Etamsylate (BioDeep_00000754783)

   


代谢物信息卡片


Ethamsylate

化学式: C10H17NO5S (263.0827)
中文名称: 酚磺乙胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNCC.C1=CC(=C(C=C1O)S(=O)(=O)O)O
InChI: 5H,3-4H2,1-2H3

描述信息

B - Blood and blood forming organs > B02 - Antihemorrhagics > B02B - Vitamin k and other hemostatics
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
C78275 - Agent Affecting Blood or Body Fluid > C78311 - Hemostatic Agent

同义名列表

2 个代谢物同义名

Ethamsylate; Etamsylate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Eu Chang Hwang, Shreyas Gandhi, Jae Hung Jung, Mari Imamura, Myung Ha Kim, Ran Pang, Philipp Dahm. Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia. The Cochrane database of systematic reviews. 2018 10; 10(?):CD007360. doi: 10.1002/14651858.cd007360.pub3. [PMID: 30306544]
  • Alison C Bryant-Smith, Anne Lethaby, Cindy Farquhar, Martha Hickey. Antifibrinolytics for heavy menstrual bleeding. The Cochrane database of systematic reviews. 2018 04; 4(?):CD000249. doi: 10.1002/14651858.cd000249.pub2. [PMID: 29656433]
  • Wenqian Nong, Anran Zhao, Jinrui Wei, Xiao Lin, Lisheng Wang, Cuiwu Lin. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorganic & medicinal chemistry letters. 2017 09; 27(18):4506-4511. doi: 10.1016/j.bmcl.2017.07.058. [PMID: 28844387]
  • Qing Yao, Ming Wu, Jie Zhou, Meiyang Zhou, Dongping Chen, Lili Fu, Rongrong Bian, Xiaohong Xing, Lijun Sun, Xiaohong Hu, Lin Li, Bing Dai, Rudolf P Wüthrich, Yiyi Ma, Chang-Lin Mei. Treatment of Persistent Gross Hematuria with Tranexamic Acid in Autosomal Dominant Polycystic Kidney Disease. Kidney & blood pressure research. 2017; 42(1):156-164. doi: 10.1159/000474961. [PMID: 28395294]
  • Hiromichi Iwamura, Takuya Koie, Osamu Soma, Teppei Matsumoto, Atsushi Imai, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Chikara Ohyama. Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized, prospective study. BMC urology. 2015 Dec; 15(?):120. doi: 10.1186/s12894-015-0115-5. [PMID: 26643109]
  • Amir A Kuperman, Benjamin Brenner, Gili Kenet. Intraventricular haemorrhage in preterm infants--can we improve outcome by addressing coagulation?. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2015 Nov; 28 Suppl 1(?):2265-7. doi: 10.3109/14767058.2013.796165. [PMID: 23968273]
  • Shinsuke Shibuya, Zhang Xia, Mikio Sugimoto, Nobufumi Ueda, Reiji Haba, Yoshiyuki Kakehi. The phytotherapeutic agent, eviprostat, suppresses stromal proliferation and inflammation even after establishment of nonbacterial prostatitis in the rat prostate. Urology. 2014 Mar; 83(3):528-34. doi: 10.1016/j.urology.2013.11.033. [PMID: 24581515]
  • Milan Dastych, Ondrej Wiewiorka, Miroslava Benovská. Ethamsylate (Dicynone) interference in determination of serum creatinine, uric acid, triglycerides, and cholesterol in assays involving the Trinder reaction; in vivo and in vitro. Clinical laboratory. 2014; 60(8):1373-6. doi: 10.7754/clin.lab.2013.130902. [PMID: 25185424]
  • Yuko Kawai, Michiko Oka, Junko Kyotani, Tatsuya Oyama, Seiji Matsumoto, Hidehiro Kakizaki. Effect of the phytotherapeutic agent eviprostat on the bladder in a rat model of bladder overdistension/emptying. Neurourology and urodynamics. 2013 Sep; 32(7):1031-7. doi: 10.1002/nau.22350. [PMID: 23143863]
  • Ondrej Wiewiorka, Milan Dastych, Zdenka Čermáková. Strong negative interference of ethamsylate (Dicynone®) in serum creatinine quantification via enzymatic assay using Trinder reaction. Scandinavian journal of clinical and laboratory investigation. 2013 Aug; 73(5):449-51. doi: 10.3109/00365513.2013.794300. [PMID: 23688203]
  • Alaa El-Gindy, Mohammad Wafaa Nassar, Khalid Abdel-Salam Attia, Hamed Hamed Abu-Seada, Mahmoud El-Ghandour. High-performance liquid chromatographic determination of Ethamsylate in urine and tablets. Journal of AOAC International. 2013 Jul; 96(4):730-6. doi: 10.5740/jaoacint.11-073. [PMID: 24000744]
  • Kai Li, Jian Yao, Yuan Chi, Norifumi Sawada, Isao Araki, Masanori Kitamura, Masayuki Takeda. Eviprostat activates cAMP signaling pathway and suppresses bladder smooth muscle cell proliferation. International journal of molecular sciences. 2013 Jun; 14(6):12107-22. doi: 10.3390/ijms140612107. [PMID: 23743824]
  • Sweety Nasrin, Eiji Masuda, Haruna Kugaya, Yoshihiko Ito, Shizuo Yamada. Improvement by phytotherapeutic agent of detrusor overactivity, down-regulation of pharmacological receptors and urinary cytokines in rats with cyclophosphamide induced cystitis. The Journal of urology. 2013 Mar; 189(3):1123-9. doi: 10.1016/j.juro.2012.09.054. [PMID: 23000860]
  • Amir A Kuperman, Benjamin Brenner, Gili Kenet. Intraventricular hemorrhage in preterm infants and coagulation--ambivalent perspectives?. Thrombosis research. 2013 Jan; 131 Suppl 1(?):S35-8. doi: 10.1016/s0049-3848(13)70018-5. [PMID: 23452738]
  • Shizuo Yamada. Editorial comment to suppression of bladder overactivity and oxidative stress by the phytotherapeutic agent, Eviprostat, in a rat model of atherosclerosis-induced chronic bladder ischemia. International journal of urology : official journal of the Japanese Urological Association. 2012 Jul; 19(7):675; author reply 675. doi: 10.1111/j.1442-2042.2012.03076.x. [PMID: 22725604]
  • Takahiro Matsui, Michiko Oka, Tomomi Fukui, Mitsushi Tanaka, Tatsuya Oyama, Koji Sagawa, Masanori Nomiya, Osamu Yamaguchi. Suppression of bladder overactivity and oxidative stress by the phytotherapeutic agent, Eviprostat, in a rat model of atherosclerosis-induced chronic bladder ischemia. International journal of urology : official journal of the Japanese Urological Association. 2012 Jul; 19(7):669-75. doi: 10.1111/j.1442-2042.2012.03000.x. [PMID: 22458726]
  • Amir A Kuperman, Gili Kenet, Emmanuel Papadakis, Benjamin Brenner. Intraventricular hemorrhage in preterm infants: coagulation perspectives. Seminars in thrombosis and hemostasis. 2011 Oct; 37(7):730-6. doi: 10.1055/s-0031-1297163. [PMID: 22187395]
  • Fathalla Belal, Amina El-Brashy, Nahed El-Enany, Manar Tolba. Conventional and first derivative synchronous fluorometric determination of ethamsylate in pharmaceutical preparations and biological fluids. Application to stability studies. Journal of fluorescence. 2011 Jul; 21(4):1371-84. doi: 10.1007/s10895-010-0819-6. [PMID: 21347837]
  • Hiroyuki Tsunemori, Mikio Sugimoto, Zhang Xia, Rikiya Taoka, Michiko Oka, Yoshiyuki Kakehi. Effect of the phytotherapeutic agent Eviprostat on inflammatory changes and cytokine production in a rat model of nonbacterial prostatitis. Urology. 2011 Jun; 77(6):1507.e15-20. doi: 10.1016/j.urology.2011.02.017. [PMID: 21624608]
  • Mikio Sugimoto, Michiko Oka, Hiroyuki Tsunemori, Motoki Yamashita, Yoshiyuki Kakehi. Effect of a phytotherapeutic agent, Eviprostat®, on prostatic and urinary cytokines/chemokines in a rat model of nonbacterial prostatitis. The Prostate. 2011 Mar; 71(4):438-44. doi: 10.1002/pros.21299. [PMID: 21254154]
  • Hanwen Sun, Lijing Wei, Yuanyuan Wu, Na Liu. Simultaneous determination of aminomethylbenzoic acid, cefminox sodium and etamsylate in human urine by capillary electrophoresis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Jul; 878(21):1899-903. doi: 10.1016/j.jchromb.2010.05.017. [PMID: 20570576]
  • Seiji Matsumoto, Tadashi Hanai, Takahiro Matsui, Michiko Oka, Mitsushi Tanaka, Hirotsugu Uemura. Eviprostat suppresses urinary oxidative stress in a rabbit model of partial bladder outlet obstruction and in patients with benign prostatic hyperplasia. Phytotherapy research : PTR. 2010 Feb; 24(2):301-3. doi: 10.1002/ptr.2909. [PMID: 19585469]
  • Michiko Oka, Makoto Ueda, Tatsuya Oyama, Junko Kyotani, Mitsushi Tanaka. Effect of the phytotherapeutic agent Eviprostat on 17beta-estradiol-induced nonbacterial inflammation in the rat prostate. The Prostate. 2009 Sep; 69(13):1404-10. doi: 10.1002/pros.20985. [PMID: 19489033]
  • Mitsuhiro Tagaya, Michiko Oka, Makoto Ueda, Kazuchika Takagaki, Mitsushi Tanaka, Tadaaki Ohgi, Junichi Yano. Eviprostat suppresses proinflammatory gene expression in the prostate of rats with partial bladder-outlet obstruction: a genome-wide DNA microarray analysis. Cytokine. 2009 Sep; 47(3):185-93. doi: 10.1016/j.cyto.2009.06.004. [PMID: 19616448]
  • Michiko Oka, Tomomi Fukui, Makoto Ueda, Mitsuhiro Tagaya, Tatsuya Oyama, Mitsushi Tanaka. Suppression of bladder oxidative stress and inflammation by a phytotherapeutic agent in a rat model of partial bladder outlet obstruction. The Journal of urology. 2009 Jul; 182(1):382-90. doi: 10.1016/j.juro.2009.02.104. [PMID: 19447421]
  • Masayuki Tomita, Shin Egawa, Isao Ikemoto, Hiroshi Nakajo, Takashi Hatano, Shinichiro Kira, Toshihiko Mizuo, Yutaka Kagami. [One-week effects of Tamsulosin on benign prostatic hyperplasia assessed with a daily symptom score]. Hinyokika kiyo. Acta urologica Japonica. 2009 Apr; 55(4):193-7. doi: ". [PMID: 19462823]
  • Masahiro Tamaki, Masakazu Nakashima, Ryuichi Nishiyama, Hiroki Ikeda, Masaru Hiura, Toshio Kanaoka, Tadasu Nakano, Tadashi Hayashi, Osamu Ogawa. [Assessment of clinical usefulness of Eviprostat for benign prostatic hyperplasia--comparison of Eviprostat tablet with a formulation containing two-times more active ingredients]. Hinyokika kiyo. Acta urologica Japonica. 2008 Jun; 54(6):435-45. doi: ". [PMID: 18634442]
  • Takehito Naruoka, Yasuyuki Suzuki, Akira Furuta, Katsuhisa Endo, Shingo Sugaya, Shin Egawa. [Evaluation of supplemental administration of Eviprostat in patients with benign prostatic hyperplasia with persistent symptoms following treatment with alpha1-adrenoceptor blocker]. Hinyokika kiyo. Acta urologica Japonica. 2008 May; 54(5):341-4. doi: ". [PMID: 18546857]
  • Mizuki Kobayashi, Masayoshi Nomura, Hisae Nishii, Seiji Matsumoto, Naohiro Fujimoto, Tetsuro Matsumoto. Effect of eviprostat on bladder overactivity in an experimental cystitis rat model. International journal of urology : official journal of the Japanese Urological Association. 2008 Apr; 15(4):356-60. doi: 10.1111/j.1442-2042.2008.01999.x. [PMID: 18380828]
  • Kimio Sugaya, Saori Nishijima, Shinsuke Tasaki, Katsumi Kadekawa, Minoru Miyazato, Yoshihide Ogawa. Mechanisms by which a phytotherapeutic drug influences bladder activity in rats. The Journal of urology. 2008 Feb; 179(2):770-4. doi: 10.1016/j.juro.2007.09.023. [PMID: 18082195]
  • Michiko Oka, Masaki Tachibana, Kumiko Noda, Naoki Inoue, Mitsushi Tanaka, Kenji Kuwabara. Relevance of anti-reactive oxygen species activity to anti-inflammatory activity of components of eviprostat, a phytotherapeutic agent for benign prostatic hyperplasia. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2007 Aug; 14(7-8):465-72. doi: 10.1016/j.phymed.2007.04.006. [PMID: 17583488]
  • Nahed El-Enany, Fathalla Belal, Mohamed Rizk. Kinetic spectrophotometric determination of ethamsylate in dosage forms. Journal of AOAC International. 2007 May; 90(3):679-85. doi: NULL. [PMID: 17580619]
  • Jianguo Li, Huangxian Ju. Simultaneous determination of ethamsylate, tramadol and lidocaine in human urine by capillary electrophoresis with electrochemiluminescence detection. Electrophoresis. 2006 Sep; 27(17):3467-74. doi: 10.1002/elps.200600135. [PMID: 16892483]
  • Yi Song, Ning-chen Li, Xiao-feng Wang, Lu-lin Ma, Ben Wan, Bao-fa Hong, Yan-qun Na. [Clinical study of Eviprostat for the treatment of benign prostatic hyperplasia]. Zhonghua nan ke xue = National journal of andrology. 2005 Sep; 11(9):674-6. doi: NULL. [PMID: 16209208]
  • Steven A Kaplan. Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia. The Journal of urology. 2005 Sep; 174(3):1011. doi: 10.1097/01.ju.0000171855.70549.4e. [PMID: 16094031]
  • Maria Rosa Hernandez, Miriam Alvarez-Guerra, Ginés Escolar, Carlo Chiavaroli, Patrick Hannaert, Ricardo P Garay. The hemostatic agent ethamsylate promotes platelet/leukocyte aggregate formation in a model of vascular injury. Fundamental & clinical pharmacology. 2004 Aug; 18(4):423-30. doi: 10.1111/j.1472-8206.2004.00256.x. [PMID: 15312148]
  • Tomonori Yamanishi, Kosaku Yasuda, Takao Kamai, Toshihiko Tsujii, Ryuji Sakakibara, Tomoyuki Uchiyama, Ken-Ichiro Yoshida. Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia. International journal of urology : official journal of the Japanese Urological Association. 2004 Jul; 11(7):501-9. doi: 10.1111/j.1442-2042.2004.00844.x. [PMID: 15242359]
  • Patrick Hannaert, Miriam Alvarez-Guerra, Hamida Hider, Carlo Chiavaroli, Ricardo P Garay. Vascular permeabilization by intravenous arachidonate in the rat peritoneal cavity: antagonism by ethamsylate. European journal of pharmacology. 2003 Apr; 466(1-2):207-12. doi: 10.1016/s0014-2999(03)01545-0. [PMID: 12679158]
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  • M Ishigooka, T Hashimoto, S Hayami, M Tomaru, T Nakada, K Mitobe. Clinical and retrospective evaluation of Eviprostat: a non-hormonal and non-neuropharmacological agent for benign prostatic hyperplasia. International urology and nephrology. 1995; 27(1):61-6. doi: 10.1007/bf02575222. [PMID: 7542229]
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