Amprolium (BioDeep_00000755298)

   


代谢物信息卡片


1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride

化学式: C14H19ClN4 (278.1298164)
中文名称: 安普罗铵
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCC1=NC=C(C(=N1)N)C[N+]2=CC=CC=C2C.[Cl-]
InChI: /p-1

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent

同义名列表

2 个代谢物同义名

1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride; Amprolium



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shahenaz M H Hassan, Rasha Zayeda, H Elakany, Sohair Badr, A Abou-Rawash, Hoda Abd-Ellatieff. Anticoccidial activity of Aloe Vera Leafs' aqueous extract and vaccination against Eimeria tenella: pathological study in broilers. Veterinary research communications. 2024 Feb; 48(1):403-416. doi: 10.1007/s11259-023-10222-x. [PMID: 37736869]
  • Fatemah Alajmi, Tahani Al-Otaibi, Saleh Al-Quraishy, Esam M Al-Shaebi, Nawal Al-Hoshani, Mohamed A Dkhil, Rewaida Abdel-Gaber. Persea americana extract protects intestinal tissue from Eimeria papillata-induced murine Infection. BMC veterinary research. 2023 Nov; 19(1):248. doi: 10.1186/s12917-023-03810-1. [PMID: 38017513]
  • Madison Hamilton, Xiaolei Ma, Brigid A McCrea, Miranda Carrisosa, Kenneth S Macklin, Chao Zhang, Xu Wang, Rüdiger Hauck. Influence of Eimeria spp. Infection on Chicken Jejunal Microbiota and the Efficacy of Two Alternative Products Against the Infection. Avian diseases. 2020 06; 64(2):123-129. doi: 10.1637/0005-2086-64.2.123. [PMID: 32550611]
  • Tauseef Ahmad Malik, Azra N Kamili, M Z Chishti, Syed Tanveer, Shazia Ahad, R K Johri. Synergistic approach for treatment of chicken coccidiosis using berberine--A plant natural product. Microbial pathogenesis. 2016 Apr; 93(?):56-62. doi: 10.1016/j.micpath.2016.01.012. [PMID: 26802524]
  • Philippa Gibbons, David Love, Thomas Craig, Christine Budke. Efficacy of treatment of elevated coccidial oocyst counts in goats using amprolium versus ponazuril. Veterinary parasitology. 2016 Mar; 218(?):1-4. doi: 10.1016/j.vetpar.2015.12.020. [PMID: 26872920]
  • Muhammad Avais, Ghazanfar Rashid, Muhammad Ijaz, Muhammad Arif Khan, Amar Nasir, Muhammad Shoaib Jahanzaib, Jawaria Ali Khan, Sajid Hameed, Michael Philipp Reichel. Evaluation of furazolidone, sulfadimidine and amprolium to treat coccidiosis in Beetal goats under field conditions. Pakistan journal of pharmaceutical sciences. 2016 Mar; 29(2):485-7. doi: . [PMID: 27087093]
  • Amira M El-Kosasy, Lobna A Hussein, N Magdy, Mahmoud M Abbas. Sensitive spectrofluorimetric methods for determination of ethopabate and amprolium hydrochloride in chicken plasma and their residues in food samples. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015; 150(?):430-9. doi: 10.1016/j.saa.2015.05.082. [PMID: 26057097]
  • Gabrielle Young, Mark L Alley, Derek M Foster, Geof W Smith. Efficacy of amprolium for the treatment of pathogenic Eimeria species in Boer goat kids. Veterinary parasitology. 2011 Jun; 178(3-4):346-9. doi: 10.1016/j.vetpar.2011.01.028. [PMID: 21333448]
  • E N Kimbita, R S Silayo, E D Mwega, A T Mtau, J B Mroso. Studies on the Eimeria of goats at Magadu Dairy Farm SUA, Morogoro, Tanzania. Tropical animal health and production. 2009 Oct; 41(7):1263-5. doi: 10.1007/s11250-009-9310-2. [PMID: 19184505]
  • N E Nweze, I S Obiwulu. Anticoccidial effects of Ageratum conyzoides. Journal of ethnopharmacology. 2009 Feb; 122(1):6-9. doi: 10.1016/j.jep.2008.11.014. [PMID: 19084586]
  • Mohamed M Ghanem, Mervat E Radwaan, Abdel Moneim M Moustafa, Mohamed H Ebeid. Comparative therapeutic effect of toltrazuril, sulphadimidine and amprolium on Eimeria bovis and Eimeria zuernii given at different times following infection in buffalo calves (Bubalus bubalis). Preventive veterinary medicine. 2008 Apr; 84(1-2):161-70. doi: 10.1016/j.prevetmed.2007.12.013. [PMID: 18262668]
  • Wenlu Song, Min Huang, Wilson Rumbeiha, Hui Li. Determination of amprolium, carbadox, monensin, and tylosin in surface water by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2007; 21(12):1944-50. doi: 10.1002/rcm.3042. [PMID: 17510929]
  • Anakalo Shitandi, Aila Oketch, Symon Mahungu. Evaluation of a Bacillus stearothermophilus tube test as a screening tool for anticoccidial residues in poultry. Journal of veterinary science. 2006 Jun; 7(2):177-80. doi: 10.4142/jvs.2006.7.2.177. [PMID: 16645344]
  • E Karagouni, F Athanassopoulou, A Lytra, C Komis, E Dotsika. Antiparasitic and immunomodulatory effect of innovative treatments against Myxobolus sp. infection in Diplodus puntazzo. Veterinary parasitology. 2005 Dec; 134(3-4):215-28. doi: 10.1016/j.vetpar.2005.07.020. [PMID: 16169152]
  • James W Carpenter, Meliton N Novilla, Jeff S Hatfield. Efficacy of selected coccidiostats in sandhill cranes (Grus canadensis) following challenge. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2005 Sep; 36(3):391-400. doi: 10.1638/02-051.1. [PMID: 17312756]
  • E Karagouni, F Athanassopoulou, P Tsagozis, E Ralli, T Moustakareas, K Lytra, E Dotsika. The impact of a successful anti-myxosporean treatment on the phagocyte functions of juvenile and adult Sparus aurata L. International journal of immunopathology and pharmacology. 2005 Jan; 18(1):121-32. doi: 10.1177/039463200501800113. [PMID: 15698517]
  • F Athanassopoulou, E Karagouni, E Dotsika, V Ragias, J Tavla, P Christofilloyanis, I Vatsos. Efficacy and toxicity of orally administrated anti-coccidial drugs for innovative treatments of Myxobolus sp. infection in Puntazzo puntazzo. Diseases of aquatic organisms. 2004 Dec; 62(3):217-26. doi: 10.3354/dao062217. [PMID: 15672877]
  • G Rindi, C Patrini, A Nauti, R Bellazzi, P Magni. Three thiamine analogues differently alter thiamine transport and metabolism in nervous tissue: an in vivo kinetic study using rats. Metabolic brain disease. 2003 Dec; 18(4):245-63. doi: 10.1023/b:mebr.0000020187.98238.58. [PMID: 15128183]
  • A Lundén, P Thebo, S Gunnarsson, P Hooshmian-Rad, R Tauson, A Uggla. Eimeria infections in litter-based, high stocking density systems for loose-housed laying hens in Sweden. British poultry science. 2000 Sep; 41(4):440-7. doi: 10.1080/713654973. [PMID: 11128384]
  • K Hamamoto, R Koike, Y Machida. Bioavailability of amprolium in fasting and nonfasting chickens after intravenous and oral administration. Journal of veterinary pharmacology and therapeutics. 2000 Feb; 23(1):9-14. doi: 10.1046/j.1365-2885.2000.00239.x. [PMID: 10747238]
  • L C Park, N Y Calingasan, K Uchida, H Zhang, G E Gibson. Metabolic impairment elicits brain cell type-selective changes in oxidative stress and cell death in culture. Journal of neurochemistry. 2000 Jan; 74(1):114-24. doi: 10.1046/j.1471-4159.2000.0740114.x. [PMID: 10617112]
  • L R McDougald, B P Seibert. Residual activity of anticoccidial drugs in chickens after withdrawal of medicated feeds. Veterinary parasitology. 1998 Jan; 74(2-4):91-9. doi: 10.1016/s0304-4017(97)00172-6. [PMID: 9561697]
  • K Hamamoto, R Koike, A Shirakura, N Sasaki, Y Machida. Rapid and sensitive determination of amprolium in chicken plasma by high-performance liquid chromatography with post-column reaction. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jun; 693(2):489-92. doi: 10.1016/s0378-4347(97)00088-1. [PMID: 9210457]
  • P R Dodd, G J Thomas, A McCloskey, D I Crane, I D Smith. The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model. Metabolic brain disease. 1996 Mar; 11(1):39-54. doi: 10.1007/bf02080930. [PMID: 8815389]
  • M G el-Sayed, M I Abd el-Aziz, M H el-Kholy. Kinetic behaviour of sulphaquinoxaline and amprolium in chickens. DTW. Deutsche tierarztliche Wochenschrift. 1995 Dec; 102(12):481-5. doi: NULL. [PMID: 8591749]
  • R K Tanwar, K S Malik, A K Gahlot. Polioencephalomalacia induced with amprolium in buffalo calves--clinicopathologic findings. Zentralblatt fur Veterinarmedizin. Reihe A. 1994 Jun; 41(5):396-404. doi: 10.1111/j.1439-0442.1994.tb00106.x. [PMID: 7817642]
  • W A Rahman. Effect of subclinical Eimeria species infections in tropical goats subsequently challenged with caprine Haemonchus contortus. The Veterinary record. 1994 Mar; 134(10):235-7. doi: 10.1136/vr.134.10.235. [PMID: 8197681]
  • C de la Fuente, M Cuquerella, L Carrera, J M Alunda. Effect of subclinical coccidiosis in kids on subsequent trichostrongylid infection after weaning. Veterinary parasitology. 1993 Jan; 45(3-4):177-83. doi: 10.1016/0304-4017(93)90072-u. [PMID: 8447060]
  • M C Cabel, R A Norton, T A Yazwinski, P W Waldroup. Efficacy of different anticoccidials against experimental coccidiosis in large white turkeys. Poultry science. 1991 Feb; 70(2):289-92. doi: 10.3382/ps.0700289. [PMID: 2027834]
  • H D Danforth, W I Anderson. The ultrastructural effect of amprolium medication on development of Eimeria adenoeides in turkeys. Avian diseases. 1989 Apr; 33(2):303-9. doi: 10.2307/1590848. [PMID: 2751563]
  • T Kasahara, S Ichijo, S Osame, T Sarashina. Clinical and biochemical findings in bovine cerebrocortical necrosis produced by oral administration of amprolium. Nihon juigaku zasshi. The Japanese journal of veterinary science. 1989 Feb; 51(1):79-85. doi: 10.1292/jvms1939.51.79. [PMID: 2927040]
  • B Koudela, J Vítovec, J Sonková, D Vobrová. [Coccidiosis in suckling calves raised on large farms]. Veterinarni medicina. 1986 Dec; 31(12):725-32. doi: NULL. [PMID: 3101268]
  • J Greenwood, O E Pratt. Comparison of the effects of some thiamine analogues upon thiamine transport across the blood-brain barrier of the rat. The Journal of physiology. 1985 Dec; 369(?):79-91. doi: 10.1113/jphysiol.1985.sp015889. [PMID: 4093890]
  • J V Ernst, D S Lindsay, W L Current. Control of Isospora suis-induced coccidiosis on a swine farm. American journal of veterinary research. 1985 Mar; 46(3):643-5. doi: NULL. [PMID: 4039545]
  • J Greenwood, O E Pratt. Inhibition of thiamine transport across the blood-brain barrier in the rat by a chemical analogue of the vitamin. The Journal of physiology. 1983 Mar; 336(?):479-86. doi: 10.1113/jphysiol.1983.sp014592. [PMID: 6875915]
  • P H Stockdale, A Sheard, G B Tiffin. Resistance to Eimeria bovis produced after chemotherapy of experimental infections in calves. Veterinary parasitology. 1982 Feb; 9(3-4):171-7. doi: 10.1016/0304-4017(82)90061-9. [PMID: 7201191]
  • R G Leek, R Fayer. Amprolium for prophylaxis of ovine Sarcocystis. The Journal of parasitology. 1980 Feb; 66(1):100-6. doi: 10.2307/3280598. [PMID: 6767828]
  • G M Horton, P H Stockdale. Effects of amprolium and monensin on oocyst discharge, feed utilization, and ruminal metabolism of lambs with coccidiosis. American journal of veterinary research. 1979 Jul; 40(7):966-70. doi: NULL. [PMID: 507500]
  • H W Smith, J F Tucker. The effect of antimicrobial feed additives on the colonization of the alimentary tract of chickens by Salmonella typhimurium. The Journal of hygiene. 1978 Apr; 80(2):217-31. doi: 10.1017/s0022172400053560. [PMID: 344789]
  • K H Beyer, R T Gelarden. Functional characteristics of the renal tubular secretion of amprolium, a quaternary organic base. The Journal of pharmacology and experimental therapeutics. 1975 Nov; 195(2):194-200. doi: NULL. [PMID: 241842]
  • R Fayer, A J Johnson. Effect of amprolium on acute sarcocystosis in experimentally infected calves. The Journal of parasitology. 1975 Oct; 61(5):932-6. doi: NULL. [PMID: 810561]
  • K E Webb, J P Fontenot. Medicinal drug residues in broiler litter and tissues from cattle fed litter. Journal of animal science. 1975 Oct; 41(4):1212-7. doi: 10.2527/jas1975.4141212x. [PMID: 1176372]
  • O Oe, A Arakawa. Effect of feed additive antibiotics on chickens infected with Eimeria tenella. Poultry science. 1975 Jul; 54(4):1008-18. doi: 10.3382/ps.0541008. [PMID: 1161694]
  • M Mitrovic, E G Schildknecht. Lasalocid: resistance and cross-resistance studies in Eimeria tenella-infected chicks. Poultry science. 1975 May; 54(3):750-6. doi: 10.3382/ps.0540750. [PMID: 1153374]
  • T K Jeffers. Eimeria tenella: incidence, distribution, and anticoccidial drug resistance of isolants in major broiler-producing areas. Avian diseases. 1974 Jan; 18(1):74-84. doi: NULL. [PMID: 4814556]
  • S Ito, K Tsunoda, H Nishikawa. Effects of robenidine and some other drugs on mice experimentally infected with toxoplasma. National Institute of Animal Health quarterly. 1974; 14(3):129-36. doi: NULL. [PMID: 4437645]
  • L M Markson, E E Edwin, G Lewis, C Richardson. The production of cerebrocortical necrosis in ruminant calves by the intraruminal administration of Amprolium. The British veterinary journal. 1974 Jan; 130(1):9-16. doi: 10.1016/s0007-1935(17)35985-7. [PMID: 4820081]
  • L R McDougald, R B Galloway. Eimeria tenella: anticoccidial drug activity in cell cultures. Experimental parasitology. 1973 Oct; 34(2):189-96. doi: 10.1016/0014-4894(73)90078-7. [PMID: 4744839]
  • H D Chapman, J A Lewis, R M Searle. The effect of naturally acquired infections of coccidia in lambs. Research in veterinary science. 1973 May; 14(3):369-75. doi: 10.1016/s0034-5288(18)33890-6. [PMID: 4805157]
  • L P Joyner, C C Norton. The drug-sensitivity of recently isolated strains of Eimeria meleagrimitis and a laboratory strain of Eimeria adenoeides in turkeys to ethopabate. Research in veterinary science. 1973 May; 14(3):279-84. doi: NULL. [PMID: 4805150]
  • C G Lilja. Cerebro-cortical necrosis (C.C.N.) in calf. An experimental reproduction of the disease. Acta veterinaria Scandinavica. 1973; 14(3):464-73. doi: 10.1186/bf03547433. [PMID: 4796625]
  • J F Ryley, R G Wilson. Comparative studies with anticoccidials and three species of chicken coccidia in vivo and in vitro. The Journal of parasitology. 1972 Aug; 58(4):664-8. doi: NULL. [PMID: 4262551]
  • P R Fitzgerald. Efficacy of monensin or amprolium in the prevention of hepatic coccidiosis in rabbits. The Journal of protozoology. 1972 May; 19(2):332-4. doi: 10.1111/j.1550-7408.1972.tb03469.x. [PMID: 5032226]
  • N F Baker, G T Walters, R A Fisk. Amprolium for control of coccidiosis in feedlot lambs. American journal of veterinary research. 1972 Jan; 33(1):83-6. doi: NULL. [PMID: 5058543]