Stiripentol (BioDeep_00000756230)
代谢物信息卡片
Stiripentol
化学式: C14H18O3 (234.1255878)
中文名称: 司替戊醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C(C=CC1=CC2=C(C=C1)OCO2)O
InChI: InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
描述信息
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94435
- KEGGdrug: D05928
- PubChem: 5311454
- DrugBank: DB09118
- ChEMBL: CHEMBL1983350
- CAS: 137767-55-6
- CAS: 131206-47-8
- CAS: 49763-96-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- J J García-Peñas, A Gil Nagel-Rein, R Sánchez-Carpintero, V Villanueva-Haba. Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Revista de neurologia.
2021 09; 73(S01):S1-S8. doi:
10.33588/rn.73s01.2021250. [PMID: 34486101] - Agnieszka Matuszewska, Beata Nowak, Anna Nikodem, Anna Merwid-Ląd, Benita Wiatrak, Tomasz Tomkalski, Diana Jędrzejuk, Ewa Szeląg, Tomasz Sozański, Maciej Danielewski, Paulina Jawień, Ireneusz Ceremuga, Marta Szandruk-Bender, Marek Bolanowski, Jarosław Filipiak, Adam Szeląg. Antiepileptic Stiripentol May Influence Bones.
International journal of molecular sciences.
2021 Jul; 22(13):. doi:
10.3390/ijms22137162. [PMID: 34281215] - Agnieszka Matuszewska, Beata Nowak, Adam Szeląg, Anna Merwid-Ląd, Agnieszka Partyka, Tomasz Tomkalski, Marzenna Podhorska-Okołów, Aleksandra Piotrowska, Joanna Kwiatkowska, Wojciech Niżański. Long-term stiripentol administration, an anticonvulsant drug, does not impair sperm parameters in rats.
Andrologia.
2021 Jul; 53(6):e14058. doi:
10.1111/and.14058. [PMID: 33792946] - Emmanuel Letavernier, Michel Daudon. [Effect of stiripentol on urine oxalate excretion].
Nephrologie & therapeutique.
2021 Apr; 17S(?):S95-S99. doi:
10.1016/j.nephro.2020.02.001. [PMID: 33910706] - Sara Meirinho, Gonçalo Campos, Márcio Rodrigues, Ana Fortuna, Amílcar Falcão, Gilberto Alves. Salting-out assisted liquid-liquid extraction method optimized by design of experiments for the simultaneous high-performance liquid chromatography analysis of perampanel and stiripentol in mouse matrices.
Journal of separation science.
2020 Dec; 43(23):4289-4304. doi:
10.1002/jssc.202000656. [PMID: 32997431] - Caroline Kempf, Anja Pfau, Johannes Holle, Karen Müller-Schlüter, Philip Bufler, Felix Knauf, Dominik Müller. Stiripentol fails to lower plasma oxalate in a dialysis-dependent PH1 patient.
Pediatric nephrology (Berlin, Germany).
2020 09; 35(9):1787-1789. doi:
10.1007/s00467-020-04585-5. [PMID: 32418144] - Nicole Trabs, Mathias Trabs, Stefan Stodieck, Patrick M House. Influence of stiripentol on perampanel serum levels.
Epilepsy research.
2020 08; 164(?):106367. doi:
10.1016/j.eplepsyres.2020.106367. [PMID: 32446162] - Emmanuel Letavernier, Michel Daudon. Stiripentol identifies a therapeutic target to reduce oxaluria.
Current opinion in nephrology and hypertension.
2020 07; 29(4):394-399. doi:
10.1097/mnh.0000000000000621. [PMID: 32452916] - Elinor Ben-Menachem, Boudewijn Gunning, Carmen María Arenas Cabrera, Kevan VanLandingham, Julie Crockett, David Critchley, Louise Wray, Bola Tayo, Gilmour Morrison, Manuel Toledo. A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy.
CNS drugs.
2020 06; 34(6):661-672. doi:
10.1007/s40263-020-00726-4. [PMID: 32350749] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Hiroko Ikeda, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Impact of CYP2C19 Phenotypes on Clinical Efficacy of Stiripentol in Japanese Patients With Dravet Syndrome.
Therapeutic drug monitoring.
2020 04; 42(2):302-308. doi:
10.1097/ftd.0000000000000676. [PMID: 31318844] - Christina M Wyatt, Tilman B Drüeke. Stiripentol for the treatment of primary hyperoxaluria and calcium oxalate nephropathy.
Kidney international.
2020 01; 97(1):17-19. doi:
10.1016/j.kint.2019.06.011. [PMID: 31451300] - Yajun Bai, Xirui He, Yujun Bai, Ying Sun, Zefeng Zhao, Xufei Chen, Bin Li, Jing Xie, Yang Li, Pu Jia, Xue Meng, Ye Zhao, Yanrui Ding, Chaoni Xiao, Shixiang Wang, Jie Yu, Sha Liao, Yajun Zhang, Zhiling Zhu, Qiang Zhang, Yuhui Zhao, Fanggang Qin, Yi Zhang, Xiaoyang Wei, Min Zeng, Jing Liang, Ye Cuan, Guangzhi Shan, Tai-Ping Fan, Biao Wu, Xiaohui Zheng. Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study.
European journal of medicinal chemistry.
2019 Dec; 183(?):111650. doi:
10.1016/j.ejmech.2019.111650. [PMID: 31539780] - Pavel Klein, Dwain Tolbert, Barry E Gidal. Drug-drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures.
Epilepsy & behavior : E&B.
2019 10; 99(?):106459. doi:
10.1016/j.yebeh.2019.106459. [PMID: 31519475] - Jacob S Stevens, Qais Al-Awqati. Lactate dehydrogenase 5: identification of a druggable target to reduce oxaluria.
The Journal of clinical investigation.
2019 05; 129(6):2201-2204. doi:
10.1172/jci128709. [PMID: 31107247] - Marine Le Dudal, Léa Huguet, Joëlle Perez, Sophie Vandermeersch, Elise Bouderlique, Ellie Tang, Carole Martori, Nicole Chemaly, Rima Nabbout, Jean-Philippe Haymann, Vincent Frochot, Laurent Baud, Georges Deschênes, Michel Daudon, Emmanuel Letavernier. Stiripentol protects against calcium oxalate nephrolithiasis and ethylene glycol poisoning.
The Journal of clinical investigation.
2019 04; 129(6):2571-2577. doi:
10.1172/jci99822. [PMID: 30946030] - Sophie Peigné, Stéphanie Chhun, Michel Tod, Elisabeth Rey, Christelle Rodrigues, Catherine Chiron, Gérard Pons, Vincent Jullien. Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy.
Clinical pharmacokinetics.
2018 06; 57(6):739-748. doi:
10.1007/s40262-017-0592-7. [PMID: 28819726] - Toshihiro Jogamoto, Yoshiaki Yamamoto, Mitsumasa Fukuda, Yuka Suzuki, Katsumi Imai, Yukitoshi Takahashi, Yushi Inoue, Yoko Ohtsuka. Add-on stiripentol elevates serum valproate levels in patients with or without concomitant topiramate therapy.
Epilepsy research.
2017 02; 130(?):7-12. doi:
10.1016/j.eplepsyres.2016.12.014. [PMID: 28081475] - Vincent Jullien, Stéphanie Chhun, Elisabeth Rey, Olivier Dulac, Michel Tod, Catherine Chiron, Gérard Pons. Pharmacokinetics of clobazam and N-desmethylclobazam in children with dravet syndrome receiving concomitant stiripentol and valproic Acid.
Clinical pharmacokinetics.
2015 May; 54(5):527-36. doi:
10.1007/s40262-014-0223-5. [PMID: 25503589] - Takeshi Kouga, Hiroko Shimbo, Mizue Iai, Sumimasa Yamashita, Atsushi Ishii, Yukiko Ihara, Shinichi Hirose, Kazuhiro Yamakawa, Hitoshi Osaka. Effect of CYP2C19 polymorphisms on stiripentol administration in Japanese cases of Dravet syndrome.
Brain & development.
2015 Feb; 37(2):243-9. doi:
10.1016/j.braindev.2014.04.003. [PMID: 24819914] - Yushi Inoue, Yoko Ohtsuka. Effectiveness of add-on stiripentol to clobazam and valproate in Japanese patients with Dravet syndrome: additional supportive evidence.
Epilepsy research.
2014 May; 108(4):725-31. doi:
10.1016/j.eplepsyres.2014.02.008. [PMID: 24630050] - Rima Nabbout, Catherine Chiron. Stiripentol: an example of antiepileptic drug development in childhood epilepsies.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.
2012 Sep; 16 Suppl 1(?):S13-7. doi:
10.1016/j.ejpn.2012.04.009. [PMID: 22695038] - Theodor W May, Rainer Boor, Thomas Mayer, Uwe Jürgens, Bernhard Rambeck, Nils Holert, Elisabeth Korn-Merker, Christian Brandt. Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication.
Therapeutic drug monitoring.
2012 Aug; 34(4):390-7. doi:
10.1097/ftd.0b013e31825dc4a6. [PMID: 22743350] - Marie-Clémence Verdier, Olivier Tribut, Danièle Bentué-Ferrer. [Therapeutic drug monitoring of stiripentol].
Therapie.
2012 Mar; 67(2):157-60. doi:
10.2515/therapie/2012014. [PMID: 22850103] - Jarogniew J Luszczki, Stanislaw J Czuczwar. Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis.
Naunyn-Schmiedeberg's archives of pharmacology.
2006 Oct; 374(1):51-64. doi:
10.1007/s00210-006-0100-3. [PMID: 16972063] - Pascale P Quilichini, Catherine Chiron, Yehezkel Ben-Ari, Henri Gozlan. Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels.
Epilepsia.
2006 Apr; 47(4):704-16. doi:
10.1111/j.1528-1167.2006.00497.x. [PMID: 16650136] - Carole Giraud, Jean-Marc Treluyer, Elisabeth Rey, Catherine Chiron, Jean Vincent, Gérard Pons, Agnès Tran. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Apr; 34(4):608-11. doi:
10.1124/dmd.105.007237. [PMID: 16415114] - N Cazali, A Tran, J M Treluyer, E Rey, P d'Athis, J Vincent, G Pons. Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human.
British journal of clinical pharmacology.
2003 Nov; 56(5):526-36. doi:
10.1046/j.0306-5251.2003.01919.x. [PMID: 14651727] - A Tran, J M Tréluyer, E Rey, J Barbet, G Ferracci, P d'Athis, J Vincent, G Pons. Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat.
Toxicology and applied pharmacology.
2001 Feb; 170(3):145-52. doi:
10.1006/taap.2000.9091. [PMID: 11162779] - J Perez, C Chiron, C Musial, E Rey, H Blehaut, P d'Athis, J Vincent, O Dulac. Stiripentol: efficacy and tolerability in children with epilepsy.
Epilepsia.
1999 Nov; 40(11):1618-26. doi:
10.1111/j.1528-1157.1999.tb02048.x. [PMID: 10565591] - A Tran, E Rey, G Pons, M Rousseau, P d'Athis, G Olive, G G Mather, F E Bishop, C J Wurden, R Labroo, W F Trager, K L Kunze, K E Thummel, J C Vincent, J M Gillardin, F Lepage, R H Levy. Influence of stiripentol on cytochrome P450-mediated metabolic pathways in humans: in vitro and in vivo comparison and calculation of in vivo inhibition constants.
Clinical pharmacology and therapeutics.
1997 Nov; 62(5):490-504. doi:
10.1016/s0009-9236(97)90044-8. [PMID: 9390105] - N K Phillips, J S Lockard. Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds.
Epilepsia.
1996 Oct; 37(10):991-9. doi:
10.1111/j.1528-1157.1996.tb00538.x. [PMID: 8822699] - A Tran, F Vauzelle-Kervroedan, E Rey, G Pous, P d'Athis, C Chiron, O Dulac, F Renard, G Olive. Effect of stiripentol on carbamazepine plasma concentration and metabolism in epileptic children.
European journal of clinical pharmacology.
1996; 50(6):497-500. doi:
10.1007/s002280050147. [PMID: 8858278] - P N Patsalos, J W Sander. Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
Drug safety.
1994 Jul; 11(1):37-67. doi:
10.2165/00002018-199411010-00005. [PMID: 7917080] - C Tang, K Zhang, F Lepage, R H Levy, T A Baillie. Metabolic chiral inversion of stiripentol in the rat. II. Influence of route of administration.
Drug metabolism and disposition: the biological fate of chemicals.
1994 Jul; 22(4):554-60. doi:
NULL. [PMID: 7956729] - J C Maurizis, M Rapp, J C Madelmont, J M Gillardin, F Lepage, P Labarre, J M Dupuy, A Veyre. Disposition of stiripentol in the pregnant and non-pregnant female rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1993 Dec; 23(12):1335-43. doi:
10.3109/00498259309059443. [PMID: 8135037] - N K Phillips, J S Lockard. Phenytoin and/or stiripentol in pregnancy: infant monkey hyperexcitability.
Epilepsia.
1993 Nov; 34(6):1117-22. doi:
10.1111/j.1528-1157.1993.tb02143.x. [PMID: 8243366] - M Bialer. Comparative pharmacokinetics of the newer antiepileptic drugs.
Clinical pharmacokinetics.
1993 Jun; 24(6):441-52. doi:
10.2165/00003088-199324060-00002. [PMID: 8513648] - J R Farwell, G D Anderson, B M Kerr, J A Tor, R H Levy. Stiripentol in atypical absence seizures in children: an open trial.
Epilepsia.
1993 Mar; 34(2):305-11. doi:
10.1111/j.1528-1157.1993.tb02416.x. [PMID: 8453942] - D D Shen, R H Levy, J L Savitch, A V Boddy, F Tombret, F Lepage. Comparative anticonvulsant potency and pharmacokinetics of (+)-and (-)-enantiomers of stiripentol.
Epilepsy research.
1992 Jun; 12(1):29-36. doi:
10.1016/0920-1211(92)90088-b. [PMID: 1526226] - A V Boddy, K Zhang, F Lepage, F Tombret, J G Slatter, T A Baillie, R H Levy. In vitro and in vivo investigations of dihydropyridine-based chemical delivery systems for anticonvulsants.
Pharmaceutical research.
1991 Jun; 8(6):690-7. doi:
10.1023/a:1015885530405. [PMID: 2062798] - B M Kerr, J M Martinez-Lage, C Viteri, J Tor, A C Eddy, R H Levy. Carbamazepine dose requirements during stiripentol therapy: influence of cytochrome P-450 inhibition by stiripentol.
Epilepsia.
1991 Mar; 32(2):267-74. doi:
10.1111/j.1528-1157.1991.tb05254.x. [PMID: 2004631] - D D Shen, R H Levy, M J Moor, J L Savitch. Efficacy of stiripentol in the intravenous pentylenetetrazol infusion seizure model in the rat.
Epilepsy research.
1990 Sep; 7(1):40-8. doi:
10.1016/0920-1211(90)90052-w. [PMID: 2292245] - R H Levy, A W Rettenmeier, G D Anderson, A J Wilensky, P N Friel, T A Baillie, A Acheampong, J Tor, M Guyot, P Loiseau. Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid.
Clinical pharmacology and therapeutics.
1990 Sep; 48(3):225-35. doi:
10.1038/clpt.1990.144. [PMID: 2119269] - J S Lockard, R H Levy. Carbamazepine plus stiripentol: is polytherapy by design possible?.
Epilepsia.
1988 Jul; 29(4):476-81. doi:
10.1111/j.1528-1157.1988.tb03748.x. [PMID: 3391151] - P Loiseau, E Strube, J Tor, R H Levy, C Dodrill. [Neurophysiological and therapeutic evaluation of stiripentol in epilepsy. Preliminary results].
Revue neurologique.
1988; 144(3):165-72. doi:
NULL. [PMID: 3368691] - T A Moreland, J Astoin, F Lepage, F Tombret, R H Levy, T A Baillie. The metabolic fate of stiripentol in man.
Drug metabolism and disposition: the biological fate of chemicals.
1986 Nov; 14(6):654-62. doi:
NULL. [PMID: 2877822] - J S Lockard, R H Levy, P H Rhodes, D F Moore. Stiripentol in acute/chronic efficacy tests in monkey model.
Epilepsia.
1985 Nov; 26(6):704-12. doi:
10.1111/j.1528-1157.1985.tb05715.x. [PMID: 4076073] - H S Lin, R H Levy. Pharmacokinetic profile of a new anticonvulsant, stiripentol, in the rhesus monkey.
Epilepsia.
1983 Dec; 24(6):692-703. doi:
10.1111/j.1528-1157.1983.tb04632.x. [PMID: 6641646] - R H Levy, H S Lin, H M Blehaut, J A Tor. Pharmacokinetics of stiripentol in normal man: evidence of nonlinearity.
Journal of clinical pharmacology.
1983 Nov; 23(11-12):523-33. doi:
10.1002/j.1552-4604.1983.tb01799.x. [PMID: 6662977] - F Pieri, R Wegmann, J Astoin. [Pharmacokinetic study of 3H-stiripentol in rats (author's transl)].
European journal of drug metabolism and pharmacokinetics.
1982 Jan; 7(1):5-10. doi:
10.1007/bf03189536. [PMID: 7067724] - R Wegmann, A Ilies, M Aurousseau. [Pharmaco-cellular enzymology of the mechanism of action of stiripentol in cardiazol-induced epilepsy. III. Protein, nucleoprotein, lipid, and proteoglycan metabolism].
Cellular and molecular biology, including cyto-enzymology.
1978; 23(4):455-80. doi:
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