Azalomycin (BioDeep_00000755268)
Secondary id: BioDeep_00000010938
代谢物信息卡片
化学式: C54H88O18 (1024.5970348)
中文名称: 阿扎霉素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1C(OC(CC1OC2CC(C(C(O2)C)O)O)(C(C)C(C(C)C3C(C=CC=CC(=O)OC(C(C=CC=CC(=O)O3)C)C(C)C(C(C)C4(CC(C(C(O4)C)CC)OC5CC(C(C(O5)C)O)O)O)O)C)O)O)C
InChI: InChI=1S/C54H88O18/c1-13-37-33(9)71-53(63,25-41(37)67-45-23-39(55)49(61)35(11)65-45)31(7)47(59)29(5)51-27(3)19-15-17-22-44(58)70-52(28(4)20-16-18-21-43(57)69-51)30(6)48(60)32(8)54(64)26-42(38(14-2)34(10)72-54)68-46-24-40(56)50(62)36(12)66-46/h15-22,27-42,45-52,55-56,59-64H,13-14,23-26H2,1-12H3/b19-15+,20-16+,21-18+,22-17+/t27-,28-,29-,30-,31-,32-,33+,34+,35-,36-,37+,38+,39-,40-,41+,42+,45-,46-,47+,48+,49+,50+,51-,52-,53+,54+/m0/s1
描述信息
A macrodiolide that is isolated from several bacteria including Streptomyces violaceoniger and other soil actinomycetes.
同义名列表
2 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:77879
- KEGG: C15844
- PubChem: 6444206
- ChEMBL: CHEMBL3740707
- KNApSAcK: C00018682
- CAS: 37318-06-2
- MetaboLights: MTBLC77879
- PubChem: 47205164
- PDB-CCD: ELO
- NIKKAJI: J443.316E
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenyan He, Wenfang Wang, Jiaxiang Ma, Guosong Zheng, Andrei A Zimin, Weihong Jiang, Jinzhong Tian, Yinhua Lu. Crossregulation of rapamycin and elaiophylin biosynthesis by RapH in Streptomyces rapamycinicus.
Applied microbiology and biotechnology.
2022 Mar; 106(5-6):2147-2159. doi:
10.1007/s00253-022-11847-9. [PMID: 35218390] - Ruoxuan Bao, Yongmei Meng, Haibo Zhang, Chen Yang, Wei Li, Cheng Zhang, Jinye Zhang, Renqiang Sun, Zengxia Li, Wei Jiang, Chensong Zhang, Changsheng Zhang, Hai-Xin Yuan, Yongjun Dang. Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK.
Cell death & disease.
2021 10; 12(11):972. doi:
10.1038/s41419-021-04264-9. [PMID: 34671010] - Larissa Buedenbender, Luke P Robertson, Leonardo Lucantoni, Vicky M Avery, D İpek Kurtböke, Anthony R Carroll. HSQC-TOCSY Fingerprinting-Directed Discovery of Antiplasmodial Polyketides from the Marine Ascidian-Derived Streptomyces sp. (USC-16018).
Marine drugs.
2018 May; 16(6):. doi:
10.3390/md16060189. [PMID: 29849004] - Sasikumar Arunachalam Palaniyandi, Seung Hwan Yang, Joo-Woh Suh. Foliar Application of Extract from an Azalomycin-Producing Streptomyces malaysiensis Strain MJM1968 Suppresses Yam Anthracnose Caused by Colletotrichum gloeosporioides.
Journal of microbiology and biotechnology.
2016 Jun; 26(6):1103-8. doi:
10.4014/jmb.1601.01018. [PMID: 26975770] - Doseung Lee, Jin-Kyu Woo, Donghern Kim, Minyoung Kim, Somi K Cho, Jae Hoon Kim, Se Pill Park, Hyo Yeon Lee, Key Zung Riu, Dong-Sun Lee. Antiviral activity of methylelaiophylin, an alpha-glucosidase inhibitor.
Journal of microbiology and biotechnology.
2011 Mar; 21(3):263-6. doi:
10.4014/jmb.1011.11002. [PMID: 21464596] - P A Grigoriev, R Schlegel, U Gräfe. Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes.
Bioelectrochemistry (Amsterdam, Netherlands).
2001 Aug; 54(1):11-5. doi:
10.1016/s0302-4598(01)00102-7. [PMID: 11506969]