharmacology. 2003 Dec; 59(10):761-6. doi: 10.1007/s00228-003-0674-3. [PMID: 14566442]
  • Risto Huupponen, Outi Paija, Markku Salonen, Harry Björklund, Juha Rouru, Markku Anttila. Pharmacokinetics of deramciclane, a novel anxiolytic agent, after intravenous and oral administration. Drugs in R&D. 2003; 4(6):339-45. doi: 10.2165/00126839-200304060-00002. [PMID: 14584962]
  • Kálmán Magyar, József Lengyel, Andrea Bolehovszky, Gyula Grézal, Imre Klebovich. Studies of the side chain cleavage of deramciclane in rats with radiolabelled compounds. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2002 Mar; 15(2):217-23. doi: 10.1016/s0928-0987(02)00003-9. [PMID: 11849919]
  • A Tolokán, V Horváth, G Horvai, A Egresi, K B Nemes, I Klebovich. Determination of deramciclane and N-desmethylderamciclane in human plasma by liquid chromatography-tandem mass spectrometry using off-line robotic sample pretreatment. Journal of chromatography. A. 2000 Oct; 896(1-2):279-90. doi: 10.1016/s0021-9673(00)00778-0. [PMID: 11093663]
  • K B Nemes, M Abermann, E Bojti, G Grézal, S Al-Behaisi, I Klebovich. Oral, intraperitoneal and intravenous pharmacokinetics of deramciclane and its N-desmethyl metabolite in the rat. The Journal of pharmacy and pharmacology. 2000 Jan; 52(1):47-51. doi: 10.1211/0022357001773670. [PMID: 10716602]
  • H Kanerva, O Kilkku, E Heinonen, A Helminen, J Rouru, S Tarpila, M Scheinin, R Huupponen, I Klebovich, S Drabant, A Urtti. The single dose pharmacokinetics and safety of deramciclane in healthy male volunteers. Biopharmaceutics & drug disposition. 1999 Oct; 20(7):327-34. doi: 10.1002/(sici)1099-081x(199910)20:7<327::aid-bdd192>3.0.co;2-8. [PMID: 10760840]
  • H Kanerva, H Vilkman, K Någren, O Kilkku, M Kuoppamäki, E Syvälahti, J Hietala. Brain 5-HT2A receptor occupancy of deramciclane in humans after a single oral administration--a positron emission tomography study. Psychopharmacology. 1999 Jul; 145(1):76-81. doi: 10.1007/s002130051034. [PMID: 10445375]
  • K Ludányi, K Vékey, J Szúnyog, E Mincsovics, T Karancsi, K Ujszászy, K B Nemes, I Klebovich. Application of overpressured layer chromatography combined with digital autoradiography and mass spectrometry in the study of deramciclane metabolism. Journal of AOAC International. 1999 Mar; 82(2):231-8. doi: 10.1093/jaoac/82.2.231. [PMID: 10191528]
  • J Lengyel, E Bojti, A Bolehovszky, G Grézal, I Klebovich, K Magyar. Pharmacokinetics of deramciclane in rabbits. Arzneimittel-Forschung. 1998 Nov; 48(11):1063-8. doi: NULL. [PMID: 9850425]
  • H Kanerva, H Huuskonen, A Alhonen-Raatesalmi, T Nevalainen, A Urtti. Pharmacokinetics of deramciclane in dogs after single oral and intravenous dosing and multiple oral dosing. Biopharmaceutics & drug disposition. 1998 Nov; 19(8):531-9. doi: 10.1002/(sici)1099-081x(1998110)19:8<531::aid-bdd135>3.0.co;2-i. [PMID: 9840215]
  • H Kanerva, I Klebovich, S Drabant, A Urtti, T Nevalainen. Different absorption profiles of deramciclane in man and in dog. The Journal of pharmacy and pharmacology. 1998 Oct; 50(10):1087-93. doi: 10.1111/j.2042-7158.1998.tb03317.x. [PMID: 9821653]
  • J Lengyel, A Bolehovszky, I Klebovich, M Aberman, K Magyar. Absorption of the new anxiolytic compound deramciclane in rats, dogs and rabbits. Arzneimittel-Forschung. 1998 May; 48(5):455-60. doi: NULL. [PMID: 9638311]
  • K Magyar, J Lengyel, I Klebovich, I Urmös, G Grézal. Distribution of deramciclane (EGIS-3886) in rat brain regions. European journal of drug metabolism and pharmacokinetics. 1998 Apr; 23(2):125-31. doi: 10.1007/bf03189327. [PMID: 9725469]
  • L A Borden, T G Dhar, K E Smith, T A Branchek, C Gluchowski, R L Weinshank. Cloning of the human homologue of the GABA transporter GAT-3 and identification of a novel inhibitor with selectivity for this site. Receptors & channels. 1994; 2(3):207-13. doi: NULL. [PMID: 7874447]