Afegostat (BioDeep_00000756252)

   


代谢物信息卡片


5-epi-Isofagomine

化学式: C6H13NO3 (147.0895388)
中文名称: Afegostat
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(C(CN1)O)O)CO
InChI: InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5-,6-/m1/s1

描述信息

C87006 - Pharmacological Chaperone

同义名列表

2 个代谢物同义名

5-epi-Isofagomine; Afegostat



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Liwen Zhang, Yongliang Bai, Shulan Su, Zhen Ouyang, Li Liu, Gang Pan, Dawei Qian, Jinao Duan. Metabolism, transformation and dynamic changes of alkaloids in silkworm during feeding mulberry leaves. Natural product research. 2019 Apr; 33(8):1182-1190. doi: 10.1080/14786419.2018.1465422. [PMID: 29862842]
  • Ying Sun, Benjamin Liou, You-Hai Xu, Brian Quinn, Wujuan Zhang, Rick Hamler, Kenneth D R Setchell, Gregory A Grabowski. Ex vivo and in vivo effects of isofagomine on acid β-glucosidase variants and substrate levels in Gaucher disease. The Journal of biological chemistry. 2012 Feb; 287(6):4275-87. doi: 10.1074/jbc.m111.280016. [PMID: 22167193]
  • Peter A Burland, Helen M I Osborn, Andrea Turkson. Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes. Bioorganic & medicinal chemistry. 2011 Sep; 19(18):5679-92. doi: 10.1016/j.bmc.2011.07.019. [PMID: 21862336]
  • Ying Sun, Huimin Ran, Benjamin Liou, Brian Quinn, Matt Zamzow, Wujuan Zhang, Jacek Bielawski, Kazuyuki Kitatani, Kenneth D R Setchell, Yusuf A Hannun, Gregory A Grabowski. Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse. PloS one. 2011 Apr; 6(4):e19037. doi: 10.1371/journal.pone.0019037. [PMID: 21533102]
  • Richie Khanna, Elfrida R Benjamin, Lee Pellegrino, Adriane Schilling, Brigitte A Rigat, Rebecca Soska, Hadis Nafar, Brian E Ranes, Jessie Feng, Yi Lun, Allan C Powe, David J Palling, Brandon A Wustman, Raphael Schiffmann, Don J Mahuran, David J Lockhart, Kenneth J Valenzano. The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of beta-glucosidase. The FEBS journal. 2010 Apr; 277(7):1618-38. doi: 10.1111/j.1742-4658.2010.07588.x. [PMID: 20148966]
  • Raquel L Lieberman, J Alejandro D'aquino, Dagmar Ringe, Gregory A Petsko. Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry. 2009 Jun; 48(22):4816-27. doi: 10.1021/bi9002265. [PMID: 19374450]
  • A Bülow, I W Plesner, M Bols. Slow inhibition of almond beta-glucosidase by azasugars: determination of activation energies for slow binding. Biochimica et biophysica acta. 2001 Feb; 1545(1-2):207-15. doi: 10.1016/s0167-4838(00)00278-8. [PMID: 11342046]