Dicyclomine hydrochloride (BioDeep_00000756249)
代谢物信息卡片
化学式: C19H36ClNO2 (345.24344260000004)
中文名称: 盐酸双环维林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:4515
- KEGGdrug: D00717
- PubChem: 441344
- ChEMBL: CHEMBL1200479
- MeSH: Dicyclomine
- CAS: 67-92-5
- medchemexpress: HY-B1339
分类词条
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代谢反应
0 个相关的代谢反应过程信息。
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- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
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- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Syed Adil Hussain Shah, Ambreen Aleem. Investigations of plausible pharmacodynamics supporting the antispasmodic, bronchodilator, and antidiarrheal activities of Berberis lycium Royle. Via in silico, in vitro, and in vivo studies.
Journal of ethnopharmacology.
2023 Apr; 305(?):116115. doi:
10.1016/j.jep.2022.116115. [PMID: 36587881] - Arpita Konar, Richa Gupta, Rajendra K Shukla, Bryan Maloney, Vinay K Khanna, Renu Wadhwa, Debomoy K Lahiri, Mahendra K Thakur. M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera.
Scientific reports.
2019 Sep; 9(1):13990. doi:
10.1038/s41598-019-48238-6. [PMID: 31570736] - Awad Ali, Ashwini Jadhav, Priyanka Jangid, Rajendra Patil, Amruta Shelar, Sankunny Mohan Karuppayil. The human muscarinic acetylcholine receptor antagonist, Dicyclomine targets signal transduction genes and inhibits the virulence factors in the human pathogen, Candida albicans.
The Journal of antibiotics.
2018 03; 71(4):456-466. doi:
10.1038/s41429-017-0013-z. [PMID: 29348527] - Shahrukh Ali, Muhammad Ovais Omer, Mueen Ahmad Chaudhry, Muhammad Ashraf, Allah Bukhsh. A pharmacological evidence for the presence of antihistaminic and anticholinergic activities in Equisetum debile Roxb.
Indian journal of pharmacology.
2017 Jan; 49(1):98-101. doi:
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Journal of clinical pharmacology.
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Phytotherapy research : PTR.
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Journal of pharmaceutical and biomedical analysis.
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BMJ (Clinical research ed.).
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Neurochemical research.
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1989; 3(3):187-96. doi:
10.1016/0890-6238(89)90006-3. [PMID: 2520522] - B J Walker, J F Lang, R A Okerholm. Quantitative analysis of dicyclomine in human plasma by capillary gas chromatography and nitrogen-selective detection.
Journal of chromatography.
1987 Apr; 416(1):150-3. doi:
10.1016/0378-4347(87)80496-6. [PMID: 3597632] - T Ogiso, M Iwaki, A Ohtori. Effect of dicyclomine on intestinal absorption, disposition and biliary excretion of dexamethasone.
Journal of pharmacobio-dynamics.
1985 Jan; 8(1):41-9. doi:
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Teratology.
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Journal of pharmacobio-dynamics.
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The Journal of urology.
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American journal of obstetrics and gynecology.
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